Crystal structure of C5b-6 suggests structural basis for priming assembly of the membrane attack complex

Journal of Biological Chemistry

Volumn 287, Issue 23, 2012, Pages 19642-19652

  Aleshin, Alexander E ^a   DiScipio, Richard G ^b   Stec, Boguslaw ^a   Liddington, Robert C ^a  

^a BURNHAM INSTITUTE   (United States)

^b TORREY PINES INSTITUTE FOR MOLECULAR STUDIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ATOMIC MODELS; HELICAL DOMAINS; HOMOLOGOUS PROTEINS; INTER-DOMAIN; MEMBRANE ATTACK COMPLEXES; MODEL OF PORE; N-TERMINALS; NET EFFECT; PORE FORMATION; PROTOMERS; RIGID BODY ROTATION; RIGID-BODY DOCKING; SMALL MOLECULES; STABLE COMPLEXES; STRUCTURAL BASIS; TRANS-MEMBRANE PORES;

RIGID STRUCTURES;

CONFORMATIONS;

COMPLEMENT COMPONENT C5B; COMPLEMENT COMPONENT C6; CYSTEINE; PERFORIN; PROPROTEIN CONVERTASE 5;

ALPHA HELIX; ARTICLE; BETA SHEET; CARBOXY TERMINAL SEQUENCE; COMPLEMENT ACTIVATION; COMPLEX FORMATION; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; CRYSTAL STRUCTURE; DISULFIDE BOND; HUMAN; HUMAN CELL; HYDROPHOBICITY; PRIORITY JOURNAL; PROTEIN ASSEMBLY; PROTEIN CLEAVAGE; PROTEIN CONFORMATION; PROTEIN DOMAIN; PROTEIN FUNCTION; PROTEIN STABILITY; PROTEIN STRUCTURE; ROOM TEMPERATURE; STRUCTURE ANALYSIS;

COMPLEMENT MEMBRANE ATTACK COMPLEX; COMPLEMENT SYSTEM PROTEINS; CRYSTALLOGRAPHY, X-RAY; HUMANS; HYDROPHOBIC AND HYDROPHILIC INTERACTIONS; PROTEIN STRUCTURE, QUATERNARY; PROTEIN STRUCTURE, SECONDARY; PROTEIN STRUCTURE, TERTIARY;

EID: 84861721290     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M112.361121     Document Type: Article

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