A toxicogenomics approach for early assessment of potential non-genotoxic hepatocarcinogenicity of chemicals in rats

Toxicology

Volumn 250, Issue 1, 2008, Pages 15-26

  Uehara, Takeki ^a   Hirode, Mitsuhiro ^a   Ono, Atsushi ^a   Kiyosawa, Naoki ^a   Omura, Ko ^a   Shimizu, Toshinobu ^a   Mizukawa, Yumiko ^a,b   Miyagishima, Toshikazu ^a   Nagao, Taku ^a,c   Urushidani, Tetsuro ^a,b  

^a NATIONAL INSTITUTE OF BIOMEDICAL INNOVATION   (Japan)

^b DOSHISHA WOMEN'S COLLEGE OF LIBERAL ARTS   (Japan)

^c NATIONAL INSTITUTE OF HEALTH SCIENCES   (Japan)

Author keywords

Hepatocarcinogenesis; Liver; Non genotoxic; Rat; Toxicogenomics

Indexed keywords

1 NAPHTHYL ISOTHIOCYANATE; ACETYLSALICYLIC ACID; AMIODARONE; BROMOBENZENE; CARBAMAZEPINE; CLOFIBRATE; COUMARIN; DIAZEPAM; DICLOFENAC; ETHIONINE; GEMFIBROZIL; HEXACHLOROBENZENE; ISONIAZID; METHAPYRILENE; NITROFURANTOIN; PARACETAMOL; PHENOBARBITAL; PHENYLBUTAZONE; PHENYTOIN; PIRINIXIC ACID; PROPYLTHIOURACIL; RIFAMPICIN; SALAZOSULFAPYRIDINE; THIOACETAMIDE; VALPROIC ACID;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; GENOTOXICITY; HISTOPATHOLOGY; LIVER CARCINOGENESIS; MICROARRAY ANALYSIS; NONHUMAN; NUCLEOTIDE SEQUENCE; OXIDATIVE STRESS; PRIORITY JOURNAL; RAT; TOXICOGENETICS; UNINDEXED SEQUENCE;

ANIMALS; CARCINOGENICITY TESTS; CARCINOGENS; GENE EXPRESSION; GLUTATHIONE; LIVER; LIVER NEOPLASMS, EXPERIMENTAL; MALE; METHAPYRILENE; MICROARRAY ANALYSIS; OXIDATIVE STRESS; RATS; RATS, SPRAGUE-DAWLEY; THIOACETAMIDE; TIME FACTORS; TOXICOGENETICS;

ANIMALIA; RATTUS;

EID: 47849128187     PISSN: 0300483X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tox.2008.05.013     Document Type: Article

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