Tmprss3, a transmembrane serine protease deficient in human DFNB8/10 deafness, is critical for cochlear hair cell survival at the onset of hearing

Journal of Biological Chemistry

Volumn 286, Issue 19, 2011, Pages 17383-17397

  Fasquelle, Lydie ^a,b,c   Scott, Hamish S ^d,e   Lenoir, Marc ^a,b   Wang, Jing ^a,b   Rebillard, Guy ^a,b   Gaboyard, Sophie ^a,b   Venteo, Stéphanie ^a,b   François, Florence ^a,b   Mausset Bonnefont, Anne Laure ^a,b   Antonarakis, Stylianos E ^c   Neidhart, Elizabeth ^c   Chabbert, Christian ^a,b   Puel, Jean Luc ^a,b   Guipponi, Michel ^c   Delprat, Benjamin ^a,b  

^a HÔPITAL SAINT ELOI   (France)

^b UNIV MONTPELLIER   (France)

^c UNIVERSITY OF GENEVA MEDICAL SCHOOL   (Switzerland)

^d CENTRE FOR CANCER BIOLOGY   (Australia)

^e UNIVERSITY OF ADELAIDE   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACIDS; CELL DEATH; MAMMALS;

AUDITORY BRAINSTEM RESPONSE; COCHLEAR FUNCTION; HISTOLOGICAL EXAMINATION; IN-SITU HYBRIDIZATION; MOLECULAR MECHANISM; PHYSIOPATHOLOGY; SENSORY HAIR CELLS; SERINE PROTEASE;

AUDITION;

SERINE PROTEINASE; TYPE 2 TRANSMEMBRANE SERINE PROTEASE 3; UNCLASSIFIED DRUG;

ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; AUDITORY THRESHOLD; AUTOSOMAL RECESSIVE DISORDER; CELL COUNT; CELL DEGENERATION; CELL SURVIVAL; COCHLEA; CONTROLLED STUDY; CORTI ORGAN; DISEASE ASSOCIATION; ENZYME DEFICIENCY; EVOKED BRAIN STEM AUDITORY RESPONSE; FEMALE; FUNCTIONAL ASSESSMENT; GENE; GENE LOCATION; GENOTYPE; HAIR CELL; HEARING IMPAIRMENT; HEARING LOSS; HISTOLOGY; HYPOACUSIS; IN SITU HYBRIDIZATION; MALE; MOUSE; NON SYNDROMIC AUTOSOMAL RECESSIVE DEAFNESS; NONHUMAN; ONSET AGE; PATHOPHYSIOLOGY; PRIORITY JOURNAL; PROTEIN FUNCTION; TMPRSS 3 GENE; VESTIBULAR DISORDER;

MUS;

EID: 79955759599     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M110.190652     Document Type: Article

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