Deletion of a novel protein kinase with PX and FYVE-related domains increases the rate of differentiation of Trypanosoma brucei

Molecular Microbiology

Volumn 41, Issue 1, 2001, Pages 33-46

  Vassella, Erik ^a,b   Krämer, Robert ^a   Turner, C Michael R ^c   Wankell, Miriam ^a   Modes, Christine ^a   Van Den Bogaard, Miriam ^a   Boshart, Michael ^a,d  

^a MAX PLANCK INSTITUTE OF BIOCHEMISTRY   (Germany)

^b UNIVERSITY OF BERN   (Switzerland)

^c UNIVERSITY OF GLASGOW   (United Kingdom)

^d FREIE UNIVERSITÄT BERLIN   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

PROTEIN KINASE; RAC PROTEIN; UNCLASSIFIED DRUG; ZINC FINGER KINASE; ZINC FINGER PROTEIN;

ARTICLE; CELL CYCLE; DISEASE CARRIER; GENE DELETION; GROWTH RATE; GROWTH REGULATION; HOST; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; SEQUENCE HOMOLOGY; STRAIN DIFFERENCE; TRYPANOSOMA BRUCEI; TSETSE FLY;

AMINO ACID SEQUENCE; ANIMALS; CELL LINE; GENE DELETION; GENE EXPRESSION REGULATION, DEVELOPMENTAL; HUMANS; MICE; MICE, INBRED BALB C; MOLECULAR SEQUENCE DATA; PROTEIN STRUCTURE, TERTIARY; PROTEIN-SERINE-THREONINE KINASES; PROTOZOAN PROTEINS; RATS; TRYPANOSOMA BRUCEI BRUCEI; TRYPANOSOMIASIS, AFRICAN; ZINC FINGERS;

EID: 0034945191     PISSN: 0950382X     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2958.2001.02471.x     Document Type: Article

References (63)

1. Gapped BLAST and PSI-BLAST: A new generation of protein database search programs
2. Trypanosoma brucei: Fluxes of the morphological variants in intact and X-irradiated mice
3. The fall and rise of sleeping sickness
4. The Pfam protein families database
5. Regulation of parasitaemia in mice infected with Trypanosoma brucei
6. Cross-species interactions between malaria parasites in humans
7. Cultivation and in vitro cloning of procyclic culture forms of Trypanosoma brucei in a semi-defined medium
8. Stimulating effect of citrate and cis-aconitate on the transformation of Trypanosoma brucei bloodstream forms to procyclic forms in vitro
9. Phosphatidylinositol (3) - Phosphate signaling mediated by specific binding to RING FYVE domains
10. DNA mediated transformation of bloodstream form Trypanosoma brucei
11. Development regulation of nuclear gene expression in Trypanosoma brucei
12. Antigenic variation in trypanosomes - Secrets surface slowly
13. Cultivation of Trypanosoma brucei ssp. in semi-defined and defined media
14. Phosphoinositide binding domains: Embracing 3-phosphate
15. Elements of the 3′ untranslated region of procyclin mRNA regulates expression in insect forms of Trypanosoma brucei by modulating RNA stability and translation
16. FYVE fingers bind Ptdlns (3) P.
17. SWISS-MODEL and the Swiss-PdbViewer: An environment for comparative protein modeling
18. The eukaryotic protein kinase superfamily
19. The protein kinase family: Conserved features and deduced phylogeny of the catalytic domains
20. A conserved stem-loop structure in the 3′ untranslated region of procyclin messenger RNAs regulates expression in Trypanosoma brucei
21. Akt signaling: Linking membrane events to life and death decisions
22. Virulence of trypanosomes in the vertebrate host
23. Continuous cultivation of Trypanosoma brucei bloodstream forms in a medium containing a low concentration of serum protein without feeder cell layers
24. The PROSITE database, its status in 1999
25. A possible role for the 3′-untranslated region in developmental regulation in Trypanosoma brucei
26. Signaling - 2000 and beyond
27. Taxonomy and function of C1 protein kinase C homology domains
28. Phosphorylation and activation of phospholipase D1 by protein kinase C in vivo: Determination of multiple phosphorylation sites
29. Phosphatidylinositol 3-phosphate recognition by the FYVE domain
30. A new method for isolating tyrosine kinase substrates used to identify fish, an SH3 and PX domain-containing protein, and Src substrate
31. Cyclic 3′, 5′-adenosine monophosphate levels during the developmental cycle of Trypanosoma brucei brucei in the rat
32. Crystal structure of the VHS and FYVE tandem domains of Hrs, a protein involved in membrane trafficking and signal transduction
33. Developments in the differentiation of Trypanosoma brucei
34. Eukaryotic expression vectors for the analysis of mutant proteins
35. Crystal structure of a phosphatidylinositol 3-phosphate-specific membrane-targeting motif, the FYVE domain of Vps27p
36. Structural basis of Rab effector specificity: Crystal structure of the small G protein Rab3A complexed with the effector domain of rabphilin- 3A
37. Isolation, characterization, and mapping of the mouse Fgd3 gene, a new Faciogenital Dysplasia (FGD1; Aarskog Syndrome) gene homologue
38. A functional Ptdlns (3) P-binding motif
39. Rapid and Sensitive Sequence Comparison with FASTP and FASTA
40. Novel domains in NADPH oxidase subunits, sorting nexins, and Ptdlns 3- kinases: Binding partners of SH3 domains?
41. Cell density triggers slender to stumpy differentiation of Trypanosoma brucei bloodstream forms in culture
42. Unravelling the procyclin coat of Trypanosoma Brucei
43. Procyclin gene expression and loss of the variant surface glycoprotein during differentiation of Trypanosoma brucei
44. Vam7p, a SNAP-25-like molecule, and Vam3p, a syntaxin homologue, function together in yeast vacuolar protein trafficking
45. SMART: A web-based tool for the study of genetically mobile domains
46. Analysis by flow cytometry of DNA synthesis during the life cycle of African trypanosomes
47. The C-terminal tripeptide of glycosomal phosphoglycerate kinase is both necessary and sufficient for import into the glycosomes of Trypanosoma brucei
48. FYVE-finger proteins-effectors of an inositol lipid
49. Endosomal localization of the autoantigen EEA1 is mediated by a zinc- binding FYVE finger
50. A novel selection regime for differentiation defects demonstrates an essential role for the stumpy form in the life cycle of the African trypanosome
51. CLUSTAL W: Improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choice
52. SARA, a FYVE domain protein that recruits Smad2 to the TGFbeta receptor
53. Antigenic variation in Trypanosoma brucei infections: An holistic view
54. Inhibition of growth of Trypanosoma brucei parasites in chronic infections
55. Replication, differentiation, growth and the virulence of Trypanosoma brucei infections
56. High molecular mass agarose matrix supports growth of bloodstream forms of pleomorphic Trypanosoma brucei strains in axenic culture
57. Control of polyadenylation and alternative splicing of transcripts from adjacent genes in a procyclin expression site - A dual role for polypyrimidine tracts in trypanosomes?
58. Differentiation of African trypansomes is controlled by a density sensing mechanism which signals cell cycle arrest via the cAMP pathway
59. Polymorphism and mitochondrial activity in sleeping sickness trypanosomes
60. Developmental cycles and biology of pathogenetic trypanosomes
61. p40phox, a third cytosolic component of the activation complex of the NADPH oxidase to contain src homology 3 domains