Knockdown of cytochrome P450 2E1 inhibits oxidative stress and apoptosis in the cTnTR141W dilated cardiomyopathy transgenic mice

Hypertension

Volumn 60, Issue 1, 2012, Pages 81-89

  Lu, Dan ^a   Ma, Yuanwu ^a   Zhang, Wei ^a   Bao, Dan ^a   Dong, Wei ^a   Lian, Hong ^a   Huang, Lan ^b   Zhang, Lianfeng ^a,b  

^a BEIJING HOSPITAL   (China)

^b PEKING UNION MEDICAL COLLEGE   (China)

Author keywords

Apoptosis; CYP2E1; Dilated cardiomyopathy; Oxidative stress; Silence

Indexed keywords

CASPASE 3; CASPASE 9; CYTOCHROME C; CYTOCHROME P450 2E1; DOXORUBICIN; GLUTATHIONE; HYDROGEN PEROXIDE; MALONALDEHYDE; MYOSIN HEAVY CHAIN ALPHA; TROPONIN T;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CONGESTIVE CARDIOMYOPATHY; CONTROLLED STUDY; ECHOCARDIOGRAPHY; ENZYME ACTIVATION; FIBROSING ALVEOLITIS; GENE OVEREXPRESSION; GENE SILENCING; HEART MUSCLE; MITOCHONDRION; MOUSE; MUSCLE FIBRIL; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN EXPRESSION; UPREGULATION; AMINO ACID SUBSTITUTION; ANIMAL; C57BL MOUSE; CELL STRAIN HEK293; CHEMICALLY INDUCED DISORDER; ECHOGRAPHY; GENETICS; HEART MITOCHONDRION; HEART VENTRICLE; HUMAN; IMMUNOBLOTTING; KAPLAN MEIER METHOD; METABOLISM; PATHOLOGY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA INTERFERENCE; SECRETION; TRANSGENIC MOUSE; TRANSMISSION ELECTRON MICROSCOPY; ULTRASTRUCTURE;

AMINO ACID SUBSTITUTION; ANIMALS; APOPTOSIS; CARDIOMYOPATHY, DILATED; CYTOCHROME P-450 CYP2E1; CYTOCHROMES C; DOXORUBICIN; ECHOCARDIOGRAPHY; GLUTATHIONE; HEART VENTRICLES; HEK293 CELLS; HUMANS; HYDROGEN PEROXIDE; IMMUNOBLOTTING; KAPLAN-MEIER ESTIMATE; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; MICROSCOPY, ELECTRON, TRANSMISSION; MITOCHONDRIA, HEART; MYOCARDIUM; OXIDATIVE STRESS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA INTERFERENCE; TROPONIN T;

EID: 84865815025     PISSN: 0194911X     EISSN: 15244563     Source Type: Journal    
DOI: 10.1161/HYPERTENSIONAHA.112.191478     Document Type: Article

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