Subtype-specific, bi-component inhibition of SK channels by low internal pH

Biochemical and Biophysical Research Communications

Volumn 343, Issue 3, 2006, Pages 943-949

  Peitersen, Torben ^a   Hougaard, Charlotte ^b   Jespersen, Thomas ^a   Jorgensen, Nanna K ^a   Olesen, Søren Peter ^a   Grunnet, Morten ^a,b  

^a UNIVERSITY OF COPENHAGEN   (Denmark)

^b NEUROSEARCH A S   (Denmark)

Author keywords

Ca2+ activated; Calmodulin; Human; Modulation; pH; Rat; SK1; SK2; SK3; Small conductance

Indexed keywords

1 ETHYL 2 BENZIMIDAZOLINONE; CALMODULIN; SMALL CONDUCTANCE CALCIUM ACTIVATED POTASSIUM CHANNEL;

ANIMAL CELL; ARTICLE; BETA CHAIN; CALCIUM CELL LEVEL; CELL PH; CONTROLLED STUDY; ELECTRIC POTENTIAL; HUMAN; HUMAN CELL; MEMBRANE CURRENT; MEMBRANE POTENTIAL; NONHUMAN; PATCH CLAMP; PRIORITY JOURNAL; RAT; SENSITIVITY ANALYSIS;

ANIMALS; BENZIMIDAZOLES; CALCIUM; CELL LINE; ELECTRIC CONDUCTIVITY; HUMANS; HYDROGEN-ION CONCENTRATION; PATCH-CLAMP TECHNIQUES; RATS; SMALL-CONDUCTANCE CALCIUM-ACTIVATED POTASSIUM CHANNELS;

EID: 33645922458     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2006.03.026     Document Type: Article

References (38)

1. + channels: molecular determinants and function of the SK family. Nat. Rev. Neurosci. 5 (2004) 758-770
2. Kohler M., Hirschberg B., Bond C.T., Kinzie J.M., Marrion N.V., Maylie J., and Adelman J.P. Small-conductance, calcium-activated potassium channels from mammalian brain. Science 273 (1996) 1709-1714
3. + channels by calcium. J. Gen. Physiol. 111 (1998) 565-581
4. Wei A.D., Gutman G.A., Aldrich R., Chandy K.G., Grissmer S., and Wulff H. International union of pharmacology. LII. Nomenclature and molecular relationships of calcium-activated potassium channels. Pharmacol. Rev. 57 (2005) 463-472
5. Xia X.M., Fakler B., Rivard A., Wayman G., Johnson-Pais T., Keen J.E., Ishii T., Hirschberg B., Bond C.T., Lutsenko S., Maylie J., and Adelman J.P. Mechanism of calcium gating in small-conductance calcium-activated potassium channels. Nature 395 (1998) 503-507
6. + channel SK3. Am. J. Physiol. Cell Physiol. 280 (2001) C836-C842
7. + channels expressed in murine colonic smooth muscle. Am. J. Physiol. Gastrointest. Liver Physiol. 281 (2001) G964-G973
8. Rimini R., Rimland J.M., and Terstappen G.C. Quantitative expression analysis of the small conductance calcium-activated potassium channels, SK1, SK2, and SK3, in human brain. Brain Res. Mol. Brain Res. 85 (2000) 218-220
9. + (SK3) channels modulates arterial tone and blood pressure. Circ. Res. 93 (2003) 124-131
10. + current in hippocampal pyramidal neurons. Proc. Natl. Acad. Sci. USA 96 (1999) 4662-4667
11. Pennefather P., Lancaster B., Adams P.R., and Nicoll R.A. Two distinct Ca-dependent K currents in bullfrog sympathetic ganglion cells. Proc. Natl. Acad. Sci. USA 82 (1985) 3040-3044
12. Sah P. Ca (2+)-activated K+ currents in neurones: types, physiological roles and modulation. Trends Neurosci. 19 (1996) 150-154
13. Hallworth N.E., Wilson C.J., and Bevan M.D. Apamin-sensitive small conductance calcium-activated potassium channels, through their selective coupling to voltage-gated calcium channels, are critical determinants of the precision, pace, and pattern of action potential generation in rat subthalamic nucleus neurons in vitro. J. Neurosci. 23 (2003) 7525-7542
14. Empson R.M., and Jefferys J.G. Ca(2+) entry through L-type Ca(2+) channels helps terminate epileptiform activity by activation of a Ca(2+) dependent after hyperpolarisation in hippocampal CA3. Neuroscience 102 (2001) 297-306
15. Lappin S.C., Dale T.J., Brown J.T., Trezise D.J., and Davies C.H. Activation of SK channels inhibits epileptiform bursting in hippocampal CA3 neurons. Brain Res. 1065 (2005) 37-46
16. Kelly T., and Church J. pH modulation of currents that contribute to the medium and slow after hyperpolarizations in rat CA1 pyramidal neurones. J. Physiol. 554 (2004) 449-466
17. + channel by intracellular acidification. Pflugers Arch. 440 (2000) 153-156
18. Mao J., Wu J., Chen F., Wang X., and Jiang C. Inhibition of G-protein-coupled inward rectifying K+ channels by intracellular acidosis. J. Biol. Chem. 278 (2003) 7091-7098
19. Xu H., Cui N., Yang Z., Qu Z., and Jiang C. Modulation of kir4.1 and kir5.1 by hypercapnia and intracellular acidosis. J. Physiol. 524 Pt. 3 (2000) 725-735
20. Yang Z., Xu H., Cui N., Qu Z., Chanchevalap S., Shen W., and Jiang C. Biophysical and molecular mechanisms underlying the modulation of heteromeric Kir4.1-Kir5.1 channels by CO2 and pH. J. Gen. Physiol. 116 (2000) 33-45
21. Peretz A., Schottelndreier H., Aharon-Shamgar L.B., and Attali B. Modulation of homomeric and heteromeric KCNQ1 channels by external acidification. J. Physiol. 545 (2002) 751-766
22. Lipton P. Ischemic cell death in brain neurons. Physiol. Rev. 79 (1999) 1431-1568
23. Siesjo B.K., Katsura K.I., Kristian T., Li P.A., and Siesjo P. Molecular mechanisms of acidosis-mediated damage. Acta Neurochir. Suppl (Wien.) 66 (1996) 8-14
24. Sattler R., and Tymianski M. Molecular mechanisms of calcium-dependent excitotoxicity. J. Mol. Med. 78 (2000) 3-13
25. Lee A.L., Dumas T.C., Tarapore P.E., Webster B.R., Ho D.Y., Kaufer D., and Sapolsky R.M. Potassium channel gene therapy can prevent neuron death resulting from necrotic and apoptotic insults. J. Neurochem. 86 (2003) 1079-1088
26. Jespersen T., Grunnet M., Angelo K., Klaerke D.A., and Olesen S.P. Dual-function vector for protein expression in both mammalian cells and Xenopus laevis oocytes. Biotechniques 32 (2002) 536-538 540
27. Grunnet M., Jespersen T., Angelo K., Frokjaer-Jensen C., Klaerke D.A., Olesen S.P., and Jensen B.S. Pharmacological modulation of SK3 channels. Neuropharmacology 40 (2001) 879-887
28. Haiech J., Klee C.B., and Demaille J.G. Effects of cations on affinity of calmodulin for calcium: ordered binding of calcium ions allows the specific activation of calmodulin-stimulated enzymes. Biochemistry 20 (1981) 3890-3897
29. 2+, pH, and temperature. J. Biochem. (Tokyo) 95 (1984) 19-28
30. 2+ binding sites in calmodulin by spectrofluorometry. Int. J. Biol. Macromol. 16 (1994) 181-186
31. W.Y. Cheung, Calmodulin Scientific American, 246 (1982), 48-56.
32. + channels. J. Biol. Chem. 276 (2001) 9762-9769
33. Woodhull A.M. Ionic blockage of sodium channels in nerve. J. Gen. Physiol. 61 (1973) 687-708
34. Engel J., Schultens H.A., and Schild D. Small conductance potassium channels cause an activity-dependent spike frequency adaptation and make the transfer function of neurons logarithmic. Biophys. J. 76 (1999) 1310-1319
35. Sattler R., and Tymianski M. Molecular mechanisms of glutamate receptor-mediated excitotoxic neuronal cell death. Mol. Neurobiol. 24 (2001) 107-129
36. Rossi D.J., Oshima T., and Attwell D. Glutamate release in severe brain ischaemia is mainly by reversed uptake. Nature 403 (2000) 316-321
37. Gribkoff V.K., Starrett Jr. J.E., Dworetzky S.I., Hewawasam P., Boissard C.G., Cook D.A., Frantz S.W., Heman K., Hibbard J.R., Huston K., Johnson G., Krishnan B.S., Kinney G.G., Lombardo L.A., Meanwell N.A., Molinoff P.B., Myers R.A., Moon S.L., Ortiz A., Pajor L., Pieschl R.L., Post-Munson D.J., Signor L.J., Srinivas N., Taber M.T., Thalody G., Trojnacki J.T., Wiener H., Yeleswaram K., and Yeola S.W. Targeting acute ischemic stroke with a calcium-sensitive opener of maxi-K potassium channels. Nat. Med. 7 (2001) 471-477
38. Fujita H., Takizawa S., Nanri K., Matsushima K., Ogawa S., and Shinohara Y. Potassium channel opener reduces extracellular glutamate concentration in rat focal cerebral ischemia. Brain Res. Bull. 43 (1997) 365-368