Synthesis and in vitro antitumour evaluation of benzothiazole-2- carbonitrile derivatives

European Journal of Medicinal Chemistry

Volumn 34, Issue 12, 1999, Pages 1053-1060

  Bénéteau, Valérie ^a   Besson, Thierry ^a   Guillard, Jérôme ^a   Léonce, Stéphane ^b   Pfeiffer, Bruno ^c  

^a UPRES 2001   (France)

^b INSTITUT DE RECHERCHES INTERNATIONALES SERVIER   (France)

^c ADIR   (France)

Author keywords

Antitumour activity; Benzodioxines; Benzothiazoles; Imino 1,2,3 dithiazoles

Indexed keywords

BENZOTHIAZOLE DERIVATIVE; CYANIDE;

ANIMAL CELL; ANTINEOPLASTIC ACTIVITY; ARTICLE; CYTOTOXICITY; DRUG EFFECT; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; NONHUMAN;

EID: 0038067133     PISSN: 02235234     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0223-5234(99)00130-0     Document Type: Article

References (16)

1. Gunawardana G.P., Kohmoto S., Gunasekara S.P., McConnel O.J., Koehn F.E. J. Am. Chem. Soc. 110:1988;4856-4858.
2. Gunawardana G.P., Kohmoto S., Burres N.S. Tetrahedron Lett. 30:1989;4359-4362.
3. Gunawardana G.P., Koehn F.E., Lee A.Y., Clardy J., He H.Y., Faulkner J.D. J. Org. Chem. 57:1992;1523-1526.
4. Carroll A.R., Scheuer P.J. J. Org. Chem. 55:1990;4426-4431.
5. Shi D.F., Bradshaw T.D., Wrigley S., McCall C.J., Lelieveld P., Fichtner I., Stevens M.F.G. J. Med. Chem. 39:1996;3375-3384.
6. Rees C.W. J. Heterocycl. Chem. 29:1992;639-651.
7. Besson T., Emayan K., Rees C.W. J. Chem. Soc. Perkin Trans. 1:1995;2097-2102.
8. Besson T., Guillaumet G., Lamazzi C., Rees C.W. Synlett. 1997;704-706.
9. Appel R., Janssen H., Siray M., Knoch F. Chem. Ber. 118:1985;1632-1643.
10. English R.F., Rakitin O.A., Rees C.W., Vlasova O.G. J. Chem. Soc. Perkin Trans. 1:1997;201-205.
11. March J. Advanced Organic Chemistry. 4th edition :1992;887 Wiley-Interscience Publication.
12. Besson T., Guillard J. Tetrahedron. 55:1999;5139-5144. In this paper the multistep synthesis of such compounds was transposed to a focused microwave oven.
13. Besson T., Ruiz N., Coudert G., Guillaumet G. Tetrahedron. 51:1995;3197-3204.
14. Léonce S., Pérez V., Casabianca-Pignède M.R., Anstett M., Bisagni E., Atassi G. Invest. New Drugs. 14:1996;169-180.
15. Csik G., Besson T., Coudert G., Guillaumet G., Nocentini S. J. Photochem. Photobiol. B: Biol. 19:1993;119-124.
16. Csik G., Ronto G., Nocentini S., Averbeck S., Averbeck D., Besson T., Coudert G., Guillaumet G. J. Photochem. Photobiol. B: Biol. 24:1994;129-139.