Chronic administration of a leupeptin-derived calpain inhibitor fails to ameliorate severe muscle pathology in a canine model of duchenne muscular dystrophy

Frontiers in Pharmacology

Volumn 3 JAN, Issue , 2012, Pages

  Childers, Martin K ^a,b   Bogan, Janet R ^c   Bogan, Daniel J ^c   Greiner, Hansel ^a,e   Holder, Melanie ^b   Grange, Robert W ^d   Kornegay, Joe N ^c  

^a WAKE FOREST UNIVERSITY HEALTH SCIENCES   (United States)

^b WAKE FOREST SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

^d VIRGINIA POLYTECHNIC INSTITUTE AND STATE UNIVERSITY   (United States)

^e CINCINNATI CHILDREN'S HOSPITAL MEDICAL CENTER   (United States)

Author keywords

Animal; Calpain; Canine; Muscular dystrophy; Protease; Skeletal muscle

Indexed keywords

C 101; CALPASTATIN; PLACEBO; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL MUSCULAR DYSTROPHY; ANIMAL TISSUE; ARTICLE; BODY FAT; CHRONIC DRUG ADMINISTRATION; CONTROLLED STUDY; DISEASE MODEL; DISEASE SEVERITY; DRUG EFFICACY; DUCHENNE MUSCULAR DYSTROPHY; FUNCTIONAL ASSESSMENT; GOLDEN RETRIEVER MUSCULAR DYSTROPHY; HISTOPATHOLOGY; JOINT CONTRACTURE; JOINT FUNCTION; JUVENILE ANIMAL; MUSCLE CONTRACTION; MUSCLE DISEASE; MUSCLE FUNCTION; MUSCLE MASS; MUSCLE STRENGTH; MUSCLE WEAKNESS; NEWBORN; NONHUMAN; OUTCOME ASSESSMENT; PELVIC GIRDLE; TREATMENT DURATION; TREATMENT RESPONSE;

EID: 84865988832     PISSN: None     EISSN: 16639812     Source Type: Journal    
DOI: 10.3389/fphar.2011.00089     Document Type: Article

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