메뉴 건너뛰기




Volumn 33, Issue 9, 2012, Pages 1170-1175

New insights into huperzine A for the treatment of Alzheimer's disease

Author keywords

acetylcholinesterase; Alzheimer's disease; controlled release; huperzine A; mitochondrion

Indexed keywords

ACETYLCHOLINE; AMYLOID BETA PROTEIN; HUPERZINE A; MESSENGER RNA; NERVE GROWTH FACTOR; NEUROTROPHIN RECEPTOR P75; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR;

EID: 84865957834     PISSN: 16714083     EISSN: 17457254     Source Type: Journal    
DOI: 10.1038/aps.2012.128     Document Type: Review
Times cited : (67)

References (59)
  • 1
    • 84863337843 scopus 로고    scopus 로고
    • Alzheimer mechanisms and therapeutic strategies
    • Huang Y, Mucke L. Alzheimer mechanisms and therapeutic strategies. Cell 2012; 148: 1204-22.
    • (2012) Cell , vol.148 , pp. 1204-22
    • Huang, Y.1    Mucke, L.2
  • 2
    • 30144437522 scopus 로고    scopus 로고
    • Progress in studies of huperzine A, a natural cholinesterase inhibitor from Chinese herbal medicine
    • DOI 10.1111/j.1745-7254.2006.00255.x
    • Wang R, Yan H, Tang XC. Progress in studies of huperzine A, a natural cholinesterase inhibitor from Chinese herbal medicine. Acta Pharmacol Sin 2006; 27: 1-26. (Pubitemid 43051942)
    • (2006) Acta Pharmacologica Sinica , vol.27 , Issue.1 , pp. 1-26
    • Wang, R.1    Yan, H.2    Tang, X.-C.3
  • 3
    • 33750943629 scopus 로고    scopus 로고
    • Neuroprotective effects of huperzine A: New therapeutic targets for neurodegenerative disease
    • DOI 10.1016/j.tips.2006.10.004, PII S0165614706002471
    • Zhang HY, Tang XC. Neuroprotective effects of huperzine A: new therapeutic targets for neurodegenerative disease. Trends Pharmacol Sci 2006; 27: 619-25. (Pubitemid 44738090)
    • (2006) Trends in Pharmacological Sciences , vol.27 , Issue.12 , pp. 619-625
    • Zhang, H.Y.1    Tang, X.C.2
  • 4
    • 84856106793 scopus 로고
    • Investigations of the amnesic properties of scopolamine and related compounds
    • Domer FR, Schueler FW. Investigations of the amnesic properties of scopolamine and related compounds. Arch Int Pharmacodyn Ther 1960; 127: 449-58.
    • (1960) Arch Int Pharmacodyn Ther , vol.127 , pp. 449-58
    • Domer, F.R.1    Schueler, F.W.2
  • 6
    • 0019972810 scopus 로고
    • The cholinergic hypothesis of geriatric memory dysfunction
    • Bartus RT, Dean RL 3rd, Beer B, Lippa AS. The cholinergic hypothesis of geriatric memory dysfunction. Science 1982; 217: 408-14.
    • (1982) Science , vol.217 , pp. 408-14
    • Bartus, R.T.1    Dean, R.L.2    Beer, B.3    Lippa, A.S.4
  • 8
    • 0028266334 scopus 로고
    • Positive feedback between acetylcholine and the neurotrophins nerve growth factor and brain-derived neurotrophic factor in the rat hippocampus
    • Knipper M, da Penha Berzaghi M, Blochl A, Breer H, Thoenen H, Lindholm D. Positive feedback between acetylcholine and the neurotrophins nerve growth factor and brain-derived neurotrophic factor in the rat hippocampus. Eur J Neurosci 1994; 6: 668-71. (Pubitemid 24106852)
    • (1994) European Journal of Neuroscience , vol.6 , Issue.4 , pp. 668-671
    • Knipper, M.1    De Penha Berzaghi, M.2    Blochl, A.3    Breer, H.4    Thoenen, H.5    Lindholm, D.6
  • 10
    • 0001059974 scopus 로고    scopus 로고
    • The regulation of amyloid precursor protein metabolism by cholinergic mechanisms and neurotrophin receptor signaling
    • DOI 10.1016/S0301-0082(98)00044-6, PII S0301008298000446
    • Rossner S, Ueberham U, Schliebs R, Perez-Polo JR, Bigl V. The regulation of amyloid precursor protein metabolism by cholinergic mechanisms and neurotrophin receptor signaling. Prog Neurobiol 1998; 56: 541-69. (Pubitemid 28407571)
    • (1998) Progress in Neurobiology , vol.56 , Issue.5 , pp. 541-569
    • Rossner, S.1    Ueberham, U.2    Schliebs, R.3    Regino Perez-Polo, J.4    Bigl, V.5
  • 11
    • 40149104224 scopus 로고    scopus 로고
    • Alpha7 nicotinic acetylcholine receptor: A link between inflammation and neurodegeneration
    • Conejero-Goldberg C, Davies P, Ulloa L. Alpha7 nicotinic acetylcholine receptor: a link between inflammation and neurodegeneration. Neurosci Biobehav Rev 2008; 32: 693-706.
    • (2008) Neurosci Biobehav Rev , vol.32 , pp. 693-706
    • Conejero-Goldberg, C.1    Davies, P.2    Ulloa, L.3
  • 12
    • 20444424188 scopus 로고    scopus 로고
    • Effects of huperzine A on secretion of nerve growth factor in cultured rat cortical astrocytes and neurite outgrowth in rat PC12 cells
    • DOI 10.1111/j.1745-7254.2005.00130.x
    • Tang LL, Wang R, Tang XC. Effects of huperzine A on secretion of nerve growth factor in cultured rat cortical astrocytes and neurite outgrowth in rat PC12 cells. Acta Pharmacol Sin 2005; 26: 673-8. (Pubitemid 40806555)
    • (2005) Acta Pharmacologica Sinica , vol.26 , Issue.6 , pp. 673-678
    • Tang, L.-L.1    Wang, R.2    Tang, X.-C.3
  • 13
    • 1842713364 scopus 로고    scopus 로고
    • Huperzine A enhances the level of secretory amyloid precursor protein and protein kinase C-α in intracerebroventricular β-amyloid-(1-40) infused rats and human embryonic kidney 293 Swedish mutant cells
    • DOI 10.1016/j.neulet.2004.01.055, PII S0304394004001326
    • Zhang HY, Yan H, Tang XC. Huperzine A enhances the level of secretory amyloid precursor protein and protein kinase C-alpha in intracerebroventricular beta-amyloid-(1-40) infused rats and human embryonic kidney 293 Swedish mutant cells. Neurosci Lett 2004; 360: 21-4. (Pubitemid 38471978)
    • (2004) Neuroscience Letters , vol.360 , Issue.1-2 , pp. 21-24
    • Zhang, H.Y.1    Yan, H.2    Tang, X.C.3
  • 14
    • 27744493126 scopus 로고    scopus 로고
    • Huperzine A protects SHSY5Y neuroblastoma cells against oxidative stress damage via nerve growth factor production
    • DOI 10.1016/j.ejphar.2005.06.026, PII S0014299905006801
    • Tang LL, Wang R, Tang XC. Huperzine A protects SHSY5Y neuroblastoma cells against oxidative stress damage via nerve growth factor production. Eur J Pharmacol 2005; 519: 9-15. (Pubitemid 43181158)
    • (2005) European Journal of Pharmacology , vol.519 , Issue.1-2 , pp. 9-15
    • Tang, L.-L.1    Wang, R.2    Tang, X.-C.3
  • 15
    • 33744517635 scopus 로고    scopus 로고
    • Effects of huperzine A on memory deficits and neurotrophic factors production after transient cerebral ischemia and reperfusion in mice
    • DOI 10.1016/j.pbb.2006.03.027, PII S0091305706000840
    • Wang ZF, Tang LL, Yan H, Wang YJ, Tang XC. Effects of huperzine A on memory deficits and neurotrophic factors production after transient cerebral ischemia and reperfusion in mice. Pharmacol Biochem Behav 2006; 83: 603-11. (Pubitemid 43817131)
    • (2006) Pharmacology Biochemistry and Behavior , vol.83 , Issue.4 , pp. 603-611
    • Wang, Z.-f.1    Tang, L.-l.2    Yan, H.3    Wang, Y.-j.4    Tang, X.-c.5
  • 16
    • 34247199363 scopus 로고    scopus 로고
    • Involvement of M1-muscarinic acetylcholine receptors, protein kinase C and mitogen-activated protein kinase in the effect of huperzine A on secretory amyloid precursor protein-α
    • DOI 10.1097/WNR.0b013e3280c1e28c, PII 0000175620070507000014
    • Yan H, Zhang HY, Tang XC. Involvement of M1-muscarinic acetylcholine receptors, protein kinase C and mitogen-activated protein kinase in the effect of huperzine A on secretory amyloid precursor protein-alpha. Neuroreport 2007; 18: 689-92. (Pubitemid 46608516)
    • (2007) NeuroReport , vol.18 , Issue.7 , pp. 689-692
    • Yan, H.1    Zhang, H.Y.2    Tang, X.C.3
  • 17
    • 33846849308 scopus 로고    scopus 로고
    • Huperzine A protects C6 rat glioma cells against oxygen-glucose deprivation-induced injury
    • DOI 10.1016/j.febslet.2007.01.016, PII S0014579307000476
    • Wang ZF, Tang XC. Huperzine A protects C6 rat glioma cells against oxygen-glucose deprivation-induced injury. FEBS Lett 2007; 581: 596-602. (Pubitemid 46216285)
    • (2007) FEBS Letters , vol.581 , Issue.4 , pp. 596-602
    • Wang, Z.F.1    Tang, X.C.2
  • 18
    • 48749121734 scopus 로고    scopus 로고
    • Huperzine A exhibits antiinflammatory and neuroprotective effects in a rat model of transient focal cerebral ischemia
    • Wang ZF, Wang J, Zhang HY, Tang XC. Huperzine A exhibits antiinflammatory and neuroprotective effects in a rat model of transient focal cerebral ischemia. J Neurochem 2008; 106: 1594-603.
    • (2008) J Neurochem , vol.106 , pp. 1594-603
    • Wang, Z.F.1    Wang, J.2    Zhang, H.Y.3    Tang, X.C.4
  • 19
    • 76549112494 scopus 로고    scopus 로고
    • Huperzine A improves chronic inflamma tion and cognitive decline in rats with cerebral hypoperfusion
    • Wang J, Zhang HY, Tang XC. Huperzine A improves chronic inflamma tion and cognitive decline in rats with cerebral hypoperfusion. J Neurosci Res 2010; 88: 807-15.
    • (2010) J Neurosci Res , vol.88 , pp. 807-15
    • Wang, J.1    Zhang, H.Y.2    Tang, X.C.3
  • 20
    • 4944234184 scopus 로고    scopus 로고
    • Regulation of nicotinic acetylcholine receptor channel function by acetylcholinesterase inhibitors in rat hippocampal CA1 interneurons
    • DOI 10.1124/mol.104.000042
    • Fayuk D, Yakel JL. Regulation of nicotinic acetylcholine receptor channel function by acetylcholinesterase inhibitors in rat hippocampal CA1 interneurons. Mol Pharmacol 2004; 66: 658-66. (Pubitemid 39329265)
    • (2004) Molecular Pharmacology , vol.66 , Issue.3 , pp. 658-666
    • Fayuk, D.1    Yakel, J.L.2
  • 21
    • 0041309915 scopus 로고    scopus 로고
    • Potentiation of nerve growth factor-induced neurite outgrowth in PC12 cells by a coptidis rhizoma extract and protoberberine alkaloids
    • Shigeta K, Ootaki K, Tatemoto H, Nakanishi T, Inada A, Muto N. Potentiation of nerve growth factor-induced neurite outgrowth in PC12 cells by a Coptidis Rhizoma extract and protoberberine alkaloids. Biosci Biotechnol Biochem 2002; 66: 2491-4. (Pubitemid 39251193)
    • (2002) Bioscience, Biotechnology and Biochemistry , vol.66 , Issue.11 , pp. 2491-2494
    • Shigeta, K.1    Ootaki, K.2    Tatemoto, H.3    Nakanishi, T.4    Inada, A.5    Muto, N.6
  • 22
    • 0029983531 scopus 로고    scopus 로고
    • The effect of cholinesterase inhibitors on the secretion of APPS from rat brain cortex
    • Giacobini E, Mori F, Lai CC. The effect of cholinesterase inhibitors on the secretion of APPS from rat brain cortex. Ann N Y Acad Sci 1996; 777: 393-8. (Pubitemid 26149220)
    • (1996) Annals of the New York Academy of Sciences , vol.777 , pp. 393-398
    • Giacobini, E.1    Mori, F.2    Lai, C.-C.3
  • 23
    • 0028918426 scopus 로고
    • Cholinesterase inhibitors increase secretion of APPs in rat brain cortex
    • Mori F, Lai CC, Fusi F, Giacobini E. Cholinesterase inhibitors increase secretion of APPs in rat brain cortex. Neuroreport 1995; 6: 633-6.
    • (1995) Neuroreport , vol.6 , pp. 633-6
    • Mori, F.1    Lai, C.C.2    Fusi, F.3    Giacobini, E.4
  • 24
    • 0034235229 scopus 로고    scopus 로고
    • The internal structure of mitochondria
    • Frey TG, Mannella CA. The internal structure of mitochondria. Trends Biochem Sci 2000; 25: 319-24.
    • (2000) Trends Biochem Sci , vol.25 , pp. 319-24
    • Frey, T.G.1    Mannella, C.A.2
  • 25
    • 79959926983 scopus 로고    scopus 로고
    • Mitochondria: The common upstream driver of amyloid-beta and tau pathology in Alzheimer's disease
    • Silva DF, Esteves AR, Oliveira CR, Cardoso SM. Mitochondria: the common upstream driver of amyloid-beta and tau pathology in Alzheimer's disease. Curr Alzheimer Res 2011; 8: 563-72.
    • (2011) Curr Alzheimer Res , vol.8 , pp. 563-72
    • Silva, D.F.1    Esteves, A.R.2    Oliveira, C.R.3    Cardoso, S.M.4
  • 26
    • 33645855623 scopus 로고    scopus 로고
    • Huperzine A attenuates mitochondrial dysfunction in beta-amyloid-treated PC12 cells by reducing oxygen free radicals accumulation and improving mitochondrial energy metabolism
    • Gao X, Tang XC. Huperzine A attenuates mitochondrial dysfunction in beta-amyloid-treated PC12 cells by reducing oxygen free radicals accumulation and improving mitochondrial energy metabolism. J Neurosci Res 2006; 83: 1048-57.
    • (2006) J Neurosci Res , vol.83 , pp. 1048-57
    • Gao, X.1    Tang, X.C.2
  • 27
    • 67349281227 scopus 로고    scopus 로고
    • Huperzine A protects isolated rat brain mitochondria against beta-amyloid peptide
    • Gao X, Zheng CY, Yang L, Tang XC, Zhang HY. Huperzine A protects isolated rat brain mitochondria against beta-amyloid peptide. Free Radic Biol Med 2009; 46: 1454-62.
    • (2009) Free Radic Biol Med , vol.46 , pp. 1454-62
    • Gao, X.1    Zheng, C.Y.2    Yang, L.3    Tang, X.C.4    Zhang, H.Y.5
  • 28
    • 84863918272 scopus 로고    scopus 로고
    • Decreased accumulation of subcellular amyloid-beta with improved mitochondrial function mediates the neuroprotective effect of huperzine A
    • Yang L, Ye CY, Huang XT, Tang XC, Zhang HY. Decreased accumulation of subcellular amyloid-beta with improved mitochondrial function mediates the neuroprotective effect of huperzine A. J Alzheimers Dis 2012; 31: 131-42.
    • (2012) J Alzheimers Dis , vol.31 , pp. 131-42
    • Yang, L.1    Ye, C.Y.2    Huang, X.T.3    Tang, X.C.4    Zhang, H.Y.5
  • 29
    • 49349110270 scopus 로고    scopus 로고
    • Huperzine A attenuates mitochondrial dysfunction after middle cerebral artery occlusion in rats
    • Zheng CY, Zhang HY, Tang XC. Huperzine A attenuates mitochondrial dysfunction after middle cerebral artery occlusion in rats. J Neurosci Res 2008; 86: 2432-40.
    • (2008) J Neurosci Res , vol.86 , pp. 2432-40
    • Zheng, C.Y.1    Zhang, H.Y.2    Tang, X.C.3
  • 30
    • 0036141139 scopus 로고    scopus 로고
    • Huperzine A attenuates amyloid betapeptide fragment 25-35-induced apoptosis in rat cortical neurons via inhibiting reactive oxygen species formation and caspase-3 activation
    • Xiao XQ, Zhang HY, Tang XC. Huperzine A attenuates amyloid betapeptide fragment 25-35-induced apoptosis in rat cortical neurons via inhibiting reactive oxygen species formation and caspase-3 activation. J Neurosci Res 2002; 67: 30-6.
    • (2002) J Neurosci Res , vol.67 , pp. 30-6
    • Xiao, X.Q.1    Zhang, H.Y.2    Tang, X.C.3
  • 31
    • 0035876056 scopus 로고    scopus 로고
    • Huperzine A attenuates cognitive dysfunction and neuronal degeneration caused by β-amyloid protein-(1-40) in rat
    • DOI 10.1016/S0014-2999(01)01030-5, PII S0014299901010305
    • Wang R, Zhang HY, Tang XC. Huperzine A attenuates cognitive dysfunction and neuronal degeneration caused by beta-amyloid protein-(1-40) in rat. Eur J Pharmacol 2001; 421: 149-56. (Pubitemid 32539415)
    • (2001) European Journal of Pharmacology , vol.421 , Issue.3 , pp. 149-156
    • Wang, R.1    Zhang, H.Y.2    Tang, X.C.3
  • 32
    • 0034625561 scopus 로고    scopus 로고
    • 25-35 induced oxidative injury in rat pheochromocytoma cells
    • DOI 10.1016/S0304-3940(00)01088-0, PII S0304394000010880
    • Xiao XQ, Wang R, Han YF, Tang XC. Protective effects of huperzine A on beta-amyloid(25-35) induced oxidative injury in rat pheochromocytoma cells. Neurosci Lett 2000; 286: 155-8. (Pubitemid 30314633)
    • (2000) Neuroscience Letters , vol.286 , Issue.3 , pp. 155-158
    • Xiao, X.Q.1    Wang, R.2    Han, Y.F.3    Tang, X.C.4
  • 33
    • 0034284410 scopus 로고    scopus 로고
    • Huperzine A and tacrine attenuate betaamyloid peptide-induced oxidative injury
    • Xiao XQ, Wang R, Tang XC. Huperzine A and tacrine attenuate betaamyloid peptide-induced oxidative injury. J Neurosci Res 2000; 61: 564-9.
    • (2000) J Neurosci Res , vol.61 , pp. 564-9
    • Xiao, X.Q.1    Wang, R.2    Tang, X.C.3
  • 34
    • 0344562900 scopus 로고    scopus 로고
    • Huperzine A protects rat pheochromocytoma cells against hydrogen peroxide-induced injury
    • DOI 10.1016/S0304-3940(99)00695-3, PII S0304394099006953
    • Xiao XQ, Yang JW, Tang XC. Huperzine A protects rat pheochromocytoma cells against hydrogen peroxide-induced injury. Neurosci Lett 1999; 275: 73-6. (Pubitemid 29502539)
    • (1999) Neuroscience Letters , vol.275 , Issue.2 , pp. 73-76
    • Xiao, X.Q.1    Yang, J.W.2    Tang, X.C.3
  • 35
    • 0003093544 scopus 로고    scopus 로고
    • Huperzine A improves cognitive deficits caused by chronic cerebral hypoperfusion in rats
    • DOI 10.1016/S0014-2999(00)00291-0, PII S0014299900002910
    • Wang LM, Han YF, Tang XC. Huperzine A improves cognitive deficits caused by chronic cerebral hypoperfusion in rats. Eur J Pharmacol 2000; 398: 65-72. (Pubitemid 30336678)
    • (2000) European Journal of Pharmacology , vol.398 , Issue.1 , pp. 65-72
    • Wang, L.M.1    Han, Y.F.2    Tang, X.C.3
  • 36
    • 0032888723 scopus 로고    scopus 로고
    • Improving effects of huperzine A on abnormal lipid peroxidation and superoxide dismutase in aged rats
    • Shang YZ, Ye JW, Tang XC. Improving effects of huperzine A on abnormal lipid peroxidation and superoxide dismutase in aged rats. Zhongguo Yao Li Xue Bao 1999; 20: 824-8.
    • (1999) Zhongguo Yao Li Xue Bao , vol.20 , pp. 824-8
    • Shang, Y.Z.1    Ye, J.W.2    Tang, X.C.3
  • 37
    • 0037430938 scopus 로고    scopus 로고
    • Huperzine A attenuates the neurotoxic effect of staurosporine in primary rat cortical neurons
    • DOI 10.1016/S0304-3940(03)00023-5
    • Zhang HY, Tang XC. Huperzine A attenuates the neurotoxic effect of staurosporine in primary rat cortical neurons. Neurosci Lett 2003; 340: 91-4. (Pubitemid 36369282)
    • (2003) Neuroscience Letters , vol.340 , Issue.2 , pp. 91-94
    • Zhang, H.Y.1    Tang, X.C.2
  • 38
    • 0037189932 scopus 로고    scopus 로고
    • Huperzine A attenuates apoptosis and mitochondria-dependent caspase-3 in rat cortical neurons
    • DOI 10.1016/S0014-5793(02)03107-1, PII S0014579302031071
    • Zhou J, Tang XC. Huperzine A attenuates apoptosis and mitochondriadependent caspase-3 in rat cortical neurons. FEBS Lett 2002; 526: 21-5. (Pubitemid 35245685)
    • (2002) FEBS Letters , vol.526 , Issue.1-3 , pp. 21-25
    • Zhou, J.1    Tang, X.C.2
  • 39
    • 0035964415 scopus 로고    scopus 로고
    • Huperzine A attenuates hydrogen peroxide-induced apoptosis by regulating expression of apoptosis-related genes in rat PC 12 cells
    • Wang R, Xiao XQ, Tang XC. Huperzine A attenuates hydrogen peroxideinduced apoptosis by regulating expression of apoptosis-related genes in rat PC12 cells. Neuroreport 2001; 12: 2629-34. (Pubitemid 32803190)
    • (2001) NeuroReport , vol.12 , Issue.12 , pp. 2629-2634
    • Wang, R.1    Xiao Qiu Xiao2    Xi Can Tang3
  • 40
    • 78649983748 scopus 로고    scopus 로고
    • Alzheimer's disease: Effects of beta-amyloid on mitochondria
    • Tillement L, Lecanu L, Papadopoulos V. Alzheimer's disease: effects of beta-amyloid on mitochondria. Mitochondrion 2011; 11: 13-21.
    • (2011) Mitochondrion , vol.11 , pp. 13-21
    • Tillement, L.1    Lecanu, L.2    Papadopoulos, V.3
  • 41
  • 42
    • 77953562457 scopus 로고    scopus 로고
    • Possible role of amyloid-beta, adenine nucleotide translocase and cyclophilin-D interaction in mitochondrial dysfunction of Alzheimer's disease
    • Singh P, Suman S, Chandna S, Das TK. Possible role of amyloid-beta, adenine nucleotide translocase and cyclophilin-D interaction in mitochondrial dysfunction of Alzheimer's disease. Bioinformation 2009; 3: 440-5.
    • (2009) Bioinformation , vol.3 , pp. 440-5
    • Singh, P.1    Suman, S.2    Chandna, S.3    Das, T.K.4
  • 44
    • 57749102902 scopus 로고    scopus 로고
    • Cytoprotective role of mitochondrial amyloid beta peptide-binding alcohol dehydrogenase against a cytotoxic aldehyde
    • Murakami Y, Ohsawa I, Kasahara T, Ohta S. Cytoprotective role of mitochondrial amyloid beta peptide-binding alcohol dehydrogenase against a cytotoxic aldehyde. Neurobiol Aging 2009; 30: 325-9.
    • (2009) Neurobiol Aging , vol.30 , pp. 325-9
    • Murakami, Y.1    Ohsawa, I.2    Kasahara, T.3    Ohta, S.4
  • 45
    • 34247507589 scopus 로고    scopus 로고
    • PPAR-γ: Therapeutic target for ischemic stroke
    • DOI 10.1016/j.tips.2007.03.004, PII S0165614707000727
    • Culman J, Zhao Y, Gohlke P, Herdegen T. PPAR-gamma: therapeutic target for ischemic stroke. Trends Pharmacol Sci 2007; 28: 244-9. (Pubitemid 46661003)
    • (2007) Trends in Pharmacological Sciences , vol.28 , Issue.5 , pp. 244-249
    • Culman, J.1    Zhao, Y.2    Gohlke, P.3    Herdegen, T.4
  • 46
  • 47
    • 66049135616 scopus 로고    scopus 로고
    • Neuronal PPARgamma deficiency increases susceptibility to brain damage after cerebral ischemia
    • Zhao X, Strong R, Zhang J, Sun G, Tsien JZ, Cui Z, et al. Neuronal PPARgamma deficiency increases susceptibility to brain damage after cerebral ischemia. J Neurosci 2009; 29: 6186-95.
    • (2009) J Neurosci , vol.29 , pp. 6186-95
    • Zhao, X.1    Strong, R.2    Zhang, J.3    Sun, G.4    Tsien, J.Z.5    Cui, Z.6
  • 48
    • 80052472505 scopus 로고    scopus 로고
    • T33, a novel peroxisome proliferator-activated receptor gamma/alpha agonist, exerts neuroprotective action via its anti-inflammatory activities
    • Wang Y, Yang YS, Tang XC, Zhang HY. T33, a novel peroxisome proliferator-activated receptor gamma/alpha agonist, exerts neuroprotective action via its anti-inflammatory activities. Acta Pharmacol Sin 2011; 32: 1100-8.
    • (2011) Acta Pharmacol Sin , vol.32 , pp. 1100-8
    • Wang, Y.1    Yang, Y.S.2    Tang, X.C.3    Zhang, H.Y.4
  • 49
    • 84863688106 scopus 로고    scopus 로고
    • Mitochondrial-and endoplasmic reticulum-associated oxidative stress in Alzheimer's disease: From pathogenesis to biomarkers
    • Ferreiro E, Baldeiras I, Ferreira IL, Costa RO, Rego AC, Pereira CF, et al. Mitochondrial-and endoplasmic reticulum-associated oxidative stress in Alzheimer's disease: from pathogenesis to biomarkers. Int J Cell Biol 2012; 2012: 735206.
    • (2012) Int J Cell Biol , vol.2012 , pp. 735206
    • Ferreiro, E.1    Baldeiras, I.2    Ferreira, I.L.3    Costa, R.O.4    Rego, A.C.5    Pereira, C.F.6
  • 50
    • 79955444505 scopus 로고    scopus 로고
    • A phase II trial of huperzine A in mild to moderate Alzheimer disease
    • Rafii MS, Walsh S, Little JT, Behan K, Reynolds B, Ward C, et al. A phase II trial of huperzine A in mild to moderate Alzheimer disease. Neurology 2011; 76: 1389-94.
    • (2011) Neurology , vol.76 , pp. 1389-94
    • Rafii, M.S.1    Walsh, S.2    Little, J.T.3    Behan, K.4    Reynolds, B.5    Ward, C.6
  • 51
    • 67349262023 scopus 로고    scopus 로고
    • Efficacy and safety of natural acetylcholinesterase inhibitor huperzine A in the treatment of Alzheimer's disease: An updated meta-analysis
    • Wang BS, Wang H, Wei ZH, Song YY, Zhang L, Chen HZ. Efficacy and safety of natural acetylcholinesterase inhibitor huperzine A in the treatment of Alzheimer's disease: an updated meta-analysis. J Neural Transm 2009; 116: 457-65.
    • (2009) J Neural Transm , vol.116 , pp. 457-65
    • Wang, B.S.1    Wang, H.2    Wei, Z.H.3    Song, Y.Y.4    Zhang, L.5    Chen, H.Z.6
  • 52
    • 33744931940 scopus 로고    scopus 로고
    • Pharmacokinetics of huperzine A in dogs following single intravenous and oral administrations
    • DOI 10.1055/s-2006-931566
    • Chu D, Liu W, Li Y, Li P, Gu J, Liu K. Pharmacokinetics of huperzine A in dogs following single intravenous and oral administrations. Planta Med 2006; 72: 552-5. (Pubitemid 43844684)
    • (2006) Planta Medica , vol.72 , Issue.6 , pp. 552-555
    • Chu, D.1    Liu, W.2    Li, Y.3    Li, P.4    Gu, J.5    Liu, K.6
  • 53
    • 73349120649 scopus 로고    scopus 로고
    • Pharmacokinetic behavior of huperzine A in plasma and cerebrospinal fluid after intranasal administration in rats
    • Wang Q, Chen G. Pharmacokinetic behavior of huperzine A in plasma and cerebrospinal fluid after intranasal administration in rats. Biopharm Drug Dispos 2009; 30: 551-5.
    • (2009) Biopharm Drug Dispos , vol.30 , pp. 551-5
    • Wang, Q.1    Chen, G.2
  • 54
    • 20144375833 scopus 로고    scopus 로고
    • Effects of formulation factors on encapsulation efficiency and release behaviour in vitro of huperzine A-PLGA microspheres
    • DOI 10.1080/02652040500162196, PII P33752354615
    • Fu X, Ping Q, Gao Y. Effects of formulation factors on encapsulation efficiency and release behaviour in vitro of huperzine A-PLGA microspheres. J Microencapsul 2005; 22: 705-14. (Pubitemid 43158192)
    • (2005) Journal of Microencapsulation , vol.22 , Issue.7 , pp. 705-714
    • Fu, X.1    Ping, Q.2    Gao, Y.3
  • 55
    • 29844458145 scopus 로고    scopus 로고
    • In Vitro and in Vivo characterization of huperzine A loaded microspheres made from end-group uncapped poly(d,l-lactide acid) and poly(d,l-lactide-co- glycolide acid)
    • DOI 10.1248/cpb.54.89
    • Gao P, Ding P, Xu H, Yuan Z, Chen D, Wei J, et al. In vitro and in vivo characterization of huperzine a loaded microspheres made from endgroup uncapped poly(d,l-lactide acid) and poly(d,l-lactide-co-glycolide acid). Chem Pharm Bull (Tokyo) 2006; 54: 89-93. (Pubitemid 43036756)
    • (2006) Chemical and Pharmaceutical Bulletin , vol.54 , Issue.1 , pp. 89-93
    • Gao, P.1    Ding, P.2    Xu, H.3    Yuan, Z.4    Chen, D.5    Wei, J.6    Chen, D.7
  • 56
    • 25844439321 scopus 로고    scopus 로고
    • Preparation and in vitro and in vivo release studies of Huperzine A loaded microspheres for the treatment of Alzheimer's disease
    • DOI 10.1016/j.jconrel.2005.03.025, PII S0168365905001860
    • Liu WH, Song JL, Liu K, Chu DF, Li YX. Preparation and in vitro and in vivo release studies of Huperzine A loaded microspheres for the treatment of Alzheimer's disease. J Control Release 2005; 107: 417-27. (Pubitemid 41393352)
    • (2005) Journal of Controlled Release , vol.107 , Issue.3 , pp. 417-427
    • Liu, W.H.1    Song, J.L.2    Liu, K.3    Chu, D.F.4    Li, Y.X.5
  • 57
    • 62349089101 scopus 로고    scopus 로고
    • Importance of circadian rhythmicity in the cholinergic treatment of Alzheimer's disease: Focus on galantamine
    • Nieoullon A, Bentue-Ferrer D, Bordet R, Tsolaki M, Forstl H. Importance of circadian rhythmicity in the cholinergic treatment of Alzheimer's disease: focus on galantamine. Curr Med Res Opin 2008; 24: 3357-67.
    • (2008) Curr Med Res Opin , vol.24 , pp. 3357-67
    • Nieoullon, A.1    Bentue-Ferrer, D.2    Bordet, R.3    Tsolaki, M.4    Forstl, H.5
  • 59
    • 84858110949 scopus 로고    scopus 로고
    • Perspective: Transforming science into medicine: How clinician-scientists can build bridges across research's "valley of death"
    • Roberts SF, Fischhoff MA, Sakowski SA, Feldman EL. Perspective: Transforming science into medicine: how clinician-scientists can build bridges across research's "valley of death". Acad Med 2012; 87: 266-70.
    • (2012) Acad Med , vol.87 , pp. 266-70
    • Roberts, S.F.1    Fischhoff, M.A.2    Sakowski, S.A.3    Feldman, E.L.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.