Thyrotropin-releasing hormone in the treatment of intractable epilepsy

Pediatric Neurology

Volumn 26, Issue 1, 2002, Pages 9-17

  Kubek, Michael J ^a,b   Garg, Bhuwan P ^b  

^a INDIANA UNIVERSITY   (United States)

^b INDIANA UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTICONVULSIVE AGENT; GAMMA BUTYROLACTONE GAMMA CARBONYLHISTIDYLPROLINAMIDE CITRATE; PROTIRELIN; PROTIRELIN TARTRATE; TETRACOSACTIDE ZINC PHOSPHATE;

CLINICAL TRIAL; DRUG EFFECT; DRUG EFFICACY; DRUG SAFETY; ELECTRIC SHOCK; FOCAL EPILEPSY; GRAND MAL SEIZURE; HUMAN; HYPOTHALAMUS; INFANTILE SPASM; INTRACTABLE EPILEPSY; LENNOX GASTAUT SYNDROME; MYOCLONUS SEIZURE; NEUROANATOMY; NEUROMODULATION; PRIORITY JOURNAL; PROTEIN ISOLATION; REVIEW; TISSUE DISTRIBUTION;

ANTICONVULSANTS; BRAIN; DRUG ADMINISTRATION ROUTES; DRUG ADMINISTRATION SCHEDULE; EPILEPSY; GLUTAMIC ACID; HUMANS; NEUROTRANSMITTER AGENTS; SYNDROME; THYROTROPIN-RELEASING HORMONE;

EID: 0036163653     PISSN: 08878994     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0887-8994(01)00321-6     Document Type: Review

References (124)

1. The identification of thyrotropin releasing hormone (TRH) in hypothalamic and extrahypothalamic loci of the human nervous system
2. Thyrotropin releasing hormone (TRH): Apparent receptor binding in rat brain membranes
3. The biology of pro-TRH-derived peptides
4. Role of TRH in seizure modulation
5. Clinical study of oral administration of DN-1417, a TRH analog, in patients with intractable epilepsy
6. Prolonged seizure suppression by a single implantable polymeric-TRH microdisk preparation
7. Clinical effects of TRH for severe epilepsy in childhood: A comparative study with ACTH therapy
8. Factors influencing effectiveness of TRH therapy for severe epilepsy in childhood: Significance of serum prolactin levels
9. Thyrotropin-releasing hormone in treatment of intractable epilepsy: Neurochemical analysis of CSF monoamine metabolites
10. A pilot study on the anticonvulsive effects of a TRH analog in intractable epilepsy
11. TRH increases cerebrospinal fluid concentration of kynurenine
12. Successful treatment of progressive myoclonus epilepsy with TRH
13. Use of TRH analogues in motorneurone disease
14. Effectiveness and safety of Posatirelin in the treatment of senile dementia: A multicenter, double blind, placebo-controlled study
15. Antenatal thyrotropin-releasing hormone to prevent lung disease in preterm infants
16. TRH (Protirelin): Role in the treatment of epilepsy
17. Thyroid function 6 years after prenatal treatment with TRH
18. Epileptic seizures induced by thyrotropin releasing hormone
19. The use of TRH in amyotrophic lateral sclerosis (ALS). TRH and diseases of the motor system
20. Further characterization of the substrate specificity of a TRH hydrolysing pyroglutamate aminopeptidase from guinea-pig brain
21. Pyroglutamyl peptidase-II ("thyroliberinase") activity in human serum: Influence of weight and thyroid status
22. TRH
23. Pyroglutamyl peptidase: An overview of the three known enzymatic forms
24. Changes in TRH and its degrading enzyme pyroglutamyl peptidase II, during the development of amygdaloid kindling
25. TRH: Localization of specific hypothalamic and extrahypothalamic sites of CNS modulation
26. Neuropathological consequences of chemically and electrically induced seizures
27. Animal models of the epilepsies
28. Kindling: Clinical relevance and anatomical substrate
29. Elevated TRH levels in pyriform cortex after partial and fully-generalized kindled seizures
30. Regional changes in central nervous system TRH after pentylenetetrazol-induced seizures in dogs
31. TRH gene expression and receptors are differentially modified in limbic foci by seizures
32. Effects of pentylenetetrazole-induced kindling on TRH biosynthesis and receptors in rat brain
33. Effects of pilocarpine- and kainate-induced seizures on thyrotropin- releasing hormone biosynthesis and receptors in the rat brain
34. Electroconvulsive seizures increase levels of PS4, the TRH-enhancing peptide [prepro-TRH(160-169)], in rat brain
35. Predominance of pGlu-His-Pro-Gly among all TRH precursor peptides in rat limbic forebrain after electroconvulsive seizures
36. Thyrotropin-releasing hormone (TRH) and TRH mRNA is increased in specific hippocampal subregions following electroconvulsive seizures (ECS) as determined by in situ hybridization (ISHH) and RIA
37. Changes in brain thyrotropin-releasing hormone (TRH) of seizure-prone EI mice
38. Inhibition by thyrotropin-releasing hormone of epileptic seizures in spontaneously epileptic rats
39. Antiepileptic effect of CNK-602A, a novel TRH analog, on absence-like and tonic seizures of spontaneously epileptic rats
40. Protective effects of TRH and its stable analogue, RGH-2202, on kainate-induced seizures and neurotoxicity in rodents
41. Animal models of intractable epilepsy
42. Modification of seizure activity by electrical stimulation: II. Motor seizure
43. Drugs effective in the therapy of the epilepsies
44. Cellular and molecular basis of epilepsy
45. The kindling model of epilepsy
46. Kindling: The first decade
47. Antiepileptic effects of TRH and its new derivative, DN-1417, examined in feline amygdaloid kindling preparation
48. The prophylactic and anticonvulsant effects of a TRH analog (DN-1417) on amygdaloid kindling model of epilepsy
49. Anti-epileptic effects of TRH-T and DN-1417
50. Anticonvulsive properties of YM-14673, a new TRH analogue, in amygdaloid-kindled rats
51. Effect of DN-1417 on photosensitivity and cortically kindled seizure in Senegalese baboons, Papio papio
52. Anticonvulsant effect of DN-1417, a derivative of TRH, and liposome-entrapped DN-1417, on amygdaloid-kindled rats
53. Effects of anticonvulsants on the electroconvulsive threshold lowered by DA, 5-HT or GABA depletion
54. Subregional changes in hippocampal TRH (TRH) after amygdaloid kindling in rats
55. Changes in TRH levels in hippocampal subregions induced by a model of human temporal lobe epilepsy: Effect of partial and complete kindling
56. Increases in TRH mRNA expression induced by a model of human temporal lobe epilepsy: Effect of partial and complete kindling
57. Alterations in mRNA of enkephalin, dynorphin and TRH during amygdala kindling: An in situ hybridization study
58. Localization by light microscopic autoradiography in rat brain using (3H)(3-Me-His2)TRH as the radioligand
59. Biochemical similarity of rat pituitary and CNS TRH receptors
60. Pituitary and CNS TRH receptors
61. Distribution of TRH receptor messenger RNA in the rat brain: An in situ hybridization study
62. Cloning and characterization of a cDNA encoding a novel subtype of rat TRH receptor
63. Quantitative autoradiography of TRH receptors in discrete brain regions of different mammalian species
64. Distribution of TRH binding sites: Autoradiographic study in infant and adult human hippocampal formation
65. TRH-R2 exhibits similar binding and acute signaling but distinct regulation and anatomic distribution compared with TRH-R1
66. Induction of c-fos mRNA expression by afterdischarge in the hippocampus of naive and kindled rats
67. Kindling stimulation induced c-fos protein(s) in granule cells of the rat dentate gyrus
68. Convulsant-induced increase in transcription factor messenger RNAs in rat brain
69. Structure of the gene encoding rat TRH
70. Colocalization of TRH mRNA and Fos-like immunoreactivity in limbic structures following amygdala kindling
71. "Epileptic" brain damage is replicated qualitatively in the rat hippocampus by central injection of glutamate or aspartate but not by GABA or acetylcholine
72. "Epileptic" brain damage in rats induced by sustained electrical stimulation of the perforant path. I. Acute electrophysiological and light microscopic studies
73. Experimental models of temporal lobe epilepsy: New insights from the study of kindling and synaptic reorganization
74. Mossy fiber reorganization induced by kindling: Time course of development, progression, and permanence
75. Hippocampal plasticity in the kindling model of epilepsy in rats
76. Mossy fiber synaptic reorganization in the epileptic human temporal lobe
77. Reorganization hypothesis of epilepsy: Granule cell sprouting in rats is associated with decreased, not increased, excitability
78. The functional organization of the hippocampal dentate gyrus and its relevance to the pathogenesis of temporal lobe epilepsy
79. Contingent tolerance to carbamazepine: Alterations in TRH mRNA and TRH receptor binding in limbic structures
80. TRH release is enhanced in hippocampal slices after electroconvulsive shock
81. Molecular and cellular biology of TRH receptors
82. Anticonvulsant effects of intra-hippocampal injection of TRH in amygdala kindled rats
83. Contingent tolerance to the anticonvulsant effects of carbamazepine: Relationship to loss of endogenous adaptive mechanisms
84. Cloning and characterization of a new subtype of TRH receptors
85. TRH-catecholamine interactions in brain and spinal cord
86. Functional interactions between TRH and 5-hydroxytryptamine (5-HT) and proctolin in rat brain and spinal cord
87. Enhancement of cerebral noradrenaline turnover by TRH
88. Effects of MK-771, a novel TRH analogue, on dopaminergic and serotonergic systems
89. Some regional anatomical relationships of TRH to 5-HT in rat limbic forebrain
90. Thyrotropin-releasing hormone (TRH) and its analog (DN-1417): Interaction with pentobarbital in choline uptake and acetylcholine synthesis of rat brain slices
91. Effects of a novel TRH analogue, JTP-2942, on extracellular acetylcholine and choline levels in the rat frontal cortex and hippocampus
92. Modulation of GABA-gated chloride currents by intracellular Ca2+ in cultured porcine melanotrophs
93. TRH selectively depresses glutamate excitation of cerebral cortical neurons
94. Thyrotropin releasing hormone (TRH): Depressant action on central neuronal activity
95. TRH inhibits [K+]-stimulated glutamate release from hippocampal slices in vitro
96. TRH (TRH) and its beta-alanine analogue: Potentiation of the anticonvulsant potency of phenobarbital in mice
97. Carbamazepine increases cerebrospinal fluid thyrotropin-releasing hormone levels in affectively ill patients
98. Thyrotropin releasing hormone (TRH): Depressant action on central neuronal activity
99. Peptides as neurotransmitters of neuromodulators
100. TRH (TRH) attenuates glutamate-stimulated increases in calcium in primary neuronal cultures
101. Basic mechanisms of kynurenine actions in the central nervous system
102. Kynurenic acid is decreased in cerebrospinal fluid of patients with infantile spasms
103. Studies on cerebrospinal fluid kynurenic acid concentrations in epileptic children
104. Regulation of the messenger ribonucleic acid for corticotropin-releasing factor in the paraventricular nucleus and other brain sites of the rat
105. Dexamethasone inhibits corticotropin-releasing factor gene expression in rat paraventricular nucleus
106. Changes in adrenal status affect hypothalamic TRH gene expression in parallel with corticotropin-releasing hormone
107. Differential regulation of basal and kindling-induced TRH mRNA expression by thyroid hormone in the hypothalamic and limbic structures
108. Glucocorticoids stimulate TRH and c-fos/c-jun gene co-expression in cultured hypothalamic neurons
109. Glucocorticoids stimulate TRH gene expression in cultured hypothalamic neurons
110. Dexamethasone rapidly regulates TRH mRNA levels in hypothalamic cell cultures: Interaction with the cAMP pathway
111. Glucocorticoids modulate the biosynthesis and processing of proTRH (proTRH)
112. Induction of corticotropin-releasing hormone gene expression by glucocorticoids: Implication for understanding the states of fear and anxiety and allostatic load
113. The in vivo proconvulsant effects of corticotropin releasing hormone in the developing rat are independent of ionotropic glutamate receptor activation
114. The pro-convulsant actions of corticotropin-releasing hormone in the hippocampus of infant rats
115. The CRF1 receptor mediates the excitatory actions of corticotropin releasing factor (CRF) in the developing rat brain: In vivo evidence using a novel, selective, non-peptide CRF receptor antagonist
116. ACTH does not control neonatal seizures induced by administration of exogenous corticotropin-releasing hormone
117. Pathophysiology of massive infantile spasms: Perspective on the putative role of the brain adrenal axis
118. Corticotropin-releasing hormone-induced seizures in infant rats originate in the amygdala
119. Corticotropin-releasing hormone is a rapid and potent convulsant in the infant rat
120. Amygdala-kindled seizures increase the expression of corticotropin-releasing factor (CRF) and CRF-binding protein in GABAergic interneurons of the dentate hilus
121. High-dose corticotropin (ACTH) versus prednisone for infantile spasms: A prospective, randomized, blinded study
122. West syndrome: Individualized ACTH therapy
123. Psychiatric disorders in children with earlier infantile spasms
124. ACTH therapy in infantile spasms: Side effects