-
1
-
-
33646577466
-
Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells
-
Bettelli, E., Y. Carrier, W. Gao, T. Korn, T. B. Strom, M. Oukka, H. L. Weiner, and V. K. Kuchroo. 2006. Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells. Nature 441: 235-238.
-
(2006)
Nature
, vol.441
, pp. 235-238
-
-
Bettelli, E.1
Carrier, Y.2
Gao, W.3
Korn, T.4
Strom, T.B.5
Oukka, M.6
Weiner, H.L.7
Kuchroo, V.K.8
-
2
-
-
0028328436
-
Impaired immune and acute-phase responses in interleukin-6-deficient mice
-
DOI 10.1038/368339a0
-
Kopf, M., H. Baumann, G. Freer, M. Freudenberg, M. Lamers, T. Kishimoto, R. Zinkernagel, H. Bluethmann, and G. Köhler. 1994. Impaired immune and acute-phase responses in interleukin-6-deficient mice. Nature 368: 339-342. (Pubitemid 24104268)
-
(1994)
Nature
, vol.368
, Issue.6469
, pp. 339-342
-
-
Kopf, M.1
Baumann, H.2
Freer, G.3
Freudenberg, M.4
Lamers, M.5
Kishimoto, T.6
Zinkernagel, R.7
Bluethmann, H.8
Kohler, G.9
-
3
-
-
0030036870
-
Interleukin-6 is required for a protective immune response to systemic Escherichia coli infection
-
Dalrymple, S. A., R. Slattery, D. M. Aud, M. Krishna, L. A. Lucian, and R. Murray. 1996. Interleukin-6 is required for a protective immune response to systemic Escherichia coli infection. Infect. Immun. 64: 3231-3235. (Pubitemid 26256170)
-
(1996)
Infection and Immunity
, vol.64
, Issue.8
, pp. 3231-3235
-
-
Dalrymple, S.A.1
Slattery, R.2
Aud, D.M.3
Krishna, M.4
Lucian, L.A.5
Murray, R.6
-
4
-
-
0029913685
-
+ T helper cell 1 development in interleukin 6-deficient mice infected with Candida albicans
-
DOI 10.1084/jem.183.4.1345
-
Romani, L., A. Mencacci, E. Cenci, R. Spaccapelo, C. Toniatti, P. Puccetti, F. Bistoni, and V. Poli. 1996. Impaired neutrophil response and CD4+ T helper cell 1 development in interleukin 6-deficient mice infected with Candida albicans. J. Exp. Med. 183: 1345-1355. (Pubitemid 26134278)
-
(1996)
Journal of Experimental Medicine
, vol.183
, Issue.4
, pp. 1345-1355
-
-
Romani, L.1
Mencacci, A.2
Cenci, E.3
Spaccapelo, R.4
Toniatti, C.5
Puccetti, P.6
Bistoni, F.7
Poli, V.8
-
5
-
-
0030734571
-
Lethal tuberculosis in interleukin-6-deficient mutant mice
-
Ladel, C. H., C. Blum, A. Dreher, K. Reifenberg, M. Kopf, and S. H. Kaufmann. 1997. Lethal tuberculosis in interleukin-6-deficient mutant mice. Infect. Immun. 65: 4843-4849. (Pubitemid 27463266)
-
(1997)
Infection and Immunity
, vol.65
, Issue.11
, pp. 4843-4849
-
-
Ladel, C.H.1
Blum, C.2
Dreher, A.3
Reifenberg, K.4
Kopf, M.5
Kaufmann, S.H.E.6
-
6
-
-
0033503152
-
Delayed onset and reduced severity of collagen-induced arthritis in interleukin-6-deficient mice
-
DOI 10.1002/1529-0131(199908)42:8<1635::AID-ANR11>3.0.CO;2-Q
-
Sasai, M., Y. Saeki, S. Ohshima, K. Nishioka, T. Mima, T. Tanaka, Y. Katada, K. Yoshizaki, M. Suemura, and T. Kishimoto. 1999. Delayed onset and reduced severity of collagen-induced arthritis in interleukin-6-deficient mice. Arthritis Rheum. 42: 1635-1643. (Pubitemid 30263631)
-
(1999)
Arthritis and Rheumatism
, vol.42
, Issue.8
, pp. 1635-1643
-
-
Sasai, M.1
Saeki, Y.2
Ohshima, S.3
Nishioka, K.4
Mima, T.5
Tanaka, T.6
Katada, Y.7
Yoshizaki, K.8
Suemura, M.9
Kishimoto, T.10
-
7
-
-
13144259627
-
Interleukin 6 plays a key role in the development of antigen-induced arthritis
-
DOI 10.1073/pnas.95.14.8222
-
Ohshima, S., Y. Saeki, T. Mima, M. Sasai, K. Nishioka, S. Nomura, M. Kopf, Y. Katada, T. Tanaka, M. Suemura, and T. Kishimoto. 1998. Interleukin 6 plays a key role in the development of antigen-induced arthritis. Proc. Natl. Acad. Sci. USA 95: 8222-8226. (Pubitemid 28326094)
-
(1998)
Proceedings of the National Academy of Sciences of the United States of America
, vol.95
, Issue.14
, pp. 8222-8226
-
-
Ohshima, S.1
Saeki, Y.2
Mima, T.3
Sasai, M.4
Nishioka, K.5
Nomura, S.6
Kopf, M.7
Katada, Y.8
Tanaka, T.9
Suemura, M.10
Kishimoto, T.11
-
8
-
-
0032534730
-
IL-6-deficient mice are resistant to experimental autoimmune encephalomyelitis: Roles of IL-6 in the activation and differentiation of autoreactive T cells
-
Samoilova, E. B., J. L. Horton, B. Hilliard, T. S. Liu, and Y. Chen. 1998. IL-6-deficient mice are resistant to experimental autoimmune encephalomyelitis: roles of IL-6 in the activation and differentiation of autoreactive T cells. J. Immunol. 161: 6480-6486. (Pubitemid 28562184)
-
(1998)
Journal of Immunology
, vol.161
, Issue.12
, pp. 6480-6486
-
-
Samoilova, E.B.1
Horton, J.L.2
Hilliard, B.3
Liu, T.-S.T.4
Chen, Y.5
-
9
-
-
16644392805
-
Reduced intestinal inflammation induced by dextran sodium sulfate in interleukin-6-deficient mice
-
Naito, Y., T. Takagi, K. Uchiyama, M. Kuroda, S. Kokura, H. Ichikawa, R. Yanagisawa, K. Inoue, H. Takano, M. Satoh, et al. 2004. Reduced intestinal inflammation induced by dextran sodium sulfate in interleukin-6-deficient mice. Int. J. Mol. Med. 14: 191-196.
-
(2004)
Int. J. Mol. Med.
, vol.14
, pp. 191-196
-
-
Naito, Y.1
Takagi, T.2
Uchiyama, K.3
Kuroda, M.4
Kokura, S.5
Ichikawa, H.6
Yanagisawa, R.7
Inoue, K.8
Takano, H.9
Satoh, M.10
-
10
-
-
68149183241
-
IL-6 is required for airway mucus production induced by inhaled fungal allergens
-
Neveu, W. A., J. B. Allard, O. Dienz, M. J. Wargo, G. Ciliberto, L. A. Whittaker, and M. Rincon. 2009. IL-6 is required for airway mucus production induced by inhaled fungal allergens. J. Immunol. 183: 1732-1738.
-
(2009)
J. Immunol.
, vol.183
, pp. 1732-1738
-
-
Neveu, W.A.1
Allard, J.B.2
Dienz, O.3
Wargo, M.J.4
Ciliberto, G.5
Whittaker, L.A.6
Rincon, M.7
-
11
-
-
78649741783
-
gp130 at the nexus of inflammation, autoimmunity, and cancer
-
Silver, J. S., and C. A. Hunter. 2010. gp130 at the nexus of inflammation, autoimmunity, and cancer. J. Leukoc. Biol. 88: 1145-1156.
-
(2010)
J. Leukoc. Biol.
, vol.88
, pp. 1145-1156
-
-
Silver, J.S.1
Hunter, C.A.2
-
12
-
-
38949164424
-
Transgenic blockade of interleukin 6 transsignaling abrogates inflammation
-
DOI 10.1182/blood-2007-07-102137
-
Rabe, B., A. Chalaris, U. May, G. H. Waetzig, D. Seegert, A. S. Williams, S. A. Jones, S. Rose-John, and J. Scheller. 2008. Transgenic blockade of interleukin 6 transsignaling abrogates inflammation. Blood 111: 1021-1028. (Pubitemid 351213379)
-
(2008)
Blood
, vol.111
, Issue.3
, pp. 1021-1028
-
-
Rabe, B.1
Chalaris, A.2
May, U.3
Waetzig, G.H.4
Seegert, D.5
Williams, A.S.6
Jones, S.A.7
Rose-John, S.8
Scheller, J.9
-
13
-
-
33646469222
-
Functional characterization of a soluble gp130 isoform and its therapeutic capacity in an experimental model of inflammatory arthritis
-
Richards, P. J., M. A. Nowell, S. Horiuchi, R. M. McLoughlin, C. A. Fielding, S. Grau, N. Yamamoto, M. Ehrmann, S. Rose-John, A. S. Williams, et al. 2006. Functional characterization of a soluble gp130 isoform and its therapeutic capacity in an experimental model of inflammatory arthritis. Arthritis Rheum. 54: 1662-1672.
-
(2006)
Arthritis Rheum.
, vol.54
, pp. 1662-1672
-
-
Richards, P.J.1
Nowell, M.A.2
Horiuchi, S.3
McLoughlin, R.M.4
Fielding, C.A.5
Grau, S.6
Yamamoto, N.7
Ehrmann, M.8
Rose-John, S.9
Williams, A.S.10
-
14
-
-
0042834261
-
Soluble IL-6 receptor governs IL-6 activity in experimental arthritis: Blockade of arthritis severity by soluble Glycoprotein 130
-
Nowell, M. A., P. J. Richards, S. Horiuchi, N. Yamamoto, S. Rose-John, N. Topley, A. S. Williams, and S. A. Jones. 2003. Soluble IL-6 receptor governs IL-6 activity in experimental arthritis: blockade of arthritis severity by soluble glycoprotein 130. J. Immunol. 171: 3202-3209. (Pubitemid 37093546)
-
(2003)
Journal of Immunology
, vol.171
, Issue.6
, pp. 3202-3209
-
-
Nowell, M.A.1
Richards, P.J.2
Horiuchi, S.3
Yamamoto, N.4
Rose-John, S.5
Topley, N.6
Williams, A.S.7
Jones, S.A.8
-
15
-
-
18344410191
-
Blockade of interleukin 6 trans signaling suppresses T-cell resistance against apoptosis in chronic intestinal inflammation: Evidence in Crohn disease and experimental colitis in vivo
-
DOI 10.1038/75068
-
Atreya, R., J. Mudter, S. Finotto, J. Müllberg, T. Jostock, S. Wirtz, M. Schütz, B. Bartsch, M. Holtmann, C. Becker, et al. 2000. Blockade of interleukin 6 trans signaling suppresses T-cell resistance against apoptosis in chronic intestinal inflammation: evidence in crohn disease and experimental colitis in vivo. Nat. Med. 6: 583-588. (Pubitemid 30305911)
-
(2000)
Nature Medicine
, vol.6
, Issue.5
, pp. 583-588
-
-
Atreya, R.1
Mudter, J.2
Finotto, S.3
Mullberg, J.4
Jostock, T.5
Wirtz, S.6
Schutz, M.7
Bartsch, B.8
Holtmann, M.9
Becker, C.10
Strand, D.11
Czaja, J.12
Schlaak, J.F.13
Lehr, H.A.14
Autschbach, F.15
Schurmann, G.16
Nishimoto, N.17
Yoshizaki, K.18
Ito, H.19
Kishimoto, T.20
Galle, P.R.21
Rose-John, S.22
Neurath, M.F.23
more..
-
16
-
-
0034960582
-
IL-6 and its soluble receptor orchestrate a temporal switch in the pattern of leukocyte recruitment seen during acute inflammation
-
DOI 10.1016/S1074-7613(01)00151-0
-
Hurst, S. M., T. S. Wilkinson, R. M. McLoughlin, S. Jones, S. Horiuchi, N. Yamamoto, S. Rose-John, G. M. Fuller, N. Topley, and S. A. Jones. 2001. Il-6 and its soluble receptor orchestrate a temporal switch in the pattern of leukocyte recruitment seen during acute inflammation. Immunity 14: 705-714. (Pubitemid 32592418)
-
(2001)
Immunity
, vol.14
, Issue.6
, pp. 705-714
-
-
Hurst, S.M.1
Wilkinson, T.S.2
McLoughlin, R.M.3
Jones, S.4
Horiuchi, S.5
Yamamoto, N.6
Rose-John, S.7
Fuller, G.M.8
Topley, N.9
Jones, S.A.10
-
17
-
-
12144255852
-
Male IL-6 gene knock out mice developed more advanced osteoarthritis upon aging
-
DOI 10.1016/j.joca.2004.09.011, PII S1063458404002122
-
de Hooge, A. S. K., F. A. J. van de Loo, M. B. Bennink, O. J. Arntz, P. de Hooge, and W. B. van den Berg. 2005. Male IL-6 gene knock out mice developed more advanced osteoarthritis upon aging. Osteoarthritis Cartilage 13: 66-73. (Pubitemid 40104265)
-
(2005)
Osteoarthritis and Cartilage
, vol.13
, Issue.1
, pp. 66-73
-
-
De Hooge, A.S.K.1
Van De, L.F.A.J.2
Bennink, M.B.3
Arntz, O.J.4
De Hooge, P.5
Van Den, B.W.B.6
-
18
-
-
4143119932
-
Enhanced airway inflammation and decreased subepithelial fibrosis in interleukin 6-deficient mice following chronic exposure to aerosolized antigen
-
DOI 10.1111/j.1365-2222.2004.02013.x
-
Qiu, Z., M. Fujimura, K. Kurashima, S. Nakao, and N. Mukaida. 2004. Enhanced airway inflammation and decreased subepithelial fibrosis in interleukin 6-deficient mice following chronic exposure to aerosolized antigen. Clin. Exp. Allergy 34: 1321-1328. (Pubitemid 39093075)
-
(2004)
Clinical and Experimental Allergy
, vol.34
, Issue.8
, pp. 1321-1328
-
-
Qiu, Z.1
Fujimura, M.2
Kurashima, K.3
Nakao, S.4
Mukaida, N.5
-
19
-
-
0032518415
-
IL-6 is an antiinflammatory cytokine required for controlling local or systemic acute inflammatory responses
-
Xing, Z., J. Gauldie, G. Cox, H. Baumann, M. Jordana, X. F. Lei, and M. K. Achong. 1998. IL-6 is an antiinflammatory cytokine required for controlling local or systemic acute inflammatory responses. J. Clin. Invest. 101: 311-320. (Pubitemid 28067327)
-
(1998)
Journal of Clinical Investigation
, vol.101
, Issue.2
, pp. 311-320
-
-
Xing, Z.1
Gauldie, J.2
Cox, G.3
Baumann, H.4
Jordana, M.5
Lei, X.-F.6
Achong, M.K.7
-
20
-
-
0032914538
-
Defective immune response and severe skin damage following UVB irradiation in interleukin-6-deficient mice
-
DOI 10.1046/j.1365-2567.1999.00733.x
-
Nishimura, N., C. Tohyama, M. Satoh, H. Nishimura, and V. E. Reeve. 1999. Defective immune response and severe skin damage following UVB irradiation in interleukin-6-deficient mice. Immunology 97: 77-83. (Pubitemid 29217263)
-
(1999)
Immunology
, vol.97
, Issue.1
, pp. 77-83
-
-
Nishimura, N.1
Tohyama, C.2
Satoh, M.3
Nishimura, H.4
Reeve, V.E.5
-
21
-
-
74149088949
-
Interleukin-6 induces prostaglandin E(2) synthesis in mouse astrocytes
-
Chikuma, T., T. Yoshimoto, M. Ohba, M. Sawada, T. Kato, T. Sakamoto, Y. Hiyama, and H. Hojo. 2009. Interleukin-6 induces prostaglandin E(2) synthesis in mouse astrocytes. J. Mol. Neurosci. 39: 175-184.
-
(2009)
J. Mol. Neurosci.
, vol.39
, pp. 175-184
-
-
Chikuma, T.1
Yoshimoto, T.2
Ohba, M.3
Sawada, M.4
Kato, T.5
Sakamoto, T.6
Hiyama, Y.7
Hojo, H.8
-
22
-
-
0023818512
-
Prostaglandin E2 regulates macrophage-derived tumor necrosis factor gene expression
-
Kunkel, S. L., M. Spengler, M. A. May, R. Spengler, J. Larrick, and D. Remick. 1988. Prostaglandin E2 regulates macrophage-derived tumor necrosis factor gene expression. J. Biol. Chem. 263: 5380-5384.
-
(1988)
J. Biol. Chem.
, vol.263
, pp. 5380-5384
-
-
Kunkel, S.L.1
Spengler, M.2
May, M.A.3
Spengler, R.4
Larrick, J.5
Remick, D.6
-
23
-
-
0022635820
-
Prostaglandins as endogenous mediators of interleukin 1 production
-
Kunkel, S. L., S. W. Chensue, and S. H. Phan. 1986. Prostaglandins as endogenous mediators of interleukin 1 production. J. Immunol. 136: 186-192. (Pubitemid 16232171)
-
(1986)
Journal of Immunology
, vol.136
, Issue.1
, pp. 186-192
-
-
Kunkel, S.L.1
Chensue, S.W.2
Phan, S.H.3
-
24
-
-
0035179970
-
Mutation of a new gene encoding a putative pyrin-like protein causes familial cold autoinflammatory syndrome and Muckle-Wells syndrome
-
DOI 10.1038/ng756
-
Hoffman, H. M., J. L. Mueller, D. H. Broide, A. A. Wanderer, and R. D. Kolodner. 2001. Mutation of a new gene encoding a putative pyrin-like protein causes familial cold autoinflammatory syndrome and Muckle-Wells syndrome. Nat. Genet. 29: 301-305. (Pubitemid 33096455)
-
(2001)
Nature Genetics
, vol.29
, Issue.3
, pp. 301-305
-
-
Hoffman, H.M.1
Mueller, J.L.2
Broide, D.H.3
Wanderer, A.A.4
Kolodner, R.D.5
-
25
-
-
0036302235
-
Chronic infantile neurological cutaneous and articular syndrome is caused by mutations in CIAS1, a gene highly expressed in polymorphonuclear cells and chondrocytes
-
DOI 10.1086/341357
-
Feldmann, J., A. M. Prieur, P. Quartier, P. Berquin, S. Certain, E. Cortis, D. Teillac-Hamel, A. Fischer, and G. de Saint Basile. 2002. Chronic infantile neurological cutaneous and articular syndrome is caused by mutations in CIAS1, a gene highly expressed in polymorphonuclear cells and chondrocytes. Am. J. Hum. Genet. 71: 198-203. (Pubitemid 34734724)
-
(2002)
American Journal of Human Genetics
, vol.71
, Issue.1
, pp. 198-203
-
-
Feldmann, J.1
Prieur, A.-M.2
Quartier, P.3
Berquin, P.4
Certain, S.5
Cortis, E.6
Teillac-Harnel, D.7
Fischer, A.8
De Saint, B.G.9
-
26
-
-
0036899758
-
De novo CIAS1 mutations, cytokine activation, and evidence for genetic heterogeneity in patients with neonatal-onset multisystem inflammatory disease (NOMID): A new member of the expanding family of pyrin-associated autoinflammatory diseases
-
DOI 10.1002/art.10688
-
Aksentijevich, I., M. Nowak, M. Mallah, J. J. Chae, W. T. Watford, S. R. Hofmann, L. Stein, R. Russo, D. Goldsmith, P. Dent, et al. 2002. De novo CIAS1 mutations, cytokine activation, and evidence for genetic heterogeneity in patients with neonatal-onset multisystem inflammatory disease (NOMID): a new member of the expanding family of pyrin-associated autoinflammatory diseases. Arthritis Rheum. 46: 3340-3348. (Pubitemid 35453546)
-
(2002)
Arthritis and Rheumatism
, vol.46
, Issue.12
, pp. 3340-3348
-
-
Aksentijevich, I.1
Nowak, M.2
Mallah, M.3
Chae, J.J.4
Watford, W.T.5
Hofmann, S.R.6
Stein, L.7
Russo, R.8
Goldsmith, D.9
Dent, P.10
Rosenberg, H.F.11
Austin, F.12
Remmers, E.F.13
Balow Jr., J.E.14
Rosenzweig, S.15
Komarow, H.16
Shoham, N.G.17
Wood, G.18
Jones, J.19
Mangra, N.20
Carrero, H.21
Adams, B.S.22
Moore, T.L.23
Schikler, K.24
Hoffman, H.25
Lovell, D.J.26
Lipnick, R.27
Barron, K.28
O'Shea, J.J.29
Kastner, D.L.30
Goldbach-Mansky, R.31
more..
-
27
-
-
1642285783
-
NALP3 forms an IL-1β-processing inflammasome with increased activity in Muckle-Wells autoinflammatory disorder
-
DOI 10.1016/S1074-7613(04)00046-9, PII S1074761304000469
-
Agostini, L., F. Martinon, K. Burns, M. F. McDermott, P. N. Hawkins, and J. Tschopp. 2004. NALP3 forms an IL-1beta-processing inflammasome with increased activity in Muckle-Wells autoinflammatory disorder. Immunity 20: 319-325. (Pubitemid 38388233)
-
(2004)
Immunity
, vol.20
, Issue.3
, pp. 319-325
-
-
Agostini, L.1
Martinon, F.2
Burns, K.3
McDermott, M.F.4
Hawkins, P.N.5
Tschopp, J.6
-
28
-
-
66949115474
-
Inflammasome-mediated disease animal models reveal roles for innate but not adaptive immunity
-
Brydges, S. D., J. L. Mueller, M. D. McGeough, C. A. Pena, A. Misaghi, C. Gandhi, C. D. Putnam, D. L. Boyle, G. S. Firestein, A. A. Horner, et al. 2009. Inflammasome-mediated disease animal models reveal roles for innate but not adaptive immunity. Immunity 30: 875-887.
-
(2009)
Immunity
, vol.30
, pp. 875-887
-
-
Brydges, S.D.1
Mueller, J.L.2
McGeough, M.D.3
Pena, C.A.4
Misaghi, A.5
Gandhi, C.6
Putnam, C.D.7
Boyle, D.L.8
Firestein, G.S.9
Horner, A.A.10
-
29
-
-
8444225132
-
Prevention of cold-associated acute inflammation in familial cold autoinflammatory syndrome by interleukin-1 receptor antagonist
-
DOI 10.1016/S0140-6736(04)17401-1, PII S0140673604174011
-
Hoffman, H. M., S. Rosengren, D. L. Boyle, J. Y. Cho, J. Nayar, J. L. Mueller, J. P. Anderson, A. A. Wanderer, and G. S. Firestein. 2004. Prevention of cold-associated acute inflammation in familial cold autoinflammatory syndrome by interleukin-1 receptor antagonist. Lancet 364: 1779-1785. (Pubitemid 39488063)
-
(2004)
Lancet
, vol.364
, Issue.9447
, pp. 1779-1785
-
-
Hoffman, H.M.1
Rosengren, S.2
Boyle, D.L.3
Cho, J.Y.4
Nayar, J.5
Mueller, J.L.6
Anderson, J.P.7
Wanderer, A.A.8
Firestein, G.S.9
-
30
-
-
66949175347
-
A mutation in the Nlrp3 gene causing inflammasome hyperactivation potentiates Th17 cell-dominant immune responses
-
Meng, G., F. Zhang, I. Fuss, A. Kitani, and W. Strober. 2009. A mutation in the Nlrp3 gene causing inflammasome hyperactivation potentiates Th17 cell-dominant immune responses. Immunity 30: 860-874.
-
(2009)
Immunity
, vol.30
, pp. 860-874
-
-
Meng, G.1
Zhang, F.2
Fuss, I.3
Kitani, A.4
Strober, W.5
-
31
-
-
77954240379
-
Role of the leucine-rich repeat domain of cryopyrin/NALP3 in monosodium urate crystal-induced inflammation in mice
-
Hoffman, H. M., P. Scott, J. L. Mueller, A. Misaghi, S. Stevens, G. D. Yancopoulos, A. Murphy, D. M. Valenzuela, and R. Liu-Bryan. 2010. Role of the leucine-rich repeat domain of cryopyrin/NALP3 in monosodium urate crystal-induced inflammation in mice. Arthritis Rheum. 62: 2170-2179.
-
(2010)
Arthritis Rheum.
, vol.62
, pp. 2170-2179
-
-
Hoffman, H.M.1
Scott, P.2
Mueller, J.L.3
Misaghi, A.4
Stevens, S.5
Yancopoulos, G.D.6
Murphy, A.7
Valenzuela, D.M.8
Liu-Bryan, R.9
-
32
-
-
0037090881
-
Efficient recombination in diverse tissues by a tamoxifen-inducible form of Cre: A tool for temporally regulated gene activation/inactivation in the mouse
-
DOI 10.1006/dbio.2002.0597
-
Hayashi, S., and A. P. McMahon. 2002. Efficient recombination in diverse tissues by a tamoxifen-inducible form of Cre: a tool for temporally regulated gene activation/inactivation in the mouse. Dev. Biol. 244: 305-318. (Pubitemid 34450645)
-
(2002)
Developmental Biology
, vol.244
, Issue.2
, pp. 305-318
-
-
Hayashi, S.1
McMahon, A.P.2
-
33
-
-
0037792866
-
Interleukin-1-receptor antagonist in the Muckle-Wells syndrome
-
Hawkins, P. N., H. J. Lachmann, and M. F. McDermott. 2003. Interleukin-1-receptor antagonist in the Muckle-Wells syndrome. N. Engl. J. Med. 348: 2583-2584.
-
(2003)
N. Engl. J. Med.
, vol.348
, pp. 2583-2584
-
-
Hawkins, P.N.1
Lachmann, H.J.2
McDermott, M.F.3
-
34
-
-
32944468985
-
Gout-associated uric acid crystals activate the NALP3 inflammasome
-
DOI 10.1038/nature04516, PII N04516
-
Martinon, F., V. Pétrilli, A. Mayor, A. Tardivel, and J. Tschopp. 2006. Gout-associated uric acid crystals activate the NALP3 inflammasome. Nature 440: 237-241. (Pubitemid 43372104)
-
(2006)
Nature
, vol.440
, Issue.7081
, pp. 237-241
-
-
Martinon, F.1
Petrilli, V.2
Mayor, A.3
Tardivel, A.4
Tschopp, J.5
-
35
-
-
70349379884
-
Hyperalgesia, synovitis and multiple biomarkers of inflammation are suppressed by interleukin 1 inhibition in a novel animal model of gouty arthritis
-
Torres, R., L. Macdonald, S. D. Croll, J. Reinhardt, A. Dore, S. Stevens, D. M. Hylton, J. S. Rudge, R. Liu-Bryan, R. A. Terkeltaub, et al. 2009. Hyperalgesia, synovitis and multiple biomarkers of inflammation are suppressed by interleukin 1 inhibition in a novel animal model of gouty arthritis. Ann. Rheum. Dis. 68: 1602-1608.
-
(2009)
Ann. Rheum. Dis.
, vol.68
, pp. 1602-1608
-
-
Torres, R.1
Macdonald, L.2
Croll, S.D.3
Reinhardt, J.4
Dore, A.5
Stevens, S.6
Hylton, D.M.7
Rudge, J.S.8
Liu-Bryan, R.9
Terkeltaub, R.A.10
-
36
-
-
68949092245
-
Fungal zymosan and mannan activate the cryopyrin inflammasome
-
Lamkanfi, M., R. K. S. Malireddi, and T. D. Kanneganti. 2009. Fungal zymosan and mannan activate the cryopyrin inflammasome. J. Biol. Chem. 284: 20574-20581.
-
(2009)
J. Biol. Chem.
, vol.284
, pp. 20574-20581
-
-
Lamkanfi, M.1
Malireddi, R.K.S.2
Kanneganti, T.D.3
-
37
-
-
0030794222
-
Interleukin-6 reduces cartilage destruction during experimental arthritis. A study in interleukin-6-deficient mice
-
van de Loo, F. A., S. Kuiper, F. H. van Enckevort, O. J. Arntz, and W. B. van den Berg. 1997. Interleukin-6 reduces cartilage destruction during experimental arthritis. A study in interleukin-6-deficient mice. Am. J. Pathol. 151: 177-191.
-
(1997)
Am. J. Pathol.
, vol.151
, pp. 177-191
-
-
Van De Loo, F.A.1
Kuiper, S.2
Van Enckevort, F.H.3
Arntz, O.J.4
Van Den Berg, W.B.5
-
38
-
-
0027984754
-
Defective inflammatory response in interleukin 6-deficient mice
-
Fattori, E., M. Cappelletti, P. Costa, C. Sellitto, L. Cantoni, M. Carelli, R. Faggioni, G. Fantuzzi, P. Ghezzi, and V. Poli. 1994. Defective inflammatory response in interleukin 6-deficient mice. J. Exp. Med. 180: 1243-1250. (Pubitemid 24289598)
-
(1994)
Journal of Experimental Medicine
, vol.180
, Issue.4
, pp. 1243-1250
-
-
Fattori, E.1
Cappelletti, M.2
Costa, P.3
Sellitto, C.4
Cantoni, L.5
Carelli, M.6
Faggioni, R.7
Fantuzzi, G.8
Ghezzi, P.9
Poli, V.10
-
39
-
-
33745880105
-
A severe case of chronic infantile neurologic, cutaneous, articular syndrome treated with biologic agents
-
DOI 10.1002/art.21965
-
Matsubara, T., M. Hasegawa, M. Shiraishi, H. M. Hoffman, T. Ichiyama, T. Tanaka, H. Ueda, T. Ishihara, and S. Furukawa. 2006. A severe case of chronic infantile neurologic, cutaneous, articular syndrome treated with biologic agents. Arthritis Rheum. 54: 2314-2320. (Pubitemid 44051090)
-
(2006)
Arthritis and Rheumatism
, vol.54
, Issue.7
, pp. 2314-2320
-
-
Matsubara, T.1
Hasegawa, M.2
Shiraishi, M.3
Hoffman, H.M.4
Ichiyama, T.5
Tanaka, T.6
Ueda, H.7
Ishihara, T.8
Furukawa, S.9
-
40
-
-
40749152243
-
Efficacy and safety of tocilizumab in patients with systemic-onset juvenile idiopathic arthritis: A randomised, double-blind, placebo-controlled, withdrawal phase III trial
-
DOI 10.1016/S0140-6736(08)60454-7, PII S0140673608604547
-
Yokota, S., T. Imagawa, M. Mori, T. Miyamae, Y. Aihara, S. Takei, N. Iwata, H. Umebayashi, T. Murata, M. Miyoshi, et al. 2008. Efficacy and safety of tocilizumab in patients with systemic-onset juvenile idiopathic arthritis: a randomised, double-blind, placebo-controlled, withdrawal phase III trial. Lancet 371: 998-1006. (Pubitemid 351389534)
-
(2008)
The Lancet
, vol.371
, Issue.9617
, pp. 998-1006
-
-
Yokota, S.1
Imagawa, T.2
Mori, M.3
Miyamae, T.4
Aihara, Y.5
Takei, S.6
Iwata, N.7
Umebayashi, H.8
Murata, T.9
Miyoshi, M.10
Tomiita, M.11
Nishimoto, N.12
Kishimoto, T.13
|