3D structure of the C3bB complex provides insights into the activation and regulation of the complement alternative pathway convertase

Proceedings of the National Academy of Sciences of the United States of America

Volumn 106, Issue 3, 2009, Pages 882-887

  Torreira, Eva ^a   Tortajada, Agustín ^a,b   Montes, Tamara ^a,b   De Córdoba, Santiago Rodríguez ^a,b   Llorca, Oscar ^a,b  

^a CENTRO DE INVESTIGACIONES BIOLÓGICAS   (Spain)

^b CENTRO DE INVESTIGACIÓN BIOMÉDICA EN RED DE ENFERMEDADES RARAS CIBERER   (Spain)

Author keywords

C3 convertase; Electron microscopy; Factor B

Indexed keywords

ALTERNATIVE COMPLEMENT PATHWAY C3 C5 CONVERTASE; C345C; CLASSICAL COMPLEMENT PATHWAY C3 C5 CONVERTASE; COMPLEMENT COMPONENT C3B; COMPLEMENT COMPONENT C3C; DIVALENT CATION; FACTOR D; SERINE PROTEINASE; UNCLASSIFIED DRUG; VON WILLEBRAND FACTOR; VON WILLEBRAND FACTOR TYPE A;

ARCHITECTURE; ARTICLE; BINDING SITE; CHEMICAL STRUCTURE; COMPLEMENT ACTIVATION; COMPLEMENT ALTERNATIVE PATHWAY; CONFORMATIONAL TRANSITION; ELECTRON MICROSCOPY; ENZYME REGULATION; FRAGMENTATION REACTION; INTROSPECTION; PLASMA PROTEIN BINDING; PRIORITY JOURNAL; PROTEIN CLEAVAGE; PROTEIN DOMAIN; PROTEIN INTERACTION; PROTEIN ISOLATION; PROTEIN STRUCTURE; THREE DIMENSIONAL IMAGING;

ANTIGENS, CD55; COMPLEMENT C3 CONVERTASE, ALTERNATIVE PATHWAY; COMPLEMENT C3B; COMPLEMENT FACTOR B; COMPLEMENT FACTOR H; ENZYME PRECURSORS; HUMANS; IMAGING, THREE-DIMENSIONAL; MICROSCOPY, ELECTRON; PROTEIN CONFORMATION; PROTEIN STRUCTURE, TERTIARY; RECEPTORS, COMPLEMENT 3B;

EID: 58849109079     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.0810860106     Document Type: Article

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