Cryptosporidium parvum antigens induce mouse and human dendritic cells to generate Th1-enhancing cytokines

Parasite Immunology

Volumn 34, Issue 10, 2012, Pages 473-485

  Bedi, B ^a   Mead, J R ^a,b  

^a ATLANTA VA MEDICAL CENTER   (United States)

^b EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Antigens; Cryptosporidium; Dendritic cells; IL 12; MyD88

Indexed keywords

CD209 ANTIGEN; CRYPTOSPORIDIAL ANTIGEN CP23; CRYPTOSPORIDIAL ANTIGEN CP40; INTERLEUKIN 12P70; INTERLEUKIN 18; INTERLEUKIN 1BETA; INTERLEUKIN 2; INTERLEUKIN 6; MYELOID DIFFERENTIATION FACTOR 88; PARASITE ANTIGEN; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; BONE MARROW; CELL ACTIVATION; CELL MATURATION; CELL STIMULATION; CONTROLLED STUDY; CRYPTOSPORIDIUM PARVUM; CYTOKINE PRODUCTION; DENDRITIC CELL; FEMALE; HUMAN; HUMAN CELL; IMMUNE RESPONSE; INNATE IMMUNITY; MONOCYTE; MOUSE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; TH1 CELL; UPREGULATION;

ANIMALS; ANTIGENS, PROTOZOAN; BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTORS; CELL ADHESION MOLECULES; CELLS, CULTURED; CRYPTOSPORIDIUM PARVUM; CYTOKINES; DENDRITIC CELLS; FEMALE; HUMANS; LECTINS, C-TYPE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MYELOID DIFFERENTIATION FACTOR 88; RECEPTORS, CELL SURFACE; TH1 CELLS;

CRYPTOSPORIDIUM; CRYPTOSPORIDIUM PARVUM;

EID: 84866153155     PISSN: 01419838     EISSN: 13653024     Source Type: Journal    
DOI: 10.1111/j.1365-3024.2012.01382.x     Document Type: Article

References (49)

1. Davies AP & Chalmers RM. Cryptosporidiosis. BMJ 2009; 339: b4168.
2. Laurent F, McCole D, Eckmann L & Kagnoff MF. Pathogenesis of Cryptosporidium parvum infection. Microbes Infect 1999; 1: 141-148.
3. Chen XM, Keithly JS, Paya CV & LaRusso NF. Cryptosporidiosis. N Engl J Med 2002; 346: 1723-1731.
4. Amadi B, Mwiya M, Sianongo S, et al. High dose prolonged treatment with nitazoxanide is not effective for cryptosporidiosis in HIV positive Zambian children: a randomised controlled trial. BMC Infect Dis 2009; 9: 195.
5. McDonald V & Bancroft GJ. Mechanisms of innate and acquired resistance to Cryptosporidium parvum infection in SCID mice. Parasite Immunol 1994; 16: 315-320.
6. Tessema TS, Schwamb B, Lochner M, Forster I, Jakobi V & Petry F. Dynamics of gut mucosal and systemic Th1/Th2 cytokine responses in interferon-gamma and interleukin-12p40 knock out mice during primary and challenge Cryptosporidium parvum infection. Immunobiology 2009; 214: 454-466.
7. Rescigno M & Di Sabatino A. Dendritic cells in intestinal homeostasis and disease. J Clin Invest 2009; 119: 2441-2450.
8. Ponnuraj EM & Hayward AR. Intact intestinal mRNAs and intestinal epithelial cell esterase, but not Cryptosporidium parvum, reach mesenteric lymph nodes of infected mice. J Immunol 2001; 167: 5321-5328.
9. Auray G, Lacroix-Lamande S, Mancassola R, Dimier-Poisson I & Laurent F. Involvement of intestinal epithelial cells in dendritic cell recruitment during C.parvum infection. Microbes Infect 2007; 9: 574-582.
10. Barakat FM, McDonald V, Foster GR, Tovey MG & Korbel DS. Cryptosporidium parvum infection rapidly induces a protective innate immune response involving type I interferon. J Infect Dis 2009; 200: 1548-1555.
11. Marques R & Boneca IG. Expression and functional importance of innate immune receptors by intestinal epithelial cells. Cell Mol Life Sci 2011; 68: 3661-3673.
12. Boonstra A, Rajsbaum R, Holman M, et al. Macrophages and myeloid dendritic cells, but not plasmacytoid dendritic cells, produce IL-10 in response to MyD88- and TRIF-dependent TLR signals, and TLR-independent signals. J Immunol 2006; 177: 7551-7558.
13. Rogers KA, Rogers AB, Leav BA, et al. MyD88-dependent pathways mediate resistance to Cryptosporidium parvum infection in mice. Infect Immun 2006; 74: 549-556.
14. O'Hara SP, Bogert PS, Trussoni CE, Chen X & LaRusso NF. TLR4 promotes Cryptosporidium parvum clearance in a mouse model of biliary cryptosporidiosis. J Parasitol 2011; 97: 813-821.
15. Wanyiri J & Ward H. Molecular basis of Cryptosporidium-host cell interactions: recent advances and future prospects. Future Microbiol 2006; 1: 201-208.
16. Cevallos AM, Zhang X, Waldor MK, et al. Molecular cloning and expression of a gene encoding Cryptosporidium parvum glycoproteins gp40 and gp15. Infect Immun 2000; 68: 4108-4116.
17. Riggs MW. Recent advances in cryptosporidiosis: the immune response. Microbes Infect 2002; 4: 1067-1080.
18. Priest JW, Kwon JP, Arrowood MJ & Lammie PJ. Cloning of the immunodominant 17-kDa antigen from Cryptosporidium parvum. Mol Biochem Parasitol 2000; 106: 261-271.
19. Priest JW, Kwon JP, Montgomery JM, et al. Cloning and characterization of the acidic ribosomal protein P2 of Cryptosporidium parvum, a new 17-kilodalton antigen. Clin Vaccine Immunol 2010; 17: 954-965.
20. Borad A & Ward H. Human immune responses in cryptosporidiosis. Future Microbiol 2010; 5: 507-519.
21. Subauste CS & Wessendarp M. Human dendritic cells discriminate between viable and killed Toxoplasma gondii tachyzoites: dendritic cell activation after infection with viable parasites results in CD28 and CD40 ligand signaling that controls IL-12-dependent and -independent T cell production of IFN-gamma. J Immunol 2000; 165: 1498-1505.
22. Benitez AJ, McNair N & Mead JR. Oral immunization with attenuated Salmonella enterica serovar Typhimurium encoding Cryptosporidium parvum Cp23 and Cp40 antigens induces a specific immune response in mice. Clin Vaccine Immunol 2009; 16: 1272-1278.
23. Benitez AJ, McNair N & Mead J. Modulation of gene expression of three Cryptosporidium parvum ATP-binding cassette transporters in response to drug treatment. Parasitol Res 2007; 101: 1611-1616.
24. Benitez A, Priest JW, Ehigiator HN, McNair N & Mead JR. Evaluation of DNA encoding acidic ribosomal protein P2 of Cryptosporidium parvum as a potential vaccine candidate for cryptosporidiosis. Vaccine 2011; 29: 9239-9245.
25. Kaisho T, Takeuchi O, Kawai T, Hoshino K & Akira S. Endotoxin-induced maturation of MyD88-deficient dendritic cells. J Immunol 2001; 166: 5688-5694.
26. Ueno H, Palucka AK & Banchereau J. The expanding family of dendritic cell subsets. Nat Biotechnol 2010; 28: 813-815.
27. Shortman K & Liu YJ. Mouse and human dendritic cell subtypes. Nat Rev Immunol 2002; 2: 151-161.
28. Mashayekhi M, Sandau MM, Dunay IR, et al. CD8alpha(+) dendritic cells are the critical source of interleukin-12 that controls acute infection by Toxoplasma gondii tachyzoites. Immunity 2011; 35: 249-259.
29. Campbell LD, Stewart JN & Mead JR. Susceptibility to Cryptosporidium parvum infections in cytokine- and chemokine-receptor knockout mice. J Parasitol 2002; 88: 1014-1016.
30. Urban JF Jr, Fayer R, Sullivan C, et al. Local TH1 and TH2 responses to parasitic infection in the intestine: regulation by IFN-gamma and IL-4. Vet Immunol Immunopathol 1996; 54: 337-344.
31. Strong WB, Gut J & Nelson RG. Cloning and sequence analysis of a highly polymorphic Cryptosporidium parvum gene encoding a 60-kilodalton glycoprotein and characterization of its 15- and 45-kilodalton zoite surface antigen products. Infect Immun 2000; 68: 4117-4134.
32. Perryman LE, Jasmer DP, Riggs MW, Bohnet SG, McGuire TC & Arrowood MJ. A cloned gene of Cryptosporidium parvum encodes neutralization-sensitive epitopes. Mol Biochem Parasitol 1996; 80: 137-147.
33. Bonafonte MT, Smith LM & Mead JR. A 23-kDa recombinant antigen of Cryptosporidium parvum induces a cellular immune response on in vitro stimulated spleen and mesenteric lymph node cells from infected mice. Exp Parasitol 2000; 96: 32-41.
34. Singh I, Theodos C & Tzipori S. Recombinant proteins of Cryptosporidium parvum induce proliferation of mesenteric lymph node cells in infected mice. Infect Immun 2005; 73: 5245-5248.
35. Smith LM, Priest JW, Lammie PJ & Mead JR. Human T and B cell immunoreactivity to a recombinant 23-kDa Cryptosporidium parvum antigen. J Parasitol 2001; 87: 704-707.
36. Chen XM, O'Hara SP, Nelson JB, et al. Multiple TLRs are expressed in human cholangiocytes and mediate host epithelial defense responses to Cryptosporidium parvum via activation of NF-kappaB. J Immunol 2005; 175: 7447-7456.
37. Pifer R & Yarovinsky F. Innate responses to Toxoplasma gondii in mice and humans. Trends Parasitol 2011; 27: 388-393.
38. Scanga CA, Aliberti J, Jankovic D, et al. Cutting edge: MyD88 is required for resistance to Toxoplasma gondii infection and regulates parasite-induced IL-12 production by dendritic cells. J Immunol 2002; 168: 5997-6001.
39. Campos MA, Almeida IC, Takeuchi O, et al. Activation of Toll-like receptor-2 by glycosylphosphatidylinositol anchors from a protozoan parasite. J Immunol 2001; 167: 416-423.
40. Krishnegowda G, Hajjar AM, Zhu J, et al. Induction of proinflammatory responses in macrophages by the glycosylphosphatidylinositols of Plasmodium falciparum: cell signaling receptors, glycosylphosphatidylinositol (GPI) structural requirement, and regulation of GPI activity. J Biol Chem 2005; 280: 8606-8616.
41. Zhu J, Krishnegowda G & Gowda DC. Induction of proinflammatory responses in macrophages by the glycosylphosphatidylinositols of Plasmodium falciparum: the requirement of extracellular signal-regulated kinase, p38, c-Jun N-terminal kinase and NF-kappaB pathways for the expression of proinflammatory cytokines and nitric oxide. J Biol Chem 2005; 280: 8617-8627.
42. Debierre-Grockiego F, Campos MA, Azzouz N, et al. Activation of TLR2 and TLR4 by glycosylphosphatidylinositols derived from Toxoplasma gondii. J Immunol 2007; 179: 1129-1137.
43. Yarovinsky F, Zhang D, Andersen JF, et al. TLR11 activation of dendritic cells by a protozoan profilin-like protein. Science 2005; 308: 1626-1629.
44. Boonstra A, Asselin-Paturel C, Gilliet M, et al. Flexibility of mouse classical and plasmacytoid-derived dendritic cells in directing T helper type 1 and 2 cell development: dependency on antigen dose and differential toll-like receptor ligation. J Exp Med 2003; 197: 101-109.
45. Kadowaki N, Ho S, Antonenko S, et al. Subsets of human dendritic cell precursors express different toll-like receptors and respond to different microbial antigens. J Exp Med 2001; 194: 863-869.
46. Nomura T, Kawamura I, Tsuchiya K, et al. Essential role of interleukin-12 (IL-12) and IL-18 for gamma interferon production induced by listeriolysin O in mouse spleen cells. Infect Immun 2002; 70: 1049-1055.
47. Kolb-Maurer A, Kammerer U, Maurer M, et al. Production of IL-12 and IL-18 in human dendritic cells upon infection by Listeria monocytogenes. FEMS Immunol Med Microbiol 2003; 35: 255-262.
48. Choudhry N, Petry F, van Rooijen N & McDonald V. A protective role for interleukin 18 in Interferon gamma-mediated innate immunity to Cryptosporidium parvum that is independent of natural killer cells. J Infect Dis 2012; 206: 117-124.
49. McDonald V, Pollok RC, Dhaliwal W, Naik S, Farthing MJ & Bajaj-Elliott M. A potential role for interleukin-18 in inhibition of the development of Cryptosporidium parvum. Clin Exp Immunol 2006; 145: 555-562.