A cloned gene of Cryptosporidium parvum encodes neutralization-sensitive epitopes

Molecular and Biochemical Parasitology

Volumn 80, Issue 2, 1996, Pages 137-147

  Perryman, Lance E ^a,b   Jasmer, Douglas P ^b   Riggs, Michael W ^c   Bohnet, Stewart G ^b   McGuire, Travis C ^b   Arrowood, Michael J ^d  

^a NORTH CAROLINA STATE UNIVERSITY   (United States)

^b WASHINGTON STATE UNIVERSITY   (United States)

^c UNIVERSITY OF ARIZONA   (United States)

^d NATL CENTER FOR INFECTIOUS DISEASES   (United States)

Author keywords

Cryptosporidium parvum; Epitope; Genes; Infectious immunity; Mouse

Indexed keywords

EPITOPE; MONOCLONAL ANTIBODY; NEUTRALIZING ANTIBODY;

ARTICLE; CONTROLLED STUDY; CRYPTOSPORIDIUM PARVUM; DNA SEQUENCE; IMMUNITY; MOLECULAR CLONING; NONHUMAN; PRIORITY JOURNAL;

CRYPTOSPORIDIUM PARVUM;

EID: 0030272344     PISSN: 01666851     EISSN: None     Source Type: Journal    
DOI: 10.1016/0166-6851(96)02681-3     Document Type: Article

References (55)

1. [1] Tyzzer, E.E. (1912) Cryptosporidium parvum (sp nov), a coccidium found in the small intestine of the common mouse. Arch. Protistenkd. 26, 394-412.
2. [2] Meisel, J.L., Perera, D.R., Meligro, C. and Rubin, C.E. (1976) Overwhelming watery diarrhea associated with a Cryptosporidium in an immunosuppressed patient. Gastroenterology 70, 1156-1160.
3. [3] Nime, F.A., Burek, J.D., Page, D.L., Holscher, M.A. and Yardley, J.H. (1976) Acute enterocolitis in a human being infected with the protozoan Cryptosporidium. Gastroenterology 70, 592-598.
4. [4] Current, W.L., Reese, N.C., Ernst, J.V., Bailey, W.S., Heyman, M.B. and Weinstein, W.M. (1983) Human cryptosporidiosis in immunocompetent and immunodeficient persons. Studies of an outbreak and experimental transmission. N. Engl. J. Med. 308, 1252-1257.
5. [5] Fayer, R. and Ungar, B.L.P. (1986) Cryptosporidium spp. and cryptosporidiosis. Microbiol. Rev. 50, 458-483.
6. [6] O'Donoghue, P.J. (1995) Cryptosporidium and cryptosporidiosis in man and animals. Int. J. Parasitol. 25, 139-195.
7. [7] DuPont, H.L., Chappell, C.L., Sterling, C.R., Okhuysen, P.C., Rose, J.B. and Jakubowski, W. (1995) The infectivity of Cryptosporidium parvum in healthy volunteers. N. Engl. J. Med. 332, 855-859.
8. [8] Ungar, B.L.P., Kao, T.C., Burris, J.A. and Finkelman, F.D. (1991) Cryptosporidium infection in an adult mouse model. Independent roles for IFN-γ and CD4+ T lymphocytes in protective immunity. J. Immunol. 147, 1014-1022.
9. [9] Aguirre, S.A., Mason, P.H. and Perryman, L.E. (1994) Susceptibility of major histocompatibility complex (MHC) class I-and MHC class II-deficient mice to Cryptosporidium parvum infection. Infect. Immun. 62, 697-699.
10. [10] Perryman, L.E., Mason, P.H. and Chrisp, C.E. (1994) Effect of spleen cell populations on resolution of Cryptosporidium parvum infection in SCID mice. Infect. Immun. 62, 1474-1477.
11. [11] Petersen, C. (1992) Cryptosporidiosis in patients infected with the human immunodeficiency virus. Clin. Infect. Dis. 15, 903-909.
12. [12] Flanigan, T., Whalen, C., Turner, J., Soave, R., Toerner, J., Havlir, D. and Kotler, D. (1992) Cryptosporidium infection and CD4 counts. Ann. Int. Med. 116, 840-842.
13. [13] Watzl, B., Huang, D.S., Alak, J., Darban, H., Jenkins, E.M. and Watson, R.R. (1993) Enhancement of resistance to Cryptosporidium parvum by pooled bovine colostrum during murine retroviral infection. Am. J. Trop. Med. Hyg. 48, 519-523.
14. [14] Fayer, R., Perryman, L.E. and Riggs, M.W. (1989) Hyperimmune bovine colostrum neutralizes Cryptosporidium sporozoites and protects mice against oocyst challenge. J. Parasitol. 75, 151-153.
15. [15] Fayer, R., Andrews, C., Ungar, B.L.P. and Blagburn, B. (1989) Efficacy of hyperimmune bovine colostrum for prophylaxis of cryptosporidiosis in neonatal calves. J. Parasitol. 75, 393-397.
16. [16] Fayer, R., Guidry, A. and Blagburn, B.L. (1990) Immunotherapeutic efficacy of bovine colostral immunoglobulins from a hyperimmunized cow against cryptosporidiosis in neonatal mice. Infect. Immun. 58, 2962-2965.
17. [17] Doyle, P.S., Crabb, J. and Petersen, C. (1993) Anti-Cryptosporidium parvum antibodies inhibit infectivity in vitro and in vivo. Infect. Immun. 61, 4079-4084.
18. [18] Riggs, M.W., Cama, V.A., Leary, H.L., Jr. and Sterling, C.R. (1994) Bovine antibody against Cryptosporidium parvum elicits a circumsporozoite precipitate-like reaction and has immunotherapeutic effect against persistent cryptosporidiosis in SCID mice. Infect. Immun. 62, 1927-1939.
19. [19] Cama, V.A. and Sterling, C.R, (1991) Hyperimmune hens as a novel source of anti-Cryptosporidium antibodies suit-able for passive immune transfer. J. Protozool. 38, 42S-43S.
20. [20] Arrowood, MJ., Mead, J.R., Mährt, J.L. and Sterling, C.R. (1989) Effects of immune colostrum and orally administered antisporozoite monoclonal antibodies on the outcome of Cryptosporidium parvum infections in neonatal mice. Infect. Immun. 57, 2283-2288.
21. [21] Bjorneby, J.M., Hunsaker, B.D., Riggs, M.W. and Perryman, L.E. (1991) Monoclonal antibody immunotherapy in nude mice persistently infected with Cryptosporidium parvum. Infect. Immun. 59, 1172-1176.
22. [22] Perryman, L.E., Riggs, M.W., Mason, P.H. and Fayer, R. (1990) Kinetics of Cryptosporidium parvum sporozoite neutralization by monoclonal antibodies, immune bovine serum, and immune bovine colostrum. Infect. Immun. 58, 257-259.
23. [23] Perryman, L.E., Kegerreis, K.A. and Mason. P.H. (1993) Effect of orally-administered monoclonal antibody on persistent Cryptosporidium parvum infection in scid mice. Infect. Immun. 61, 4906-4908.
24. [24] Tilley, M., Upton, S.J., Fayer, R., Barta, J.R., Chrisp, C.E., Freed, P.S., Blagburn, B.L., Anderson, B.C. and Barnard, S.M. (1991) Identification of a 15-kilodalton surface glycoprotein on sporozoites of Cryptosporidium parvum. Infect. Immun. 59, 1002-1007.
25. [25] Arrowood, M.J., Sterling, C.R. and Healey, M.C. (1991) Immunofluorescent microscopical visualization of trails left by gliding Cryptosporidium parvum sporozoites. J. Parasitol. 77, 315-317.
26. [26] Riggs, M.W., McGuire, T.C., Mason, P.H. and Perryman, L.E. (1989) Neutralization-sensitive epitopes are exposed on the surface of infectious Cryptosporidium parvum sporozoites. J. Immunol. 143, 1340-1345.
27. [27] Heine, J., Pohlenz, J.F.L., Moon, H.W. and Woode, G.N. (1984) Enteric lesions and diarrhea in gnotobiotic calves monoinfected with Cryptosporidium species. J. Infect. Dis. 150, 768-775.
28. [28] Uhl, E.W., O'Connor, R.M., Perryman, L.E. and Riggs, M.W. (1992) Neutralization-sensitive epitopes are conserved among geographically diverse isolates of Cryptosporidium parvum. Infect. Immun. 60, 1703-1706.
29. [29] Riggs, M.W. and Perryman, L.E. (1987) Infectivity and neutralization of Cryptosporidium parvum sporozoites. Infect. Immun. 55, 2081-2087.
30. [30] Riggs, M.W., Stone, A.L., Arrowood, M.J., Langer, R.C., Bahle, J. and Yount, P. (1994) Molecular targets for passive immunotherapy of cryptosporidiosis. 47th Ann. Meet. Soc. Protozool. and 3rd Workshop on Pneumocystis, Toxoplasma, Cryptosporidum and Microsporidia. June 24-29, Cleveland, OH Abst. C46, 76.
31. [31] Woodward, M.P., Young, W.W., Jr. and Bloodgood, R.A. (1985) Detection of monoclonal antibodies specific for carbohydrate epitopes using periodate oxidation. J. Immunol. Methods 78, 143-153.
32. [32] Chomczynski, P. and Sacchi, N. (1987) Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal. Biochem. 162, 156-159.
33. [33] Reduker, D.W., Jasmer, D.P., Goff, W.L., Perryman, L.E., Davis, W.C. and McGuire, T.C. (1989) A recombinant surface protein of Babesia bovis elicits bovine antibodies that react with live merozoites. Mol. Biochem. Parasitol. 35, 239-248.
34. [34] Jasmer, D.P., Reduker, D.W., Goff, W.L., Stiller, D. and McGuire, T.C. (1990) DNA probes distinguish geographic isolates and identify a novel DNA of Babesia bovis. J. Parasitol. 76, 834-841.
35. [35] Jasmer, D.P. (1993) Trichinella spiralis infected skeletal muscle cells arrest in G2/M and cease muscle gene expression. J. Cell Biol. 121, 785-793.
36. [36] Perryman, L.E. and Bjorneby, J.M. (1991) Immunotherapy of cryptosporidiosis in immunodeficient animal models. J. Protozool, 38, 98S-100S.
37. [37] Whitmire, W.M. and Harp, J.A. (1991) Characterization of bovine cellular and serum antibody responses during infection by Cryptosporidium parvum. Infect. Immun. 59, 990-995.
38. [38] Reperant, J.-M, Naciri, M., lochmann, S., Tilley, M. and Bout, D.T. (1994) Major antigens of Cryptosporidium parvum recognised by serum antibodies from different infected animal species and man. Vet. Parasitol. 55, 1-13.
39. [39] Mead, J.R., Arrowood, MJ. and Sterling, C.R. (1988) Antigens of Cryptosporidium sporozoites recognized by immune serum of infected animals and humans. J. Para-sitol. 74, 135-143.
40. [40] Tilley, M., Eggleston, M.T. and Upton, S.J. (1993) Multiple oral inoculations with Cryptosporidium parvum as a means of immunization for production of monoclonal antibodies. FEMS Microbiol. Lett. 113, 235-240.
41. [41] Jones, D.E., Tu, T.D., Mathur, S., Sweeney, R.W. and Clark, D.P. (1995) Molecular cloning and characterization of a Cryptosporidium parvum elongation factor-2 gene. Mol. Biochem. Parasitol. 71, 143-147.
42. [42] Luft, B.J., Payne, D., Woodmansee, D. and Kim, C.W. (1987) Characterization of Cryptosporidium antigens from sporulated oocysts of Cryptosporidium parvum. Infect. Immun. 55, 2436-2441.
43. [43] Petersen, C., Gut, J., Nelson, R.G. and Leech, J.H. (1991) Characterization of a Cryptosporidium parvum sporozoite glycoprotein. J. Protozool. 38, 20S-21S.
44. r Cryptosporidium parvum sporozoite glycoprotein recognized by protective hyperimmune bovine colostral immunoglobulin. Infect. Immun. 60, 5132-5138.
45. [45] Lally, N.C., Baird, G.D., McQuay, S.J., Wright, F. and Oliver, J.J. (1992) A 2359-base pair DNA fragment from Cryptosporidium parvum encoding a repetitive oocyst protein. Mol. Biochem. Parasitol. 56, 69-78.
46. [46] Ranucci, L., Muller, H.-M., La Rosa. G., Reckmann, I., Morales, M.A.G., Spano, F., Pozio, E. and Crisanti, A. (1993) Characterization and immunolocalization of a Cryptosporidium protein containing repeated amino acid motifs. Infect. Immun. 61, 2347-2356.
47. [47] Jenkins, M.C., Fayer, R., Tilley, M. and Upton. S.J. (1993) Cloning and expression of a cDNA encoding epitopes shared by 15-and 60-kilodalton proteins of Cryptosporidium parvum sporozoites. Infect. Immun. 61, 2377-2382.
48. [48] Jenkins, M.C. and Fayer, R. (1995) Cloning and expression of cDNA encoding an antigenic Cryptosporidium parvum protein. Mol. Biochem. Parasitol. 71, 149-152.
49. [49] Nelson, R.G., Kim, K., Gooze, L., Petersen, C. and Gut, J. (1991) Identification and isolation of Cryptosporidium parvum genes encoding microtubule and microfilament proteins. J. Protozool. 38, 52S-55S.
50. [50] Gooze, L., Kim, K., Petersen, C., Gut, J. and Nelson, R.G. (1991) Amplification of a Cryptosporidium parvum gene fragment encoding thymidylate synthase. J. Protozool. 38, 56S-58S.
51. [51] Kim, K., Gooze, L., Petersen, C., Gut, J. and Nelson, R.G. (1992) Isolation, sequence and molecular karyotype analysis of the actin gene of Cryptosporidium parvum. Mol. Biochem. Parasitol. 50, 105-114.
52. [52] Dykstra, C.C., Blagburn, B.L. and Tidwell, R.R. (1991) Construction of genomic libraries of Cryptosporidium parvum and identification of antigen-encoding genes. J. Protozool. 38, 76S-78S.
53. [53] Khramstov, N.V., Tilley, M., Blunt, D.S., Montelone, B.A. and Upton, S.J. (1995) Cloning and analysis of a Cryptosporidium parvum gene encoding a protein with homology to cytoplasmic form Hsp70. J. Euk. Microbiol. 42, 416-422.
54. [54] Steele, M.I., Kuhls, T.L., Nida, K., Meka, C.S.R., Halabi, I.M., Mosier, D.A., Elliot, W., Crawford, D.L. and Greenfield, R.A. (1995) A Cryptosporidium parvum genomic region encoding hemolytic activity. Infect. Immun. 63, 3840-3845.
55. [55] Fasman, G.D., Park, K. and Schlesinger, D.H. (1990) Conformational analysis on the immunodominant epitopes of the circumsporozoite protein of Plasmodium falciparum and knowlesi. Biopolymers 29, 123-130.