Insulin sensitization with a peroxisome proliferator-activated receptor γ agonist prevents adrenocortical lipid infiltration and secretory changes induced by a high-sucrose diet

Journal of Endocrinology

Volumn 214, Issue 3, 2012, Pages 267-276

  Calejman, Camila Martinez ^a   Di Gruccio, Juan M ^a   Mercau, María E ^a   Repetto, Esteban M ^a   Astort, Francisco ^a   Sanchez, Rocío ^a   Pandolfi, Matías ^b   Berg, Gabriela ^b   Schreier, Laura ^b   Arias, Pablo ^c   Cymeryng, Cora B ^a  

^a Centre de Estudios Farmacologicos y Botanicos   (Argentina)

^b UNIVERSIDAD DE BUENOS AIRES   (Argentina)

^c UNIVERSIDAD NACIONAL DE ROSARIO   (Argentina)

Author keywords

[No Author keywords available]

Indexed keywords

CD36 ANTIGEN; CORTISONE; GLUCOSE; INSULIN; LIPID; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA AGONIST; ROSIGLITAZONE; SUCROSE; TRIACYLGLYCEROL;

ADIPOSE TISSUE; ADRENAL CORTEX FUNCTION; ADRENAL GLAND; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BODY WEIGHT; CALORIC INTAKE; CONTROLLED STUDY; FLUID INTAKE; GLUCOSE BLOOD LEVEL; HISTOCHEMISTRY; HORMONE RELEASE; INSULIN RESISTANCE; INSULIN SENSITIVITY; MALE; NONHUMAN; PRIORITY JOURNAL; RADIOIMMUNOASSAY; RAT; REAL TIME POLYMERASE CHAIN REACTION; STAINING; TRIACYLGLYCEROL BLOOD LEVEL;

ADRENAL CORTEX; ADRENOCORTICOTROPIC HORMONE; ANIMALS; CORTICOSTERONE; DIETARY SUCROSE; ENERGY INTAKE; HORMONES; HYPOGLYCEMIC AGENTS; INSULIN; INSULIN RESISTANCE; LIPID METABOLISM DISORDERS; MALE; PPAR GAMMA; RATS; RATS, WISTAR; THIAZOLIDINEDIONES; TRIGLYCERIDES;

EID: 84866271497     PISSN: 00220795     EISSN: 14796805     Source Type: Journal    
DOI: 10.1530/JOE-12-0193     Document Type: Article

References (59)

1. Bernal CA, Gutman RA & Lombardo YB 1995 The duration of feeding on a sucrose-rich diet determines variable in vitro effects of insulin and fructose on rat liver triglyceride metabolism. Journal of Nutritional Biochemistry 6 422-430.
2. Betz MJ, Shapiro I, Fassnacht M, Hahner S, Reincke M & Beuschlein F 2005 Peroxisome proliferator-activated receptor-g agonists suppress adrenocortical tumor cell proliferation and induce differentiation. Journal of Clinical Endocrinology and Metabolism 90 3886-3896.
3. Bjorntorp P & Rosmond R 1999 Visceral obesity and diabetes. Drugs 58 (Suppl 1) 13-18 (discussion 75-82).
4. Bornstein SR, Rutkowski H & Vrezas I 2004 Cytokines and steroidogenesis. Molecular and Cellular Endocrinology 215 135-141.
5. Bray GA, Nielsen SJ & Popkin BM 2004 Consumption of high-fructose corn syrup in beverages may play a role in the epidemic of obesity. American Journal of Clinical Nutrition 79 537-543.
6. Buchenauer T, Behrendt P, Bode FJ, Horn R, Brabant G, Stephan M & Nave H 2009 Diet-induced obesity alters behavior as well as serum levels of corticosterone in F344 rats. Physiology & Behavior 98 563-569.
7. Bugger H & Abel ED 2008 Molecular mechanisms for myocardial mitochondrial dysfunction in the metabolic syndrome. Clinical Science 114 195-210.
8. Cano P, Jimenez-Ortega V, Larrad A, Reyes Toso CF, Cardinali DP & Esquifino AI 2008 Effect of a high-fat diet on 24-h pattern of circulating levels of prolactin, luteinizing hormone, testosterone, corticosterone, thyroid-stimulating hormone and glucose, and pineal melatonin content, in rats. Endocrine 33 118-125.
9. Chicco A, D'Alessandro ME, Karabatas L, Pastorale C, Basabe JC & Lombardo YB 2003 Muscle lipid metabolism and insulin secretion are altered in insulin-resistant rats fed a high sucrose diet. Journal of Nutrition 133 127-133.
10. Consitt LA, Bell JA & Houmard JA 2009 Intramuscular lipid metabolism, insulin action, and obesity. IUBMB Life 61 47-55.
11. Cymeryng CB, Dada LA & Podesta EJ 1998 Effect of nitric oxide on rat adrenal zona fasciculata steroidogenesis. Journal of Endocrinology 158 197-203.
12. Dallman MF, la Fleur SE, Pecoraro NC, Gomez F, Houshyar H & Akana SF 2004 Minireview: glucocorticoids - food intake, abdominal obesity, and wealthy nations in 2004. Endocrinology 145 2633-2638.
13. Ehrhart-Bornstein M, Lamounier-Zepter V, Schraven A, Langenbach J, Willenberg HS, Barthel A, Hauner H, McCann SM, Scherbaum WA & Bornstein SR 2003 Human adipocytes secrete mineralocorticoid-releasing factors. PNAS 100 14211-14216.
14. Engstrom L, Rosen K, Angel A, Fyrberg A, Mackerlova L, Konsman JP, Engblom D & Blomqvist A 2008 Systemic immune challenge activates an intrinsically regulated local inflammatory circuit in the adrenal gland. Endocrinology 149 1436-1450.
15. Grayson BE, Levasseur PR, Williams SM, Smith MS, Marks DL & Grove KL 2010 Changes in melanocortin expression and inflammatory pathways in fetal offspring of nonhuman primates fed a high-fat diet. Endocrinology 151 1622-1632.
16. Harms PG & Ojeda SR 1974 A rapid and simple procedure for chronic cannulation of the rat jugular vein. Journal of Applied Physiology 36 391-392.
17. Jessop DS, Dallman MF, Fleming D & Lightman SL 2001 Resistance to glucocorticoid feedback in obesity. Journal of Clinical Endocrinology and Metabolism 86 4109-4114.
18. Jiang G, Dallas-Yang Q, Li Z, Szalkowski D, Liu F, Shen X, Wu M, Zhou G, Doebber T, Berger J et al. 2002 Potentiation of insulin signaling in tissues of Zucker obese rats after acute and long-term treatment with PPARγ agonists. Diabetes 51 2412-2419.
19. Kadowaki T, Yamauchi T, Kubota N, Hara K, Ueki K & Tobe K 2006 Adiponectin and adiponectin receptors in insulin resistance, diabetes, and the metabolic syndrome. Journal of Clinical Investigation 116 1784-1792.
20. Kaplan NM 1989 The deadly quartet. Upper-body obesity, glucose intolerance, hypertriglyceridemia, and hypertension. Archives of Internal Medicine 149 1514-1520.
21. Kotelevtsev Y, HolmesMC, Burchell A, Houston PM, Schmoll D, Jamieson P, Best R, Brown R, Edwards CR, Seckl JR et al. 1997 11b-Hydroxysteroid dehydrogenase type 1 knockout mice show attenuated glucocorticoidinducible responses and resist hyperglycemia on obesity or stress. PNAS 94 14924-14929.
22. Krebs M & Roden M 2004 Nutrient-induced insulin resistance in human skeletal muscle. Current Medicinal Chemistry 11 901-908.
23. l'Allemand D, Penhoat A, Lebrethon MC, Ardevol R, Baehr V, OelkersW& Saez JM 1996 Insulin-like growth factors enhance steroidogenic enzyme and corticotropin receptor messenger ribonucleic acid levels and corticotropin steroidogenic responsiveness in cultured human adrenocortical cells. Journal of Clinical Endocrinology and Metabolism 81 3892-3897.
24. Lara-Castro C & Garvey WT 2008 Intracellular lipid accumulation in liver and muscle and the insulin resistance syndrome. Endocrinology and Metabolism Clinics of North America 37 841-856.
25. Lehmann JM, Moore LB, Smith-Oliver TA, Wilkison WO, Willson TM & Kliewer SA 1995 An antidiabetic thiazolidinedione is a high affinity ligand for peroxisome proliferator-activated receptor γ (PPAR γ). Journal of Biological Chemistry 270 12953-12956.
26. Li P, Sun F, Cao HM, Ma QY, Pan CM, Ma JH, Zhang XN, Jiang H, Song HD & Chen MD 2009 Expression of adiponectin receptors in mouse adrenal glands and the adrenocortical Y-1 cell line: adiponectin regulates steroidogenesis. Biochemical and Biophysical Research Communications 390 1208-1213.
27. Lichtenauer UD, Duchniewicz M, Kolanczyk M, Hoeflich A, Hahner S, Else T, Bicknell AB, Zemojtel T, Stallings NR, Schulte DM et al. 2007 Pre-B-cell transcription factor 1 and steroidogenic factor 1 synergistically regulate adrenocortical growth and steroidogenesis. Endocrinology 148 693-704.
28. Listenberger LL, Han X, Lewis SE, Cases S, FareseRV Jr,Ory DS & Schaffer JE 2003 Triglyceride accumulation protects against fatty acid-induced lipotoxicity. PNAS 100 3077-3082.
29. Manna PR, Dyson MT & Stocco DM 2009 Regulation of the steroidogenic acute regulatory protein gene expression: present and future perspectives. Molecular Human Reproduction 15 321-333.
30. Masuzaki H & Flier JS 2003 Tissue-specific glucocorticoid reactivating enzyme, 11 β-hydroxysteroid dehydrogenase type 1 (11 β-HSD1) - a promising drug target for the treatment of metabolic syndrome. Current Drug Targets. Immune, Endocrine and Metabolic Disorders 3 255-262.
31. Masuzaki H, Paterson J, Shinyama H, Morton NM, Mullins JJ, Seckl JR & Flier JS 2001 A transgenic model of visceral obesity and the metabolic syndrome. Science 294 2166-2170.
32. Michl P, Beikler T, Engelhardt D & Weber MM 2000 Interleukin-3 and interleukin-6 stimulate bovine adrenal cortisol secretion through different pathways. Journal of Neuroendocrinology 12 23-28.
33. Mikhaylova IV, Kuulasmaa T, Jaaskelainen J & Voutilainen R 2007 Tumor necrosis factor-α regulates steroidogenesis, apoptosis, and cell viability in the human adrenocortical cell line NCI-H295R. Endocrinology 148 386-392.
34. Miller WL 1995 Mitochondrial specificity of the early steps in steroidogenesis. Journal of Steroid Biochemistry and Molecular Biology 55 607-616.
35. Miyazaki Y & DeFronzo RA 2008 Rosiglitazone and pioglitazone similarly improve insulin sensitivity and secretion, glucose tolerance and adipocytokines in type 2 diabetic patients. Diabetes, Obesity & Metabolism 10 1204-1211.
36. Oakes ND, Thalen PG, Jacinto SM & Ljung B 2001 Thiazolidinediones increase plasma-adipose tissue FFA exchange capacity and enhance insulin-mediated control of systemic FFA availability. Diabetes 50 1158-1165.
37. Parks EJ & Hellerstein MK 2000 Carbohydrate-induced hypertriacylglycerolemia: historical perspective and review of biological mechanisms. American Journal of Clinical Nutrition 71 412-433.
38. Paschke L, Zemleduch T, Rucinski M, Ziolkowska A, Szyszka M & Malendowicz LK 2010 Adiponectin and adiponectin receptor system in the rat adrenal gland: ontogenetic and physiologic regulation, and its involvement in regulating adrenocortical growth and steroidogenesis. Peptides 31 1715-1724.
39. Pasquali R, Vicennati V, Cacciari M & Pagotto U 2006 The hypothalamic- pituitary-adrenal axis activity in obesity and the metabolic syndrome. Annals of the New York Academy of Sciences 1083 111-128.
40. Paterson JM, Morton NM, Fievet C, Kenyon CJ, Holmes MC, Staels B, Seckl JR & Mullins JJ 2004 Metabolic syndrome without obesity: hepatic overexpression of 11β-hydroxysteroid dehydrogenase type 1 in transgenic mice. PNAS 101 7088-7093.
41. Potenza MA, Marasciulo FL, Tarquinio M, Quon MJ & Montagnani M 2006 Treatment of spontaneously hypertensive rats with rosiglitazone and/or enalapril restores balance between vasodilator and vasoconstrictor actions of insulin with simultaneous improvement in hypertension and insulin resistance. Diabetes 55 3594-3603.
42. Rabano M, Pena A, Brizuela L, Marino A, Macarulla JM, Trueba M & Gomez-Munoz A 2003 Sphingosine-1-phosphate stimulates cortisol secretion. FEBS Letters 535 101-105.
43. Radosh L 2009 Drug treatments for polycystic ovary syndrome. American Family Physician 79 671-676.
44. Reaven GM 1995 Pathophysiology of insulin resistance in human disease. Physiological Reviews 75 473-486.
45. Ruan X, Zheng F & Guan Y 2008 PPARs and the kidney in metabolic syndrome. American Journal of Physiology. Renal Physiology 294 F1032-F1047.
46. Ryu MH & Cha YS 2003 The effects of a high-fat or high-sucrose diet on serum lipid profiles, hepatic acyl-CoA synthetase, carnitine palmitoyltransferase-I, and the acetyl-CoA carboxylase mRNA levels in rats. Journal of Biochemistry and Molecular Biology 36 312-318.
47. Sarel I & Widmaier EP 1995 Stimulation of steroidogenesis in cultured rat adrenocortical cells by unsaturated fatty acids. American Journal of Physiology 268 R1484-R1490.
48. Sharabi Y, Oron-Herman M, Kamari Y, Avni I, Peleg E, Shabtay Z,Grossman E & Shamiss A 2007 Effect of PPAR-γ agonist on adiponectin levels in the metabolic syndrome: lessons from the high fructose fed rat model. American Journal of Hypertension 20 206-210.
49. Shimomura Y, Bray GA & Lee M 1987 Adrenalectomy and steroid treatment in obese (ob/ob) and diabetic (db/db) mice. Hormone and Metabolic Research 19 295-299.
50. Soria A, D'Alessandro ME & Lombardo YB 2001 Duration of feeding on a sucrose-rich diet determines metabolic and morphological changes in rat adipocytes. Journal of Applied Physiology 91 2109-2116.
51. Strauss JF III, Kallen CB, Christenson LK, Watari H, Devoto L, Arakane F, Kiriakidou M & Sugawara T 1999 The steroidogenic acute regulatory protein (StAR): a window into the complexities of intracellular cholesterol trafficking. Recent Progress in Hormone Research 54 369-394 (discussion 394-395).
52. Unger RH & Orci L 2002 Lipoapoptosis: its mechanism and its diseases. Biochimica et Biophysica Acta 1585 202-212.
53. Uruno A, Matsuda K, Noguchi N, Yoshikawa T, Kudo M, Satoh F, Rainey WE, Hui XG, Akahira J, Nakamura Y et al. 2011 Peroxisome proliferator-activated receptor-{γ} suppresses CYP11B2 expression and aldosterone production. Journal of Molecular Endocrinology 46 37-49.
54. Voutilainen R 1998 Adrenocortical cells are the site of secretion and action of insulin-like growth factors and TNF-α. Hormone and Metabolic Research 30 432-435.
55. Waddell BJ, Bollen M, Wyrwoll CS, Mori TA & Mark PJ 2010 Developmental programming of adult adrenal structure and steroidogenesis: effects of fetal glucocorticoid excess and postnatal dietary omega-3 fatty acids. Journal of Endocrinology 205 171-178.
56. Walker BR 2006 Cortisol - cause and cure for metabolic syndrome? Diabetic Medicine 23 1281-1288
57. Yang R & Barouch LA 2007 Leptin signaling and obesity: cardiovascular consequences. Circulation Research 101 545-559.
58. Yki-Jarvinen H 2004 Thiazolidinediones. New England Journal of Medicine 351 1106-1118.
59. Zago V, Lucero D, Macri EV, Cacciagiu L, Gamba CA, Miksztowicz V, Berg G, Wikinski R, Friedman S & Schreier L 2010 Circulating verylow-density lipoprotein characteristics resulting from fatty liver in an insulin resistance rat model. Annals of Nutrition & Metabolism 56 198-206.