Biodegradable nanoparticles containing doxorubicin-PLGA conjugate for sustained release

Pharmaceutical Research

Volumn 16, Issue 7, 1999, Pages 1114-1118

  Yoo, Hyuk Sang ^a   Oh, Jong Eun ^b   Lee, Keun Hyeung ^b   Park, Tae Gwan ^a  

^a Korea Advanced Institute of Science and Technology (KAIST)   (South Korea)

^b Mogam Biotechnology Research Institute   (South Korea)

Author keywords

Conjugation; Doxorubicin; Nanoparticles; Poly(lactic co glycolic acid); Sustained release

Indexed keywords

DOXORUBICIN; NANOPARTICLE; POLYGLACTIN;

ARTICLE; BIODEGRADATION; CONTROLLED STUDY; CYTOTOXICITY; DRUG CONJUGATION; DRUG DEGRADATION; DRUG FORMULATION; DRUG MANUFACTURE; DRUG SOLUBILITY; HUMAN; HUMAN CELL; HYDROPHOBICITY; PRIORITY JOURNAL; SUSTAINED RELEASE PREPARATION;

ANTINEOPLASTIC AGENTS; BIOCOMPATIBLE MATERIALS; CHEMISTRY, PHARMACEUTICAL; DELAYED-ACTION PREPARATIONS; DIFFUSION; DOXORUBICIN; EMULSIONS; LACTIC ACID; PARTICLE SIZE; POLYGLYCOLIC ACID; POLYMERS; SOLVENTS;

EID: 0032767088     PISSN: 07248741     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1018908421434     Document Type: Article

References (19)

1. R. Duncan. Drug-polymer conjugates: potential for improved chemotherapy. Anti-cancer Drugs 3:175-210 (1992).
2. H. Maeda, M. Ueda, T. Morinaga, and T. Matsumoto. Conjugation of poly(styrene-co-maleic acid) derivatives to the antitumor protein neocarzinostatin: pronounced improvements in pharmacological properties. J. Med. Chem. 28:455-461 (1985).
3. T. Minko, P. Kopeckova, V. Pozharov, and J. Kopecek. HPMA copolmer bound adriamycin overcomes MDRI gene encoded resistance in a human ovarian carcinoma cell line. J. Contr. Rel. 54:223-233 (1998).
4. H. Maeda and Y. Matsumura. Tumoritropic and lymphotropic principles of macromolecular drugs. CRC Crit. Rev. Ther. Drug Carrier Sys. 6:193-210 (1989).
5. L. W. Seymour. Passive tumor targeting of soluble macromolecules and drug conjugates. CRC Crit. Rev. Ther. Drug Carrier Sys. 9:132-187 (1992).
6. V. Omelyanenko, P. Kopeckova, C. Gentry, and J. Kopecek. Targetable HPMA copolymer-adriamycin conjugates. Recognition, internalization, and subcellular fate. J. Contr. Rel. 53:25-37 (1998).
7. M. Yokoyama, G. S. Kwon, T. Okano, Y. Sakurai, T. Seto, and K. Kataoka. Preparation of micelle-forming polymer-drug conjugates. Bioconjugate Chem. 3:295-301 (1992).
8. J. Leroux, E. Doelker, and R. Gurny. Microencapsulation: Methods and Industrial Applications, S. Benita Ed., Marcel Dekker, New York, 535-576 (1996).
9. P. Couvreur and C. Vauthier. Polyalkylcyanoacrylate nanoparticles as drug carrier: present state and perspectives. J. Contr. Rel. 17:187-198 (1991).
10. Y. Morimoto, K. Sugibayashi, and Y. Kato. A antitumor effect of microsphere-entrapped adriamycin of liver metastasis of AH 7974 cells in rats. Chem. Pharm. Bull. 29:1433-1439 (1981).
11. A. A. Gabizon, Y. Barenholz, and M. Bialer. Prolongation of the circulation time of doxorubicin encapsulated in liposomes containing a polyethylene glycol-derivatized phospholipid: pharmacokinetic studies in rodents and dogs. Pharm. Res. 10:703-708 (1993).
12. K. Yachi, H. Kikuchi, N. Suzuki, R. Atsumi, M. Aonuma, and Y. Kawato. Pharmaceutical and biological properties of doxorubicin encapsulated in liposomes (L-ADM): the effect of repeated administration on the systemic phagocytic activity and pharmacokinetics. Biopharm. Drug Dispos. 16:653-667 (1995).
13. J. E. Oh, Y. S. Nam, K. H. Lee, and T. G. Park. Conjugation of drug to poly(D,L-lactic co-glycolic acid) for controlled release from biodegradable microspheres. J. Contr. Rel. 57:269-280 (1999).
14. H. Fessi, F. Puisieux, J. P. Devissaguet, N. Ammoury, and S. Benita. Nanocapsule formation by interfacial polymer deposition following solvent displacement. Int. J. Pharm. 55:R1-R4 (1989).
15. R. I. Freshney. Measurement of Viability and Cytotoxicity, Chapter 19 in Culture of Animal Cells, Third Edition., Wiley-Liss Inc., New York, 1994, pp. 287-307.
16. J. Kreuter. Nanoparticle-based drug delivery systems. J. Contr. Rel. 16:169-171 (1991).
17. T. G. Park. Degradation of poly(D,L-lactic)microsphere: effect of molecular weight. J. Contr. Rel. 30:161-173 (1994).
18. A. M. Reed and D. K. Gilding. Biodegradable polymers for use in surgery-poly(glycolci)/poly(lactic acid) homo and copolymers. 2. In vitro degradation, Polymer 22:494-498 (1981).
19. E. B. Yang, W. Y. Tang, K. Zhang, L. Y. Cheng, and P. O. Mack. Norcantharidin inhibits growth of human HepG2 cell-transplanted tumor in nude mice and prolongs host survival. Cancer Letter 117:93-98 (1997).