Fetal programming of the neuroendocrine-immune system and metabolic disease

Journal of Pregnancy

Volumn 2012, Issue , 2012, Pages

  Fisher, R E ^a   Steele, M ^a   Karrow, N A ^a  

^a UNIVERSITY OF GUELPH   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

CARDIOVASCULAR DISEASE; FEMALE; FETUS DEVELOPMENT; HUMAN; IMMUNE SYSTEM; MATERNAL NUTRITION; NEUROSECRETION; NON INSULIN DEPENDENT DIABETES MELLITUS; OBESITY; PHYSIOLOGY; PREGNANCY; PRENATAL DEVELOPMENT; PRENATAL EXPOSURE; REVIEW;

CARDIOVASCULAR DISEASES; DIABETES MELLITUS, TYPE 2; FEMALE; FETAL DEVELOPMENT; HUMANS; IMMUNE SYSTEM; NEUROSECRETORY SYSTEMS; OBESITY; PREGNANCY; PRENATAL EXPOSURE DELAYED EFFECTS; PRENATAL NUTRITIONAL PHYSIOLOGICAL PHENOMENA;

EID: 84866154375     PISSN: 20902727     EISSN: 20902735     Source Type: Journal    
DOI: 10.1155/2012/792934     Document Type: Review

References (104)

1. Chadio S. E., Kotsampasi B., Papadomichelakis G., Deligeorgis S., Kalogiannis D., Menegatos I., Zervas G., Impact of maternal undernutrition in the hypothalamic-pituitary-adrenal axis responsiveness in sheep at different ages postnatal. Journal of Endocrinology 2007 192 3 495 503 2-s2.0-33947420499 10.1677/JOE-06-0172 (Pubitemid 46455954)
2. Bloomfield F. H., Oliver M. H., Giannoulias C. D., Gluckman P. D., Harding J. E., Challis J. R. G., Brief undernutrition in late-gestation sheep programs the hypothalamic-pituitary-adrenal axis in adult offspring. Endocrinology 2003 144 7 2933 2940 2-s2.0-0037998898 10.1210/en.2003-0189 (Pubitemid 36819896)
3. Fisher R. E., Karrow N. A., Quinton M., Finegan E. J., Miller S. P., Atkinson J. L., Boermans H. J., Endotoxin exposure during late pregnancy alters ovine offspring febrile and hypothalamic-pituitary-adrenal axis responsiveness later in life. Stress 2010 13 4 334 342 2-s2.0-77953454654 10.3109/ 10253891003663762
4. Ravelli A. C. J., Van Der Meulen J. H. P., Osmond C., Barker D. J. P., Bleker O. P., Obesity at the age of 50 y in men and women exposed to famine prenatally. American Journal of Clinical Nutrition 1999 70 5 811 816 2-s2.0-0032716565 (Pubitemid 29512905)
5. Gluckman P. D., Cutfield W., Hofman P., Hanson M. A., The fetal, neonatal, and infant environments-the long-term consequences for disease risk. Early Human Development 2005 81 1 51 59 2-s2.0-13544255602 10.1016/j.earlhumdev. 2004.10.003 (Pubitemid 40221981)
6. Hales C. N., Barker D. J. P., The thrifty phenotype hypothesis. British Medical Bulletin 2001 60 5 20 2-s2.0-0035704552 10.1093/bmb/60.1.5 (Pubitemid 34123501)
7. Vickers M. H., Developmental programming of the metabolic syndromecritical windows for intervention. The World Journal of Diabetes 2011 2 9 137 148
8. Barker D. J. P., Winter P. D., Osmond C., Margetts B., Simmonds S. J., Weight in infancy and death from ischaemic heart disease. Lancet 1989 2 8663 577 580 2-s2.0-0024469193 (Pubitemid 19216205)
9. Barker D. J. P., Bull A. R., Osmond C., Simmonds S. J., Fetal and placental size and risk of hypertension in adult life. British Medical Journal 1990 301 6746 259 262 2-s2.0-0025297450 (Pubitemid 20241224)
10. Osmond C., Barker D. J. P., Slattery J. M., Risk of death from cardiovascular disease and chronic bronchitis determined by place of birth in England and Wales. Journal of Epidemiology and Community Health 1990 44 2 139 141 2-s2.0-0025375671 (Pubitemid 20190436)
11. Law C. M., Barker D. J. P., Osmond C., Fall C. H. D., Simmonds S. J., Early growth and abdominal fatness in adult life. Journal of Epidemiology and Community Health 1992 46 3 184 186 2-s2.0-0026645483
12. Bavdekar A., Yajnik C. S., Fall C. H. D., Bapat S., Pandit A. N., Deshpande V., Bhave S., Kellingray S. D., Joglekar C., Insulin resistance syndrome in 8-year-old Indian children: small at birth, big at 8 years, or both? Diabetes 1999 48 12 2422 2429 2-s2.0-0033499584 (Pubitemid 30395435)
13. Gopalan C., Child care in India: emerging challenges. Yojana 1993 37 10 6 8 2-s2.0-0027917571
14. Mohan M., Prasad S. R., Chellani H. K., Kapani V., Intrauterine growth curves in north Indian babies: weight, length, head circumference and ponderal index. Indian Pediatrics 1990 27 1 43 51 2-s2.0-0025097088
15. Gupta R., Gupta V. P., Meta-analysis of coronary heart disease prevalence in India. Indian Heart Journal 1996 48 3 241 245 2-s2.0-0030138901 (Pubitemid 126496338)
16. Flegal K. M., Ogden C. L., Yanovski J. A., Freedman D. S., Shepherd J. A., Graubard B. I., Borrud L. G., High adiposity and high body mass index-for-age in US children and adolescents overall and by race-ethnic group. American Journal of Clinical Nutrition 2010 91 4 1020 1026 2-s2.0-77950475199 10.3945/ajcn.2009.28589
17. Alfaradhi M. Z., Ozanne S. E., Developmental programming in response to maternal overnutrition. Frontiers in Genetics 2011 2, article 27
18. Pufal M. A., Moulin C. C., Casagrande D. S., Prevalence of overweight in children of obese patients: a dietary overview. Obesity Surgery 2012 22 8 1220 1224
19. Colín-Ramírez E., Castillo-Martínez L., Orea-Tejeda A., Villa Romero A. R., Castañeda A. V., Asensio Lafuente E., Waist circumference and fat intake are associated with high blood pressure in mexican children aged 8 to 10 years. Journal of the American Dietetic Association 2009 109 6 996 1003 2-s2.0-65649149796 10.1016/j.jada.2009.03.011
20. Symonds M. E., Pope M., Sharkey D., Budge H., Adipose tissue and fetal programming. Diabetologia 2012 55 6 1597 1606
21. Ornoy A., Prenatal origin of obesity and their complications: gestational diabetes, maternal overweight and the paradoxical effects of fetal growth restriction and macrosomia. Reproductive Toxicology 2011 32 2 205 212 2-s2.0-79960847990 10.1016/j.reprotox.2011.05.002
22. Cai D., Liu T., Hypothalamic inflammation: a double-edged sword to nutritional diseases. Annals of the New York Academy of Sciences 2011 1243 E1 E39
23. Weiss T. W., Seljeflot I., Hjerkinn E. M., Arnesen H., Adipose tissue pro-inflammatory gene expression is associated with cardiovascular disease. International Journal of Clinical Practice 2011 65 9 939 944
24. Fain J. N., Release of interleukins and other inflammatory cytokines by human adipose tissue is enhanced in obesity and primarily due to the nonfat cells. Vitamins and Hormones 2006 74 443 477 2-s2.0-33846201363 10.1016/S0083-6729(06)74018-3
25. Kleinridders A., Schenten D., Könner A. C., Belgardt B. F., Mauer J., Okamura T., Wunderlich F. T., Medzhitov R., Brüning J. C., MyD88 signaling in the CNS is required for development of fatty acid-induced leptin resistance and diet-induced obesity. Cell Metabolism 2009 10 4 249 259 2-s2.0-70349484212 10.1016/j.cmet.2009.08.013
26. Ramírez F., Fowell D. J., Puklavec M., Simmonds S., Mason D., Glucocorticoids promote a Th2 cytokine response by CD4+ T cells in vitro. Journal of Immunology 1996 156 7 2406 2412 2-s2.0-0029925751 (Pubitemid 26091564)
27. Jensen L. E., Whitehead A. S., Regulation of serum amyloid A protein expression during the acute-phase response. Biochemical Journal 1998 334, part 3 489 503 2-s2.0-0032530560 (Pubitemid 28457193)
28. Carter-Su C., Okamoto K., Effect of insulin and glucocorticoids on glucose transporters in rat adipocytes. American Journal of PhysiologyEndocrinology and Metabolism 1987 252 4, part 1 E441 E453 2-s2.0-0023197796
29. Heron M., Deaths: leading causes for 2007. National Vital Statistics Reports 2011 59 8 1 95
30. Barker D. J. P., In utero programming of chronic disease. Clinical Science 1998 95 2 115 128 2-s2.0-0031661215 (Pubitemid 28401260)
31. Roseboom T. J., Van der Meulen J. H. P., Ravelli A. C. J., Osmond C., Barker D. J. P., Bleker O. P., Effects of prenatal exposure to the Dutch famine on adult disease in later life: an overview. Molecular and Cellular Endocrinology 2001 185 1-2 93 98 2-s2.0-0035924082 10.1016/S0303-7207(01)00721-3 (Pubitemid 33103957)
32. Crespi E. J., A mechanistic understanding of ageing revealed by studying the young. Molecular Ecology 2012 21 6 1307 1310
33. Ravelli A. C., Bleker O. P., Roseboom T. J., van Montfrans G. A., Osmond C., Barker D. J., Cardiovascular disease in survivors of the Dutch famine. Nestlé Nutrition Institute Workshop Series: Pediatric Program 2005 55 183 195
34. Roseboom T. J., Van der Meulen J. H. P., Osmond C., Barker D. J. P., Ravelli A. C. J., Bleker O. P., Plasma lipid profiles in adults after prenatal exposure to the Dutch famine. American Journal of Clinical Nutrition 2000 72 5 1101 1106 2-s2.0-0033753663
35. Roseboom T. J., van der Meulen J. H. P., Osmond C., Barker D. J. P., Ravelli A. C. J., Schroeder-Tanka J. M., Van Montfrans G. A., Michels R. P. J., Bleker O. P., Coronary heart disease after prenatal exposure to the Dutch famine, 1944-45. Heart 2000 84 6 595 598 2-s2.0-0033652166
36. Ravelli A. C. J., Van Der Meulen J. H. P., Michels R. P. J., Osmond C., Barker D. J. P., Hales C. N., Bleker O. P., Glucose tolerance in adults after prenatal exposure to famine. Lancet 1998 351 9097 173 177 2-s2.0-0032539468 10.1016/S0140-6736(97)07244-9 (Pubitemid 28037007)
37. De Rooij S. R., Painter R. C., Phillips D. I., Osmond C., Michels R. P. J., Godsland I. F., Bossuyt P. M. M., Bleker O. P., Roseboom T. J., Impaired insulin secretion after prenatal exposure to the Dutch famine. Diabetes Care 2006 29 8 1897 1901 2-s2.0-33746614653 10.2337/dc06-0460 (Pubitemid 44156649)
38. Sancakli O., Darendeliler F., Bas F., Gokcay G., Disci R., Aki S., Eskiyurt N., Insulin, adiponectin, IGFBP-1 levels and body composition in small for gestational age born non-obese children during prepubertal ages. Clinical Endocrinology 2008 69 1 88 92 2-s2.0-45349092440 10.1111/j.1365-2265.2007.03138. x (Pubitemid 351847257)
39. Yajnik C. S., Obesity epidemic in India: intrauterine origins? Proceedings of the Nutrition Society 2004 63 3 387 396 2-s2.0-4344608444 10.1079/PNS2004365 (Pubitemid 39145497)
40. Yajnik C. S., Fall C. H. D., Coyaji K. J., Hirve S. S., Rao S., Barker D. J. P., Joglekar C., Kellingray S., Neonatal anthropometry: the thin-fat Indian baby. The Pune maternal nutrition study. International Journal of Obesity 2003 27 2 173 180 2-s2.0-0037327541 10.1038/sj.ijo.802219 (Pubitemid 36255798)
41. Yajnik C. S., Joglekar C. V., Pandit A. N., Bavdekar A. R., Bapat S. A., Bhave S. A., Leary S. D., Fall C. H. D., Higher offspring birth weight predicts the metabolic syndrome in mothers but not fathers 8 years after delivery: the Pune children's study. Diabetes 2003 52 8 2090 2096 2-s2.0-0041765685 10.2337/diabetes.52.8.2090 (Pubitemid 36919803)
42. Yogev Y., Catalano P. M., Pregnancy and obesity. Obstetrics and Gynecology Clinics of North America 2009 36 2 285 300 2-s2.0-66549119926 10.1016/j.ogc.2009.03.003
43. Boney C. M., Verma A., Tucker R., Vohr B. R., Metabolic syndrome in childhood: association with birth weight, maternal obesity, and gestational diabetes mellitus. Pediatrics 2005 115 3 e290 e296 2-s2.0-20344382306 10.1542/peds.2004-1808 (Pubitemid 43373011)
44. Heerwagen M. J. R., Miller M. R., Barbour L. A., Friedman J. E., Maternal obesity and fetal metabolic programming: a fertile epigenetic soil. American Journal of PhysiologyRegulatory Integrative and Comparative Physiology 2010 299 3 R711 R722 2-s2.0-77956660200 10.1152/ajpregu.00310.2010
45. Lain K. Y., Catalano P. M., Metabolic changes in pregnancy. Clinical Obstetrics and Gynecology 2007 50 4 938 948 2-s2.0-35848961430 10.1097/GRF.0b013e31815a5494 (Pubitemid 350059291)
46. Challier J. C., Basu S., Bintein T., Minium J., Hotmire K., Catalano P. M., Hauguel-de Mouzon S., Obesity in pregnancy stimulates macrophage accumulation and inflammation in the placenta. Placenta 2008 29 3 274 281 2-s2.0-40649100721 10.1016/j.placenta.2007.12.010
47. Hayes E. K., Lechowicz A., Petrik J. J., Adverse fetal and neonatal outcomes associated with a life-long high fat diet: role of altered development of the placental vasculature. PLoS One 2012 7 3, article e33370
48. Challier J. C., Basu S., Bintein T., Minium J., Hotmire K., Catalano P. M., Hauguel-de Mouzon S., Obesity in pregnancy stimulates macrophage accumulation and inflammation in the placenta. Placenta 2008 29 3 274 281 2-s2.0-40649100721 10.1016/j.placenta.2007.12.010
49. Férézou-Viala J., Roy A. F., Sérougne C., Gripois D., Parquet M., Bailleux V., Gertler A., Delplanque B., Djiane J., Riottot M., Taouis M., Long-term consequences of maternal high-fat feeding on hypothalamic leptin sensitivity and diet-induced obesity in the offspring. American Journal of PhysiologyRegulatory Integrative and Comparative Physiology 2007 293 3 R1056 R1062 2-s2.0-34548428677 10.1152/ajpregu.00117.2007 (Pubitemid 47358924)
50. Palou M., Konieczna J., Torrens J. M., Impaired insulin and leptin sensitivity in the offspring of moderate caloric-restricted dams during gestation is early programmed. The Journal of Nutritional Biochemistry. In press
51. Gupta A., Srinivasan M., Thamadilok S., Patel M. S., Hypothalamic alterations in fetuses of high fat diet-fed obese female rats. Journal of Endocrinology 2009 200 3 293 300 2-s2.0-67449152696 10.1677/JOE-08-0429
52. Banks W. A., Coon A. B., Robinson S. M., Moinuddin A., Shultz J. M., Nakaoke R., Morley J. E., Triglycerides induce leptin resistance at the blood-brain barrier. Diabetes 2004 53 5 1253 1260 2-s2.0-2342449315 10.2337/diabetes.53.5.1253 (Pubitemid 38569011)
53. Morris M. J., Chen H., Established maternal obesity in the rat reprograms hypothalamic appetite regulators and leptin signaling at birth. International Journal of Obesity 2009 33 1 115 122 2-s2.0-58149490989 10.1038/ijo.2008.213
54. El-Haschimi K., Pierroz D. D., Hileman S. M., Bjorbæk C., Flier J. S., Two defects contribute to hypothalamic leptin resistance in mice with diet-induced obesity. Journal of Clinical Investigation 2000 105 12 1827 1832 2-s2.0-0033931981 (Pubitemid 30421764)
55. Frühbeck G., Intracellular signalling pathways activated by leptin. Biochemical Journal 2006 393 1 7 20 2-s2.0-30044434035 10.1042/BJ20051578 (Pubitemid 43049298)
56. Belkacemi L., Jelks A., Chen C. H., Ross M., Desai M., Altered placental development in undernourished rats: role of maternal glucocorticoids. Reproductive Biology and Endocrinology 2011 9, article 105 2-s2.0-79960884695 10.1186/1477-7827-9-105
57. Lesage J., Blondeau B., Grino M., Bréant B., Dupouy J. P., Maternal undernutrition during late gestation induces fetal overexposure to glucocorticoids and intrauterine growth retardation, and disturbs the hypothalamo-pituitary adrenal axis in the newborn rat. Endocrinology 2001 142 5 1692 1702 2-s2.0-0035047054 10.1210/en.142.5.1692 (Pubitemid 32405922)
58. Sugden M. C., Langdown M. L., Munns M. J., Holness M. J., Maternal glucocorticoid treatment modulates placental leptin and leptin receptor expression and materno-fetal leptin physiology during late pregnancy, and elicits hypertension associated with hyperleptinaemia in the early-growth-retarded adult offspring. European Journal of Endocrinology 2001 145 4 529 539 2-s2.0-0034804294 (Pubitemid 32927083)
59. Smith J. T., Waddell B. J., Leptin distribution and metabolism in the pregnant rat: transplacental leptin passage increases in late gestation but is reduced by excess glucocorticoids. Endocrinology 2003 144 7 3024 3030 2-s2.0-0038649327 10.1210/en.2003-0145 (Pubitemid 36819904)
60. Tamashiro K. L. K., Moran T. H., Perinatal environment and its influences on metabolic programming of offspring. Physiology and Behavior 2010 100 5 560 566 2-s2.0-77953724327 10.1016/j.physbeh.2010.04.008
61. Malcher-Lopes R., Di S., Marcheselli V. S., Weng F. J., Stuart C. T., Bazan N. G., Tasker J. G., Opposing crosstalk between leptin and glucocorticoids rapidly modulates synaptic excitation via endocannabinoid release. Journal of Neuroscience 2006 26 24 6643 6650 2-s2.0-33745768460 10.1523/JNEUROSCI.5126-05. 2006 (Pubitemid 44318346)
62. Langley-Evans S. C., Critical differences between two low protein diet protocols in the programming of hypertension in the rat. International Journal of Food Sciences and Nutrition 2000 51 1 11 17 2-s2.0-0033976772 (Pubitemid 30103043)
63. Barker D. J. P., Fetal origins of coronary heart disease. British Medical Journal 1995 311 6998 171 174 2-s2.0-0029050563
64. Khoury M., Manlhiot C., Dobbin S., Gibson D., Chahal N., Wong H., Role of waist measures in characterizing the lipid and blood pressure assessment of adolescents classified by body mass index. Archives of Pediatrics & Adolescent Medicine. In press
65. Bertram C., Trowern A. R., Copin N., Jackson A. A., Whorwood C. B., The maternal diet during pregnancy programs altered expression of the glucocorticoid receptor and type 2 11 β -hydroxysteroid dehydrogenase: potential molecular mechanisms underlying the programming of hypertension in utero. Endocrinology 2001 142 7 2841 2853 2-s2.0-0034991503 10.1210/en.142.7.2841 (Pubitemid 32575519)
66. Gardner D. S., Jackson A. A., Langley-Evans S. C., Maintenance of maternal diet-induced hypertension in the rat is dependent on glucocorticoids. Hypertension 1997 30 6 1525 1530 2-s2.0-0030693236 (Pubitemid 27528099)
67. Langley-Evans S. C., Phillips G. J., Benediktsson R., Gardner D. S., Edwards C. R. W., Jackson A. A., Seckl J. R., Protein intake in pregnancy, placental glucocorticoid metabolism and the programming of hypertension in the rat. Placenta 1996 17 2-3 169 172 2-s2.0-0029912988 10.1016/S0143-4004(96)80010- 5 (Pubitemid 26117220)
68. Tangalakis K., Lumbers E. R., Moritz K. M., Towstoless M. K., Wintour E. M., Effect of cortisol on blood pressure and vascular reactivity in the ovine fetus. Experimental Physiology 1992 77 5 709 717 2-s2.0-0026706443
69. Edwards C. R. W., Benediktsson R., Lindsay R. S., Seckl J. R., Dysfunction of placental glucocorticoid barrier: link between fetal environment and adult hypertension? Lancet 1993 341 8841 355 357 2-s2.0-0027530474 10.1016/0140-6736(93)90148-A (Pubitemid 23039711)
70. Wintour E. M., Moritz K. M., Johnson K., Ricardo S., Samuel C. S., Dodic M., Reduced nephron number in adult sheep, hypertensive as a result of prenatal glucocorticoid treatment. Journal of Physiology 2003 549 3 929 935 2-s2.0-0037821215 10.1113/jphysiol.2003.042408 (Pubitemid 36889780)
71. Whorwood C. B., Ricketts M. L., Stewart P. M., Regulation of sodium-potassium adenosine triphosphate subunit gene expression by corticosteroids and 11 β -hydroxysteroid dehydrogenase activity. Endocrinology 1994 135 3 901 910 2-s2.0-0028037644 10.1210/en.135.3.901 (Pubitemid 24271178)
72. Whorwood C. B., Firth K. M., Budge H., Symonds M. E., Maternal undernutrition during early to midgestation programs tissue-specific alterations in the expression of the glucocorticoid receptor, 11 β -hydroxysteroid dehydrogenase isoforms, and type 1 angiotensin II receptor in neonatal sheep. Endocrinology 2001 142 7 2854 2864 2-s2.0-0034987734 10.1210/en.142.7.2854 (Pubitemid 32575520)
73. Mesquita F. F., Gontijo J. A. R., Boer P. A., Expression of renin-angiotensin system signalling compounds in maternal protein-restricted rats: effect on renal sodium excretion and blood pressure. Nephrology Dialysis Transplantation 2010 25 2 380 388 2-s2.0-75649124168 10.1093/ndt/gfp505
74. Chou H. C., Wang L. F., Lu K. S., Chen C. M., Effects of maternal undernutrition on renal angiotensin II and chymase in hypertensive offspring. Acta Histochemica 2008 110 6 497 504 2-s2.0-55549096756 10.1016/j.acthis.2008. 01.002
75. Rivière G., Michaud A., Breton C., VanCamp G., Laborie C., Enache M., Lesage J., Deloof S., Corvol P., Vieau D., Angiotensin-converting enzyme 2 (ACE2) and ACE activities display tissue-specific sensitivity to undernutrition-programmed hypertension in the adult rat. Hypertension 2005 46 5 1169 1174 2-s2.0-27444433984 10.1161/01.HYP.0000185148.27901.fe (Pubitemid 41533021)
76. Wyrwoll C. S., Mark P. J., Waddell B. J., Developmental programming of renal glucocorticoid sensitivity and the renin-angiotensin system. Hypertension 2007 50 3 579 584 2-s2.0-34548171998 10.1161/HYPERTENSIONAHA.107.091603 (Pubitemid 47312247)
77. Barker D. J. P., Gelow J., Thornburg K., Osmond C., Kajantie E., Eriksson J. G., The early origins of chronic heart failure: impaired placental growth and initiation of insulin resistance in childhood. European Journal of Heart Failure 2010 12 8 819 825 2-s2.0-77955457588 10.1093/eurjhf/hfq069
78. Barker D. J. P., Fetal programming of coronary heart disease. Trends in Endocrinology and Metabolism 2002 13 9 364 368 2-s2.0-0036833795 10.1016/S1043-2760(02)00689-6 (Pubitemid 36723587)
79. Eriksson J. G., Forsén T., Tuomilehto J., Osmond C., Barker D. J. P., Early growth and coronary heart disease in later life: longitudinal study. British Medical Journal 2001 322 7292 949 953 2-s2.0-0035926032 (Pubitemid 32374683)
80. Yudkin J. S., Kumari M., Humphries S. E., Mohamed-Ali V., Inflammation, obesity, stress and coronary heart disease: is interleukin-6 the link? Atherosclerosis 2000 148 2 209 214 2-s2.0-0033984744 10.1016/S0021-9150(99) 00463-3 (Pubitemid 30064452)
81. Yudkin J. S., Stehouwer C. D. A., Emeis J. J., Coppack S. W., C-reactive protein in healthy subjects: associations with obesity, insulin resistance, and endothelial dysfunction: a potential role for cytokines originating from adipose tissue? Arteriosclerosis, Thrombosis, and Vascular Biology 1999 19 4 972 978 2-s2.0-0032943709 (Pubitemid 29177345)
82. Kleemann R., Zadelaar S., Kooistra T., Cytokines and atherosclerosis: a comprehensive review of studies in mice. Cardiovascular Research 2008 79 3 360 376 2-s2.0-48749110858 10.1093/cvr/cvn120
83. Grenon S. M., Aguado-Zuniga J., Hatton J. P., Owens C. D., Conte M. S., Hughes-Fulford M., Effects of fatty acids on endothelial cells: inflammation and monocyte adhesion. Journal of Surgical Research. In press
84. Li G., Xiao Y., Estrella J. L., Ducsay C. A., Gilbert R. D., Zhang L., Effect of fetal hypoxia on heart susceptibility to ischemia and reperfusion injury in the adult rat. Journal of the Society for Gynecologic Investigation 2003 10 5 265 274 2-s2.0-0037674471 10.1016/S1071-5576(03)00074-1 (Pubitemid 36802327)
85. Xue Q., Dasgupta C., Chen M., Zhang L., Foetal hypoxia increases cardiac AT2R expression and subsequent vulnerability to adult ischaemic injury. Cardiovascular Research 2011 89 2 300 308 2-s2.0-78751498302 10.1093/cvr/cvq303
86. Soto N., Bazaes R. A., Peña V., Salazar T., Ávila A., Iñiguez G., Ong K. K., Dunger D. B., Mericq M. V., Insulin sensitivity and secretion are related to catch-up growth in small-for-gestational-age infants at age 1 year: results from a prospective cohort. Journal of Clinical Endocrinology and Metabolism 2003 88 8 3645 3650 2-s2.0-0042885569 10.1210/jc.2002-030031 (Pubitemid 37034508)
87. Ibáñez L., Ong K., Dunger D. B., De Zegher F., Early development of adiposity and insulin resistance after catch-up weight gain in small-for-gestational-age children. Journal of Clinical Endocrinology and Metabolism 2006 91 6 2153 2158 2-s2.0-33744952660 10.1210/jc.2005-2778 (Pubitemid 43854998)
88. Fabricius-Bjerre S., Jensen R. B., Færch K., Larsen T., Molgaard C., Michaelsen K. F., Vaag A., Greisen G., Impact of birth weight and early infant weight gain on insulin resistance and associated cardiovascular risk factors in adolescence. PLoS ONE 2011 6 6, article e20595 2-s2.0-79957964460 10.1371/journal.pone.0020595
89. Bazaes R. A., Mericq V., Premature birth and insulin resistance. The New England Journal of Medicine 2005 352 9 939 940 2-s2.0-14544267583 10.1056/NEJM200503033520920 (Pubitemid 40300308)
90. Catalano P. M., Presley L., Minium J., Mouzon S. H. D., Fetuses of obese mothers develop insulin resistance in utero. Diabetes Care 2009 32 6 1076 1080 2-s2.0-66549089201 10.2337/dc08-2077
91. Garofano A., Czernichow P., Bréant B., In utero undernutrition impairs rat beta-cell development. Diabetologia 1997 40 10 1231 1234 2-s2.0-0030798732 10.1007/s001250050812 (Pubitemid 27421897)
92. Theys N., Ahn M. T., Bouckenooghe T., Reusens B., Remacle C., Maternal malnutrition programs pancreatic islet mitochondrial dysfunction in the adult offspring. Journal of Nutritional Biochemistry 2011 22 10 985 994 2-s2.0-78650499884 10.1016/j.jnutbio.2010.08.015
93. Holemans K., Aerts L., Van Assche F. A., Lifetime consequences of abnormal fetal pancreatic development. Journal of Physiology 2003 547, part 1 11 20 2-s2.0-0037440723 10.1113/jphysiol.2002.036582 (Pubitemid 36285157)
94. Simmons R. A., Developmental origins of diabetes: the role of epigenetic mechanisms. Current Opinion in Endocrinology, Diabetes and Obesity 2007 14 1 13 16 2-s2.0-33847723947 10.1097/MED.0b013e328013da5b (Pubitemid 46375382)
95. Maechler P., Novel regulation of insulin secretion: the role of mitochondria. Current Opinion in Investigational Drugs 2003 4 10 1166 1172 2-s2.0-0242658614 (Pubitemid 37420102)
96. Portha B., Chavey A., Movassat J., Early-life origins of type 2 diabetes: fetal programming of the beta-cell mass. Experimental Diabetes Research 2011 2011 105076
97. Zeng C. J., Zhang L., Yang H. X., Effects of severe hyperglycaemia in pregnancy and early overfeeding on islet development and insulin resistance. Zhonghua Fu Chan Ke Za Zhi 2010 45 9 658 663
98. Taylor P. D., McConnell J., Khan I. Y., Holemans K., Lawrence K. M., Asare-Anane H., Persaud S. J., Jones P. M., Petrie L., Hanson M. A., Poston L., Impaired glucose homeostasis and mitochondrial abnormalities in offspring of rats fed a fat-rich diet in pregnancy. American Journal of PhysiologyRegulatory Integrative and Comparative Physiology 2005 288 1 R134 R139 2-s2.0-19944423057 10.1152/ajpregu.00355.2004 (Pubitemid 40023923)
99. Liu F., Xia Y., Parker A. S., Verma I. M., IKK biology. Immunological Reviews 2012 246 1 239 253
100. Sabapathy K., Role of the JNK pathway in human diseases. Progress in Molecular Biology and Translational Science 2012 106 145 169
101. Rother E., Kuschewski R., Alcazar M. A., Oberthuer A., Bae-Gartz I., Vohlen C., Hypothalamic JNK1 and IKKbeta activation and impaired early postnatal glucose metabolism after maternal perinatal high-fat feeding. Endocrinology 2012 153 2 770 781
102. Prada P. O., Zecchin H. G., Gasparetti A. L., Torsoni M. A., Ueno M., Hirata A. E., Corezola Do Amaral M. E., Höer N. F., Boschero A. C., Saad M. J. A., Western diet modulates insulin signaling, c-jun N-terminal kinase activity, and insulin receptor substrate-1ser307 phosphorylation in a tissue-specific fashion. Endocrinology 2005 146 3 1576 1587 2-s2.0-20044364733 10.1210/en.2004-0767 (Pubitemid 40289349)
103. Tsukumo D. M. L., Carvalho-Filho M. A., Carvalheira J. B. C., Prada P. O., Hirabara S. M., Schenka A. A., Araújo E. P., Vassallo J., Curi R., Velloso L. A., Saad M. J. A., Loss-of-function mutation in toll-like receptor 4 prevents diet-induced obesity and insulin resistance. Diabetes 2007 56 8 1986 1998 2-s2.0-34547602916 10.2337/db06-1595 (Pubitemid 47195825)
104. Poggi M., Bastelica D., Gual P., Iglesias M. A., Gremeaux T., Knauf C., Peiretti F., Verdier M., Juhan-Vague I., Tanti J. F., Burcelin R., Alessi M. C., C3H/HeJ mice carrying a toll-like receptor 4 mutation are protected against the development of insulin resistance in white adipose tissue in response to a high-fat diet. Diabetologia 2007 50 6 1267 1276 2-s2.0-34247884376 10.1007/s00125-007-0654-8 (Pubitemid 46701560)