CD34+ progenitors from MDS patients are unresponsive to SDF-1, despite high levels of SDF-1 in bone marrow plasma [8]

Leukemia

Volumn 18, Issue 5, 2004, Pages 1038-1040

  Matsuda, M ^a   Morita, Y ^a   Hanamoto, H ^a   Tatsumi, Y ^a   Maeda, Y ^a   Kanamaru, A ^a  

^a KINKI UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CD34 ANTIGEN; CHEMOKINE; CHEMOKINE RECEPTOR CXCR4; STROMAL CELL DERIVED FACTOR 1; ALPHA CHEMOKINE;

ADULT; AGED; APOPTOSIS; BONE MARROW; BONE MARROW BIOPSY; CELL SEPARATION; CLINICAL ARTICLE; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; FLOW CYTOMETRY; HEMATOPOIESIS; HUMAN; HUMAN CELL; IMMUNOMAGNETIC SEPARATION; LETTER; MALE; MONONUCLEAR CELL; MYELODYSPLASTIC SYNDROME; PRIORITY JOURNAL; STEM CELL; BLOOD; CHEMOTAXIS; HEMATOPOIETIC STEM CELL; MIDDLE AGED; PHYSIOLOGY;

ADULT; AGED; ANTIGENS, CD34; APOPTOSIS; CHEMOKINES, CXC; CHEMOTAXIS; FEMALE; HEMATOPOIETIC STEM CELLS; HUMANS; MALE; MIDDLE AGED; MYELODYSPLASTIC SYNDROMES; RECEPTORS, CXCR4;

EID: 2342473250     PISSN: 08876924     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.leu.2403301     Document Type: Letter

References (8)

1. Jacob A, Clark RE. Pathogenesis and clinical variations in the myelodysplastic syndromes. Clin Haematol 1986; 15: 925-951.
2. Yoshida Y. Hypothesis: apoptosis may be the mechanism responsible for the premature intramedullary cell death in the myelodysplastic syndrome. Leukemia 1993; 7: 144-146.
3. Rollins BJ. Chemokines. Blood 1997; 90: 909-928.
4. Nagasawa T, Hirota S, Tachibana K, Takakura N, Nishikawa S, Kitamura Y et al. Defects of B-cell lymphopoiesis and bone-marrow myelopoiesis in mice lacking the CXC chemokine PBSF/SDF-1. Nature 1996; 382: 635-638.
5. + progenitors to peripheral blood. J Exp Med 1997; 185: 111-120.
6. Broxmeyer HE, Cooper S, Kohli L, Hangoc G, Lee Y, Mantel C et al. Transgenic expression of stromal cell-derived factor-1/CXC chemokine ligand 12 enhances myeloid progenitor cell survival/antiapoptosis in vitro in response to growth factor withdrawal and enhances myelopoiesis in vivo. J Immunol 2003; 170: 421-429.
7. Greenberg P, Cox C, LeBeau MM, Fenaux P, Morel P, Sanz G et al. International scoring system for evaluating prognosis in myelodysplastic syndromes. Blood 1997; 89: 2079-2088.
8. Parker JE, Mufti GJ, Rasool F, Mijovic A, Devereux S, Pagliuca A. The role of apoptosis, proliferation, and the Bcl-2-related proteins in the myelodysplastic syndromes and acute myeloid leukemia secondary to MDS. Blood 2000; 96: 3932-3938.