Drosophila as a tool for studying the conserved genetics of pain

Clinical Genetics

Volumn 82, Issue 4, 2012, Pages 359-366

  Milinkeviciute, G ^a   Gentile, C ^a   Neely, G Gregory ^a  

^a GARVAN INSTITUTE OF MEDICAL RESEARCH   (Australia)

Author keywords

Conserved genetics; Drosophila; Functional genomics; Pain

Indexed keywords

CALCIUM SIGNALING; CONSERVATION GENETICS; DROSOPHILA MELANOGASTER; FUNCTIONAL ASSESSMENT; GENE FUNCTION; GENE IDENTIFICATION; HIGH THROUGHPUT SCREENING; HUMAN; NOCICEPTION; NONHUMAN; PAIN; PRIORITY JOURNAL; REVIEW; SENSORY NERVE CELL;

ANIMALS; CALCIUM SIGNALING; DROSOPHILA MELANOGASTER; MODELS, ANIMAL; NOCICEPTION; PAIN;

ANIMALIA; DROSOPHILA MELANOGASTER;

EID: 84866175191     PISSN: 00099163     EISSN: 13990004     Source Type: Journal    
DOI: 10.1111/j.1399-0004.2012.01941.x     Document Type: Review

References (78)

1. Young EE, Lariviere WR, Belfer I. Genetic basis of pain variability: recent advances. J Med Genet 2012: 49: 1-9.
2. Neely GG, Hess A, Costigan M et al. A genome-wide Drosophila screen for heat nociception identifies alpha2delta3 as an evolutionarily conserved pain gene. Cell 2010: 143: 628-638.
3. Patapoutian A, Tate S, Woolf CJ. Transient receptor potential channels: targeting pain at the source. Nat Rev Drug Discov 2009: 8: 55-68.
4. Savoia G, Ambrosio F, Paoletti F et al. SIAARTI recommendations for the treatment of postoperative pain. Minerva Anestesiol 2002: 68: 735-750.
5. Sudano I, Flammer AJ, Roas S, Enseleit F, Noll G, Ruschitzka F. Nonsteroidal antiinflammatory drugs, acetaminophen, and hypertension. Curr Hypertens Rep 2012: 14: 304-309.
6. Im SH, Galko MJ. Pokes, sunburn, and hot sauce: Drosophila as an emerging model for the biology of nociception. Dev Dyn 2012: 241: 16-26.
7. Babcock DT, Shi S, Jo J, Shaw M, Gutstein HB, Galko MJ. Hedgehog signaling regulates nociceptive sensitization. Curr Biol 2011: 21: 1525-1533.
8. Gerdle B, Bjork J, Henriksson C, Bengtsson A. Prevalence of current and chronic pain and their influences upon work and healthcare-seeking: a population study. J Rheumatol 2004: 31: 1399-1406.
9. Mobily PR, Herr KA, Nicholson AC. Validation of cutaneous stimulation interventions for pain management. Int J Nurs Stud 1994: 31: 533-544.
10. Hendler N. Depression caused by chronic pain. J Clin Psychiatry 1984: 45: 30-38.
11. Staud R. Peripheral pain mechanisms in chronic widespread pain. Best Pract Res Clin Rheumatol 2011: 25: 155-164.
12. Denk F, McMahon SB. Chronic pain: emerging evidence for the involvement of epigenetics. Neuron 2012: 73: 435-444.
13. Mogil JS, Sorge RE, LaCroix-Fralish ML et al. Pain sensitivity and vasopressin analgesia are mediated by a gene-sex-environment interaction. Nat Neurosci 2011: 14: 1569-1573.
14. Dai F, Belfer I, Schwartz CE et al. Association of catechol-O-methyltransferase genetic variants with outcome in patients undergoing surgical treatment for lumbar degenerative disc disease. Spine J 2010: 10: 949-957.
15. Kim DH, Dai F, Belfer I et al. Polymorphic variation of the guanosine triphosphate cyclohydrolase 1 gene predicts outcome in patients undergoing surgical treatment for lumbar degenerative disc disease. Spine (Phila Pa 1976) 2010: 35: 1909-1914.
16. Costigan M, Belfer I, Griffin RS et al. Multiple chronic pain states are associated with a common amino acid-changing allele in KCNS1. Brain 2010: 133: 2519-2527.
17. Reimann F, Cox JJ, Belfer I et al. Pain perception is altered by a nucleotide polymorphism in SCN9A. Proc Natl Acad Sci U S A 2010: 107: 5148-5153.
18. Diatchenko L, Nackley AG, Slade GD et al. Catechol-O-methyltransferase gene polymorphisms are associated with multiple pain-evoking stimuli. Pain 2006: 125: 216-224.
19. Tegeder I, Costigan M, Griffin RS et al. GTP cyclohydrolase and tetrahydrobiopterin regulate pain sensitivity and persistence. Nat Med 2006: 12: 1269-1277.
20. Latremoliere A, Costigan M. GCH1, BH4 and pain. Curr Pharm Biotechnol 2011: 12: 1728-1741.
21. Mackie GO. Central neural circuitry in the jellyfish Aglantha: a model 'simple nervous system'. Neurosignals 2004: 13: 5-19.
22. Giuffre C, Hinow P, Vogel R et al. The ciliate Paramecium shows higher motility in non-uniform chemical landscapes. PLoS One 2011: 6: e15274.
23. Muller WE. The origin of metazoan complexity: porifera as integrated animals. Integr Comp Biol 2003: 43: 3-10.
24. Elliott G, Leys S. Evidence for glutamate, GABA and NO in coordinating behaviour in the sponge, Ephydatia muelleri (Demospongiae, Spongillidae). J Exp Biol 2010: 213: 2310-2321.
25. Leys S, Meech R. Physiology of coordination in sponges. Can J Zool 2006: 84: 288-306.
26. Satterlie RA. Do jellyfish have central nervous systems? J Exp Biol 2011: 214: 1215-1223.
27. Hansson L, Kultima K. Behavioural response of the scyphozoan jellyfish Aurelia aurita (L.) upon contact with the predatory jellyfish Cyanea capillata (L.). Mar Freshw Behav Physiol 1995: 26: 131-137.
28. Watson G, Hessinger D. Antagonistic frequency tuning of hair bundles by different chemoreceptors regulates nematocyst discharge. J Exp Biol 1994: 187: 57-73.
29. Albert DJ. Adaptive behaviours of the jellyfish Aurelia labiata in Roscoe Bay on the west coast of Canada. J Sea Res 2008: 59: 198-201.
30. Koopowitz H, Keenan L. The primitive brains of the platyhelminthes. Trends Neurosci 1982: 5: 77-79.
31. Faisst J, Keenan CL, Koopowitz H. Neuronal repair and avoidance behavior in the flatworm, Notoplana acticola. J Neurobiol 1980: 11: 1-14.
32. Pickard GE. Circadian rhythm of nociception in the golden hamster. Brain Res 1987: 425: 395-400.
33. Kavaliers M, Hirst M, Teskey GC. A functional role for an opiate system in snail thermal behavior. Science 1983: 220: 99-101.
34. Walters ET, Erickson MT. Directional control and the functional organization of defensive responses in Aplysia. J Comp Physiol A 1986: 159: 339-351.
35. Achaval M, Penha MA, Swarowsky A et al. The terrestrial Gastropoda Megalobulimus abbreviatus as a useful model for nociceptive experiments: effects of morphine and naloxone on thermal avoidance behavior. Braz J Med Biol Res 2005: 38: 73-80.
36. Zabala NA, Gomez MA. Morphine analgesia, tolerance and addiction in the cricket Pteronemobius sp. (Orthoptera, Insecta). Pharmacol Biochem Behav 1991: 40: 887-891.
37. Bier E. Drosophila, the golden bug, emerges as a tool for human genetics. Nat Rev Genet 2005: 6: 9-23.
38. Margolis B, Skolnik EY. Activation of Ras by receptor tyrosine kinases. J Am Soc Nephrol 1994: 5: 1288-1299.
39. Costa R, Speretta E, Crowther DC, Cardoso I. Testing the therapeutic potential of doxycycline in a Drosophila melanogaster model of Alzheimer disease. J Biol Chem 2011: 286: 41647-41655.
40. Neely GG, Kuba K, Cammarato A et al. A global in vivo Drosophila RNAi screen identifies NOT3 as a conserved regulator of heart function. Cell 2010: 141: 142-153.
41. Cronin SJ, Nehme NT, Limmer S et al. Genome-wide RNAi screen identifies genes involved in intestinal pathogenic bacterial infection. Science 2009: 325: 340-343.
42. Brembs B, Heisenberg M. Conditioning with compound stimuli in Drosophila melanogaster in the flight simulator. J Exp Biol 2001: 204: 2849-2859.
43. Brembs B. Operant conditioning in invertebrates. Curr Opin Neurobiol 2003: 13: 710-717.
44. Williams DW, Truman JW. Cellular mechanisms of dendrite pruning in Drosophila: insights from in vivo time-lapse of remodeling dendritic arborizing sensory neurons. Development 2005: 132: 3631-3642.
45. Tracey WD Jr, Wilson RI, Laurent G, Benzer S. painless, a Drosophila gene essential for nociception. Cell 2003: 113: 261-273.
46. Grueber WB, Ye B, Moore AW et al. Dendrites of distinct classes of Drosophila sensory neurons show different capacities for homotypic repulsion. Curr Biol 2003: 13: 618-626.
47. Hwang SW, Oh U. Current concepts of nociception: nociceptive molecular sensors in sensory neurons. Curr Opin Anaesthesiol 2007: 20: 427-434.
48. Grueber WB, Ye B, Yang CH et al. Projections of Drosophila multidendritic neurons in the central nervous system: links with peripheral dendrite morphology. Development 2007: 134: 55-64.
49. Woolf CJ, Ma Q. Nociceptors--noxious stimulus detectors. Neuron 2007: 55: 353-364.
50. Aldrich BT, Kasuya J, Faron M, Ishimoto H, Kitamoto T. The amnesiac gene is involved in the regulation of thermal nociception in Drosophila melanogaster. J Neurogenet 2010: 24: 33-41.
51. Coste B, Mathur J, Schmidt M et al. Piezo1 and Piezo2 are essential components of distinct mechanically activated cation channels. Science 2010: 330: 55-60.
52. Manev H, Dimitrijevic N. Drosophila model for in vivo pharmacological analgesia research. Eur J Pharmacol 2004: 491: 207-208.
53. Babcock DT, Landry C, Galko MJ. Cytokine signaling mediates UV-induced nociceptive sensitization in Drosophila larvae. Curr Biol 2009: 19: 799-806.
54. Oswald M, Rymarczyk B, Chatters A, Sweeney S. A novel thermosensitive escape behavior in Drosophila larvae. Fly (Austin) 2011: 5: 304-306.
55. Xu SY, Cang CL, Liu XF et al. Thermal nociception in adult Drosophila: behavioral characterization and the role of the painless gene. Genes Brain Behav 2006: 5: 602-613.
56. Benzer S. Behavioral mutants of Drosophila isolated by countercurrent distribution. Proc Natl Acad Sci U S A 1967: 58: 1112-1119.
57. Kim SH, Chung JM. An experimental model for peripheral neuropathy produced by segmental spinal nerve ligation in the rat. Pain 1992: 50: 355-363.
58. Zhong L, Hwang RY, Tracey WD. Pickpocket is a DEG/ENaC protein required for mechanical nociception in Drosophila larvae. Curr Biol 2010: 20: 429-434.
59. Kim SE, Coste B, Chadha A, Cook B, Patapoutian A. The role of Drosophila Piezo in mechanical nociception. Nature 2012: 483: 209-212.
60. Chen CC, Zimmer A, Sun WH, Hall J, Brownstein MJ. A role for ASIC3 in the modulation of high-intensity pain stimuli. Proc Natl Acad Sci U S A 2002: 99: 8992-8997.
61. Darboux I, Lingueglia E, Pauron D, Barbry P, Lazdunski M. A new member of the amiloride-sensitive sodium channel family in Drosophila melanogaster peripheral nervous system. Biochem Biophys Res Commun 1998: 246: 210-216.
62. Coste B, Xiao B, Santos JS et al. Piezo proteins are pore-forming subunits of mechanically activated channels. Nature 2012: 483: 176-181.
63. Cunha FQ, Poole S, Lorenzetti BB, Ferreira SH. The pivotal role of tumour necrosis factor alpha in the development of inflammatory hyperalgesia. Br J Pharmacol 1992: 107: 660-664.
64. Neely GG, Keene AC, Duchek P et al. TrpA1 regulates thermal nociception in Drosophila. PLoS One 2011: 6: e24343.
65. Lindfors PH, Voikar V, Rossi J, Airaksinen MS. Deficient nonpeptidergic epidermis innervation and reduced inflammatory pain in glial cell line-derived neurotrophic factor family receptor alpha2 knock-out mice. J Neurosci 2006: 26: 1953-1960.
66. Tegeder I, Del Turco D, Schmidtko A et al. Reduced inflammatory hyperalgesia with preservation of acute thermal nociception in mice lacking cGMP-dependent protein kinase I. Proc Natl Acad Sci U S A 2004: 101: 3253-3257.
67. Bohn LM, Lefkowitz RJ, Gainetdinov RR, Peppel K, Caron MG, Lin FT. Enhanced morphine analgesia in mice lacking beta-arrestin 2. Science 1999: 286: 2495-2498.
68. Ledent C, Vaugeois JM, Schiffmann SN et al. Aggressiveness, hypoalgesia and high blood pressure in mice lacking the adenosine A2a receptor. Nature 1997: 388: 674-678.
69. Bura SA, Nadal X, Ledent C, Maldonado R, Valverde O. A 2A adenosine receptor regulates glia proliferation and pain after peripheral nerve injury. Pain 2008: 140: 95-103.
70. Blakeman KH, Hao JX, Xu XJ et al. Hyperalgesia and increased neuropathic pain-like response in mice lacking galanin receptor 1 receptors. Neuroscience 2003: 117: 221-227.
71. Niederberger E, Schmidtko A, Gao W, Kuhlein H, Ehnert C, Geisslinger G. Impaired acute and inflammatory nociception in mice lacking the p50 subunit of NF-kappaB. Eur J Pharmacol 2007: 559: 55-60.
72. Inoue M, Rashid MH, Fujita R, Contos JJ, Chun J, Ueda H. Initiation of neuropathic pain requires lysophosphatidic acid receptor signaling. Nat Med 2004: 10: 712-718.
73. Cheng HY, Pitcher GM, Laviolette SR et al. DREAM is a critical transcriptional repressor for pain modulation. Cell 2002: 108: 31-43.
74. Veraksits A, Runkorg K, Kurrikoff K et al. Altered pain sensitivity and morphine-induced anti-nociception in mice lacking CCK2 receptors. Psychopharmacology 2003: 166: 168-175.
75. Kang K, Pulver SR, Panzano VC et al. Analysis of Drosophila TRPA1 reveals an ancient origin for human chemical nociception. Nature 2010: 464: 597-600.
76. Bautista DM, Jordt SE, Nikai T et al. TRPA1 mediates the inflammatory actions of environmental irritants and proalgesic agents. Cell 2006: 124: 1269-1282.
77. Kremeyer B, Lopera F, Cox JJ et al. A gain-of-function mutation in TRPA1 causes familial episodic pain syndrome. Neuron 2010: 66: 671-680.
78. Taylor CP, Angelotti T, Fauman E. Pharmacology and mechanism of action of pregabalin: the calcium channel alpha2-delta (alpha2-delta) subunit as a target for antiepileptic drug discovery. Epilepsy Res 2007: 73: 137-150.