The GNB3 C825T polymorphism as a pharmacogenetic marker in the treatment of hypertension, obesity, and depression

Pharmacogenetics and Genomics

Volumn 21, Issue 9, 2011, Pages 594-606

  Klenke, Stefanie ^a   Kussmann, Martin ^b,c   Siffert, Winfried ^a  

^a UNIVERSITY OF DUISBURG ESSEN   (Germany)

^b NESTLÉ RESEARCH CENTER   (Switzerland)

^c AARHUS UNIVERSITY   (Denmark)

Author keywords

depression; G protein; GNB3; hypertension; obesity pharmacogenetics; polymorphism; sibutramine

Indexed keywords

ANGIOTENSIN RECEPTOR ANTAGONIST; ANTIDEPRESSANT AGENT; ANTIHYPERTENSIVE AGENT; ATENOLOL; BETA ADRENERGIC RECEPTOR BLOCKING AGENT; CALCIUM CHANNEL BLOCKING AGENT; CITALOPRAM; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; DIURETIC AGENT; ESCITALOPRAM; FLUOXETINE; FLUVOXAMINE; GUANINE NUCLEOTIDE BINDING PROTEIN BETA SUBUNIT; GUANINE NUCLEOTIDE BINDING PROTEIN BETA SUBUNIT 3; HYDROCHLOROTHIAZIDE; IMIPRAMINE; LOFEPRAMINE; MIRTAZAPINE; NEFAZODONE; NORTRIPTYLINE; PAROXETINE; PHENELZINE; PLACEBO; SERTRALINE; SIBUTRAMINE; THIAZIDE DIURETIC AGENT; UNCLASSIFIED DRUG; VENLAFAXINE;

DISEASE SEVERITY; ELECTROCONVULSIVE THERAPY; ESSENTIAL HYPERTENSION; ETHNICITY; EXON; GENE EXPRESSION; GENE FREQUENCY; GENETIC ASSOCIATION; GENETIC POLYMORPHISM; HUMAN; HYPERTENSION; MAJOR DEPRESSION; MULTICENTER STUDY (TOPIC); OBESITY; PATHOGENESIS; PHARMACOGENETICS; PHENOTYPE; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL (TOPIC); REVIEW; RNA SPLICING; SIGNAL TRANSDUCTION; TREATMENT RESPONSE; WEIGHT REDUCTION;

EID: 80051784938     PISSN: 17446872     EISSN: 17446880     Source Type: Journal    
DOI: 10.1097/FPC.0b013e3283491153     Document Type: Review

References (40)

1. Siffert W, Rosskopf D, Siffert G, Busch S, Moritz A, Erbel R, et al. Association of a human G-protein beta3 subunit variant with hypertension. Nat Genet 1998;18:45-48. (Pubitemid 28027877)
2. Rosskopf D, Manthey I, Siffert W. Identification and ethnic distribution of major haplotypes in the gene GNB3 encoding the G-protein beta3 subunit. Pharmacogenetics 2002;12:209-220. (Pubitemid 34596785)
3. Siffert W, Forster P, Jockel KH, Mvere DA, Brinkmann B, Naber C, et al. Worldwide ethnic distribution of the G protein beta3 subunit 825T allele and its association with obesity in Caucasian, Chinese, and Black African individuals. J Am Soc Nephrol 1999;10:1921-1930. (Pubitemid 29402513)
4. Bagos PG, Elefsinioti AL, Nikolopoulos GK, Hamodrakas SJ. The GNB3 C825T polymorphism and essential hypertension: a meta-analysis of 34 studies including 14 094 cases and 17 760 controls. J Hypertens 2007;25:487-500. (Pubitemid 46213782)
5. Turner ST, Schwartz GL, Chapman AB, Boerwinkle E. C825T polymorphism of the G protein beta (3)-subunit and antihypertensive response to a thiazide diuretic. Hypertension 2001;37:739-743. (Pubitemid 32199059)
6. Filigheddu F, Reid JE, Troffa C, PinnaParpaglia P, Argiolas G, Testa A, et al. Genetic polymorphisms of the beta-adrenergic system: association with essential hypertension and response to beta-blockade. Pharmacogenomics J 2004;4:154-160. (Pubitemid 38786553)
7. Schelleman H, Stricker BH, Verschuren WM, De BA, Kroon AA, De Leeuw PW, et al. Interactions between five candidate genes and antihypertensive drug therapy on blood pressure. Pharmacogenomics J 2006;6:22-26. (Pubitemid 43118307)
8. Filigheddu F, Argiolas G, Degortes S, Zaninello R, Frau F, Pitzoi S, et al. Haplotypes of the adrenergic system predict the blood pressure response to beta-blockers in women with essential hypertension. Pharmacogenomics 2010;11:319-325.
9. Schunkert H, Hense HW, Doring A, Riegger GA, Siffert W. Association between a polymorphism in the G protein beta3 subunit gene and lower renin and elevated diastolic blood pressure levels. Hypertension 1998;32:510-513. (Pubitemid 28429141)
10. Brand E, Wang JG, Herrmann SM, Staessen JA. An epidemiological study of blood pressure and metabolic phenotypes in relation to the Gbeta3 C825T polymorphism. J Hypertens 2003;21:729-737. (Pubitemid 36549668)
11. Stefan N, Stumvoll M, Machicao F, Koch M, Haring HU, Fritsche A. C825T polymorphism of the G protein beta3 subunit is associated with obesity but not with insulin sensitivity. Obes Res 2004;12:679-683. (Pubitemid 41132511)
12. Hegele RA, Anderson C, Young TK, Connelly PW. G-protein beta3 subunit gene splice variant and body fat distribution in Nunavut Inuit. Genome Res 1999;9:972-977. (Pubitemid 29525205)
13. Poch E, Giner V, Gonzalez-Nunez D, Coll E, Oriola J, De la SA. Association of the G protein beta3 subunit T allele with insulin resistance in essential hypertension. Clin Exp Hypertens 2002;24:345-353. (Pubitemid 34743398)
14. Siffert W, Naber C, Walla M, Ritz E. G protein beta3 subunit 825T allele and its potential association with obesity in hypertensive individuals. J Hypertens 1999;17:1095-1098. (Pubitemid 29389556)
15. Benjafield AV, Lin RC, Dalziel B, Gosby AK, Caterson ID, Morris BJ. G-protein beta3 subunit gene splice variant in obesity and overweight. Int J Obes Relat Metab Disord 2001;25:777-780. (Pubitemid 32601368)
16. Rankinen T, Rice T, Leon AS, Skinner JS, Wilmore JH, Rao DC, et al. G protein beta 3 polymorphism and hemodynamic and body composition phenotypes in the HERITAGE Family Study. Physiol Genomics 2002;8:151-157. (Pubitemid 135707311)
17. Ryden M, Faulds G, Hoffstedt J, Wennlund A, Arner P. Effect of the (C825T) Gbeta (3) polymorphism on adrenoceptor-mediated lipolysis in human fat cells. Diabetes 2002;51:1601-1608. (Pubitemid 34826631)
18. Hauner H, Rohrig K, Siffert W. Effects of the G-protein beta3 subunit 825T allele on adipogenesis and lipolysis in cultured human preadipocytes and adipocytes. Horm Metab Res 2002;34:475-480. (Pubitemid 35192232)
19. Hauner H, Meier M, Jockel KH, Frey UH, Siffert W. Prediction of successful weight reduction under sibutramine therapy through genotyping of the G-protein beta3 subunit gene (GNB3) C825T polymorphism. Pharmacogenetics 2003;13:453-459. (Pubitemid 37034587)
20. Grudell AB, Sweetser S, Camilleri M, Eckert DJ, Vazquez-Roque MI, Carlson PJ, et al. A controlled pharmacogenetic trial of sibutramine on weight loss and body composition in obese or overweight adults. Gastroenterology 2008;135:1142-1154.
21. Hsiao DJ, Wu LS, Huang SY, Lin E. Weight loss and body fat reduction under sibutramine therapy in obesity with the C825T polymorphism in the GNB3 gene. Pharmacogenet Genomics 2009;19:730-733.
22. Hauner H, Meier M, Wendland G, Kurscheid T, Lauterbach K. Weight reduction by sibutramine in obese subjects in primary care medicine: the SAT Study. Exp Clin Endocrinol Diabetes 2004;112:201-207. (Pubitemid 38639291)
23. Gutersohn A, Naber C, Muller N, Erbel R, Siffert W. G protein beta3 subunit 825TT genotype and post-pregnancy weight retention. Lancet 2000;355:1240-1241. (Pubitemid 30184536)
24. Frey UH, Hauner H, Jockel KH, Manthey I, Brockmeyer N, Siffert W. A novel promoter polymorphism in the human gene GNAS affects binding of transcription factor upstream stimulatory factor 1, Galphas protein expression and body weight regulation. Pharmacogenet Genomics 2008;18:141-151.
25. Zill P, Baghai TC, Zwanzger P, Schule C, Minov C, Riedel M, et al. Evidence for an association between a G-protein beta3-gene variant with depression and response to antidepressant treatment. Neuroreport 2000;11:1893-1897. (Pubitemid 30429131)
26. Rasenick MM, Chaney KA, Chen J. G protein-mediated signal transduction as a target of antidepressant and antibipolar drug action: evidence from model systems. J Clin Psychiatry 1996;57(Suppl 13):49-55. (Pubitemid 26427819)
27. Hudson CJ, Young LT, Li PP, Warsh JJ. CNS signal transduction in the pathophysiology and pharmacotherapy of affective disorders and schizophrenia. Synapse 1993;13:278-293. (Pubitemid 23098080)
28. Lopez-Leon S, Janssens AC, Gonzalez-Zuloeta Ladd AM, Del-Favero J, Claes SJ, Oostra BA, et al. Meta-analyses of genetic studies on major depressive disorder. Mol Psychiatry 2008;13:772-785. (Pubitemid 352032108)
29. Serretti A, Lorenzi C, Cusin C, Zanardi R, Lattuada E, Rossini D, et al. SSRIs antidepressant activity is influenced by G beta 3 variants. Eur Neuropsychopharmacol 2003;13:117-122. (Pubitemid 36313286)
30. Joyce PR, Mulder RT, Luty SE, McKenzie JM, Miller AL, Rogers GR, et al. Age-dependent antidepressant pharmacogenomics: polymorphisms of the serotonin transporter and G protein beta3 subunit as predictors of response to fluoxetine and nortriptyline. Int J Neuropsychopharmacol 2003;6:339-346. (Pubitemid 38146251)
31. Lee HJ, Cha JH, Ham BJ, Han CS, Kim YK, Lee SH, et al. Association between a G-protein beta 3 subunit gene polymorphism and the symptomatology and treatment responses of major depressive disorders. Pharmacogenomics J 2004;4:29-33.
32. Hong CJ, Chen TJ, Yu YW, Tsai SJ. Response to fluoxetine and serotonin 1A receptor (C-1019G) polymorphism in Taiwan Chinese major depressive disorder. Pharmacogenomics J 2006;6:27-33. (Pubitemid 43118308)
33. Wilkie MJ, Smith D, Reid IC, Day RK, Matthews K, Wolf CR, et al. A splice site polymorphism in the G-protein beta subunit influences antidepressant efficacy in depression. Pharmacogenet Genomics 2007;17:207-215. (Pubitemid 46668005)
34. Kang RH, Hahn SW, Choi MJ, Lee MS. Relationship between G-protein beta-3 subunit C825T polymorphism and mirtazapine responses in Korean patients with major depression. Neuropsychobiology 2007;56:1-5.
35. Kato M, Wakeno M, Okugawa G, Fukuda T, Takekita Y, Hosoi Y, et al. Antidepressant response and intolerance to SSRI is not influenced by G-protein beta3 subunit gene C825T polymorphism in Japanese major depressive patients. Prog Neuropsychopharmacol Biol Psychiatry 2008;32:1041-1044. (Pubitemid 351609242)
36. Lin E, Chen PS, Chang HH, Gean PW, Tsai HC, Yang YK, et al. Interaction of serotonin-related genes affects short-term antidepressant response in major depressive disorder. Prog Neuropsychopharmacol Biol Psychiatry 2009;33:1167-1172.
37. Keers R, Bonvicini C, Scassellati C, Uher R, Placentino A, Giovannini C, et al. Variation in GNB3 predicts response and adverse reactions to antidepressants. J Psychopharmacol 2010 doi: 10.1177/0269881110376683
38. Kato M, Serretti A. Review and meta-analysis of antidepressant pharmacogenetic findings in major depressive disorder. Mol Psychiatry 2010;15:473-500.
39. Michalsen A, Knoblauch NT, Lehmann N, Grossman P, Kerkhoff G, Wilhelm FH, et al. Effects of lifestyle modification on the progression of coronary atherosclerosis, autonomic function, and angina-the role of GNB3 C825T polymorphism. Am Heart J 2006;151:870-877.
40. Michalsen A, Frey UH, Merse S, Siffert W, Dobos GJ. Hunger and mood during extended fasting are dependent on the GNB3 C825T polymorphism. Ann Nutr Metab 2009;54:184-188.