Diabetes, metallothionein, and zinc interactions: A review

BioFactors

Volumn 29, Issue 4, 2007, Pages 203-212

  Islam, Md Shahidul ^a   Loots, Du Toit ^a  

^a NORTH WEST UNIVERSITY   (South Africa)

Author keywords

Diabetes; Metallothionein; Oxidative stress; Reactive oxygen species; Zinc

Indexed keywords

METALLOTHIONEIN; ZINC;

DIABETES MELLITUS; DISEASE ASSOCIATION; DNA DAMAGE; HUMAN; HYPERGLYCEMIA; IN VIVO STUDY; KNOCKOUT MOUSE; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN SYNTHESIS; REVIEW; ZINC DEFICIENCY;

ANIMALS; ANTIOXIDANTS; DIABETES COMPLICATIONS; DIABETES MELLITUS; DIETARY SUPPLEMENTS; HUMANS; METALLOTHIONEIN; MICE; OXIDATIVE STRESS; RATS; TRACE ELEMENTS; ZINC;

ANIMALIA; MUS;

EID: 36549010010     PISSN: 09516433     EISSN: None     Source Type: Journal    
DOI: 10.1002/biof.5520290404     Document Type: Review

References (99)

1. J. Abel and N. de Ruiter, Inhibition of hydroxyl-radical-generated DNA degradation by metallothionein, Toxicol Lett 47 (1989), 191-196.
2. Y. Adachi, J. Yoshida, Y. Kodera, T. Kiss, T. Jakusch, E.A. Enyedy, Y. Yoshikawa and H. Sakurai, Oral administration of a zinc complex improves type diabetes and metabolic syndromes, Biochem Biophys Res Commun 351 (2006), 165-170.
3. R.A. Al-Maroof and S.S. Al-Sharbatti, Serum zinc levels in diabetic patients and effect of zinc supplementation on glycemic control of type 2 diabetes, Saudi Med J 27 (2006), 344-350.
4. American Diabetes Association, Standards of medical care for patients with diabetes mellitus, Diabetes Care 1 (2001), S100-S108.
5. A.F. Amos, D.J. McCarty and P. Zimmet, The rising global burden of diabetes and its complications: estimates and projections by 2010, Diabetic Med 14 (1997), S5-85.
6. G.K. Andrews, K. Kage, P. Paliter-Thomas and M.P. Sarras, Metal ions induced expression of metallothionein in pancreatic exocrine and endocrine cells, Pancreas 5 (1990), 548-554.
7. M.D. Apostolova, K.H. Choo, A.E. Michalska and C. Tohyama, Analysis of the possible protective role of metallothionein in streptozotocin-induced diabetes using metallothionein-null mice, J Trace Elem Med Biol 11 (1997), 1-7.
8. P. Arda-Pirincci, S. Bolkent and R. Yanardag, The role of zinc sulfate and metallothionein in protection against ethanol-induced gastric damage in rats, Dig Dis Sci 51 (2006), 2353-2360.
9. P.V.A. Babu, K.E. Sabitha and C.S. Shyamaladevi, Therapeutic effect of green tea on oxidative stress in aorta and heart of streptozotocin diabetic rats, Chico-Biol Int 162 (2006), 114-120.
10. M.N. Batista, L. Cuppari, C. de Fatima, L. Pedrosa, M.G. Almeida, J.B. de Almeida, A.C. de Medeiros and M.E. Canziani, Effect of end-stage renal disease and diabetes on zinc and copper status, Biol Trace Elem Res 112 (2006), 1-12.
11. M. Beltramini, P. Zambenedetti, M. Raso, M.I. Ibnlkayat, P. Zatta, The effect of Zn(II) and streptozotocin administration in the mouse brain, Brain Res, 1109 (2006), 207-218.
12. P.A. Binz and J.H.R. Kagi, Metallothionein: molecular evolution and classification, in: Metallothionein IV, C.D. Klaassen, ed., Birkhauser Verlag, Basel, 1997.
13. S. Bolkent, R. Yanardag, S. Bolkent, O. Mutlu, S. Yildirim, K. Kangawa, Y. Minegishi and H. Suzuaki, The effect of zinc supplementation on ghrelin-mmunoreactive cells and lipid parameters in gastrointestinal tissue of streptozotocin-induced female diabetic rats, Mol Cell Biochem 286 (2006), 77-85.
14. C. Brugnara, Iron deficiency and erythropoiesis: new diagnostic approaches, Clin Chem 49 (2003), 1573-1578.
15. L. Cai, J. Wang, Y. Li, X. Sun, L. Wang, Z. Zhou and Y.J. Kang, Inhibition of superoxide generation and associated nitrosative damage is involve in metallothionein prevention of diabetic cardiomyopathy, Diabetes 54 (2005), 1829-1837.
16. L. Cai and M.G. Cherian, Zinc-metallothionein protects from DNA damage induced by radiation better than glutathion and copper- or cadmium- metallothioneins, Toxicol Lett 136 (2003), 193-198.
17. L. Cai, Suppression of nitrative damage by metallothionein in diabetic heart contributes to the prevention of cardiomyopathy, Free Radic Biol Med 41 (2006), 851-861.
18. L. Cai, X.K. Li, Y. Song and M.G. Cherian, Essentiality and toxicology of zinc and copper and its chelation therapy, Curr Medicinal Chem 12 (2005), 2753-2763.
19. L. Cai, Y. Wang, G. Zhou, T. Chen, Y. Song, X. Li and Y.J. Kang, Attenuation by metallothionein of early cardiac cell death via suppression of mitochondrial oxidative stress results in a prevention of diabetic cardiomyopathy, J Am Coll Cardiol 48 (2006), 1688-1697.
20. A.B. Chausmer, Zinc, insuline and diabetes, J Am Coll Nutr 17 (1998), 109-115.
21. H. Chen, E.C. E.C. Carlson, L. Pellet, J.T. Moritz, P.N. Epstein, Over expression of metallothionein in pancreatic β-cells reduces streptozotocin-induced DNA damage and diabetes, Diabetes 50 (2001), 2040-2046.
22. W.Q. Chen, Y.Y. Cheng, X.L. Zhao, S.T. Li, Y. Hou and Y. Hong, Effects of zinc on the induction of metallothionein isoforms in hippocampus in stress rats, Exp Biol Med (Maywood) 231 (2006), 1564-1568.
23. J.E. Coleman, Zinc proteins: enzymes, storage proteins, transcription factors, and replication proteins, Annu Rev Biochem 61 (1992), 897-946.
24. R.J. Cousins, Toward a molecular understanding of zinc metabolism, Clin Phyiol Biochem 4 (1986), 20-30.
25. P. Coyle, J.C. Philcox, L.C. Carey and A.M. Rofe, Metallothionein: the multipurpose protein, Cell Mol Life Sci 59 (2002), 627-647.
26. N.E. Craft and M.L. Failla, Zinc, iron, and copper absorption in the streptozotocin-diabetic rat, Am J Physiol 244 (1983), E122-E128.
27. J.J. Cunningham, A. Fu, P.L. Mearkle and R.G. Brown, Hiperzincuria in individuals with insulin-dependent diabetes mellitus: concurrent zinc status and the effect of high-dose zinc supplementation, Metabolism 43 (1994), 1558-1562.
28. R.C. De Lisle, M.P. Sarras, J. Hidalgo and G.K. Andrews, Metallothionein is a component of exocrine pancreas secretion: implications for zinc homeostasis, Am J Physiol 271 (1996), C1103-C1110.
29. O. Escobar, M. Sandoval, A. Vargas and J.M. Hempe, Role of metallothionein and cysterie rich intestinal protein in the regulation of zinc absorption by diabetic rats, Pediatr Res 37 (1995), 321-327.
30. G.W. Evans, Transferrin function in zinc absorption and transport, Proc Soc Exp Biol Med 151 (1976), 775-778.
31. P. Faure, Protective effects of antioxidant micronutrients (vitamin E, zinc and selenium) in type 2 diabetes mellitus, Clin Chem Lab Med 41 (2003), 995-998.
32. J.C. Fleet, G.K. Andrews and C.C. McCormick, Iron-induced metallothionein in chick liver: a rapid, route-dependent effect independent of zinc status, J Nutr 120 (1990), 1214-1222.
33. C.J. Frederickson, M.D. Hernandez and J.F. McGinty, Translocation of zinc may contribute to seizure-induced death of neurons, Brain Res 480 (1989), 317-321.
34. L.E. Fridlyand and L.H. Philipson, Reactive oxygen species and early manifestation of insulin resistance in type 2 diabetes, Diabetes Obes Metab 8 (2006), 136-145.
35. L. Gille, P. Schott-Ohly, N. Fresen, I.M. Schulte, S. Walde, N. Udilova, H. Nowl and H. Gleichmann, Generation of hydroxyl radicals mediated by streptozotocin in pancreatic islets of mice in vitro, Pharmcol Toxicol 90 (2002), 317-326.
36. D.A. Greene and S.A. Lattimer, The polyol pathway in dysfunction of diabetic peripheral nerve, Diabetic Med 2 (1985), 206-210.
37. F. Haq, M. Mahoney and J. Koropatnick, Signaling events for metallothionein induction, Mutat Res 533 (2003), 211-226.
38. M.A. Hayee, Q.D. Mohammad and A. Haque, Diabetic neuropathy and zinc therapy, Bangladesh Med Res Counc Bull 31 (2005), 62-67.
39. J. Hidalgo, M. Aschner, P. Zatta and M. Vasak, Roles of the metallothionein family of proteins in the central nervous system, Brain Res Bull 55 (2001), 133-145.
40. E. Ho, N. Quan, Y.H. Tsai, W. Lai and T.M. Bray, Dietary zinc supplementation inhibits NfkappaB activation and protects against chemically induced diabetes in CD1 mice, Exp Biol Med (Maywood) 226 (2001), 103-111.
41. N. Houstis, E.D. Rosen and E.S. Lander, Reactive oxygen species have a causal role in multiple forms of insulin resistance, Nature 440 (2006), 944-948.
42. J.V. Hunt, C.C. Smith and S.P.Wolff, Autoxidation glycosylation and possible involvement of peroxides and free radicals in LDL modification by glucose, Diabetes 39 (1990), 1420-1424.
43. S.A. Hussain, H.M. Khadim, B.H. Khalaf, S.H. Ismail, K.I. Hussain and A.S. Sahib, Effects of melatonin and zinc on glycemic control in type 2 diabetic patients poorly controlled with metformin, Saudi Med J 27 (2006), 1483-488.
44. M. Iqbal, R. Noor, R. Mizuno and S. Okada, Protective role of zinc-metallothionein (Zn-MT) in iron nitrilotriacetate (Fe-NTA)-induced renal oxidative damage, Redox Rep 8 (2003), 163-167.
45. D. Jay, H. Hitomi, K. Kobayashi and K.K. Griendling, Oxidative stress and diabetic cardiovascular complications, Free Radic Biol Med 40 (2006), 183-192.
46. T. Jensen, S. Stender and T. Deckert, Abnormalities in plasmas concentrations of lipoproteins and fibrinogen in type 1 (insulin-dependent) diabetic patients with increased urinary albumin excretion, Diabetologia 31 (1988), 142-145.
47. H. Kaneto, N. Katakami, D. Kawamori, T. Miyatsuka, K. Sakamoto, T.A. Matsuoka, M. Matsuhisa and Y. Yamasaki, Involvement of oxidative stress in the pathogenesis of diabetes, Antoxid Redox Signal (Jan 1, 2007), (Epub ahead of print).
48. B.J. Kim, Y.H. Kim, S. Kim, J.W. Kim, J.Y. Koh, S.H. Oh, M.K. Lee, K.W. Kim and M.S. Lee, Zinc as a paracrine effector in pancreatic islets cell death, Diabetes 49 (2000), 367-372.
49. K. Kobayashi, J. Kuroda, N. Shibata, T. Hasegawa, Y. Seko, M. Satoh, C. Tohyama, H. Takano, N. Imura, K. Sakabe, H. Fujishiro and S. Himeno, Induction of metallothionein by manganese is completely dependent on interleukin-6 production, J Pharmacol Exp Ther 320 (2006), 721-727.
50. J.Y. Koh, S.W. Suh, B.J. Gwag, Y.Y. He, C.Y. Hsu and D.W. Choi, The role of zinc in selective neuronal death after transient global cerebral ischemia, Science 272 (1996), 1013-1016.
51. K. Komosinska-Vassev, K. Otczyk, P. Olczyk and K. Winsz-Szczotaka, Effects of metabolic control and vascular complications on indices of oxidative stress in type 2 patients, Diabetes Res Clin Pract 68 (2005), 207-216.
52. J. Koropatnick and R.K. Zalups, Toxic and essential metals in the cellular response to signals, in: Molecular Biology and Toxicology of Metals, Taylor and Francis, London, UK, 2000, pp. 551-576.
53. E. Kurtoglu, A. Ugur, A.K. Baltaci and L. Undar, Effect of iron supplementation on oxidative stress and antioxidant status in iron-deficiency anemia, Biol Trace Elem Res 96 (2003), 117-123.
54. X. Li, H. Chen and P.N. Epstein, Metalloprotein protects islets from hypoxia and extends islet graft survival by scavenging most kind of reactive oxygen species, J Biol Chem 279 (2004), 765-771.
55. Q. Liang, E.C. Carlson, R.V. Donthi, P.M. Kralik, X. Shen and P.N. Epstein, Overexperession of metallothionein reduces diabetic cardiomyopathy, Diabetes 51 (2002), 174-181.
56. W. Maret and H.H. Sandstead, Zinc requirements and the risks of benefits of zinc supplementation, J Trace Elem Med Biol 20 (2006), 3-18.
57. V. Marie, P. Gonzalez, M. Baudrimont, I. Boutet, D. Moraga, J.P. Bourdineaud and A. Boudou, Metallothionein gene expression and protein levels in triploid and diploid oysters Crassostrea gigas after exposure to cadmium and zinc, Environ Toxicol Chem 25 (2006), 412-418.
58. G. Marra, P. Cotroneo, D. Pitocco, A. Manto, M.A. Di Leo, V. Ruotolo, S. Caputo, B. Giardina, G. Ghirlanda and S.A. Santini, Early increase of oxidative stress and reduced antioxidant defenses in patients with uncomplicated type 1 diabetes: a case for gender difference, Diabetes Care 25 (2002), 370-375.
59. H. Masaki, Y. Ochiai, Y. Okano, A. Yagami, H. Akamatsu, K. Matsunaga, H. Sakurai and K. Suzuki, A zinc(II)-glycine complex is an effective inducer of metallothionein and removes oxidative stress, J Dermatol Sci 45 (2007), 73-75.
60. P. Masiello, Animal model of type 2 diabetes with reduced pancreatic beta-cell mass, Int J Biochem Cell Biol 38 (2006), 873-893.
61. C.C. McCormick, Induction and accumulation of metallothionein in liver and pancreas of chicks given oral zinc: a tissue comparison, J Nutr 114 (1984), 191-203.
62. M.P. Menard and R.J. Cousins, Zinc transport by brush border membrane vesicles from rat intestine, J Nutr 113 (1983), 1434-1442.
63. A.T. Miles, G.M. Hawksworth, J.H. Beattie and V. Rodilla, Induction, regulation, degradation, and biological significance of mammalian metallothioneins, Crit Rev Biochem Biol 135 (2000), 35-70.
64. T. Minami, M. Shimizu, H. Tanaka, Y. Okazaki and M.G. Cherian, Metalothionein does not protect mouse endocrine cells from damage induced by alloxan injection, Toxicology 132 (1999), 33-41.
65. B.L. O'Dell, Cysteine-rich intestinal protein (CRIP): a new intestinal zinc transport protein, Nutr Rev 50 (1992), 232-233.
66. P. Ohly, C. Dohle, J. Abel, J. Seissler and H. Gleichmann, Zinc sulphate induces metallothionein in pancreatic islets of mice and protects against diabetes induced multiple low doses of streptozotocin, Diabetologia 43 (2000), 1020-1030.
67. P. Ohly, Z. Wang, J. Abel and H. Gleichmann, Zinc sulphate induced metallothionein in pancreatic islets and protected against the diabetogenic toxin streptozotocin, Talanta 46 (1998), 355-359.
68. G. Partida-Hernandez, F. Arreola, B. Fenton, M. Cabeza, R. Romman-Ramos and M.C. Revilla-Monsalve, Effect of zinc replacement on lipids and lipoproteins in type 2 diabetic patients, Biomed Pharmacother 60 (2006), 161-168.
69. S. Penckofer, D. Schwertz and K. Florczak, Oxidative stress and cardiovascular disease in type 2 diabetes: the role of antioxidants and pro-oxidants, J Cardivasc Nurs 16 (2002), 68-85.
70. M. Penkowa, Metallothionein expression and roles in the central nervous system, Biomed Rev 13 (2002), 1-15.
71. O. Pinhas-Hamiel and O. Zeitler, The global spread of type 2 diabetes mellitus in children and adolescents, J Pediatr 146 (2005), 693-700.
72. A.S. Prasad, Zinc deficiency in women, infants and children, J Am Coll Nutr 15 (1996), 113-120.
73. D. Quilliot, E. Walter, J.P. Bonte, J.C. Fruchart, P. Duriez and O. Ziegler, Diabetes mellitus worsen antioxidant status in patients with chronic pancreatitis, Am J Clin Nutr 81 (2005), 1111-1117.
74. F. Radtke, R. Heuchel, O. Georgiev, M. Hergersberg, M. Gariglio, Z. Dembic and W. Schaffner, Cloned transcription factor MTF-1 activates the mouse metallothionein I promoter, EMBO J 12 (1993), 1355-1362.
75. J. Rao and V. Jagadeesan, Lipid peroxidation and activities of antioxidant enzymes in iron deficiency and effect of carcinogen feeding, Free Radic Biol Med 21 (1996), 103-108.
76. M.P. Richards and R.J. Cousins, Metallothionein and its relationship to the metabolism of dietary zinc in rats, J Nutr 106 (1976), 1591-1599.
77. R. Ross, The pathogenesis of atherosclerosis: an update, N Engl J Med 314 (1986), 488-500.
78. H.P. Roth and M. Kirchgessner, Zn metalloenzyme activities. Changes and biochemical aspects in Zn deficiency, World Rev Nutr Diet 34 (1980), 144-160.
79. C. Scheede-Bergdahl, M. Pendowa, J. Hidlgo, D.B. Olsen, P. Schjerling, C. Prats, R. Boushel, P. Schott-Ohly, A. Lgssiar, H.J. Partke, M. Hassan, N. Friensen and H. Gleichmann, Prevention of spontaneous and experimentally induced diabetes in mice with zinc sulphate-enriched drinking water is associated with activation and reduction of NFkB and AP-1 in islets, respectively, Exp Biol Med 229 (2004), 1177-1185.
80. +) and inhibition of glycolysis, J Neurosci 20 (2000), 3139-3146.
81. Y. Song, J, Wang, Y. Li, Y. Du, G.E. Arteel, J.T. Aaari, Y.J. Knag and L. Cai, Cardiac metallothionein synthesis in streptozotocin-induced diabetic mice, and its protection against diabetes-induced cardiac injury, Am J Pathol 167 (2005), 17-26.
82. D.L. Tallman and C.G. Taylor, Potential interactions of zinc in the neuroendocrine-endocrine disturbances of diabetes mellitus type 2, Can J Physiol Pharmacol 77 (1999), 919-933.
83. C.G. Taylor, Zinc, the pancreas, and diabetes: insights from rodent studies and future directions, Biometals 18 (2005), 305-312.
84. M. Tiedge, S. Lortz, J. Drinkgern and S. Lenzen, Relation between antioxidant enzyme gene expression and antioxidative defense status of insulin-producing cells, Diabetes 46 (1997), 1733-1742.
85. N. Tonder, F.F. Johansen, C.J. Frederickson, J. Zimmer and N.H. Dremer, Possible role of zinc in the selective degeneration of dentate hilar neurons after cerebral ischemia in the adult rats, Neurosci Lett 109 (1990), 247-252.
86. C.D. Tran, H. Huynh, F. Campbell, P. Coyle and R. Butler, Metallothionein-null mouse: a potential model of helicobacter pylori-induced gastritis, J Gastroenterol Hepatol 16S (2001), A122.
87. H. Tsubouchi, T. Inoguchi, T. Sonta, N. Sato, N. Sekiguchi, K. Kobayashi, H. Smimoto, H. Utsumi and H. Nawata, Statin attenuates high glucose-induced and diabetes-induced oxidative stress in vitro and in vivo evaluated by electron spin resonance measurement, Free Radic Biol Med 39 (2005), 444-452.
88. R. Tudor, P.D. Zalewski and R.N. Ratnaike, Zinc in health and chronic disease, J Nutr Health Aging 9 (2005), 45-51.
89. J. Umbreit, Iron deficiency: a concise review, Am J Hematol 78 (2005), 225-231.
90. M. Umeta, C.E. West, H. Verhoef, J. Haidar and J.G. Hautvast, Factors associated with stunting in infants aged 5-11 months in the Dodota-Sire District, rural Ethiopia, J Nutr 133 (2003), 1064-1069.
91. M. Valko, D. Leibfritz, J. Mocol, M.T. Cronin, M. Mazur and J. Telser, Free radicals and antioxidants in normal physiological functions and human disease, Int J Biochem Cell Biol 39 (2007), 44-84.
92. B.L. Vallee and K.H. Falchuk, The biochemical basis of zinc physiology, Physiol Rev 73 (1993), 79-118.
93. J. Wang, Y. Song, L. Elsherif, Z. Song, G. Shou, S.D. Prabhu, J.T. Saari and L. Cai, Cardiac metallothionein induction plays the major role in the prevention of diabetic cardiomyopathy by zinc supplementation, Circulation 113 (2006), 544-554.
94. WHO/Acadia, Rapport de la journe internationale de, Diabetes, 14 October 1992.
95. World Health Organization (WHO) report, Global strategy on diet, physical activity and health, 2000.
96. J. Yang and M.G. Cherian, Protective effects of metallothionein on streptozotocin-induced diabetes in rats, Life Sci 55 (1994), 43-51.
97. G. Ye, N.S. Metreveli, J. Ren and P.N. Epstein, Metallothionein prevents diabetes-induced deficits in cardiomyocytes by inhibiting reactive oxygen species production, Diabetes 52 (2003), 777-783.
98. Y. Yoshikawa, Y. Adachi and H. Sakurai, A new type of orally active anti-diabetic Zn(II)-dithiocarbamate complex, Life Sci 80 (2006), 759-766.
99. S. Zimny, F. Gogolin, J. Abel and H. Gleichmann, Metallothionein in isolated pancreatic islets of mice: induction by zinc and streptozotocin, a naturally occurring diabetogen, Arch Toxicol 67 (1993), 61-65.