G protein β3 gene: Structure, promoter, and additional polymorphisms

Hypertension

Volumn 36, Issue 1, 2000, Pages 33-41

  Rosskopf, Dieter ^a   Busch, Stefan ^a   Manthey, Iris ^a   Siffert, Winfried ^a  

^a UNIVERSITY HOSPITAL ESSEN   (Germany)

Author keywords

G proteins; Genetics; Hypertension, essential; Obesity; Race

Indexed keywords

GUANINE NUCLEOTIDE BINDING PROTEIN;

ANIMAL CELL; ARTICLE; DNA POLYMORPHISM; EXON; FEMALE; GENE FREQUENCY; GENE STRUCTURE; HAPLOTYPE; HUMAN; HYPERTENSION; INTRON; MAJOR CLINICAL STUDY; MALE; NONHUMAN; OBESITY; PRIORITY JOURNAL; PROMOTER REGION;

EID: 0033852571     PISSN: 0194911X     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.HYP.36.1.33     Document Type: Article

References (28)

1. Siffert, W, Rosskopf D, Siffert G, Busch S, Moritz A, Erbel R, Sharma AM, Ritz E, Wichmann H-E, Jakobs KH, Horsthemke B. Association of a human G-protein β3 subunit variant with hypertension. Nat Genet. 1998;18:45-48.
2. Neer EJ. Heterotrimeric G proteins: organizers of transmembrane signals. Cell. 1995;80:249-257.
3. Hamm HE. The many faces of G protein signaling. J Biol Chem. 1998; 273:669-672.
4. Schunkert H, Hense H-W, Döring A, Riegger GA, Siffert W. Association between a polymorphism in the G protein β3-subunit gene and lower renin and elevated diastolic blood pressure levels. Hypertension. 1998; 32:510-513.
5. Benjafield AV, Jeyasingam CL, Nyholt DR, Griffiths LR, Morris BJ. G-protein β3 subunit gene (GNB3) variant in causation of essential hypertension. Hypertension. 1998;32:1094-1097.
6. Beige J, Hohenbleicher H, Distler A, Sharma AY. G-protein β3 subunit C825T variant and ambulatory blood pressure in essential hypertension. Hypertension. 1999;33:1049-1051.
7. Dong Y, Zhu H, Sagnella GA, Carter ND, Cook DG, Cappuccio FP. Association between the C825T polymorphism of the G protein β3-subunit gene and hypertension in blacks. Hypertension. 1999;34: 1193-1196.
8. Siffert W, Forster P, Jöckel K-H, Mvere DA. Brinkmann B, Naber C, Crookes R, Heyns AdP, Epplen JT, Fridey J, Freedman BI, Müller N, Stolke D, Sharma AM, al Moutaery K, Grosse-Wilde H, Buerbaum B, Ehrlich T, Ahmad HR, Horsthemke B, du Toit ED, Tilikainen A, Ge J, Wang Y, Yang D, Hüsing D, Rosskopf D. Worldwide ethnic distribution of the G protein β3 subunit 825T allele and its association with obesity in Caucasians, Chinese, and black African individuals. J Am Soc Nephrol. 1999;10:1921-1930.
9. Siffert W, Naber C, Walla M, Ritz E. G protein β3 subunit 825T allele and its potential association with obesity in hypertensive individuals. J Hypertens. 1999;17:1-4.
10. Hegele RA, Anderson C, Young TK, Connelly PW. G-protein β3 subunit gene splice variant and body fat distribution in Nunavut Inuit. Genome Res. 1999;9:972-977.
11. Kato N, Sugiyama T, Morito H, Kurihara H, Yamori Y, Yazaki Y. G protein β3 subunit variant and essential hypertension in Japanese. Hypertension. 1998;32:935-938.
12. Hegele, RA, Harris SB, Hanley AJG, Cao H, Zinman B. G protein β3 subunit gene variant and blood pressure variation in Canadian Oji-Cree. Hypertension. 1998;32:688-692.
13. Siffert W, Rosskopf D, Moritz A, Wieland T, Kaldenberg-Stasch S, Kettler N, Hartung K, Beckmann S, Jakobs KH. Enhanced G protein activation in immortalized lymphoblasts from patients with essential hypertension. J Clin Invest. 1995;96:759-766.
14. 2-adrenoceptor activation. Circ Res. 1999;85: 965-969.
15. Virchow S, Ansorge N, Rübben H, Siffert G, Siffert W. Enhanced fMLP-stimulated chemotaxis in human neutrophils from individuals carrying the G protein β3 subunit 825 T allele. FEBS Lett. 1998;436: 155-158.
16. Virchow S, Ansorge N, Rosskopf D, Rübben H, Siffert W. The G protein β3 subunit splice variant Gβ3-s causes enhanced chemotaxis of human neutrophils in response to interleukin-8. Naunyn-Schmiedeberg's Arch Pharmacol. 1999;369:27-32.
17. Clapham DE, Neer EJ. G protein βγ subunits. Annu Rev Pharmacol Toxicol. 1997;37:167-203.
18. A protein βγ dimer at 2.1 Å resolution. Nature. 1996;379: 369-374.
19. Neer EJ, Schmidt CJ, Nambudripad R, Smith TF. The ancient regulatory protein family of WD-repeat proteins. Nature. 1994;371:297-300.
20. Iiri T, Bourne HR. G proteins propel surprise. Nat Genet. 1998;18:8-10.
21. Iiri T, Farfel Z, Bourne HR. G-protein diseases furnish a model for the turn-on switch. Nature. 1998;394:35-38.
22. Stallings-Mann ML, Ludwiczak RL, Klinger KW, Rottman F. Alternative splicing of exon 3 on the human growth hormone receptor is the result of an unusual genetic polymorphism. Proc Natl Acad Sci U S A. 1996;93: 12394-12399.
23. Liu W, Qian C, Francke U. Silent mutation induces exon skipping of fibrillin-1 gene in Marfan syndrome. Nat Genet. 1997;16:328-329.
24. Halushka MK, Fan J-B, Bentley K, Hsie L, Shen N, Weder A, Cooper R, Lipshutz R, Chakravarti A. Patterns of single-nucleotide polymorphisms in candidate genes for blood-pressure homeostasis. Nat Genet. 1999;22: 239-247.
25. Levine MA, Smallwood PM, Moen PT Jr, Helman LJ, Ahn TG. Molecular cloning of β3 subunit, a third form of the G protein β-subunit polypeptide. Proc Natl Acad Sci U S A. 1990;80:2329-2333.
26. Ansari-Lari MA, Muzny DM, Lu J, Lu F, Lilley CE, Spanos S, Malley T, Gibbs RA. A gene-rich cluster between CD4 and triosephosphate isomerase genes at human chromosome 12p13. Genome Res. 1996;6: 314-326.
27. Gao YQ, Danciger M, Akhmedov NB, Zhao DY, Heckenlively JR, Fishman GA, Weleber RG, Jacobson SG, Farber DB. Exon screening of the genes encoding the β- and γ-subunits of cone transducin in patients with inherited retinal diseases. Mol Vision. 1998;4:16-20.
28. Lewin B. Nuclear splicing. In: Lewin B. Genes. New York. NY: Oxford University Press; 1997:885-913.