M1 muscarinic agonists as potential disease-modifying agents in Alzheimer's disease: Rationale and perspectives

Annals of the New York Academy of Sciences

Volumn 920, Issue , 2000, Pages 315-320

  Fisher, A ^a   Michaelson, D M ^b   Brandeis, R ^a   Haring, R ^b   Chapman, S ^a   Pittel, Z ^b  

^a ISRAEL INSTITUTE FOR BIOLOGICAL RESEARCH   (Israel)

^b TEL AVIV UNIVERSITY   (Israel)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLCHOLINE; AF 150 S; AMYLOID BETA PROTEIN; AMYLOID PRECURSOR PROTEIN; CEVIMELINE; GLYCOGEN SYNTHASE KINASE 3; GUANINE NUCLEOTIDE BINDING PROTEIN; MUSCARINIC M1 RECEPTOR; MUSCARINIC M1 RECEPTOR AGONIST; PHOSPHATASE; TAU PROTEIN; UNCLASSIFIED DRUG;

ALZHEIMER DISEASE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; BINDING SITE; CHOLINERGIC SYSTEM; COGNITIVE DEFECT; CONFERENCE PAPER; CONTROLLED STUDY; DISEASE ASSOCIATION; ENZYME ACTIVATION; KNOCKOUT MOUSE; MOUSE; NONHUMAN; PROTEIN PHOSPHORYLATION; PROTEIN PROCESSING; RAT; SIGNAL TRANSDUCTION;

ANIMALIA;

EID: 0034528416     PISSN: 00778923     EISSN: None     Source Type: Book Series    
DOI: 10.1111/j.1749-6632.2000.tb06941.x     Document Type: Conference Paper

References (13)

1. Muscarinic receptor agonists in Alzheimer's disease. More than just symptomatic treatment
2. Release of Alzheimer amyloid precursor derivatives stimulated by activation of muscarinic acetylcholine receptors
3. Cerebrospinal fluid levels of α-secretase-cleaved soluble amyloid precursor protein mirror cognition in Swedish family with Alzheimer disease and a gene mutation
4. Turnover of amyloid betaprotein in mouse brain and acute reduction of its level by phorbol ester
5. In vivo regulation of amyloid precursor protein secretion in rat neocortex by cholinergic activity
6. Immunotoxin-induced cortical cholinergic denervation leads to vascular beta-amyloid deposition: A model of cerebral amyloid angiopathy
7. Cognitive changes and modified processing of amyloid precursor protein in the cortical and hippocampal system after cholinergic synapse loss and muscarinic receptor activation
8. Activation of M1-muscarinic acetylcholine receptor regulates tau phosphorylation in transfected PC12 cells
9. Muscarinic agonists reduce tau phosphorylation in transfected cells and in neurons
10. Site-specific dephosphorylation of tau in apolipoprotein E-deficient and control mice by M1 muscarinic agonist treatment
11. M1 muscarinic agonist treatment reverses cognitive and cholinergic impairments of apolipoprotein E-deficient mice
12. The effects of the acetylcholinesterase inhibitor ENA713 and the M1 agonist AF150(S) on apolipoprotein E deficient mice