Transcriptome analysis of the human T lymphocyte cell line Jurkat and human peripheral blood mononuclear cells exposed to deoxynivalenol (DON): New mechanistic insights

Toxicology and Applied Pharmacology

Volumn 264, Issue 1, 2012, Pages 51-64

  Katika, Madhumohan R ^a,b,d   Hendriksen, Peter J M ^a,d   Shao, Jia ^a,b,d   van Loveren, Henk ^b,c,d   Peijnenburg, Ad ^a,d  

^a WAGENINGEN UNIVERSITY   (Netherlands)

^b MAASTRICHT UNIVERSITY   (Netherlands)

^c NATIONAL INSTITUTE FOR PUBLIC HEALTH AND THE ENVIRONMENT   (Netherlands)

^d Netherlands Toxicogenomics Centre   (Netherlands)

Author keywords

Apoptosis; Deoxynivalenol (DON); ER stress; Human peripheral blood mononuclear cells (PBMCs); Immunotoxicity; Jurkat cells; Microarrays; NF B; NFAT; Oxidative stress; T cell activation

Indexed keywords

CALCINEURIN; CALPAIN 2; DNA; TRANSCRIPTOME; VOMITOXIN;

APOPTOSIS; ARTICLE; CELL FUNCTION; CELL STRUCTURE; CONTROLLED STUDY; DNA MICROARRAY; DRUG EXPOSURE; DRUG MECHANISM; ENDOPLASMIC RETICULUM STRESS; GENE EXPRESSION; HUMAN; HUMAN CELL; IMMUNOTOXICITY; INTRACELLULAR SIGNALING; LEUKEMIA CELL LINE; PERIPHERAL BLOOD MONONUCLEAR CELL; RECEPTOR UPREGULATION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RIBOSOME; RNA ANALYSIS; RNA PROCESSING; RNA SYNTHESIS; T LYMPHOCYTE ACTIVATION;

CALCIUM; DOSE-RESPONSE RELATIONSHIP, DRUG; ENDOPLASMIC RETICULUM STRESS; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; HUMANS; JURKAT CELLS; LEUKOCYTES, MONONUCLEAR; NFATC TRANSCRIPTION FACTORS; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; OXIDATIVE STRESS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; T-LYMPHOCYTES; TIME FACTORS; TRICHOTHECENES; UP-REGULATION;

FUSARIUM;

EID: 84865962817     PISSN: 0041008X     EISSN: 10960333     Source Type: Journal    
DOI: 10.1016/j.taap.2012.07.017     Document Type: Article

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