T33, a novel peroxisome proliferator-activated receptor γ/α agonist, exerts neuroprotective action via its anti-inflammatory activities

Acta Pharmacologica Sinica

Volumn 32, Issue 9, 2011, Pages 1100-1108

  Wang, Ying ^a   Yang, Yu She ^a   Tang, Xi Can ^a   Zhang, Hai Yan ^a  

^a SHANGHAI INSTITUTE OF MATERIA MEDICA   (China)

Author keywords

astrocytes; BV 2 cells; inflammation; middle cerebral artery occlusion; nuclear factorkappa B; oxygen glucose deprivation; peroxisome proliferator activated receptor ; stroke; T33

Indexed keywords

2 CHLORO 5 NITROBENZANILIDE; ANTIINFLAMMATORY AGENT; BENZOPYRAN DERIVATIVE; CYCLOOXYGENASE 2; GLUCOSE; I KAPPA B ALPHA; I KAPPA B KINASE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INITIATION FACTOR 2ALPHA; INTERLEUKIN 1BETA; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE P38; NEUROPROTECTIVE AGENT; OXYGEN; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA AGONIST; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA AGONIST; T 33; TRANSCRIPTION FACTOR RELA; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ARTICLE; ASTROCYTE; BRAIN INFARCTION; BRAIN ISCHEMIA; CELL HYPOXIA; CONTROLLED STUDY; CYTOKINE RELEASE; DRUG EFFECT; ENZYME LINKED IMMUNOSORBENT ASSAY; GENE EXPRESSION; GENETIC TRANSCRIPTION; ISCHEMIC PENUMBRA; MALE; MIDDLE CEREBRAL ARTERY OCCLUSION; NEUROPROTECTION; NONHUMAN; POLYMERASE CHAIN REACTION; PROTEIN DEGRADATION; PROTEIN PHOSPHORYLATION; PROTEIN SYNTHESIS; RAT; REPERFUSION; RNA TRANSLATION; SCORING SYSTEM;

ANIMALS; ANTI-INFLAMMATORY AGENTS; ASTROCYTES; BENZOPYRANS; CELLS, CULTURED; INFARCTION, MIDDLE CEREBRAL ARTERY; MALE; NEUROPROTECTIVE AGENTS; NF-KAPPA B; PPAR ALPHA; PPAR GAMMA; RATS; RATS, SPRAGUE-DAWLEY;

EID: 80052472505     PISSN: 16714083     EISSN: 17457254     Source Type: Journal    
DOI: 10.1038/aps.2011.69     Document Type: Article

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