Increased activity of calcium leak channels caused by proteolysis near sarcolemmal ruptures

Journal of Membrane Biology

Volumn 176, Issue 2, 2000, Pages 169-174

  McCarter, G C ^a   Steinhardt, R A ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Calcium channel; Membrane wound; Muscular dystrophy; Myotube; Proteolysis; Sarcolemma

Indexed keywords

CALCIUM CHANNEL; DYSTROPHIN;

ANIMAL CELL; ARTICLE; CALCIUM CELL LEVEL; CELL ADHESION; CELL DEATH; CONTROLLED STUDY; MOUSE; MUSCLE CELL; MUSCLE FIBER MEMBRANE; MUSCLE FIBRIL; MUSCULAR DYSTROPHY; NONHUMAN; PATCH CLAMP; PROTEIN DEGRADATION; PROTEIN STRUCTURE; SARCOLEMMA;

ANIMALS; CALCIUM CHANNELS; CELLS, CULTURED; CYSTEINE ENDOPEPTIDASES; CYSTEINE PROTEINASE INHIBITORS; LEUPEPTINS; MICE; MUSCLE, SKELETAL; SARCOLEMMA;

ANIMALIA;

EID: 0033863129     PISSN: 00222631     EISSN: None     Source Type: Journal    
DOI: 10.1007/s002320001086     Document Type: Article

References (22)

1. Calcium influx through calcium leak channels is responsible for the elevated levels of calcium-dependent proteolysis in dystrophic myotubes
2. 2+ levels in myotubes grown from the skeletal muscle of dystrophic (mdx) and normal mice
3. Calcium-regulated exocytosis is required for cell membrane resealing
4. Loss of cytoplasmic basic fibroblast growth factor from physiologically wounded myofibers of normal and dystrophic muscle
5. Calcium-activated neutral protease (calpain) system: Structure, function, and regulation
6. Heterokaryon myotubes with normal mouse and Duchenne nuclei exhibit sarcolemmal dystrophin staining and efficient intracellular free calcium control
7. Satellite cell from dystrophic (mdx) mouse muscles are stimulated by fibroblast growth factor in vitro
8. Increased activity of calcium leak channels in myotubes of Duchenne human and mdx mouse origin
9. Calcium entry through stretch-inactivated ion channels in mdx myotubes
10. A capacitative calcium current in cultured skeletal muscle cells is mediated by the calcium-specific leak channel and inhibited by dihydropyridine compounds
11. A critical evaluation of resting intracellular free calcium regulation in dystrophic mdx muscle
12. Lipofection of a cDNA plasmid containing the dystrophin gene lowers intracellular free calcium and calcium leak channel activity in mdx myotubes
13. Extent of shock-induced membrane leakage in human and mouse myotubes depends on dystrophin
14. Mechanical function of dystrophin in muscle cells
15. Dystrophin protects the sarcolemma from stresses developed during muscle contraction
16. Cell membrane resealing by a vesicular mechanism similar to neurotransmitter release
17. Muscular dystrophies and the dystrophin-glycoprotein complex
18. The mechanism of facilitated cell membrane resealing
19. Increased calcium influx in dystrophic muscle
20. Proteolysis results in altered leak channel kinetics and elevated free calcium in mdx muscle
21. Increased protein degradation results from elevated free calcium levels found in muscle from mdx mice
22. Increased calcium entry into dystrophin-deficient muscle fibres of mdx and ADR-mdx mice is reduced by ion channel blockers