Enzyme catalyzed formation of radicals from S-adenosylmethionine and inhibition of enzyme activity by the cleavage products

Biochimica et Biophysica Acta - Proteins and Proteomics

Volumn 1824, Issue 11, 2012, Pages 1165-1177

  Hiscox, Martyn J ^a   Driesener, Rebecca C ^a   Roach, Peter L ^a  

^a UNIVERSITY OF SOUTHAMPTON   (United Kingdom)

Author keywords

3 Amino 3 carboxypropane; 5 Deoxyadenosine; 5 Methylthioadenosine; Product inhibition; Radical enzyme mechanism; Radical SAM

Indexed keywords

5' DEOXYADENOSINE; AMIDE; DEOXYADENOSINE DERIVATIVE; GLYCEROL DEHYDRATASE-; HYDROLYASE; RADICAL; S ADENOSYLMETHIONINE; SULFUR; UNCLASSIFIED DRUG;

BIOSYNTHESIS; CATALYSIS; CHEMICAL BINDING; CHEMICAL REACTION; CHEMICAL STRUCTURE; ELECTRON TRANSPORT; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME INHIBITION; NONHUMAN; PRIORITY JOURNAL; PROTEIN CLEAVAGE; PROTEIN MOTIF; PROTEIN TRANSPORT; REDUCTION; REVIEW; THERMODYNAMICS; X RAY ABSORPTION SPECTROSCOPY;

BACTERIAL PROTEINS; COENZYMES; DEOXYADENOSINES; EUKARYOTA; FEEDBACK, PHYSIOLOGICAL; FREE RADICALS; IRON-SULFUR PROTEINS; KINETICS; MODELS, MOLECULAR; OXIDATION-REDUCTION; PROTONS; S-ADENOSYLMETHIONINE; THERMODYNAMICS;

EID: 84866046539     PISSN: 15709639     EISSN: 18781454     Source Type: Journal    
DOI: 10.1016/j.bbapap.2012.03.013     Document Type: Review

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