The Gβ3 splice variant associated with the C825T gene polymorphism is an unstable and functionally inactive protein

Cellular Signalling

Volumn 24, Issue 12, 2012, Pages 2349-2359

  Sun, Zhizeng ^a   Runne, Caitlin ^a   Tang, Xiaoyun ^a   Lin, Fang ^a   Chen, Songhai ^a  

^a UNIVERSITY OF IOWA   (United States)

Author keywords

Chemotaxis; GNB3; GPCR; Heterotrimeric G protein; Polymorphism; Signaling

Indexed keywords

GUANINE NUCLEOTIDE EXCHANGE FACTOR; PHOSPHATIDYLINOSITOL 3 KINASE; STROMAL CELL DERIVED FACTOR 1ALPHA;

ANIMAL CELL; ARTICLE; BIOLUMINESCENCE RESONANCE ENERGY TRANSFER; CELL MEMBRANE; CHEMOTAXIS; CONTROLLED STUDY; DOWN REGULATION; GBETA3S GENE; GENE; GENETIC POLYMORPHISM; GENETIC VARIABILITY; HOMOZYGOSITY; HUMAN; HUMAN CELL; IMMUNOPRECIPITATION; LIPID ANALYSIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; PROTEIN STABILITY; PURIFICATION; SIGNAL TRANSDUCTION;

AMINO ACID SUBSTITUTION; ANIMALS; CELL LINE; CERCOPITHECUS AETHIOPS; CHEMOKINE CXCL12; COS CELLS; DIMERIZATION; FLUORESCENCE RESONANCE ENERGY TRANSFER; GTP-BINDING PROTEIN ALPHA SUBUNITS; GTP-BINDING PROTEIN BETA SUBUNITS; GTP-BINDING PROTEIN GAMMA SUBUNITS; HEK293 CELLS; HUMANS; POLYMORPHISM, GENETIC; RNA SPLICING; SIGNAL TRANSDUCTION;

EID: 84865971313     PISSN: 08986568     EISSN: 18733913     Source Type: Journal    
DOI: 10.1016/j.cellsig.2012.08.011     Document Type: Article

References (53)

1. Oldham W.M., Hamm H.E. Nature Reviews Molecular Cell Biology 2008, 9:60-71.
2. Tesmer J.J. Nature Structural & Molecular Biology 2010, 17:650-652.
3. Vassart G., Costagliola S. Nature Reviews Endocrinology 2011, 7:362-372.
4. Thathiah A., De Strooper B. Nature Reviews Neuroscience 2011, 12:73-87.
5. Brinks H.L., Eckhart A.D. Biochimica et Biophysica Acta 2010, 1802:1268-1275.
6. Lappano R., Maggiolini M. Nature Reviews Drug Discovery 2011, 10:47-60.
7. Tiwari A. Current Opinion in Investigational Drugs 2010, 11:385-393.
8. Whalen E.J., Rajagopal S., Lefkowitz R.J. Trends in Molecular Medicine 2011, 17:126-139.
9. Smrcka A.V. Cellular and Molecular Life Sciences : CMLS 2008, 65:2191-2214.
10. Siffert W., Rosskopf D., Siffert G., Busch S., Moritz A., Erbel R., Sharma A.M., Ritz E., Wichmann H.E., Jakobs K.H., Horsthemke B. Nature Genetics 1998, 18:45-48.
11. Rosskopf D., Busch S., Manthey I., Siffert W. Hypertension 2000, 36:33-41.
12. Rosskopf D., Kielbik M., Manthey I., Bilmen G., Eisenhardt A., Siffert W. Biochimica et Biophysica Acta 2003, 1626:33-42.
13. Rosskopf D., Manthey I., Habich C., Kielbik M., Eisenhardt A., Nikula C., Urban M., Kohnen S., Graf E., Ravens U., Siffert W. Biochemical Journal 2003, 371:223-232.
14. Klenke S., Kussmann M., Siffert W. Pharmacogenetics and Genomics 2011, 21:594-606.
15. Siffert W. Annual Review of Medicine 2005, 56:17-28.
16. Lopez-Leon S., Janssens A.C., Gonzalez-Zuloeta Ladd A.M., Del-Favero J., Claes S.J., Oostra B.A., van Duijn C.M. Molecular Psychiatry 2008, 13:772-785.
17. Sheu S.Y., Handke S., Brocker-Preuss M., Gorges R., Frey U.H., Ensinger C., Ofner D., Farid N.R., Siffert W., Schmid K.W. The Journal of Pathology 2007, 211:60-66.
18. Holmen O.L., Romundstad S., Melien O. American Journal of Hypertension 2010, 23:1121-1127.
19. Plat A.W., Stoffers H.E., Klungel O.H., van Schayck C.P., de Leeuw P.W., Soomers F.L., Schiffers P.M., Kester A.D., Kroon A.A. Journal of Human Hypertension 2009, 23:659-667.
20. Kato M., Wakeno M., Okugawa G., Fukuda T., Takekita Y., Hosoi Y., Azuma J., Kinoshita T., Serretti A. Progress in Neuro-Psychopharmacology & Biological Psychiatry 2008, 32:1041-1044.
21. Kurnik D., Muszkat M., Sofowora G.G., Friedman E.A., Dupont W.D., Scheinin M., Wood A.J., Stein C.M. Hypertension 2008, 51:406-411.
22. Meirhaeghe A., Cottel D., Amouyel P., Dallongeville J. Molecular Genetics and Metabolism 2005, 86:293-299.
23. Rosskopf D., Koch K., Habich C., Geerdes J., Ludwig A., Wilhelms S., Jakobs K.H., Siffert W. Cellular Signalling 2003, 15:479-488.
24. Ruiz-Velasco V., Ikeda S.R. Physiological Genomics 2003, 13:85-95.
25. Dingus J., Wells C.A., Campbell L., Cleator J.H., Robinson K., Hildebrandt J.D. Biochemistry 2005, 44:11882-11890.
26. Sun Z., Tang X., Lin F., Chen S. Journal of Biological Chemistry 2011, 286:43902-43912.
27. Pfleger K.D., Seeber R.M., Eidne K.A. Nature Protocols 2006, 1:337-345.
28. Oner S.S., An N., Vural A., Breton B., Bouvier M., Blumer J.B., Lanier S.M. Journal of Biological Chemistry 2010, 285:33949-33958.
29. Chen S., Dell E.J., Lin F., Sai J., Hamm H.E. Journal of Biological Chemistry 2004, 279:17861-17868.
30. Hampf M., Gossen M. Analytical Biochemistry 2006, 356:94-99.
31. Virchow S., Ansorge N., Rubben H., Siffert G., Siffert W. FEBS Letters 1998, 436:155-158.
32. Chen S., Lin F., Shin M.E., Wang F., Shen L., Hamm H.E. Molecular Biology of the Cell 2008, 19:3909-3922.
33. Muntz K.H., Sternweis P.C., Gilman A.G., Mumby S.M. Molecular Biology of the Cell 1992, 3:49-61.
34. Poon L.S., Chan A.S., Wong Y.H. Cellular Signalling 2009, 21:737-744.
35. Takida S., Wedegaertner P.B. Journal of Biological Chemistry 2003, 278:17284-17290.
36. Higgins J.B., Casey P.J. Journal of Biological Chemistry 1994, 269:9067-9073.
37. Ueda H., Nagae R., Kozawa M., Morishita R., Kimura S., Nagase T., Ohara O., Yoshida S., Asano T. Journal of Biological Chemistry 2008, 283:1946-1953.
38. Hill C.S., Wynne J., Treisman R. Cell 1995, 81:1159-1170.
39. Virchow S., Ansorge N., Rosskopf D., Rubben H., Siffert W. Naunyn-Schmiedeberg's Archives of Pharmacology 1999, 360:27-32.
40. Jones M.B., Garrison J.C. Analytical Biochemistry 1999, 268:126-133.
41. McIntire W.E., MacCleery G., Garrison J.C. Journal of Biological Chemistry 2001, 276:15801-15809.
42. Maier U., Babich A., Macrez N., Leopoldt D., Gierschik P., Illenberger D., Nurnberg B. Journal of Biological Chemistry 2000, 275:13746-13754.
43. Sondek J., Bohm A., Lambright D.G., Hamm H.E., Sigler P.B. Nature 1996, 379:369-374.
44. Smith T.F., Gaitatzes C., Saxena K., Neer E.J. Trends in Biochemical Sciences 1999, 24:181-185.
45. Murzin A.G. Proteins 1992, 14:191-201.
46. Ansari-Lari M.A., Muzny D.M., Lu J., Lu F., Lilley C.E., Spanos S., Malley T., Gibbs R.A. Genome Research 1996, 6:314-326.
47. Ryden M., Faulds G., Hoffstedt J., Wennlund A., Arner P. Diabetes 2002, 51:1601-1608.
48. Liang J.J., Cockett M., Khawaja X.Z. Journal of Neurochemistry 1998, 71:345-355.
49. Hwang J.I., Fraser I.D., Choi S., Qin X.F., Simon M.I. Proceedings of the National Academy of Sciences of the United States of America 2004, 101:488-493.
50. Kleuss C., Scherubl H., Hescheler J., Schultz G., Wittig B. Nature 1992, 358:424-426.
51. Baumgart D., Naber C., Haude M., Oldenburg O., Erbel R., Heusch G., Siffert W. Circulation Research 1999, 85:965-969.
52. Naber C., Hermann B.L., Vietzke D., Altmann C., Haude M., Mann K., Rosskopf D., Siffert W. FEBS Letters 2000, 484:199-201.
53. Lindemann M., Virchow S., Ramann F., Barsegian V., Kreuzfelder E., Siffert W., Muller N., Grosse-Wilde H. FEBS Letters 2001, 495:82-86.