Antidepressant response and intolerance to SSRI is not influenced by G-protein β3 subunit gene C825T polymorphism in Japanese major depressive patients

Progress in Neuro-Psychopharmacology and Biological Psychiatry

Volumn 32, Issue 4, 2008, Pages 1041-1044

  Kato, Masaki ^a,b   Wakeno, Masataka ^a   Okugawa, Gaku ^a   Fukuda, Tsuyoshi ^c   Takekita, Yoshiteru ^a   Hosoi, Yuka ^c   Azuma, Junichi ^c   Kinoshita, Toshihiko ^a   Serretti, Alessandro ^b  

^a KANSAI MEDICAL UNIVERSITY   (Japan)

^b UNIVERSITY OF BOLOGNA   (Italy)

^c OSAKA UNIVERSITY   (Japan)

Author keywords

Depression; G protein 3; Pharmacogenetics; Side effects; Treatment response

Indexed keywords

FLUVOXAMINE; GUANINE NUCLEOTIDE BINDING PROTEIN BETA SUBUNIT; GUANINE NUCLEOTIDE BINDING PROTEIN BETA SUBUNIT 3; PAROXETINE;

ADULT; ARTICLE; CONTROLLED STUDY; DISEASE SEVERITY; DNA POLYMORPHISM; DRUG HYPERSENSITIVITY; DRUG TOLERANCE; FEMALE; GASTROINTESTINAL SYMPTOM; GENE FREQUENCY; GENETIC VARIABILITY; GENOTYPE; HAMILTON SCALE; HUMAN; MAJOR CLINICAL STUDY; MAJOR DEPRESSION; MALE; TREATMENT RESPONSE;

ADULT; ANTIDEPRESSIVE AGENTS; DEPRESSIVE DISORDER, MAJOR; FEMALE; FLUVOXAMINE; GENOTYPE; HETEROTRIMERIC GTP-BINDING PROTEINS; HUMANS; JAPAN; MALE; MIDDLE AGED; PAROXETINE; POLYMORPHISM, GENETIC; PSYCHIATRIC STATUS RATING SCALES; SEROTONIN UPTAKE INHIBITORS;

EID: 42949125355     PISSN: 02785846     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.pnpbp.2008.01.019     Document Type: Article

References (24)

1. Birnbaumer L., Abramowitz J., and Brown A.M. Receptor-effector coupling by G proteins. Biochim Biophys Acta 1031 (1990) 163-224
2. Bishop J.R., Moline J., Ellingrod V.L., Schultz S.K., and Clayton A.H. Serotonin 2A-1438 G/A and G-protein Beta3 subunit C825T polymorphisms in patients with depression and SSRI-associated sexual side-effects. Neuropsychopharmacology 31 (2006) 2281-2288
3. Cavalli Sforza L. The history and geography of human genes (1994), Princeton University Press, Princeton, New Jersey, USA
4. Cohen J. Statistical power analysis for the behavioral sciences (1988), Lawrence Erlbaum Associates, Hillsdale, New Jersey
5. Deckert J., Catalano M., Heils A., Di Bella D., Friess F., Politi E., et al. Functional promoter polymorphism of the human serotonin transporter: lack of association with panic disorder. Psychiatr Genet 7 (1997) 45-47
6. Fava M. Diagnosis and definition of treatment-resistant depression. Biol Psychiatry 53 (2003) 649-659
7. Fava M., and Davidson K.G. Definition and epidemiology of treatment-resistant depression. Psychiatr Clin North Am 19 (1996) 179-200
8. First M.B., Spitzer R.L., Gibbon M., and Williams J.B. Structured clinical interview for DSM-IV Axis I Disorders-patient edition (SCID-I/P, version 2.0) (1995), Biometrics Research Department, New York State Psychiatric Institute, New York
9. Gilman A.G. G proteins: transducers of receptor-generated signals. Ann Rev Biochem 56 (1987) 615-649
10. Hamilton M. Development of a rating scale for primary depressive illness. Br J Soc Clin Psychol 6 (1967) 278-296
11. Joyce P.R., Mulder R.T., Luty S.E., McKenzie J.M., Miller A.L., Rogers G.R., et al. Age-dependent antidepressant pharmacogenomics: polymorphisms of the serotonin transporter and G protein beta3 subunit as predictors of response to fluoxetine and nortriptyline. Int J Neuropsychopharmacol 6 (2003) 339-346
12. Kang R.H., Hahn S.W., Choi M.J., and Lee M.S. Relationship between G-protein beta-3 subunit C825T polymorphism and mirtazapine responses in Korean patients with major depression. Neuropsychobiology 56 (2007) 1-5
13. Kato M., Fukuda T., Wakeno M., Fukuda K., Okugawa G., Ikenaga Y., et al. Effects of the serotonin type 2A, 3A and 3B receptor and the serotonin transporter genes on paroxetine and fluvoxamine efficacy and adverse drug reactions in depressed Japanese patients. Neuropsychobiology 53 (2006) 186-195
14. Kendler K.S. "A gene for." the nature of gene action in psychiatric disorders. Am J Psychiatry 162 (2005) 1243-1252
15. Lee H.J., Cha J.H., Ham B.J., Han C.S., Kim Y.K., Lee S.H., et al. Association between a G-protein beta3 subunit gene polymorphism and the symptomatology and treatment responses of major depressive disorders. Pharmacogenomics J 4 (2004) 29-33
16. Nestler E.J., and Duman R.S. G-proteins and cyclic nucleotides in the nervous system. In: Siegel G., Agranoff B., Albers R.W., and Molinoff P. (Eds). Basic neurochemistry (1994), Raven Press, New York 449-474
17. Pollock B.G., Ferrell R.E., Mulsant B.H., Mazumdar S., Miller M., Sweet R.A., et al. Allelic variation in the serotonin transporter promoter affects onset of paroxetine treatment response in late-life depression. Neuropsychopharmacology 23 (2000) 587-590
18. Rosskopf D., Busch S., Manthey I., and Siffert W. G protein beta 3 gene: structure, promoter, and additional polymorphisms. Hypertension 36 (2000) 33-41
19. Serretti A., Lorenzi C., Cusin C., Zanardi R., Lattuada E., Rossini D., et al. SSRIs antidepressant activity is influenced by Gbeta3 variants. Eur Neuropsychopharmacol 13 (2003) 117-122
20. Serretti A., Kato M., De Ronchi D., and Kinoshita T. Meta-analysis of serotonin transporter gene promoter polymorphism (5-HTTLPR) association with selective serotonin reuptake inhibitor efficacy in depressed patients. Mol Psychiatry 12 (2007) 247-257
21. Siffert W., Rosskopf D., Siffert G., Busch S., Moritz A., Erbel R., et al. Association of a human G-protein beta3 subunit variant with hypertension. Nat Genet 18 (1998) 45-48
22. Simon M.I., Strathmann M.P., and Gautam N. Diversity of G proteins in signal transduction. Science 252 (1991) 802-808
23. Wilkie M.J., Smith D., Reid I.C., Day R.K., Matthews K., Wolf C.R., et al. A splice site polymorphism in the G-protein beta subunit influences antidepressant efficacy in depression. Pharmacogenet Genomics 17 (2007) 207-215
24. Zill P., Baghai T.C., Zwanzger P., Schule C., Minov C., Riedel M., et al. Evidence for an association between a G-protein beta3-gene variant with depression and response to antidepressant treatment. Neuroreport 11 (2000) 1893-1897