Pharmacokinetic behavior of huperzine A in plasma and cerebrospinal fluid after intranasal administration in rats

Biopharmaceutics and Drug Disposition

Volumn 30, Issue 9, 2009, Pages 551-555

  Wang, Qiao ^a   Chen, Guoshen ^a  

^a INSTITUTE OF MATERIA MEDICA   (China)

Author keywords

Cerebrospinal fluid; Huperzine A; Intranasal administration; Pharmacokinetic; Plasma

Indexed keywords

HUPERZINE A;

ANIMAL EXPERIMENT; AREA UNDER THE CURVE; ARTICLE; BLOOD ANALYSIS; BLOOD LEVEL; BLOOD SAMPLING; BONE MARROW BIOPSY; CEREBROSPINAL FLUID ANALYSIS; CONTROLLED STUDY; DRUG ADMINISTRATION ROUTE; DRUG BLOOD LEVEL; DRUG TRANSPORT; DRUG UPTAKE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; MALE; NONHUMAN; OLFACTORY SYSTEM; PUNCTURE; RAT; STEREOTACTIC PROCEDURE; TANDEM MASS SPECTROMETRY;

ADMINISTRATION, INTRANASAL; ANIMALS; AREA UNDER CURVE; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; INFUSIONS, INTRAVENOUS; MALE; MASS SPECTROMETRY; NEUROPROTECTIVE AGENTS; RATS; RATS, SPRAGUE-DAWLEY; SESQUITERPENES; TISSUE DISTRIBUTION;

EID: 73349120649     PISSN: 01422782     EISSN: 1099081X     Source Type: Journal    
DOI: 10.1002/bdd.686     Document Type: Article

References (24)

1. Illum L. Nasal drug delivery-possibilities, problems and solutions. J Control Rel 2003; 87: 187-198.
2. Illum L. Transport of drugs from the nasal cavity to the central nervous system. Eur J Pharm Sci 2000; 11: 1-18.
3. Zhu XZ, Li XY, Liu J. Recent pharmacological studies on natural products in China. Eur J Pharmacol 2004; 500: 221-230.
4. Wang ZF, Tang LL, Yan H, Wang YJ, Tang XC. Effects of huperzine A on memory deficits and neurotrophic factors production after transient cerebral ischemia and reperfusion in mice. Pharmacol Biochem Behav 2006; 83: 603-611.
5. Wang D, Gao Y, Yun L. Study on brain targeting of raltitrexed following intranasal administration in rats. Cancer Chemother Pharmacol 2006; 57: 97-104.
6. Zhang ZX, Wang XD, Chen QT, Shu L, Wang JZ, Shan GL. Clinical efficacy and safety of huperzine A in treatment of mild to moderate Alzheimer disease, a placebo-controlled, double-blind, randomized trial. Nat Med J China 2002; 82: 941-944.
7. Sun QQ, Xu SS, Pan JL, Guo HM, Cao WQ. Huperzine-A capsules enhance memory and learning performance in 34 pairs of matched adolescent students. Acta Pharmacol Sin 1999; 20: 601-603.
8. Zhang HY, Yan H, Tang XC. Non-cholinergic effects of huperzine A: beyond inhibition of acetylcholinesterase. Cell Mol Neurobiol 2008; 28: 173-183.
9. Gordon RK, Haigh JR, Garcia GE, Feaster SR, Riel MA, Lenz DE, Aisen PS, Doctor BP. Oral administration of pyridostigmine bromide and huperzine A protect S human whole blood cholinesterases from ex vivo exposure to soman. Chem Biol Interact 2005; 157-158: 239-246.
10. Jiang H, Luo X, Bai D. Progress in clinical, pharmacological, chemical and structural biological studies of huperzine A: a drug of traditional Chinese medicine origin for the treatment of Alzheimer's disease. Curr Med Chem 2003; 10: 2231-2252.
11. Ma XC, Xin J, Wang HX, Zhang T, Tu ZH. Acute effects of huperzine A and tacrine on rat liver. Acta Pharmacol Sin 2003; 24: 247-250.
12. Chu D, Liu W, Li Y, Li P, Gu J, Liu K. Pharmacokinetics of huperzine A in dogs following single intravenous and oral administrations. Planta Med 2006; 72: 552-555.
13. Tao T, Zhao Y, Yue P, Dong W, Chen Q. Preparation of huperzine A nasal in situ gel and evaluation of its brain targeting following intranasal administration. Acta Pharm Sin 2006; 41: 1104-1110.
14. Zhao Y, Yue P, Tao T, Chen Q. Drug brain distribution following intranasal administration of huperzine A in situ gel in rats. Acta Pharm Sin 2007; 28: 273-278.
15. Yue P, Tao T, Zhao Y, Ren J, Chai X. Huperzine A in rat plasma and CSF following intranasal administration. Int J Pharm 2007; 337: 127-132.
16. Wang Q, Chen GS, Zeng S. Pharmacokinetics of Gastrodin in rat plasma and CSF after i.n. and i.v.. Int J Pharm 2007; 341: 20-25.
17. Van den Berg MP, Romeijn SG, Verhoef JC, Merkus FW. Serial cerebrospinal fluid sampling in a rat model to study drug uptake from the nasal cavity. J Neuosci Meth 2002; 116: 99-107.
18. Van den Berg MP, Verhoef JC, Romeijn SG, Merkus FW. Uptake of estradiol or progesterone into the CSF following intranasal and intravenous delivery in rats. Eur J Pharm Biopharm 2004; 58: 131-135.
19. Shi Z, Zhang Q, Jiang X. Pharmacokinetic behavior in plasma, cerebrospinal fluid and cerebral cortex after intranasal administration of hydrochloride meptazinol. Life Sci 2005; 77: 2574-2583.
20. Pan J, Wang Q, Shao Q, Cheng Y, Qu H. Development and validation of a column-switching LC-ESI-MS assay for determination of huperzine A in rat plasma and cerebrospinal fluid. Chromatographia 2009; 69: 445-451.
21. Tao T, Zhao Y, Chen QH. Determination of dissociation constant, apparent solubility and apparent partition coefficient of huperzine A. Chin J Pharm 2005; 36: 487-489.
22. Wang Q, Chen GS. Determination of huperzine A in rat plasma and brain tissue by HPLC method. Chin J New Drugs 2009; 18: 91-94.
23. Zhang L, Zhang J,Wang L, Xia H. Ocular pharmacokinetics and availability of topically applied baicalein in rabbits. Curr Eye Res 2009; 34: 257-263.
24. Yu S, Zhao Y, Wu F, Zhang X, Lü W, Zhang H, Zhang Q. Nasal insulin delivery in the chitosan solution: in vitro and in vivo studies. Int J Pharm 2004; 281: 11-23.