Reduced Prostasin (CAP1/PRSS8) Activity Eliminates HAI-1 and HAI-2 Deficiency-Associated Developmental Defects by Preventing Matriptase Activation

PLoS Genetics

Volumn 8, Issue 8, 2012, Pages

  Szabo, Roman ^a   Uzzun Sales, Katiuchia ^a   Kosa, Peter ^a   Shylo, Natalia A ^a   Godiksen, Sine ^a,b,c   Hansen, Karina K ^a   Friis, Stine ^a   Gutkind, J Silvio ^a   Vogel, Lotte K ^b   Hummler, Edith ^d   Camerer, Eric ^e,f   Bugge, Thomas H ^a  

^a NATIONAL INSTITUTE OF DENTAL AND CRANIOFACIAL RESEARCH   (United States)

^b UNIVERSITY OF COPENHAGEN   (Denmark)

^c UNIVERSITY OF COPENHAGEN   (Denmark)

^d UNIVERSITY OF LAUSANNE   (Switzerland)

^e PARIS CARDIOVASCULAR RESEARCH CENTER   (France)

^f UNIVERSITÉ PARIS DESCARTES   (France)

Author keywords

[No Author keywords available]

Indexed keywords

ENZYME INHIBITOR; EPITHELIAL SODIUM CHANNEL ALPHA SUBUNIT; HEPATOCYTE GROWTH FACTOR ACTIVATOR INHIBITOR 1; HEPATOCYTE GROWTH FACTOR ACTIVATOR INHIBITOR 2; MATRIPTASE; PROSTASIN; PROTEINASE ACTIVATED RECEPTOR 1; PROTEINASE ACTIVATED RECEPTOR 2; SCATTER FACTOR; SCATTER FACTOR RECEPTOR; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DEVELOPMENTAL DISORDER; EMBRYO; EMBRYO DEVELOPMENT; EMBRYONIC LETHALITY; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME ANALYSIS; ENZYME ASSAY; ENZYME DEFICIENCY; ENZYME INHIBITION; FEMALE; GENE; GENE CONVERSION; GENE DOSAGE; GENE TARGETING; GENETIC EPISTASIS; LETHALITY; MOUSE; NEURAL TUBE DEFECT; NONHUMAN; PHENOTYPE; PROTEIN EXPRESSION; ST14 GENE;

ANIMALS; EMBRYONIC DEVELOPMENT; EPISTASIS, GENETIC; FEMALE; GENES, LETHAL; MEMBRANE GLYCOPROTEINS; MEMBRANE PROTEINS; MICE; NEURAL TUBE; PLACENTATION; PREGNANCY; RECEPTORS, PROTEINASE-ACTIVATED; SERINE ENDOPEPTIDASES;

MUS;

EID: 84866159866     PISSN: 15537390     EISSN: 15537404     Source Type: Journal    
DOI: 10.1371/journal.pgen.1002937     Document Type: Article

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