C-reactive protein (CRP) promoter polymorphisms influence circulating CRP levels in a genome-wide association study of African Americans

Human Molecular Genetics

Volumn 21, Issue 13, 2012, Pages 3063-3072

  Doumatey, Ayo P ^a   Chen, Guanjie ^a   Ayele, Fasil Tekola ^a   Zhou, Jie ^a   Erdos, Michael ^a   Shriner, Daniel ^a   Huang, Hanxia ^a   Adeleye, Jokotade ^b   Balogun, Williams ^b   Fasanmade, Olufemi ^c   Johnson, Thomas ^c   Oli, Johnnie ^d   Okafor, Godfrey ^d   Amoah, Albert ^e   Eghan, Benjamin A ^f   Agyenim Boateng, Kofi ^f   Acheampong, Joseph ^f   Adebamowo, Clement ^b,g   Gerry, Norman P ^h   Christman, Michael F ^h   Adeyemo, Adebowale ^a   Rotimi, Charles N ^a   more..

^a NATIONAL HUMAN GENOME RESEARCH INSTITUTE   (United States)

^b UNIVERSITY OF IBADAN   (Nigeria)

^c UNIVERSITY OF LAGOS   (Nigeria)

^d UNIVERSITY OF NIGERIA   (Nigeria)

^e UNIVERSITY OF GHANA   (Ghana)

^f KWAME NKRUMAH UNIVERSITY OF SCIENCE AND TECHNOLOGY   (Ghana)

^g UNIVERSITY OF MARYLAND SCHOOL OF MEDICINE   (United States)

^h Laboratory of Molecular and Cellular Biology of Hematopoiesis   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

C REACTIVE PROTEIN;

ADULT; AFRICAN AMERICAN; ARTICLE; COHORT ANALYSIS; CONTROLLED STUDY; EUROPE; FEMALE; GENE LINKAGE DISEQUILIBRIUM; GENE LOCUS; GENE REPLICATION; GENETIC ASSOCIATION; GENETIC MODEL; GENETIC VARIABILITY; GENOTYPE; HAPLOTYPE MAP; HUMAN; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN BLOOD LEVEL; PSEUDOGENE; SINGLE NUCLEOTIDE POLYMORPHISM;

AFRICAN AMERICANS; C-REACTIVE PROTEIN; EUROPEAN CONTINENTAL ANCESTRY GROUP; FEMALE; GENOME-WIDE ASSOCIATION STUDY; GENOTYPE; HAPMAP PROJECT; HUMANS; LINKAGE DISEQUILIBRIUM; MALE; MIDDLE AGED; POLYMORPHISM, SINGLE NUCLEOTIDE; PROMOTER REGIONS, GENETIC;

EID: 84863508195     PISSN: 09646906     EISSN: 14602083     Source Type: Journal    
DOI: 10.1093/hmg/dds133     Document Type: Article

References (39)

1. Clyne, B. and Olshaker, J.S. (1999) The C-reactive protein. J. Emerg. Med., 17, 1019-1025.
2. Ganapathi, M.K., May, L.T., Schultz, D., Brabenec, A., Weinstein, J., Sehgal, P.B. and Kushner, I. (1988) Role of interleukin-6 in regulating synthesis of C-reactive protein and serum amyloid A in human hepatoma cell lines. Biochem. Biophys. Res. Commun., 157, 271-277.
3. Castell, J.V., Gomez-Lechon, M.J., David, M., Andus, T., Geiger, T., Trullenque, R., Fabra, R. and Heinrich, P.C. (1989) Interleukin-6 is the major regulator of acute phase protein synthesis in adult human hepatocytes. FEBS Lett., 242, 237-239.
4. Ridker, P.M. (2009) C-reactive protein: eighty years from discovery to emergence as a major risk marker for cardiovascular disease. Clin. Chem., 55, 209-215.
5. Weinhold, B. and Ruther, U. (1997) Interleukin-6-dependent and -independent regulation of the human C-reactive protein gene. Biochem. J., 327, 425-429.
6. Fox, E.R., Benjamin, E.J., Sarpong, D.F., Rotimi, C.N., Wilson, J.G., Steffes, M.W., Chen, G., Adeyemo, A., Taylor, J.K., Samdarshi, T.E. et al. (2008) Epidemiology, heritability, and genetic linkage of C-reactive protein in African Americans (from the Jackson Heart Study). Am. J. Cardiol., 102, 835-841.
7. Florez, H., Castillo-Florez, S., Mendez, A., Casanova-Romero, P., Larreal-Urdaneta, C., Lee, D. and Goldberg, R. (2006) C-reactive protein is elevated in obese patients with the metabolic syndrome. Diabetes Res. Clin. Pract., 71, 92-100.
8. Elliott, P., Chambers, J.C., Zhang, W., Clarke, R., Hopewell, J.C., Peden, J.F., Erdmann, J., Braund, P., Engert, J.C., Bennett, D. et al. (2009) Genetic Loci associated with C-reactive protein levels and risk of coronary heart disease. JAMA, 302, 37-48.
9. Ridker, P.M., Cushman, M., Stampfer, M.J., Tracy, R.P. and Hennekens, C.H. (1997) Inflammation, aspirin, and the risk of cardiovascular disease in apparently healthy men. N. Eng. J. Med., 336, 973-979.
10. Yeh, E.T. (2005) High-sensitivity C-reactive protein as a risk assessment tool for cardiovascular disease. Clin. Cardiol., 28, 408-412.
11. Lee, C.C., You, N.C., Song, Y., Hsu, Y.H., Manson, J., Nathan, L., Tinker, L. and Liu, S. (2009) Relation of genetic variation in the gene coding for C-reactive protein with its plasma protein concentrations: findings from the Women's Health Initiative Observational Cohort. Clin. Chem., 55, 351-360.
12. Dehghan, A., Kardys, I., de Maat, M.P., Uitterlinden, A.G., Sijbrands, E.J., Bootsma, A.H., Stijnen, T., Hofman, A., Schram, M.T. and Witteman, J.C. (2007) Genetic variation, C-reactive protein levels, and incidence of diabetes. Diabetes, 56, 872-878.
13. Hage, F.G. and Szalai, A.J. (2007) C-reactive protein gene polymorphisms, C-reactive protein blood levels, and cardiovascular disease risk. J. Am. Coll. Cardiol., 50, 1115-1122.
14. Reiner, A.P., Barber, M.J., Guan, Y., Ridker, P.M., Lange, L.A., Chasman, D.I., Walston, J.D., Cooper, G.M., Jenny, N.S., Rieder, M.J. et al. (2008) Polymorphisms of the HNF1A gene encoding hepatocyte nuclear factor-1 alpha are associated with C-reactive protein. Am. J. Hum. Genet., 82, 1193-1201.
15. Ridker, P.M., Pare, G., Parker, A., Zee, R.Y., Danik, J.S., Buring, J.E., Kwiatkowski, D., Cook, N.R., Miletich, J.P. and Chasman, D.I. (2008) Loci related to metabolic-syndrome pathways including LEPR,HNF1A, IL6R, and GCKR associate with plasma C-reactive protein: the Women's Genome Health Study. Am. J. Hum. Genet., 82, 1185-1192.
16. Dehghan, A., Dupuis, J., Barbalic, M., Bis, J.C., Eiriksdottir, G., Lu, C., Pellikka, N., Wallaschofski, H., Kettunen, J., Henneman, P. et al. (2011) Meta-analysis of genome-wide association studies in .80 000 subjects identifies multiple loci for C-reactive protein levels. Circulation, 123, 731-738.
17. Okada, Y., Takahashi, A., Ohmiya, H., Kumasaka, N., Kamatani, Y., Hosono, N., Tsunoda, T., Matsuda, K., Tanaka, T., Kubo, M. et al. (2011) Genome-wide association study for C-reactive protein levels identified pleiotropic associations in the IL6 locus. Hum. Mol. Genet., 20, 1224-1231.
18. Wu, Y., McDade, T.W., Kuzawa, C.W., Borja, J., Li, Y., Adair, L.S., Mohlke, K.L. and Lange, L.A. (2011) Genome-wide Association with C-Reactive Protein Levels in CLHNS: evidence for the CRP and HNF1A loci and their interaction with exposure to a pathogenic environment. Inflammation, doi:10.1007/s10753-011-9348-y
19. Patel, D.A., Srinivasan, S.R., Xu, J.H., Li, S., Chen, W. and Berenson, G.S. (2006) Distribution and metabolic syndrome correlates of plasma C-reactive protein in biracial (black-white) younger adults: the Bogalusa Heart Study. Metab. Clin. Exp., 55, 699-705.
20. Rosenberg, N.A., Huang, L., Jewett, E.M., Szpiech, Z.A., Jankovic, I. and Boehnke, M. (2010) Genome-wide association studies in diverse populations. Nat. Rev. Genet., 11, 356-366.
21. Crawford, D.C., Sanders, C.L., Qin, X., Smith, J.D., Shephard, C., Wong, M., Witrak, L., Rieder, M.J. and Nickerson, D.A. (2006) Genetic variation is associated with C-reactive protein levels in the Third National Health and Nutrition Examination Survey. Circulation, 114, 2458-2465.
22. Carlson, C.S., Aldred, S.F., Lee, P.K., Tracy, R.P., Schwartz, S.M., Rieder, M., Liu, K., Williams, O.D., Iribarren, C., Lewis, E.C. et al. (2005) Polymorphisms within the C-reactive protein (CRP) promoter region are associated with plasma CRP levels. Am. J. Hum. Genet., 77, 64-77.
23. Shriner, D., Adeyemo, A., Gerry, N.P., Herbert, A., Chen, G., Doumatey, A., Huang, H., Zhou, J., Christman, M.F. and Rotimi, C.N. (2009) Transferability and fine-mapping of genome-wide associated loci for adult height across human populations. PLoS ONE, 4, e8398.
24. Crawford, D.C., Yi, Q., Smith, J.D., Shephard, C., Wong, M., Witrak, L., Livingston, R.J., Rieder, M.J. and Nickerson, D.A. (2006) Allelic spectrum of the natural variation in CRP. Hum. Genet., 119, 496-504.
25. Chanock, S.J., Manolio, T., Boehnke, M., Boerwinkle, E., Hunter, D.J., Thomas, G., Hirschhorn, J.N., Abecasis, G., Altshuler, D., Bailey-Wilson, J.E. et al. (2007) Replicating genotype-phenotype associations. Nature, 447, 655-660.
26. Greene, C.S., Penrod, N.M., Williams, S.M. and Moore, J.H. (2009) Failure to replicate a genetic association may provide important clues about genetic architecture. PLoS ONE, 4, e5639.
27. Charles, B.A., Shriner, D., Doumatey, A., Chen, G., Zhou, J., Huang, H., Herbert, A., Gerry, N.P., Christman, M.F., Adeyemo, A. et al. (2011) A genome-wide association study of serum uric acid in African Americans. BMC Med. Genomics, 4, 17.
28. Chen, G., Ramos, E., Adeyemo, A., Shriner, D., Zhou, J., Doumatey, A.P., Huang, H., Erdos, M.R., Gerry, N.P., Herbert, A. et al. (2011) UGT1A1 is a major locus influencing bilirubin levels in African Americans. Eur. J. Hum. Genet., doi:10.1038/ejhg.2011.206.
29. Zabaneh, D. and Balding, D.J. (2010) A genome-wide association study of the metabolic syndrome in Indian Asian men. PLoS ONE, 5, e11961.
30. Speliotes, E.K., Willer, C.J., Berndt, S.I., Monda, K.L., Thorleifsson, G., Jackson, A.U., Allen, H.L., Lindgren, C.M., Luan, J.A., Magi, R. et al. (2010) Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index. Nat. Genet., 42, 937-948.
31. Adeyemo, A., Gerry, N., Chen, G., Herbert, A., Doumatey, A., Huang, H., Zhou, J., Lashley, K., Chen, Y., Christman, M. et al. (2009) A genome-wide association study of hypertension and blood pressure in African Americans. PLoS Genet., 5, e1000564.
32. Gao, X. and Starmer, J.D. (2008) AWclust: point-and-click software for non-parametric population structure analysis. BMC Bioinf., 9, 77.
33. Price, A.L., Patterson, N.J., Plenge, R.M., Weinblatt, M.E., Shadick, N.A. and Reich, D. (2006) Principal components analysis corrects for stratification in genome-wide association studies. Nat. Genet., 38, 904- 909.
34. Rotimi, C.N., Dunston, G.M., Berg, K., Akinsete, O., Amoah, A., Owusu, S., Acheampong, J., Boateng, K., Oli, J., Okafor, G. et al. (2001) In search of susceptibility genes for type 2 diabetes in West Africa: the design and results of the first phase of the AADM study. Ann. Epidemiol., 11, 51-58.
35. Rotimi, C.N., Chen, G., Adeyemo, A.A., Furbert-Harris, P., Parish-Gause, D., Zhou, J., Berg, K., Adegoke, O., Amoah, A., Owusu, S. et al. (2004) A genome-wide search for type 2 diabetes susceptibility genes in West Africans: the Africa America Diabetes Mellitus (AADM) Study. Diabetes, 53, 838-841.
36. Willer, C.J., Li, Y. and Abecasis, G.R. (2010) METAL: fast and efficient meta-analysis of genomewide association scans. Bioinformatics, 26, 2190-2191.
37. Higgins, J.P., Thompson, S.G., Deeks, J.J. and Altman, D.G. (2003) Measuring inconsistency in meta-analyses. BMJ, 327, 557-560.
38. Ramos, E., Chen, G., Shriner, D., Doumatey, A., Gerry, N.P., Herbert, A., Huang, H., Zhou, J., Christman, M.F., Adeyemo, A. et al. (2011) Replication of genome-wide association studies (GWAS) loci for fasting plasma glucose in African-Americans. Diabetologia, 54, 783-788.
39. Bretherton, C.S., Widmann, M., Dymnikov, V.P., Wallace, J.M. and Bladé, I. (1999) The effective number of spatial degrees of freedom of a time-varying field. J. Clim., 12, 1990-2009.