-
1
-
-
84863337843
-
Alzheimer mechanisms and therapeutic strategies
-
Huang Y, Mucke L. Alzheimer mechanisms and therapeutic strategies. Cell 2012; 148: 1204-22.
-
(2012)
Cell
, vol.148
, pp. 1204-22
-
-
Huang, Y.1
Mucke, L.2
-
2
-
-
30144437522
-
Progress in studies of huperzine A, a natural cholinesterase inhibitor from Chinese herbal medicine
-
DOI 10.1111/j.1745-7254.2006.00255.x
-
Wang R, Yan H, Tang XC. Progress in studies of huperzine A, a natural cholinesterase inhibitor from Chinese herbal medicine. Acta Pharmacol Sin 2006; 27: 1-26. (Pubitemid 43051942)
-
(2006)
Acta Pharmacologica Sinica
, vol.27
, Issue.1
, pp. 1-26
-
-
Wang, R.1
Yan, H.2
Tang, X.-C.3
-
3
-
-
33750943629
-
Neuroprotective effects of huperzine A: New therapeutic targets for neurodegenerative disease
-
DOI 10.1016/j.tips.2006.10.004, PII S0165614706002471
-
Zhang HY, Tang XC. Neuroprotective effects of huperzine A: new therapeutic targets for neurodegenerative disease. Trends Pharmacol Sci 2006; 27: 619-25. (Pubitemid 44738090)
-
(2006)
Trends in Pharmacological Sciences
, vol.27
, Issue.12
, pp. 619-625
-
-
Zhang, H.Y.1
Tang, X.C.2
-
4
-
-
84856106793
-
Investigations of the amnesic properties of scopolamine and related compounds
-
Domer FR, Schueler FW. Investigations of the amnesic properties of scopolamine and related compounds. Arch Int Pharmacodyn Ther 1960; 127: 449-58.
-
(1960)
Arch Int Pharmacodyn Ther
, vol.127
, pp. 449-58
-
-
Domer, F.R.1
Schueler, F.W.2
-
6
-
-
0019972810
-
The cholinergic hypothesis of geriatric memory dysfunction
-
Bartus RT, Dean RL 3rd, Beer B, Lippa AS. The cholinergic hypothesis of geriatric memory dysfunction. Science 1982; 217: 408-14.
-
(1982)
Science
, vol.217
, pp. 408-14
-
-
Bartus, R.T.1
Dean, R.L.2
Beer, B.3
Lippa, A.S.4
-
7
-
-
0022931112
-
Pharmacologic modelling of Alzheimer's disease
-
Sunderland T, Tariot PN, Weingartner H, Murphy DL, Newhouse PA, Mueller EA, et al. Pharmacologic modelling of Alzheimer's disease. Prog Neuropsychopharmacol Biol Psychiatry 1986; 10: 599-610.
-
(1986)
Prog Neuropsychopharmacol Biol Psychiatry
, vol.10
, pp. 599-610
-
-
Sunderland, T.1
Tariot, P.N.2
Weingartner, H.3
Murphy, D.L.4
Newhouse, P.A.5
Mueller, E.A.6
-
8
-
-
0028266334
-
Positive feedback between acetylcholine and the neurotrophins nerve growth factor and brain-derived neurotrophic factor in the rat hippocampus
-
Knipper M, da Penha Berzaghi M, Blochl A, Breer H, Thoenen H, Lindholm D. Positive feedback between acetylcholine and the neurotrophins nerve growth factor and brain-derived neurotrophic factor in the rat hippocampus. Eur J Neurosci 1994; 6: 668-71. (Pubitemid 24106852)
-
(1994)
European Journal of Neuroscience
, vol.6
, Issue.4
, pp. 668-671
-
-
Knipper, M.1
De Penha Berzaghi, M.2
Blochl, A.3
Breer, H.4
Thoenen, H.5
Lindholm, D.6
-
9
-
-
0034528416
-
M1 muscarinic agonists as potential disease-modifying agents in Alzheimer's disease: Rationale and perspectives
-
Fisher A, Michaelson DM, Brandeis R, Haring R, Chapman S, Pittel Z. M1 muscarinic agonists as potential disease-modifying agents in Alzheimer's disease. Rationale and perspectives. Ann N Y Acad Sci 2000; 920: 315-20. (Pubitemid 32056587)
-
(2000)
Annals of the New York Academy of Sciences
, vol.920
, pp. 315-320
-
-
Fisher, A.1
Michaelson, D.M.2
Brandeis, R.3
Haring, R.4
Chapman, S.5
Pittel, Z.6
-
10
-
-
0001059974
-
The regulation of amyloid precursor protein metabolism by cholinergic mechanisms and neurotrophin receptor signaling
-
DOI 10.1016/S0301-0082(98)00044-6, PII S0301008298000446
-
Rossner S, Ueberham U, Schliebs R, Perez-Polo JR, Bigl V. The regulation of amyloid precursor protein metabolism by cholinergic mechanisms and neurotrophin receptor signaling. Prog Neurobiol 1998; 56: 541-69. (Pubitemid 28407571)
-
(1998)
Progress in Neurobiology
, vol.56
, Issue.5
, pp. 541-569
-
-
Rossner, S.1
Ueberham, U.2
Schliebs, R.3
Regino Perez-Polo, J.4
Bigl, V.5
-
11
-
-
40149104224
-
Alpha7 nicotinic acetylcholine receptor: A link between inflammation and neurodegeneration
-
Conejero-Goldberg C, Davies P, Ulloa L. Alpha7 nicotinic acetylcholine receptor: a link between inflammation and neurodegeneration. Neurosci Biobehav Rev 2008; 32: 693-706.
-
(2008)
Neurosci Biobehav Rev
, vol.32
, pp. 693-706
-
-
Conejero-Goldberg, C.1
Davies, P.2
Ulloa, L.3
-
12
-
-
20444424188
-
Effects of huperzine A on secretion of nerve growth factor in cultured rat cortical astrocytes and neurite outgrowth in rat PC12 cells
-
DOI 10.1111/j.1745-7254.2005.00130.x
-
Tang LL, Wang R, Tang XC. Effects of huperzine A on secretion of nerve growth factor in cultured rat cortical astrocytes and neurite outgrowth in rat PC12 cells. Acta Pharmacol Sin 2005; 26: 673-8. (Pubitemid 40806555)
-
(2005)
Acta Pharmacologica Sinica
, vol.26
, Issue.6
, pp. 673-678
-
-
Tang, L.-L.1
Wang, R.2
Tang, X.-C.3
-
13
-
-
1842713364
-
Huperzine A enhances the level of secretory amyloid precursor protein and protein kinase C-α in intracerebroventricular β-amyloid-(1-40) infused rats and human embryonic kidney 293 Swedish mutant cells
-
DOI 10.1016/j.neulet.2004.01.055, PII S0304394004001326
-
Zhang HY, Yan H, Tang XC. Huperzine A enhances the level of secretory amyloid precursor protein and protein kinase C-alpha in intracerebroventricular beta-amyloid-(1-40) infused rats and human embryonic kidney 293 Swedish mutant cells. Neurosci Lett 2004; 360: 21-4. (Pubitemid 38471978)
-
(2004)
Neuroscience Letters
, vol.360
, Issue.1-2
, pp. 21-24
-
-
Zhang, H.Y.1
Yan, H.2
Tang, X.C.3
-
14
-
-
27744493126
-
Huperzine A protects SHSY5Y neuroblastoma cells against oxidative stress damage via nerve growth factor production
-
DOI 10.1016/j.ejphar.2005.06.026, PII S0014299905006801
-
Tang LL, Wang R, Tang XC. Huperzine A protects SHSY5Y neuroblastoma cells against oxidative stress damage via nerve growth factor production. Eur J Pharmacol 2005; 519: 9-15. (Pubitemid 43181158)
-
(2005)
European Journal of Pharmacology
, vol.519
, Issue.1-2
, pp. 9-15
-
-
Tang, L.-L.1
Wang, R.2
Tang, X.-C.3
-
15
-
-
33744517635
-
Effects of huperzine A on memory deficits and neurotrophic factors production after transient cerebral ischemia and reperfusion in mice
-
DOI 10.1016/j.pbb.2006.03.027, PII S0091305706000840
-
Wang ZF, Tang LL, Yan H, Wang YJ, Tang XC. Effects of huperzine A on memory deficits and neurotrophic factors production after transient cerebral ischemia and reperfusion in mice. Pharmacol Biochem Behav 2006; 83: 603-11. (Pubitemid 43817131)
-
(2006)
Pharmacology Biochemistry and Behavior
, vol.83
, Issue.4
, pp. 603-611
-
-
Wang, Z.-f.1
Tang, L.-l.2
Yan, H.3
Wang, Y.-j.4
Tang, X.-c.5
-
16
-
-
34247199363
-
Involvement of M1-muscarinic acetylcholine receptors, protein kinase C and mitogen-activated protein kinase in the effect of huperzine A on secretory amyloid precursor protein-α
-
DOI 10.1097/WNR.0b013e3280c1e28c, PII 0000175620070507000014
-
Yan H, Zhang HY, Tang XC. Involvement of M1-muscarinic acetylcholine receptors, protein kinase C and mitogen-activated protein kinase in the effect of huperzine A on secretory amyloid precursor protein-alpha. Neuroreport 2007; 18: 689-92. (Pubitemid 46608516)
-
(2007)
NeuroReport
, vol.18
, Issue.7
, pp. 689-692
-
-
Yan, H.1
Zhang, H.Y.2
Tang, X.C.3
-
17
-
-
33846849308
-
Huperzine A protects C6 rat glioma cells against oxygen-glucose deprivation-induced injury
-
DOI 10.1016/j.febslet.2007.01.016, PII S0014579307000476
-
Wang ZF, Tang XC. Huperzine A protects C6 rat glioma cells against oxygen-glucose deprivation-induced injury. FEBS Lett 2007; 581: 596-602. (Pubitemid 46216285)
-
(2007)
FEBS Letters
, vol.581
, Issue.4
, pp. 596-602
-
-
Wang, Z.F.1
Tang, X.C.2
-
18
-
-
48749121734
-
Huperzine A exhibits antiinflammatory and neuroprotective effects in a rat model of transient focal cerebral ischemia
-
Wang ZF, Wang J, Zhang HY, Tang XC. Huperzine A exhibits antiinflammatory and neuroprotective effects in a rat model of transient focal cerebral ischemia. J Neurochem 2008; 106: 1594-603.
-
(2008)
J Neurochem
, vol.106
, pp. 1594-603
-
-
Wang, Z.F.1
Wang, J.2
Zhang, H.Y.3
Tang, X.C.4
-
19
-
-
76549112494
-
Huperzine A improves chronic inflamma tion and cognitive decline in rats with cerebral hypoperfusion
-
Wang J, Zhang HY, Tang XC. Huperzine A improves chronic inflamma tion and cognitive decline in rats with cerebral hypoperfusion. J Neurosci Res 2010; 88: 807-15.
-
(2010)
J Neurosci Res
, vol.88
, pp. 807-15
-
-
Wang, J.1
Zhang, H.Y.2
Tang, X.C.3
-
20
-
-
4944234184
-
Regulation of nicotinic acetylcholine receptor channel function by acetylcholinesterase inhibitors in rat hippocampal CA1 interneurons
-
DOI 10.1124/mol.104.000042
-
Fayuk D, Yakel JL. Regulation of nicotinic acetylcholine receptor channel function by acetylcholinesterase inhibitors in rat hippocampal CA1 interneurons. Mol Pharmacol 2004; 66: 658-66. (Pubitemid 39329265)
-
(2004)
Molecular Pharmacology
, vol.66
, Issue.3
, pp. 658-666
-
-
Fayuk, D.1
Yakel, J.L.2
-
21
-
-
0041309915
-
Potentiation of nerve growth factor-induced neurite outgrowth in PC12 cells by a coptidis rhizoma extract and protoberberine alkaloids
-
Shigeta K, Ootaki K, Tatemoto H, Nakanishi T, Inada A, Muto N. Potentiation of nerve growth factor-induced neurite outgrowth in PC12 cells by a Coptidis Rhizoma extract and protoberberine alkaloids. Biosci Biotechnol Biochem 2002; 66: 2491-4. (Pubitemid 39251193)
-
(2002)
Bioscience, Biotechnology and Biochemistry
, vol.66
, Issue.11
, pp. 2491-2494
-
-
Shigeta, K.1
Ootaki, K.2
Tatemoto, H.3
Nakanishi, T.4
Inada, A.5
Muto, N.6
-
22
-
-
0029983531
-
The effect of cholinesterase inhibitors on the secretion of APPS from rat brain cortex
-
Giacobini E, Mori F, Lai CC. The effect of cholinesterase inhibitors on the secretion of APPS from rat brain cortex. Ann N Y Acad Sci 1996; 777: 393-8. (Pubitemid 26149220)
-
(1996)
Annals of the New York Academy of Sciences
, vol.777
, pp. 393-398
-
-
Giacobini, E.1
Mori, F.2
Lai, C.-C.3
-
23
-
-
0028918426
-
Cholinesterase inhibitors increase secretion of APPs in rat brain cortex
-
Mori F, Lai CC, Fusi F, Giacobini E. Cholinesterase inhibitors increase secretion of APPs in rat brain cortex. Neuroreport 1995; 6: 633-6.
-
(1995)
Neuroreport
, vol.6
, pp. 633-6
-
-
Mori, F.1
Lai, C.C.2
Fusi, F.3
Giacobini, E.4
-
24
-
-
0034235229
-
The internal structure of mitochondria
-
Frey TG, Mannella CA. The internal structure of mitochondria. Trends Biochem Sci 2000; 25: 319-24.
-
(2000)
Trends Biochem Sci
, vol.25
, pp. 319-24
-
-
Frey, T.G.1
Mannella, C.A.2
-
25
-
-
79959926983
-
Mitochondria: The common upstream driver of amyloid-beta and tau pathology in Alzheimer's disease
-
Silva DF, Esteves AR, Oliveira CR, Cardoso SM. Mitochondria: the common upstream driver of amyloid-beta and tau pathology in Alzheimer's disease. Curr Alzheimer Res 2011; 8: 563-72.
-
(2011)
Curr Alzheimer Res
, vol.8
, pp. 563-72
-
-
Silva, D.F.1
Esteves, A.R.2
Oliveira, C.R.3
Cardoso, S.M.4
-
26
-
-
33645855623
-
Huperzine A attenuates mitochondrial dysfunction in beta-amyloid-treated PC12 cells by reducing oxygen free radicals accumulation and improving mitochondrial energy metabolism
-
Gao X, Tang XC. Huperzine A attenuates mitochondrial dysfunction in beta-amyloid-treated PC12 cells by reducing oxygen free radicals accumulation and improving mitochondrial energy metabolism. J Neurosci Res 2006; 83: 1048-57.
-
(2006)
J Neurosci Res
, vol.83
, pp. 1048-57
-
-
Gao, X.1
Tang, X.C.2
-
27
-
-
67349281227
-
Huperzine A protects isolated rat brain mitochondria against beta-amyloid peptide
-
Gao X, Zheng CY, Yang L, Tang XC, Zhang HY. Huperzine A protects isolated rat brain mitochondria against beta-amyloid peptide. Free Radic Biol Med 2009; 46: 1454-62.
-
(2009)
Free Radic Biol Med
, vol.46
, pp. 1454-62
-
-
Gao, X.1
Zheng, C.Y.2
Yang, L.3
Tang, X.C.4
Zhang, H.Y.5
-
28
-
-
84863918272
-
Decreased accumulation of subcellular amyloid-beta with improved mitochondrial function mediates the neuroprotective effect of huperzine A
-
Yang L, Ye CY, Huang XT, Tang XC, Zhang HY. Decreased accumulation of subcellular amyloid-beta with improved mitochondrial function mediates the neuroprotective effect of huperzine A. J Alzheimers Dis 2012; 31: 131-42.
-
(2012)
J Alzheimers Dis
, vol.31
, pp. 131-42
-
-
Yang, L.1
Ye, C.Y.2
Huang, X.T.3
Tang, X.C.4
Zhang, H.Y.5
-
29
-
-
49349110270
-
Huperzine A attenuates mitochondrial dysfunction after middle cerebral artery occlusion in rats
-
Zheng CY, Zhang HY, Tang XC. Huperzine A attenuates mitochondrial dysfunction after middle cerebral artery occlusion in rats. J Neurosci Res 2008; 86: 2432-40.
-
(2008)
J Neurosci Res
, vol.86
, pp. 2432-40
-
-
Zheng, C.Y.1
Zhang, H.Y.2
Tang, X.C.3
-
30
-
-
0036141139
-
Huperzine A attenuates amyloid betapeptide fragment 25-35-induced apoptosis in rat cortical neurons via inhibiting reactive oxygen species formation and caspase-3 activation
-
Xiao XQ, Zhang HY, Tang XC. Huperzine A attenuates amyloid betapeptide fragment 25-35-induced apoptosis in rat cortical neurons via inhibiting reactive oxygen species formation and caspase-3 activation. J Neurosci Res 2002; 67: 30-6.
-
(2002)
J Neurosci Res
, vol.67
, pp. 30-6
-
-
Xiao, X.Q.1
Zhang, H.Y.2
Tang, X.C.3
-
31
-
-
0035876056
-
Huperzine A attenuates cognitive dysfunction and neuronal degeneration caused by β-amyloid protein-(1-40) in rat
-
DOI 10.1016/S0014-2999(01)01030-5, PII S0014299901010305
-
Wang R, Zhang HY, Tang XC. Huperzine A attenuates cognitive dysfunction and neuronal degeneration caused by beta-amyloid protein-(1-40) in rat. Eur J Pharmacol 2001; 421: 149-56. (Pubitemid 32539415)
-
(2001)
European Journal of Pharmacology
, vol.421
, Issue.3
, pp. 149-156
-
-
Wang, R.1
Zhang, H.Y.2
Tang, X.C.3
-
32
-
-
0034625561
-
25-35 induced oxidative injury in rat pheochromocytoma cells
-
DOI 10.1016/S0304-3940(00)01088-0, PII S0304394000010880
-
Xiao XQ, Wang R, Han YF, Tang XC. Protective effects of huperzine A on beta-amyloid(25-35) induced oxidative injury in rat pheochromocytoma cells. Neurosci Lett 2000; 286: 155-8. (Pubitemid 30314633)
-
(2000)
Neuroscience Letters
, vol.286
, Issue.3
, pp. 155-158
-
-
Xiao, X.Q.1
Wang, R.2
Han, Y.F.3
Tang, X.C.4
-
33
-
-
0034284410
-
Huperzine A and tacrine attenuate betaamyloid peptide-induced oxidative injury
-
Xiao XQ, Wang R, Tang XC. Huperzine A and tacrine attenuate betaamyloid peptide-induced oxidative injury. J Neurosci Res 2000; 61: 564-9.
-
(2000)
J Neurosci Res
, vol.61
, pp. 564-9
-
-
Xiao, X.Q.1
Wang, R.2
Tang, X.C.3
-
34
-
-
0344562900
-
Huperzine A protects rat pheochromocytoma cells against hydrogen peroxide-induced injury
-
DOI 10.1016/S0304-3940(99)00695-3, PII S0304394099006953
-
Xiao XQ, Yang JW, Tang XC. Huperzine A protects rat pheochromocytoma cells against hydrogen peroxide-induced injury. Neurosci Lett 1999; 275: 73-6. (Pubitemid 29502539)
-
(1999)
Neuroscience Letters
, vol.275
, Issue.2
, pp. 73-76
-
-
Xiao, X.Q.1
Yang, J.W.2
Tang, X.C.3
-
35
-
-
0003093544
-
Huperzine A improves cognitive deficits caused by chronic cerebral hypoperfusion in rats
-
DOI 10.1016/S0014-2999(00)00291-0, PII S0014299900002910
-
Wang LM, Han YF, Tang XC. Huperzine A improves cognitive deficits caused by chronic cerebral hypoperfusion in rats. Eur J Pharmacol 2000; 398: 65-72. (Pubitemid 30336678)
-
(2000)
European Journal of Pharmacology
, vol.398
, Issue.1
, pp. 65-72
-
-
Wang, L.M.1
Han, Y.F.2
Tang, X.C.3
-
36
-
-
0032888723
-
Improving effects of huperzine A on abnormal lipid peroxidation and superoxide dismutase in aged rats
-
Shang YZ, Ye JW, Tang XC. Improving effects of huperzine A on abnormal lipid peroxidation and superoxide dismutase in aged rats. Zhongguo Yao Li Xue Bao 1999; 20: 824-8.
-
(1999)
Zhongguo Yao Li Xue Bao
, vol.20
, pp. 824-8
-
-
Shang, Y.Z.1
Ye, J.W.2
Tang, X.C.3
-
37
-
-
0037430938
-
Huperzine A attenuates the neurotoxic effect of staurosporine in primary rat cortical neurons
-
DOI 10.1016/S0304-3940(03)00023-5
-
Zhang HY, Tang XC. Huperzine A attenuates the neurotoxic effect of staurosporine in primary rat cortical neurons. Neurosci Lett 2003; 340: 91-4. (Pubitemid 36369282)
-
(2003)
Neuroscience Letters
, vol.340
, Issue.2
, pp. 91-94
-
-
Zhang, H.Y.1
Tang, X.C.2
-
38
-
-
0037189932
-
Huperzine A attenuates apoptosis and mitochondria-dependent caspase-3 in rat cortical neurons
-
DOI 10.1016/S0014-5793(02)03107-1, PII S0014579302031071
-
Zhou J, Tang XC. Huperzine A attenuates apoptosis and mitochondriadependent caspase-3 in rat cortical neurons. FEBS Lett 2002; 526: 21-5. (Pubitemid 35245685)
-
(2002)
FEBS Letters
, vol.526
, Issue.1-3
, pp. 21-25
-
-
Zhou, J.1
Tang, X.C.2
-
39
-
-
0035964415
-
Huperzine A attenuates hydrogen peroxide-induced apoptosis by regulating expression of apoptosis-related genes in rat PC 12 cells
-
Wang R, Xiao XQ, Tang XC. Huperzine A attenuates hydrogen peroxideinduced apoptosis by regulating expression of apoptosis-related genes in rat PC12 cells. Neuroreport 2001; 12: 2629-34. (Pubitemid 32803190)
-
(2001)
NeuroReport
, vol.12
, Issue.12
, pp. 2629-2634
-
-
Wang, R.1
Xiao Qiu Xiao2
Xi Can Tang3
-
40
-
-
78649983748
-
Alzheimer's disease: Effects of beta-amyloid on mitochondria
-
Tillement L, Lecanu L, Papadopoulos V. Alzheimer's disease: effects of beta-amyloid on mitochondria. Mitochondrion 2011; 11: 13-21.
-
(2011)
Mitochondrion
, vol.11
, pp. 13-21
-
-
Tillement, L.1
Lecanu, L.2
Papadopoulos, V.3
-
41
-
-
51349110166
-
The amyloid beta-peptide is imported into mitochondria via the TOM import machinery and localized to mitochondrial cristae
-
Hansson Petersen CA, Alikhani N, Behbahani H, Wiehager B, Pavlov PF, Alafuzoff I, et al. The amyloid beta-peptide is imported into mitochondria via the TOM import machinery and localized to mitochondrial cristae. Proc Natl Acad Sci U S A 2008; 105: 13145-50.
-
(2008)
Proc Natl Acad Sci U S A
, vol.105
, pp. 13145-50
-
-
Hansson Petersen, C.A.1
Alikhani, N.2
Behbahani, H.3
Wiehager, B.4
Pavlov, P.F.5
Alafuzoff, I.6
-
42
-
-
77953562457
-
Possible role of amyloid-beta, adenine nucleotide translocase and cyclophilin-D interaction in mitochondrial dysfunction of Alzheimer's disease
-
Singh P, Suman S, Chandna S, Das TK. Possible role of amyloid-beta, adenine nucleotide translocase and cyclophilin-D interaction in mitochondrial dysfunction of Alzheimer's disease. Bioinformation 2009; 3: 440-5.
-
(2009)
Bioinformation
, vol.3
, pp. 440-5
-
-
Singh, P.1
Suman, S.2
Chandna, S.3
Das, T.K.4
-
43
-
-
11144353586
-
ABAD Directly Links Aβ to Mitochondrial Toxicity in Alzheimer's Disease
-
DOI 10.1126/science.1091230
-
Lustbader JW, Cirilli M, Lin C, Xu HW, Takuma K, Wang N, et al. ABAD directly links Abeta to mitochondrial toxicity in Alzheimer's disease. Science 2004; 304: 448-52. (Pubitemid 38495942)
-
(2004)
Science
, vol.304
, Issue.5669
, pp. 448-452
-
-
Lustbader, J.W.1
Cirilli, M.2
Lin, C.3
Xu, H.W.4
Takuma, K.5
Wang, N.6
Caspersen, C.7
Chen, X.8
Pollak, S.9
Chaney, M.10
Trinchese, F.11
Liu, S.12
Gunn-Moore, F.13
Lue, L.-F.14
Walker, D.G.15
Kappasamy, P.16
Zewier, Z.L.17
Arancio, O.18
Stern, D.19
Yan, S.S.D.20
Wu, H.21
more..
-
44
-
-
57749102902
-
Cytoprotective role of mitochondrial amyloid beta peptide-binding alcohol dehydrogenase against a cytotoxic aldehyde
-
Murakami Y, Ohsawa I, Kasahara T, Ohta S. Cytoprotective role of mitochondrial amyloid beta peptide-binding alcohol dehydrogenase against a cytotoxic aldehyde. Neurobiol Aging 2009; 30: 325-9.
-
(2009)
Neurobiol Aging
, vol.30
, pp. 325-9
-
-
Murakami, Y.1
Ohsawa, I.2
Kasahara, T.3
Ohta, S.4
-
45
-
-
34247507589
-
PPAR-γ: Therapeutic target for ischemic stroke
-
DOI 10.1016/j.tips.2007.03.004, PII S0165614707000727
-
Culman J, Zhao Y, Gohlke P, Herdegen T. PPAR-gamma: therapeutic target for ischemic stroke. Trends Pharmacol Sci 2007; 28: 244-9. (Pubitemid 46661003)
-
(2007)
Trends in Pharmacological Sciences
, vol.28
, Issue.5
, pp. 244-249
-
-
Culman, J.1
Zhao, Y.2
Gohlke, P.3
Herdegen, T.4
-
46
-
-
77955085757
-
Anti-apoptotic actions of PPAR-gamma against ischemic stroke
-
Fong WH, Tsai HD, Chen YC, Wu JS, Lin TN. Anti-apoptotic actions of PPAR-gamma against ischemic stroke. Mol Neurobiol 2010; 41: 180-6.
-
(2010)
Mol Neurobiol
, vol.41
, pp. 180-6
-
-
Fong, W.H.1
Tsai, H.D.2
Chen, Y.C.3
Wu, J.S.4
Lin, T.N.5
-
47
-
-
66049135616
-
Neuronal PPARgamma deficiency increases susceptibility to brain damage after cerebral ischemia
-
Zhao X, Strong R, Zhang J, Sun G, Tsien JZ, Cui Z, et al. Neuronal PPARgamma deficiency increases susceptibility to brain damage after cerebral ischemia. J Neurosci 2009; 29: 6186-95.
-
(2009)
J Neurosci
, vol.29
, pp. 6186-95
-
-
Zhao, X.1
Strong, R.2
Zhang, J.3
Sun, G.4
Tsien, J.Z.5
Cui, Z.6
-
48
-
-
80052472505
-
T33, a novel peroxisome proliferator-activated receptor gamma/alpha agonist, exerts neuroprotective action via its anti-inflammatory activities
-
Wang Y, Yang YS, Tang XC, Zhang HY. T33, a novel peroxisome proliferator-activated receptor gamma/alpha agonist, exerts neuroprotective action via its anti-inflammatory activities. Acta Pharmacol Sin 2011; 32: 1100-8.
-
(2011)
Acta Pharmacol Sin
, vol.32
, pp. 1100-8
-
-
Wang, Y.1
Yang, Y.S.2
Tang, X.C.3
Zhang, H.Y.4
-
49
-
-
84863688106
-
Mitochondrial-and endoplasmic reticulum-associated oxidative stress in Alzheimer's disease: From pathogenesis to biomarkers
-
Ferreiro E, Baldeiras I, Ferreira IL, Costa RO, Rego AC, Pereira CF, et al. Mitochondrial-and endoplasmic reticulum-associated oxidative stress in Alzheimer's disease: from pathogenesis to biomarkers. Int J Cell Biol 2012; 2012: 735206.
-
(2012)
Int J Cell Biol
, vol.2012
, pp. 735206
-
-
Ferreiro, E.1
Baldeiras, I.2
Ferreira, I.L.3
Costa, R.O.4
Rego, A.C.5
Pereira, C.F.6
-
50
-
-
79955444505
-
A phase II trial of huperzine A in mild to moderate Alzheimer disease
-
Rafii MS, Walsh S, Little JT, Behan K, Reynolds B, Ward C, et al. A phase II trial of huperzine A in mild to moderate Alzheimer disease. Neurology 2011; 76: 1389-94.
-
(2011)
Neurology
, vol.76
, pp. 1389-94
-
-
Rafii, M.S.1
Walsh, S.2
Little, J.T.3
Behan, K.4
Reynolds, B.5
Ward, C.6
-
51
-
-
67349262023
-
Efficacy and safety of natural acetylcholinesterase inhibitor huperzine A in the treatment of Alzheimer's disease: An updated meta-analysis
-
Wang BS, Wang H, Wei ZH, Song YY, Zhang L, Chen HZ. Efficacy and safety of natural acetylcholinesterase inhibitor huperzine A in the treatment of Alzheimer's disease: an updated meta-analysis. J Neural Transm 2009; 116: 457-65.
-
(2009)
J Neural Transm
, vol.116
, pp. 457-65
-
-
Wang, B.S.1
Wang, H.2
Wei, Z.H.3
Song, Y.Y.4
Zhang, L.5
Chen, H.Z.6
-
52
-
-
33744931940
-
Pharmacokinetics of huperzine A in dogs following single intravenous and oral administrations
-
DOI 10.1055/s-2006-931566
-
Chu D, Liu W, Li Y, Li P, Gu J, Liu K. Pharmacokinetics of huperzine A in dogs following single intravenous and oral administrations. Planta Med 2006; 72: 552-5. (Pubitemid 43844684)
-
(2006)
Planta Medica
, vol.72
, Issue.6
, pp. 552-555
-
-
Chu, D.1
Liu, W.2
Li, Y.3
Li, P.4
Gu, J.5
Liu, K.6
-
53
-
-
73349120649
-
Pharmacokinetic behavior of huperzine A in plasma and cerebrospinal fluid after intranasal administration in rats
-
Wang Q, Chen G. Pharmacokinetic behavior of huperzine A in plasma and cerebrospinal fluid after intranasal administration in rats. Biopharm Drug Dispos 2009; 30: 551-5.
-
(2009)
Biopharm Drug Dispos
, vol.30
, pp. 551-5
-
-
Wang, Q.1
Chen, G.2
-
54
-
-
20144375833
-
Effects of formulation factors on encapsulation efficiency and release behaviour in vitro of huperzine A-PLGA microspheres
-
DOI 10.1080/02652040500162196, PII P33752354615
-
Fu X, Ping Q, Gao Y. Effects of formulation factors on encapsulation efficiency and release behaviour in vitro of huperzine A-PLGA microspheres. J Microencapsul 2005; 22: 705-14. (Pubitemid 43158192)
-
(2005)
Journal of Microencapsulation
, vol.22
, Issue.7
, pp. 705-714
-
-
Fu, X.1
Ping, Q.2
Gao, Y.3
-
55
-
-
29844458145
-
In Vitro and in Vivo characterization of huperzine A loaded microspheres made from end-group uncapped poly(d,l-lactide acid) and poly(d,l-lactide-co- glycolide acid)
-
DOI 10.1248/cpb.54.89
-
Gao P, Ding P, Xu H, Yuan Z, Chen D, Wei J, et al. In vitro and in vivo characterization of huperzine a loaded microspheres made from endgroup uncapped poly(d,l-lactide acid) and poly(d,l-lactide-co-glycolide acid). Chem Pharm Bull (Tokyo) 2006; 54: 89-93. (Pubitemid 43036756)
-
(2006)
Chemical and Pharmaceutical Bulletin
, vol.54
, Issue.1
, pp. 89-93
-
-
Gao, P.1
Ding, P.2
Xu, H.3
Yuan, Z.4
Chen, D.5
Wei, J.6
Chen, D.7
-
56
-
-
25844439321
-
Preparation and in vitro and in vivo release studies of Huperzine A loaded microspheres for the treatment of Alzheimer's disease
-
DOI 10.1016/j.jconrel.2005.03.025, PII S0168365905001860
-
Liu WH, Song JL, Liu K, Chu DF, Li YX. Preparation and in vitro and in vivo release studies of Huperzine A loaded microspheres for the treatment of Alzheimer's disease. J Control Release 2005; 107: 417-27. (Pubitemid 41393352)
-
(2005)
Journal of Controlled Release
, vol.107
, Issue.3
, pp. 417-427
-
-
Liu, W.H.1
Song, J.L.2
Liu, K.3
Chu, D.F.4
Li, Y.X.5
-
57
-
-
62349089101
-
Importance of circadian rhythmicity in the cholinergic treatment of Alzheimer's disease: Focus on galantamine
-
Nieoullon A, Bentue-Ferrer D, Bordet R, Tsolaki M, Forstl H. Importance of circadian rhythmicity in the cholinergic treatment of Alzheimer's disease: focus on galantamine. Curr Med Res Opin 2008; 24: 3357-67.
-
(2008)
Curr Med Res Opin
, vol.24
, pp. 3357-67
-
-
Nieoullon, A.1
Bentue-Ferrer, D.2
Bordet, R.3
Tsolaki, M.4
Forstl, H.5
-
59
-
-
84858110949
-
Perspective: Transforming science into medicine: How clinician-scientists can build bridges across research's "valley of death"
-
Roberts SF, Fischhoff MA, Sakowski SA, Feldman EL. Perspective: Transforming science into medicine: how clinician-scientists can build bridges across research's "valley of death". Acad Med 2012; 87: 266-70.
-
(2012)
Acad Med
, vol.87
, pp. 266-70
-
-
Roberts, S.F.1
Fischhoff, M.A.2
Sakowski, S.A.3
Feldman, E.L.4
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