The biological behavior of SDF-1/CXCR4 in patients with myelodysplastic syndrome

Medical Oncology

Volumn 29, Issue 2, 2012, Pages 1202-1208

  Yang, Rui ^a,b   Pu, Jie ^c   Guo, Juan ^a   Xu, Feng ^a   Zhang, Zheng ^a   Zhao, Youshan ^a,b   Zhang, Xi ^a   Gu, ShuCheng ^a   Chang, ChunKang ^a   Li, Xiao ^a  

^a SHANGHAI JIAO TONG UNIVERSITY AFFILIATED SIXTH PEOPLE S HOSPITAL   (China)

^b SOOCHOW UNIVERSITY   (China)

^c GUILIN MEDICAL UNIVERSITY   (China)

Author keywords

Adhesion; Migration; Myelodysplastic syndromes; SDF 1

Indexed keywords

CHEMOKINE RECEPTOR CXCR4; CHOLECYSTOKININ OCTAPEPTIDE; LIPOCORTIN 5; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLSERINE; STROMAL CELL DERIVED FACTOR 1; WORTMANNIN; CXCL12 PROTEIN, HUMAN; CXCR4 PROTEIN, HUMAN;

ACUTE GRANULOCYTIC LEUKEMIA; APOPTOSIS; ARTICLE; CELL ADHESION; CELL MIGRATION; CLINICAL ARTICLE; CYTOPENIA; HUMAN; HUMAN CELL; MYELODYSPLASTIC SYNDROME; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN BLOOD LEVEL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; BONE MARROW; CANCER GRADING; CASE CONTROL STUDY; CELL MOTION; COMPARATIVE STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; FLOW CYTOMETRY; METABOLISM; PATHOLOGY; STROMA CELL; TUMOR CELL CULTURE;

APOPTOSIS; BONE MARROW; CASE-CONTROL STUDIES; CELL ADHESION; CELL MOVEMENT; CHEMOKINE CXCL12; ENZYME-LINKED IMMUNOSORBENT ASSAY; FLOW CYTOMETRY; HUMANS; MYELODYSPLASTIC SYNDROMES; NEOPLASM GRADING; PHOSPHATIDYLINOSITOL 3-KINASES; RECEPTORS, CXCR4; SIGNAL TRANSDUCTION; SINCALIDE; STROMAL CELLS; TUMOR CELLS, CULTURED;

EID: 84866293640     PISSN: 13570560     EISSN: 1559131X     Source Type: Journal    
DOI: 10.1007/s12032-011-9943-7     Document Type: Article

References (26)

1. Federsppiel B, Melhado IG, Duncan AM, et al. Molecular cloning of the cDNA and chromosomalclocalization of the gene for a putative seven-transmembrane segment (7-TMS) receptor isolated from human spleen. Genomics. 1993;16(3):707-12.
2. Nagasawa T, Kikutani H, Kishimoto T. Molecular cloning and structure of a pre-B-cell growth-stimulating factor. Proc Natl Acad Sci USA. 1994;91(6):2305-9.
3. + progenitors to peripheral blood. J Exp Med. 1997;185(1):111-20.
4. Broxmeyer HE, Cooper S, Kohli L, et al. Transgenic expression of stromal cell-derived factor-1/CXC chemokine ligand 12 enhances myeloid progenitor cell survival/antiapoptosis in vitro in response to growth factor withdrawal and enhances myelopoiesis in vivo. J Immunol. 2003;170(1):421-9.
5. Peled A, Petit I, Kollet O, et al. Dependence of human stem cell engraftment and repopulation of NOD/SCID mice on CXCR4. Science. 1999;283(5403):845-8.
6. Lapidot T. Mechanism of human stem cell migration and repopulation of NOD/SCID and B2mnull NOD/SCID mice. Ann N Y Acad Sci. 2001;938:83-95.
7. Möhle R, Bautz F, Rafii S, Moore MAS, Brugger W, Kanz L. The chemokine receptor CXCR4 is expressed on CD34+ hematopoietic progenitors and leukemic cells and mediates transendothelial migration induced by stromal cell-derived factor-1. Blood. 1998;91(12):4523-30.
8. Lapidot T, Petit I. Current understanding of stem cell mobilization: the roles of chemokines, proteolytic enzymes, adhesion molecules, cytokines, and stromal cells. Exp Hematol. 2002;30(9): 973-81.
9. Petit I, Szyper-Kravitz M, Nagler A, et al. G-CSF induces stem cell mobilization by decreasing bone marrow SDF-1 and up-regulating CXCR4. Nat Immunol. 2002;3(7):687-94.
10. Shen H, Cheng T, Olszak I, et al. CXCR-4 desensitization is associated with tissue localization of hemopoietic progenitor cells. J Immunol. 2001;166(8):5027-33.
11. Hanada M, Feng J, Hemmings BA. Structure, regulation and function of PKB/AKT-a major therapeutic target. Biochim Biophys Acta. 2004;1697(1-2):3-16.
12. Vanhaesebroeck B, Leevers SJ, Ahmadi K, et al. Synthesis and function of 3-phosphorylated inositol lipids. Annu Rev Biochem. 2001;70:535-602.
13. Liang Z, Brooks J, Willard M, et al. CXCR4/CXCL12 axis promotes VEGF-mediated tumor angiogenesis through Akt signaling pathway. Biochem Biophys Res Commun. 2007;359(3): 716-22.
14. Greenberg P, Cox C, LeBeau MM, et al. International scoring system for evaluating prognosis in myelodysplastic syndromes. Blood. 1997;89(6):2079-88.
15. + progenitors from MDS patients are unresponsive to SDF-1, despite high levels of SDF-1 in bone marrow plasma. Leukemia. 2004;18(5): 1038-40.
16. Broxmeyer HE, Cooper S, Hangoc G, et al. Stromal cell-derived factor-1/CXCL12 selectively counteracts inhibitory effects of myelosuppressive chemokines on hematopoietic progenitor cell proliferation in vitro. Stem Cells Dev. 2005;14(2):199-203.
17. Broxmeyer HE, Kohli L, Kim CH, et al. Stromal cell-derived factor-1/CXCL12 directly enhances survival/antiapoptosis of myeloid progenitor cells through CXCR4 and G(alpha)i proteins and enhances engraftment of competitive, repopulating stem cells. J Leukoc Biol. 2003;73(5):630-8.
18. Yin Q, Jin P, Liu X, et al. SDF-1a inhibits hypoxia and serum deprivation-induced apoptosis in mesenchymal stem cells through PI3K/Akt and ERK1/2 signaling pathways. Mol Biol Rep. 2011;38(1):9-16.
19. Fuhler GM, Drayer AL, Vellenga E. Decreased phosphorylation of protein kinase B and extracellular signal-regulated kinase in neutrophils from patients with myelodysplasia. Blood. 2003; 101(3):1172-80.
20. +cells from patients with myelodysplasia. Blood. 2008;111(1):359-68.
21. Zhang W, Zhung X, Fan X, et al. Effect of ICAM-1 and LFA-1 in hyperleukocytic acute myeloid leukaemia. Clin Lab Haematol. 2006;28(3):177-82.
22. Kimura T, Boehmler AM, Seitz G, et al. The sphingosine 1-phosphate receptor agonist FTY720 supports CXCR4-dependent migration and bone marrow homing of human CD34+ progenitor cells. Blood. 2004;103(12):4478-86.
23. Li S, Deng L, Gong L, et al. Upregulation of CXCR4 favoring neural-like cells migration via AKT activation. Neurosci Res. 2010;67(4):293-9.
24. Bleul CC, Fuhlbrigge RC, Casasnovas JM, et al. A highly efficacious lymphocyte chemoattractant, stromal cell-derived factor 1 (SDF-1). J Exp Med. 1996;184(3):1101-9.
25. Dutt P, Wang JF, Groopman JE. Stromal cell-derived factor-1 alpha and stem cell factor/kit ligand share signaling pathways in hemopoietic progenitors: a potential mechanism for cooperative induction of chemotaxis. J Immunol. 1998;161(7):3652-8.
26. Kim CH, Broxmeyer HE. In vitro behavior of hematopoietic progenitor cells under the influence of chemoattractants: stromal cell-derived factor-1, steel factor, and the bone marrow environment. Blood. 1998;91(1):100-10.