The effects of dehydrocostus lactone on osteoblastic MC3T3-E1 cells in redox changes and PI3K/Akt/CREB

Immunopharmacology and Immunotoxicology

Volumn 34, Issue 5, 2012, Pages 810-814

  Seo, Min Su ^a   Choi, Eun Mi ^a  

^a Kyung Hee University   (South Korea)

Author keywords

Antimycin A; Dehydrocostus lactone; Osteoblast; Oxidative stress; PI3K Akt CREB

Indexed keywords

3 NITROTYROSINE; ANTIMYCIN A1; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; DEHYDROCOSTUS LACTONE; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; THIOREDOXIN REDUCTASE;

ANIMAL CELL; ANTIOXIDANT ACTIVITY; ARTICLE; CELL PROTECTION; CELL VIABILITY; DRUG EFFECT; ENZYME ACTIVITY; ENZYME INACTIVATION; NITRATION; NONHUMAN; OSTEOBLAST; OXIDATION REDUCTION REACTION; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION;

ANIMALS; ANTI-BACTERIAL AGENTS; ANTIMYCIN A; CELL LINE; CYCLIC AMP RESPONSE ELEMENT-BINDING PROTEIN; LACTONES; MICE; OSTEOBLASTS; OXIDATION-REDUCTION; PHOSPHATIDYLINOSITOL 3-KINASES; PHOSPHORYLATION; PROTO-ONCOGENE PROTEINS C-AKT; SESQUITERPENES; SIGNAL TRANSDUCTION;

EID: 84866236046     PISSN: 08923973     EISSN: 15322513     Source Type: Journal    
DOI: 10.3109/08923973.2012.657799     Document Type: Article

References (27)

1. Andreyev, A.Y., Kushnareva, Y.E., Starkov, A.A. Mitochondrial metabolism of reactive oxygen species. Biochemistry Mosc 2005, 70, 200-214
2. Maguire, J.J., Kagan, V.E., Packer, L. Electron transport between cytochrome c and alpha tocopherol. Biochem Biophys Res Commun 1992, 188, 190-197
3. Baudry, N., Laemmel, E., Vicaut, E. In vivo reactive oxygen species production induced by ischemia in muscle arterioles of mice: Involvement of xanthine oxidase and mitochondria. Am J Physiol Heart Circ Physiol 2008, 294, H821-H828
4. Franke, T.F., Kaplan, D.R., Cantley, L.C. PI3K: Downstream AKTion blocks apoptosis. Cell 1997, 88, 435-437
5. Du, K., Montminy, M. CREB is a regulatory target for the protein kinase Akt/PKB. J Biol Chem 1998, 273, 32377-32379
6. Cammarota, M., Paratcha, G., Bevilaqua, L.R., Levi de Stein, M., Lopez, M., Pellegrino de Iraldi, A., Izquierdo, I., Medina, J.H. Cyclic AMP-responsive element binding protein in brain mitochondria. J Neurochem 1999, 72, 2272-2277
7. Ryu, H., Lee, J., Impey, S., Ratan, R.R., Ferrante, R.J. Antioxidants modulate mitochondrial PKA and increase CREB binding to D-loop DNA of the mitochondrial genome in neurons. Proc Natl Acad Sci USA 2005, 102, 13915-13920
8. Damre, A.A., Damre, A.S., Saraf, M.N. Evaluation of sesquiterpene lactone fraction of Saussurea lappa on transudative, exudative and proliferative phases of inflammation. Phytother Res 2003, 17, 722-725
9. Rüngeler, P., Castro, V., Mora, G., Gören, N., Vichnewski, W., Pahl, H.L., Merfort, I., Schmidt, T.J. Inhibition of transcription factor NF-κB by sesquiterpene lactones: A proposed molecular mechanism of action. Bioorg Med Chem 1999, 7, 2343-2352
10. Lee, H.J., Kim, N.Y., Jang, M.K., Son, H.J., Kim, K.M., Sohn, D.H., Lee, S.H., Ryu, J.H. A sesquiterpene, dehydrocostus lactone, inhibits the expression of inducible nitric oxide synthase and TNF-alpha in LPS-activated macrophages. Planta Med 1999, 65, 104-108
11. Choi, E.M., Kim, G.H., Lee, Y.S. Protective effects of dehydrocostus lactone against hydrogen peroxide-induced dysfunction and oxidative stress in osteoblastic MC3T3-E1 cells. Toxicol In Vitro 2009, 23, 862-867
12. Quarles, L.D., Yohay, D.A., Lever, L.W., Caton, R., Wenstrup, R.J. Distinct proliferative and differentiated stages of murine MC3T3-E1 cells in culture: An in vitro model of osteoblast development. J Bone Miner Res 1992, 7, 68C3-692
13. Downward, J. PI 3-kinase, Akt and cell survival. Semin Cell Dev Biol 2004, 15, 177-182
14. Sarbassov, D.D., Ali, S.M., Kim, D.H., Guertin, D.A., Latek, R.R., Erdjument-Bromage, H., Tempst, P., Sabatini, D.M. Rictor, a novel binding partner of mTOR, defines a rapamycin-insensitive and raptor-independent pathway that regulates the cytoskeleton. Curr Biol 2004, 14, 1296-1302
15. Yao, R., Cooper, G.M. Requirement for phosphatidylinositol-3 kinase in the prevention of apoptosis by nerve growth factor. Science 1995, 267, 2003-2006
16. del Peso, L., González-García, M., Page, C., Herrera, R., Nuñez, G. Interleukin-3-induced phosphorylation of BAD through the protein kinase Akt. Science 1997, 278, 687-689
17. Ozes, O.N., Mayo, L.D., Gustin, J.A., Pfeffer, S.R., Pfeffer, L.M., Donner, D.B. NF-κB activation by tumour necrosis factor requires the Akt serine-threonine kinase. Nature 1999, 401, 82-85
18. Lauder, A., Castellanos, A., Weston, K. c-Myb transcription is activated by protein kinase B (PKB) following interleukin 2 stimulation of Tcells and is required for PKB-mediated protection from apoptosis. Mol Cell Biol 2001, 21, 5797-5805
19. Mayr, B., Montminy, M. Transcriptional regulation by the phosphorylation-dependent factor CREB. Nat Rev Mol Cell Biol 2001, 2, 599-609
20. Brami-Cherrier, K., Valjent, E., Garcia, M., Pagès, C., Hipskind, R.A., Caboche, J. Dopamine induces a PI3-kinase-independent activation of Akt in striatal neurons: A new route to cAMP response element-binding protein phosphorylation. J Neurosci 2002, 22, 8911-8921
21. Fiol, C.J., Williams, J.S., Chou, C.H., Wang, Q.M., Roach, P.J., Andrisani, O.M. A secondary phosphorylation of CREB341 at Ser129 is required for the cAMP-mediated control of gene expression. A role for glycogen synthase kinase-3 in the control of gene expression. J Biol Chem 1994, 269, 32187-32193
22. Grimes, C.A., Jope, R.S. CREB DNA binding activity is inhibited by glycogen synthase kinase-3 β and facilitated by lithium. J Neurochem 2001, 78, 1219-1232
23. Berndt, C., Lillig, C.H., Holmgren, A. Thiol-based mechanisms of the thioredoxin and glutaredoxin systems: Implications for diseases in the cardiovascular system. Am J Physiol Heart Circ Physiol 2007, 292, H1227-H1236
24. Yamawaki, H., Haendeler, J., Berk, B.C. Thioredoxin: A key regulator of cardiovascular homeostasis. Circ Res 2003, 93, 1029-1033
25. Myers, J.M., Myers, C.R. The effects of hexavalent chromium on thioredoxin reductase and peroxiredoxins in human bronchial epithelial cells. Free Radic Biol Med 2009, 47, 1477-1485
26. Belenky, P., Bogan, K.L., Brenner, C. NAD+ metabolism in health and disease. Trends Biochem Sci 2007, 32, 12-19
27. Pollak, N., Dölle, C., Ziegler, M. The power to reduce: Pyridine nucleotides-small molecules with a multitude of functions. Biochem J 2007, 402, 205-218