Immunoregulation of skin sensitization and regulatory T cells

Contact Dermatitis

Volumn 67, Issue 4, 2012, Pages 179-183

  Kimber, Ian ^a   Travis, Mark A ^a,b   Martin, Stefan F ^c   Dearman, Rebecca J ^a  

^a UNIVERSITY OF MANCHESTER   (United Kingdom)

^b UNIVERSITY OF MANCHESTER   (United Kingdom)

^c UNIVERSITY OF FREIBURG   (Germany)

Author keywords

immunoregulation; regulatory T cells; skin sensitization

Indexed keywords

ALLERGEN; NICKEL;

HUMAN; HUMAN CELL; IMMUNE RESPONSE; IMMUNOREGULATION; PHENOTYPE; REGULATORY T LYMPHOCYTE; REVIEW; SKIN SENSITIZATION;

ANIMALS; DERMATITIS, ALLERGIC CONTACT; HUMANS; IMMUNITY, CELLULAR; MICE; SKIN; T-LYMPHOCYTES, HELPER-INDUCER; T-LYMPHOCYTES, REGULATORY;

EID: 84866059544     PISSN: 01051873     EISSN: 16000536     Source Type: Journal    
DOI: 10.1111/j.1600-0536.2012.02148.x     Document Type: Review

References (58)

1. Watanabe H, Gaide O, Petrilli V et al., Activation of the IL-1beta-processing inflammasome is involved in contact hypersensitivity. J Invest Dermatol 2007: 127: 1956-1963.
2. Martin S F, Dudda J C, Bachtanian E et al., Toll-like receptor and IL-12 signalling control susceptibility to contact hypersensitivity. J Exp Med 2008: 205: 2151-2162.
3. Antonopoulos C, Cumberbatch M, Mee J B, Dearman R J, Wie X Q, Liew F Y, Kimber I, Groves R W., IL-18 is a key proximal mediator of contact hypersensitivity and allergen-induced Langerhans cell migration in murine epidermis. J Leukoc Biol 2008: 83: 361-367.
4. Kimber I, Basketter D A, Gerberick G F, Ryan C A, Dearman R J., Chemical allergy: translating biology into hazard characterization. Toxicol Sci 2011: 120: S238-S268.
5. Igyarto B Z, Kaplan D H., The evolving function of Langerhans cells in adaptive skin immunity. Immunol Cell Biol 2010: 88: 361-365.
6. Martin S F, Esser P R, Weber F C, Jakob T, Freudenberg M A, Schmidt M, Goebeler M., Mechanisms of chemical-induced innate immunity in allergic contact dermatitis. Allergy 2011: 66: 1152-1163.
7. Kaplan D H, Igyarto B Z, Gaspari A A., Early immune events in the induction of allergic contact dermatitis. Nat Rev Immunol 2012: 12: 114-124.
8. Martin S F., Contact dermatitis: from pathomechanisms to immunotoxicology. Exp Dermatol 2012: 21: 382-389.
9. + type 1 cytotoxic T cells both play a crucial role in the full development of contact hypersensitivity. J Immunol 2000: 165: 6783-6790.
10. Girolomoni G, Sebastiani S, Albanesi C, Cavani A., T-cell subpopulations in the development of atopic and contact allergy. Curr Opin Immunol 2001: 13: 733-737.
11. Kimber I, Dearman R J., Allergic contact dermatitis: the cellular effectors. Contact Dermatitis 2002: 46: 1-5.
12. Grabbe S, Schwarz T., Immunoregulatory mechanisms involved in elicitation of allergic contact hypersensitivity. Immunol Today 1998: 19: 37-44.
13. + T cells. J Invest Dermatol 1998: 111: 621-628.
14. Lopez C B, Kalergic A M, Becker M I, Garbarino J A, De Ioannes A E., CD8+ T cells are the effectors of the contact dermatitis induced by urushiol in mice and are regulated by CD4+ T cells. Int Arch Allergy Immunol 1998: 117: 194-129.
15. + T lymphocytes with remarkable regulatory functions on dendritic cells and nickel-specific Th1 immune responses. J Invest Dermatol 2000: 114: 295-302.
16. Cavani A, Albanesi C, Traidl C, Sebastiani S, Girolomoni G., Effector and regulatory T cells in allergic contact dermatitis. Trends Immunol 2001: 22: 118-120.
17. Cavani A., T regulatory cells in contact hypersensitivity. Curr Opin Allergy Clin Immunol 2008: 8: 294-298.
18. Vocanson M, Hennino A, Rozieres A, Poyet G, Nicolas J-F., Effector and regulatory mechanisms in allergic contact dermatitis. Allergy 2009: 64: 1699-1714.
19. Honda T, Miyachi Y, Kabashima K., Regulatory T cells in cutaneous immune responses. J Dermatol Sci 2011: 63: 75-82.
20. + regulatory T cells in immunological tolerance to self and non-self. Nat Immunol 2005: 6: 345-352.
21. Sakaguchi S, Sakaguchi N, Asano M, Itoh M, Toda T., Immunologic self-tolerance maintained by activated T cell expressing IL-2 receptor alpha chains (CD25). Breakdown of a single mechanism of self tolerance causes various autoimmune diseases. J Immunol 1995: 155: 1151-1164.
22. Brunkow M E, Jeffery E W, Hjerrild K A et al., Disruption of a new forkhead/winged-helix protein, scurfin, results in fatal lymphoproliferative disorder of the scurfy mouse. Nat Genet 2001: 27: 68-73.
23. Hori S, Nomura T, Sakaguchi S., Control of regulatory T cell development by the transcription factor Foxp3. Science 2003: 299: 1057-1061.
24. Sakaguchi S, Yamaguchi T, Nomura T, Ono M., Regulatory T cells and immune tolerance. Cell 2008: 133: 775-787.
25. Zhou X, Bailey-Bucktrout S, Jeker L T, Bluestone J A., Plasticity of CD4+Foxp3+ T cells. Curr Opin Immunol 2009: 21: 281-285.
26. Bailey-Bucktrout S L, Bluestone J A., Regulatory T cells: stability revisited. Trends Immunol 2011: 32: 301-306.
27. + T-cell subset inhibits antigen-specific T-cell responses and prevents colitis. Nature 1997: 389: 737-742.
28. Mills K H, McGuirk P., Antigen-specific regulatory T cells-their induction and role in infection. Semin Immunol 2004: 16: 107-117.
29. + regulatory T cells. J Immunol 2004: 172: 5986-5993.
30. Shevach E M., From vanilla to 28 flavours: multiple varieties of T regulatory cells. Immunity 2006: 25: 195-201.
31. Vignali D., How many mechanisms do regulatory T cells need. Eur J Immunol 2008: 38: 908-911.
32. Vignali D A A, Collison L W, Workman C J., How regulatory T cells work. Nat Rev Immunol 2008: 8: 523-532.
33. Corthay A., How do regulatory T cells work. Scand J Immunol 2009: 70: 326-336.
34. Li L, Boussiotis A A., Molecular and functional heterogeneity of T regulatory cells. Clin Immunol 2011: 141: 244-252.
35. Loser K, Beissert S., Regulatory T cells: banned for decades. J Invest Dermatol 2012: 132: 864-871.
36. Hawrylowicz C M, O'Garra A., Potential role of interleukin-10-secreting regulatory T cells in allergy and asthma. Nat Rev Immunol 2005: 5: 271-283.
37. + T cells through TGF-β-TGF-β receptor interactions in type 1 diabetes. Proc Natl Acad Sci USA 2003: 100: 10878-10883.
38. Collison L W, Workman C J, Kuo T T et al., The inhibitory cytokine contributes to regulatory T-cell function. Nature 2007: 450: 566-569.
39. + T cells selectively kill B lymphocytes. Blood 2006: 107: 3925-3932.
40. Ren X, Ye F, Jiang Z, Chu Y, Xiong S, Wang Y., Involvement of cellular death in TRAIL/DR5-dependent suppression induced by CD4(+)CD25(+) regulatory T cells. Cell Death Differ 2007: 14: 2076-2084.
41. + Treg cells: hydrolysis of extracellular ATP and immune suppression. Blood 2007: 110: 1225-1232.
42. Thornton A M, Shevach E M., CD4+CD25+ immunoregulatory T cells suppress polyclonal T cell activation in vitro by inhibiting interleukin 2 production. J Exp Med 1998: 188: 287-296.
43. + T cells and dendritic cells in vivo. J Exp Med 2006: 203: 505-511.
44. Tang Q, Adams J Y, Tooley A J et al., Visualizing regulatory T cell control of autoimmune responses in nonobese diabetic mice. Nat Immunol 2006: 7: 83-92.
45. Vocanson M, Hennino A, Cluzel-Tailhardat M et al., CD8+ T cells are effector cells of contact dermatitis to common skin allergens in mice. J Invest Dermatol 2006: 126: 815-820.
46. Vocanson M, Hennino A, Rozierea A et al., Skin exposure to weak and moderate contact allergens induces IFN-Î production by lymph node cells of CD4 T-cell-depleted mice. J Invest Dermatol 2009: 129: 1185-1191.
47. Lass C, Vocanson M, Wagner S, Nicolas J-F, Merfort I, Martin S F., Anti-inflammatory and immune-regulatory mechanisms prevent contact hypersensitivity to Arnica Montana. Exp Dermatol 2008: 17: 849-857.
48. Vocanson M, Rozieres A, Hennino A et al., Inducible costimulator (ICOS) is a marker for highly suppressive antigen-specific T cells sharing features of TH17/TH1 and regulatory T cells. J Allergy Clin Immunol 2010: 126: 280-289.
49. Wing K, Onishi Y, Prieto-Martin P, Yamaguchi T, Miyara M, Fehervari Z, Nomura T, Sakaguchi S., CTLA-4 control over Foxp3+ regulatory T cell function. Science 2008: 322: 271-275.
50. Honda T, Otsuka A, Tanizaki H et al., Enhanced murine contact hypersensitivity by depletion of endogenous regulatory T cells in the sensitization phase. J Dermatol Sci 2011: 61: 144-147.
51. + natural regulatory T cells preferentially form aggregates on dendritic cells in vitro and actively inhibit their maturation. Proc Natl Acad Sci USA 2008: 105: 10113-10118.
52. + effector cell pool size via IL-2 restriction. J Immunol 2011: 187: 3186-3197.
53. Ring S, Karakhanova S, Johnson T, Enk A H, Mahnke K., Gap junctions between regulatory T cells and dendritic cells prevent sensitization of CD8(+) T cells. J Allergy Clin Immunol 2010: 125: 237-246.
54. Kimber I, Shepherd C J, Mitchell J A, Turk J L, Baker D., Regulation of lymphocyte proliferation in contact sensitivity: homeostatic mechanisms and a possible explanation of antigenic competition. Immunology 1989: 66: 577-582.
55. Kimber I, Foster J R, Baker D, Turk J L., Selective impairment of T lymphocyte activation following contact sensitization with oxazolone. Int Arch Allergy Appl Immunol 1991: 95: 142-148.
56. Rubin I M C, Dabelsteen S, Nielsen M M, White I R, Jihansen J D, Geisler C, Bonefeld C M., Repeated exposure to hair dye induces regulatory T cells in mice. Br J Dermatol 2010: 163: 992-998.
57. Seneschal J, Clark R A, Gehad A, Baecher-Allan C M, Kupper T S., Human epidermal Langerhans cells maintain immune homeostasis in skin by activating skin resident regulatory T cells. Immunity 2012: 36: 1-12.
58. Tomura M, Honda T, Tanizaki H et al., Activated regulatory T cells are the major T cell type emigrating from the skin during a cutaneous immune response in mice. J Clin Invest 2010: 120: 883-893.