Polymorphic variation of the guanosine triphosphate cyclohydrolase 1 gene predicts outcome in patients undergoing surgical treatment for lumbar degenerative disc disease

Spine

Volumn 35, Issue 21, 2010, Pages 1909-1914

  Kim, David H ^a   Dai, Feng ^b,c   Belfer, Inna ^b   Banco, Robert J ^a   Martha, Julia F ^d   Tighiouart, Hocine ^a   Tromanhauser, Scott G ^a   Jenis, Louis G ^a   Hunter, David J ^d   Schwartz, Carolyn E ^e  

^a TUFTS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF PITTSBURGH   (United States)

^c UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^d NEW ENGLAND BAPTIST HOSPITAL   (United States)

^e DeltaQuest Foundation Inc   (United States)

Author keywords

degenerative disc disease; diagnosis; GCH1; genetic testing; genetics; pain; risk factors; surgery

Indexed keywords

GENOMIC DNA; GUANOSINE TRIPHOSPHATE CYCLOHYDROLASE I;

ADULT; AGED; ALLELE; ARTHROPLASTY; ARTICLE; BLOOD SAMPLING; DNA SEQUENCE; FEMALE; GENETIC ASSOCIATION; GENETIC VARIABILITY; GENOTYPE; HAPLOTYPE; HUMAN; INTERVERTEBRAL DISK DEGENERATION; LUMBAR SPINE; MAJOR CLINICAL STUDY; MALE; OSWESTRY DISABILITY INDEX; PAIN; PRIORITY JOURNAL; PROSPECTIVE STUDY; SINGLE NUCLEOTIDE POLYMORPHISM; SPINE FUSION; SPINE SURGERY; TREATMENT OUTCOME; VENOUS BLOOD;

ADULT; COHORT STUDIES; FEMALE; GENETIC ASSOCIATION STUDIES; GENETIC PREDISPOSITION TO DISEASE; GTP CYCLOHYDROLASE; HAPLOTYPES; HUMANS; INTERVERTEBRAL DISK DEGENERATION; LUMBAR VERTEBRAE; MALE; MIDDLE AGED; PILOT PROJECTS; POLYMORPHISM, GENETIC; PREDICTIVE VALUE OF TESTS; PROSPECTIVE STUDIES; YOUNG ADULT;

EID: 77958006809     PISSN: 03622436     EISSN: 15281159     Source Type: Journal    
DOI: 10.1097/BRS.0b013e3181eea007     Document Type: Article

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