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Volumn 20, Issue 6, 2011, Pages 1224-1231

Genome-wide association study for C-reactive protein levels identified pleiotropic associations in the IL6 locus

Author keywords

[No Author keywords available]

Indexed keywords

BIOLOGICAL MARKER; C REACTIVE PROTEIN; HEMOGLOBIN; INTERLEUKIN 6; SERUM GLOBULIN;

EID: 79952019307     PISSN: 09646906     EISSN: 14602083     Source Type: Journal    
DOI: 10.1093/hmg/ddq551     Document Type: Article
Times cited : (77)

References (39)
  • 1
    • 0033081409 scopus 로고    scopus 로고
    • The physiological structure of human C-reactive protein and its complex with phosphocholine
    • Thompson, D., Pepys, M.B. and Wood, S.P. (1999) The physiological structure of human C-reactive protein and its complex with phosphocholine. Structure, 7, 169-177.
    • (1999) Structure , vol.7 , pp. 169-177
    • Thompson, D.1    Pepys, M.B.2    Wood, S.P.3
  • 2
    • 0042744797 scopus 로고    scopus 로고
    • C-reactive protein: a critical update
    • Pepys, M.B. and Hirschfield, G.M. (2003) C-reactive protein: a critical update. J. Clin. Invest., 111, 1805-1812.
    • (2003) J. Clin. Invest. , vol.111 , pp. 1805-1812
    • Pepys, M.B.1    Hirschfield, G.M.2
  • 3
    • 60849107744 scopus 로고    scopus 로고
    • The role of C-reactive protein polymorphisms in inflammation and cardiovascular risk
    • Hage, F.G. and Szalai, A.J. (2009) The role of C-reactive protein polymorphisms in inflammation and cardiovascular risk. Curr. Atheroscler. Rep., 11, 124-130.
    • (2009) Curr. Atheroscler. Rep. , vol.11 , pp. 124-130
    • Hage, F.G.1    Szalai, A.J.2
  • 5
    • 51649121111 scopus 로고    scopus 로고
    • The association of C-reactive protein and CRP genotype with coronary heart disease: findings from five studies with 4,610 cases amongst 18,637 participants
    • Lawlor, D.A., Harbord, R.M., Timpson, N.J., Lowe, G.D., Rumley, A., Gaunt, T.R., Baker, I., Yarnell, J.W., Kivimaki, M., Kumari, M. et al. (2008) The association of C-reactive protein and CRP genotype with coronary heart disease: findings from five studies with 4,610 cases amongst 18,637 participants. PLoS One, 3, e3011.
    • (2008) PLoS One , vol.3
    • Lawlor, D.A.1    Harbord, R.M.2    Timpson, N.J.3    Lowe, G.D.4    Rumley, A.5    Gaunt, T.R.6    Baker, I.7    Yarnell, J.W.8    Kivimaki, M.9    Kumari, M.10
  • 7
    • 14844355637 scopus 로고    scopus 로고
    • C-reactive protein levels are not associated with increased risk for colorectal cancer in women
    • Zhang, S.M., Buring, J.E., Lee, I.M., Cook, N.R. and Ridker, P.M. (2005) C-reactive protein levels are not associated with increased risk for colorectal cancer in women. Ann. Intern. Med., 142, 425-432.
    • (2005) Ann. Intern. Med. , vol.142 , pp. 425-432
    • Zhang, S.M.1    Buring, J.E.2    Lee, I.M.3    Cook, N.R.4    Ridker, P.M.5
  • 8
    • 42749092252 scopus 로고    scopus 로고
    • Loci related to metabolic-syndrome pathways including LEPR,HNF1A, IL6R, and GCKR associate with plasma C-reactive protein: the Women's Genome Health Study
    • Ridker, P.M., Pare, G., Parker, A., Zee, R.Y., Danik, J.S., Buring, J.E., Kwiatkowski, D., Cook, N.R., Miletich, J.P. and Chasman, D.I. (2008) Loci related to metabolic-syndrome pathways including LEPR,HNF1A, IL6R, and GCKR associate with plasma C-reactive protein: the Women's Genome Health Study. Am. J. Hum. Genet., 82, 1185-1192.
    • (2008) Am. J. Hum. Genet. , vol.82 , pp. 1185-1192
    • Ridker, P.M.1    Pare, G.2    Parker, A.3    Zee, R.Y.4    Danik, J.S.5    Buring, J.E.6    Kwiatkowski, D.7    Cook, N.R.8    Miletich, J.P.9    Chasman, D.I.10
  • 11
    • 27644462219 scopus 로고    scopus 로고
    • The relationship between blood pressure and C-reactive protein in the Multi-Ethnic Study of Atherosclerosis (MESA)
    • Lakoski, S.G., Cushman, M., Palmas, W., Blumenthal, R., D'Agostino, R.B. Jr. and Herrington, D.M. (2005) The relationship between blood pressure and C-reactive protein in the Multi-Ethnic Study of Atherosclerosis (MESA). J. Am. Coll. Cardiol., 46, 1869-1874.
    • (2005) J. Am. Coll. Cardiol. , vol.46 , pp. 1869-1874
    • Lakoski, S.G.1    Cushman, M.2    Palmas, W.3    Blumenthal, R.4    D'Agostino Jr., R.B.5    Herrington, D.M.6
  • 13
    • 34648854433 scopus 로고    scopus 로고
    • A low level of C-reactive protein in Japanese adults and its association with cardiovascular risk factors: the Japan NCVC-Collaborative Inflammation Cohort (JNIC) study
    • Saito, I., Sato, S., Nakamura, M., Kokubo, Y., Mannami, T., Adachi, H., Konishi, M., Okada, K., Iso, H., Kario, K. et al. (2007) A low level of C-reactive protein in Japanese adults and its association with cardiovascular risk factors: the Japan NCVC-Collaborative Inflammation Cohort (JNIC) study. Atherosclerosis, 194, 238-244.
    • (2007) Atherosclerosis , vol.194 , pp. 238-244
    • Saito, I.1    Sato, S.2    Nakamura, M.3    Kokubo, Y.4    Mannami, T.5    Adachi, H.6    Konishi, M.7    Okada, K.8    Iso, H.9    Kario, K.10
  • 14
  • 15
    • 33746512512 scopus 로고    scopus 로고
    • Principal components analysis corrects for stratification in genome-wide association studies
    • Price, A.L., Patterson, N.J., Plenge, R.M., Weinblatt, M.E., Shadick, N.A. and Reich, D. (2006) Principal components analysis corrects for stratification in genome-wide association studies. Nat. Genet., 38, 904-909.
    • (2006) Nat. Genet. , vol.38 , pp. 904-909
    • Price, A.L.1    Patterson, N.J.2    Plenge, R.M.3    Weinblatt, M.E.4    Shadick, N.A.5    Reich, D.6
  • 16
    • 79959503826 scopus 로고    scopus 로고
    • The international HapMap project
    • The International HapMap, Consortium
    • The International HapMap, Consortium (2003) The international HapMap project. Nature, 426, 789-796.
    • (2003) Nature , vol.426 , pp. 789-796
  • 18
    • 69049088712 scopus 로고    scopus 로고
    • Rank-based inverse normal transformations are increasingly used, but are they merited?
    • Beasley, T.M., Erickson, S. and Allison, D.B. (2009) Rank-based inverse normal transformations are increasingly used, but are they merited? Behav. Genet., 39, 580-595.
    • (2009) Behav. Genet. , vol.39 , pp. 580-595
    • Beasley, T.M.1    Erickson, S.2    Allison, D.B.3
  • 19
    • 0032714352 scopus 로고    scopus 로고
    • Genomic control for association studies
    • Devlin, B. and Roeder, K. (1999) Genomic control for association studies. Biometrics, 55, 997-1004.
    • (1999) Biometrics , vol.55 , pp. 997-1004
    • Devlin, B.1    Roeder, K.2
  • 20
    • 84925549112 scopus 로고    scopus 로고
    • The paradigm of IL-6: from basic science to medicine
    • Naka, T., Nishimoto, N. and Kishimoto, T. (2002) The paradigm of IL-6: from basic science to medicine. Arthritis Res., 4(Suppl. 3), S233-S242.
    • (2002) Arthritis Res. , vol.4 , Issue.SUPPL. 3
    • Naka, T.1    Nishimoto, N.2    Kishimoto, T.3
  • 22
    • 70349325941 scopus 로고    scopus 로고
    • Iron sequestration and anemia of inflammation
    • Ganz, T. and Nemeth, E. (2009) Iron sequestration and anemia of inflammation. Semin. Hematol., 46, 387-393.
    • (2009) Semin. Hematol. , vol.46 , pp. 387-393
    • Ganz, T.1    Nemeth, E.2
  • 24
    • 3342892420 scopus 로고    scopus 로고
    • Inhibition of IL-6 for the treatment of inflammatory diseases
    • Nishimoto, N. and Kishimoto, T. (2004) Inhibition of IL-6 for the treatment of inflammatory diseases. Curr. Opin. Pharmacol., 4, 386-391.
    • (2004) Curr. Opin. Pharmacol. , vol.4 , pp. 386-391
    • Nishimoto, N.1    Kishimoto, T.2
  • 25
    • 60149105639 scopus 로고    scopus 로고
    • Study of active controlled tocilizumab monotherapy for rheumatoid arthritis patients with an inadequate response to methotrexate (SATORI): significant reduction in disease activity and serum vascular endothelial growth factor by IL-6 receptor inhibition therapy
    • Nishimoto, N., Miyasaka, N., Yamamoto, K., Kawai, S., Takeuchi, T., Azuma, J. and Kishimoto, T. (2009) Study of active controlled tocilizumab monotherapy for rheumatoid arthritis patients with an inadequate response to methotrexate (SATORI): significant reduction in disease activity and serum vascular endothelial growth factor by IL-6 receptor inhibition therapy. Mod. Rheumatol., 19, 12-19.
    • (2009) Mod. Rheumatol. , vol.19 , pp. 12-19
    • Nishimoto, N.1    Miyasaka, N.2    Yamamoto, K.3    Kawai, S.4    Takeuchi, T.5    Azuma, J.6    Kishimoto, T.7
  • 26
    • 36348929325 scopus 로고    scopus 로고
    • IL-6 gene variation is associated with IL-6 and C-reactive protein levels but not cardiovascular outcomes in the Cardiovascular Health Study
    • Walston, J.D., Fallin, M.D., Cushman, M., Lange, L., Psaty, B., Jenny, N., Browner, W., Tracy, R., Durda, P. and Reiner, A. (2007) IL-6 gene variation is associated with IL-6 and C-reactive protein levels but not cardiovascular outcomes in the Cardiovascular Health Study. Hum. Genet., 122, 485-494.
    • (2007) Hum. Genet. , vol.122 , pp. 485-494
    • Walston, J.D.1    Fallin, M.D.2    Cushman, M.3    Lange, L.4    Psaty, B.5    Jenny, N.6    Browner, W.7    Tracy, R.8    Durda, P.9    Reiner, A.10
  • 27
    • 34548768914 scopus 로고    scopus 로고
    • Interleukin-6 genetic variability and adiposity: associations in two prospective cohorts and systematic review in 26,944 individuals
    • Qi, L., Zhang, C., van Dam, R.M. and Hu, F.B. (2007) Interleukin-6 genetic variability and adiposity: associations in two prospective cohorts and systematic review in 26,944 individuals. J. Clin. Endocrinol. Metab., 92, 3618-3625.
    • (2007) J. Clin. Endocrinol. Metab. , vol.92 , pp. 3618-3625
    • Qi, L.1    Zhang, C.2    van Dam, R.M.3    Hu, F.B.4
  • 28
    • 39749133713 scopus 로고    scopus 로고
    • Genetic variants of IL6 gene promoter influence on C-reactive protein levels but are not associated with susceptibility to invasive pulmonary aspergillosis in haematological patients
    • Sainz, J., Perez, E., Gomez-Lopera, S., Lopez-Fernandez, E., Moratalla, L., Oyonarte, S. and Jurado, M. (2008) Genetic variants of IL6 gene promoter influence on C-reactive protein levels but are not associated with susceptibility to invasive pulmonary aspergillosis in haematological patients. Cytokine, 41, 268-278.
    • (2008) Cytokine , vol.41 , pp. 268-278
    • Sainz, J.1    Perez, E.2    Gomez-Lopera, S.3    Lopez-Fernandez, E.4    Moratalla, L.5    Oyonarte, S.6    Jurado, M.7
  • 30
    • 0029903287 scopus 로고    scopus 로고
    • Regulation of human C-reactive protein gene expression by two synergistic IL-6 responsive elements
    • Li, S.P. and Goldman, N.D. (1996) Regulation of human C-reactive protein gene expression by two synergistic IL-6 responsive elements. Biochemistry, 35, 9060-9068.
    • (1996) Biochemistry , vol.35 , pp. 9060-9068
    • Li, S.P.1    Goldman, N.D.2
  • 31
    • 0021330196 scopus 로고
    • Normal values for peripheral blood white cell counts in women of four different ethnic origins
    • Bain, B., Seed, M. and Godsland, I. (1984) Normal values for peripheral blood white cell counts in women of four different ethnic origins. J. Clin. Pathol., 37, 188-193.
    • (1984) J. Clin. Pathol. , vol.37 , pp. 188-193
    • Bain, B.1    Seed, M.2    Godsland, I.3
  • 32
    • 39049105963 scopus 로고    scopus 로고
    • Ethnic difference in the relationship between acute inflammation and serum ferritin in US adult males
    • Pan, Y. and Jackson, R.T. (2008) Ethnic difference in the relationship between acute inflammation and serum ferritin in US adult males. Epidemiol. Infect., 136, 421-431.
    • (2008) Epidemiol. Infect. , vol.136 , pp. 421-431
    • Pan, Y.1    Jackson, R.T.2
  • 34
    • 77649184039 scopus 로고    scopus 로고
    • Genome-wide association study of hematological and biochemical traits in a Japanese population
    • Kamatani, Y., Matsuda, K., Okada, Y., Kubo, M., Hosono, N., Daigo, Y., Nakamura, Y. and Kamatani, N. (2010) Genome-wide association study of hematological and biochemical traits in a Japanese population. Nat. Genet., 42, 210-215.
    • (2010) Nat. Genet. , vol.42 , pp. 210-215
    • Kamatani, Y.1    Matsuda, K.2    Okada, Y.3    Kubo, M.4    Hosono, N.5    Daigo, Y.6    Nakamura, Y.7    Kamatani, N.8
  • 38
    • 53049090475 scopus 로고    scopus 로고
    • Japanese population structure, based on SNP genotypes from 7003 individuals compared to other ethnic groups: effects on population-based association studies
    • Yamaguchi-Kabata, Y., Nakazono, K., Takahashi, A., Saito, S., Hosono, N., Kubo, M., Nakamura, Y. and Kamatani, N. (2008) Japanese population structure, based on SNP genotypes from 7003 individuals compared to other ethnic groups: effects on population-based association studies. Am. J. Hum. Genet., 83, 445-456.
    • (2008) Am. J. Hum. Genet. , vol.83 , pp. 445-456
    • Yamaguchi-Kabata, Y.1    Nakazono, K.2    Takahashi, A.3    Saito, S.4    Hosono, N.5    Kubo, M.6    Nakamura, Y.7    Kamatani, N.8


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