Third target of rapamycin complex negatively regulates development of quiescence in Trypanosoma brucei

Proceedings of the National Academy of Sciences of the United States of America

Volumn 109, Issue 36, 2012, Pages 14399-14404

  Barquilla, Antonio ^a   Saldivia, Manuel ^a   Diaz, Rosario ^a   Bart, Jean Mathieu ^a,b   Vidal, Isabel ^a   Calvo, Enrique ^c   Hall, Michael N ^d   Navarro, Miguel ^a  

^a INSTITUTO DE PARASITOLOGÍA Y BIOMEDICINA LÓPEZ NEYRA   (Spain)

^b Red de Investigación de Centros de Enfermedades Tropicales RICET Madrid   (Spain)

^c CENTRO NACIONAL DE INVESTIGACIONES CARDIOVASCULARES CNIC   (Spain)

^d UNIVERSITY OF BASEL   (Switzerland)

Author keywords

Cell biology; Kinetoplastida; Parasitology

Indexed keywords

ARMADILLO DOMAIN PROTEIN; CYCLIC AMP; TARGET OF RAPAMYCIN KINASE;

ANIMAL CELL; ARTICLE; CELL DIFFERENTIATION; CELL PROLIFERATION; CONTROLLED STUDY; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEPLETION; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; TRYPANOSOMA BRUCEI;

ADAPTATION, PHYSIOLOGICAL; ADENOSINE MONOPHOSPHATE; BLOTTING, WESTERN; CYCLIC AMP; GENE EXPRESSION REGULATION; IMMUNOPRECIPITATION; MICROSCOPY, FLUORESCENCE; MULTIPROTEIN COMPLEXES; SIGNAL TRANSDUCTION; TOR SERINE-THREONINE KINASES; TRYPANOSOMA BRUCEI BRUCEI; VAULT RIBONUCLEOPROTEIN PARTICLES;

ARMADILLO; GLOSSINA (GENUS); KINETOPLASTIDA; MAMMALIA; PROTOZOA; TRYPANOSOMA BRUCEI;

EID: 84866002513     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1210465109     Document Type: Article

References (31)

1. Fenn K, Matthews KR (2007) The cell biology of Trypanosoma brucei differentiation. Curr Opin Microbiol 10:539-546. (Pubitemid 350186135)
2. Turner CM, Aslam N, Dye C (1995) Replication, differentiation, growth and the virulence of Trypanosoma brucei infections. Parasitology 111:289-300.
3. Matthews KR, Gull K (1997) Commitment to differentiation and cell cycle re-entry are coincident but separable events in the transformation of African trypanosomes from their bloodstream to their insect form. J Cell Sci 110:2609-2618. (Pubitemid 27484262)
4. Soulard A, Cohen A, Hall MN (2009) TOR signaling in invertebrates. Curr Opin Cell Biol 21:825-836.
5. Barquilla A, Crespo JL, Navarro M (2008) Rapamycin inhibits trypanosome cell growth by preventing TOR complex 2 formation. Proc Natl Acad Sci USA 105:14579-14584.
6. de Jesus TC, et al. (2010) Target of rapamycin (TOR)-like 1 kinase is involved in the control of polyphosphate levels and acidocalcisome maintenance in Trypanosoma brucei. J Biol Chem 285:24131-24140.
7. Madeira da Silva L, Beverley SM (2010) Expansion of the target of rapamycin (TOR) kinase family and function in Leishmania shows that TOR3 is required for acid-ocalcisome biogenesis and animal infectivity. Proc Natl Acad Sci USA 107:11965-11970.
8. Wullschleger S, Loewith R, Oppliger W, Hall MN (2005) Molecular organization of target of rapamycin complex 2. J Biol Chem 280:30697-30704. (Pubitemid 41291798)
9. Loewith R, et al. (2002) Two TOR complexes, only one of which is rapamycin sensitive, have distinct roles in cell growth control. Mol Cell 10:457-468. (Pubitemid 35284167)
10. Kim DH, et al. (2003) GbetaL, a positive regulator of the rapamycin-sensitive pathway required for the nutrient-sensitive interaction between raptor and mTOR. Mol Cell 11:895-904.
11. Sarbassov DD, et al. (2004) Rictor, a novel binding partner of mTOR, defines a rapamycin-insensitive and raptor-independent pathway that regulates the cytoskeleton. Curr Biol 14:1296-1302.
12. Matsuo T, Otsubo Y, Urano J, Tamanoi F, Yamamoto M (2007) Loss of the TOR kinase Tor2 mimics nitrogen starvation and activates the sexual development pathway in fission yeast. Mol Cell Biol 27:3154-3164. (Pubitemid 46581326)
13. Tang G, et al. (2008) Autophagy induced by Alexander disease-mutant GFAP accumulation is regulated by p38/MAPK and mTOR signaling pathways. Hum Mol Genet 17:1540-1555. (Pubitemid 351737159)
14. Kolli S, Zito CI, Mossink MH, Wiemer EA, Bennett AM (2004) The major vault protein is a novel substrate for the tyrosine phosphatase SHP-2 and scaffold protein in epidermal growth factor signaling. J Biol Chem 279:29374-29385. (Pubitemid 38915816)
15. Berger W, Steiner E, Grusch M, Elbling L, Micksche M (2009) Vaults and the major vault protein: Novel roles in signal pathway regulation and immunity. Cell Mol Life Sci 66:43-61.
16. Tyson JJ, Chen KC, Novak B (2003) Sniffers, buzzers, toggles and blinkers: Dynamics of regulatory and signaling pathways in the cell. Curr Opin Cell Biol 15:221-231. (Pubitemid 36332198)
17. Blomen VA, Boonstra J (2007) Cell fate determination during G1 phase progression. Cell Mol Life Sci 64:3084-3104. (Pubitemid 351152236)
18. Vassella E, Reuner B, Yutzy B, Boshart M (1997) Differentiation of African trypanosomes is controlled by a density sensing mechanism which signals cell cycle arrest via the cAMP pathway. J Cell Sci 110:2661-2671. (Pubitemid 27499424)
19. Nolan DP, Rolin S, Rodriguez JR, Van Den Abbeele J, Pays E (2000) Slender and stumpy bloodstream forms of Trypanosoma brucei display a differential response to extracellular acidic and proteolytic stress. Eur J Biochem 267:18-27. (Pubitemid 30029733)
20. Kabani S, et al. (2009) Genome-wide expression profiling of in vivo-derived bloodstream parasite stages and dynamic analysis of mRNA alterations during synchronous differentiation in Trypanosoma brucei. BMC Genomics 10:427.
21. Navarro M, Gull K (2001) A pol I transcriptional body associated with VSG mono-allelic expression in Trypanosoma brucei. Nature 414:759-763. (Pubitemid 34000774)
22. Dean S, Marchetti R, Kirk K, Matthews KR (2009) A surface transporter family conveys the trypanosome differentiation signal. Nature 459:213-217.
23. Tyler WA, et al. (2009) Activation of the mammalian target of rapamycin (mTOR) is essential for oligodendrocyte differentiation. J Neurosci 29:6367-6378.
24. Laxman S, Riechers A, Sadilek M, Schwede F, Beavo JA (2006) Hydrolysis products of cAMP analogs cause transformation of Trypanosoma brucei from slender to stumpy-like forms. Proc Natl Acad Sci USA 103:19194-19199. (Pubitemid 350002849)
25. Shertz CA, Bastidas RJ, Li W, Heitman J, Cardenas ME (2010) Conservation, duplication, and loss of the Tor signaling pathway in the fungal kingdom. BMC Genomics 11:510.
26. Müller IB, Domenicali-Pfister D, Roditi I, Vassella E (2002) Stage-specific requirement of a mitogen-activated protein kinase by Trypanosoma brucei. Mol Biol Cell 13:3787-3799.
27. Vassella E, et al. (2001) Deletion of a novel protein kinase with PX and FYVE-related domains increases the rate of differentiation of Trypanosoma brucei. Mol Microbiol 41:33-46. (Pubitemid 32660981)
28. Patursky-Polischuk I, et al. (2009) The TSC-mTOR pathway mediates translational activation of TOP mRNAs by insulin largely in a raptor- or rictor-independent manner. Mol Cell Biol 29:640-649.
29. Landeira D, Bart JM, Van Tyne D, Navarro M (2009) Cohesin regulates VSG monoallelic expression in trypanosomes. J Cell Biol 186:243-254.
30. Engstler M, Boshart M (2004) Cold shock and regulation of surface protein trafficking convey sensitization to inducers of stage differentiation in Trypanosoma brucei. Genes Dev 18:2798-2811. (Pubitemid 39507772)
31. Estévez AM, Kempf T, Clayton C (2001) The exosome of Trypanosoma brucei. EMBO J 20:3831-3839.