Chronic hypoxia suppresses pregnancy-induced upregulation of large-conductance Ca2+-activated K+ channel activity in uterine arteries

Hypertension

Volumn 60, Issue 1, 2012, Pages 214-222

  Hu, Xiang Qun ^a   Xiao, Daliao ^a   Zhu, Ronghui ^a   Huang, Xiaohui ^a   Yang, Shumei ^b   Wilson, Sean M ^a   Zhang, Lubo ^a  

^a LOMA LINDA UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b CALIFORNIA STATE UNIVERSITY   (United States)

Author keywords

BKCa channel; Hypoxia; Myogenic tone; Pregnancy; Steroids; Uterine artery

Indexed keywords

LARGE CONDUCTANCE CALCIUM ACTIVATED POTASSIUM CHANNEL; LARGE CONDUCTANCE CALCIUM ACTIVATED POTASSIUM CHANNEL BETA SUBUNIT; LARGE CONDUCTANCE CALCIUM ACTIVATED POTASSIUM CHANNEL BETA1 SUBUNIT; PROTEIN KINASE C; UNCLASSIFIED DRUG; 4 AMINOPYRIDINE; ESTRADIOL; IBERIOTOXIN; PEPTIDE; PHORBOL DIBUTYRATE; POTASSIUM CHANNEL BLOCKING AGENT; PROGESTERONE; TETRYLAMMONIUM;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTERY TONE; ARTICLE; CHANNEL GATING; CHRONIC DISEASE; CHRONIC HYPOXIA; CONTROLLED STUDY; DOWN REGULATION; ELECTRIC CURRENT; ENZYME INHIBITION; FEMALE; HYPOXIA; NONHUMAN; PREGNANCY; PRIORITY JOURNAL; PROTEIN FUNCTION; SHEEP; UPREGULATION; UTERINE ARTERY; ACCLIMATIZATION; ALTITUDE; ANIMAL; ANOXIA; CELL CULTURE; CELL MEMBRANE POTENTIAL; CYTOLOGY; DRUG ANTAGONISM; DRUG EFFECT; IN VITRO STUDY; METABOLISM; MUSCLE CELL; PATHOPHYSIOLOGY; PHYSIOLOGY; TIME; VASOCONSTRICTION; WESTERN BLOTTING;

4-AMINOPYRIDINE; ACCLIMATIZATION; ALTITUDE; ANIMALS; ANOXIA; BLOTTING, WESTERN; CELLS, CULTURED; CHRONIC DISEASE; ESTRADIOL; FEMALE; LARGE-CONDUCTANCE CALCIUM-ACTIVATED POTASSIUM CHANNEL BETA SUBUNITS; MEMBRANE POTENTIALS; MUSCLE CELLS; PEPTIDES; PHORBOL 12,13-DIBUTYRATE; POTASSIUM CHANNEL BLOCKERS; PREGNANCY; PROGESTERONE; PROTEIN KINASE C; SHEEP; TETRAETHYLAMMONIUM; TIME FACTORS; UP-REGULATION; UTERINE ARTERY; VASOCONSTRICTION;

EID: 84865805749     PISSN: 0194911X     EISSN: 15244563     Source Type: Journal    
DOI: 10.1161/HYPERTENSIONAHA.112.196097     Document Type: Article

References (56)

1. Osol G, Mandala M. Maternal uterine vascular remodeling during pregnancy. Physiology (Bethesda). 2009;24:58-71.
2. Ni Y, May V, Braas K, Osol G. Pregnancy augments uteroplacental vascular endothelial growth factor gene expression and vasodilator effects. Am J Physiol. 1997;273:H938-H944.
3. Nelson SH, Steinsland OS, Suresh MS, Lee NM. Pregnancy augments nitric oxide-dependent dilator response to acetylcholine in the human uterine artery. Hum Reprod. 1998;13:1361-1367.
4. Gangula PR, Zhao H, Supowit S, Wimalawansa S, Di Pette D, Yallampalli C. Pregnancy and steroid hormones enhance the vasodilation responses to CGRP in rats. Am J Physiol. 1999;276:H284-H288.
5. 2+. Am J Physiol Heart Circ Physiol. 2001;281:H183-H190.
6. Weiner C, Liu KZ, Thompson L, Herrig J, Chestnut D. Effect of pregnancy on endothelium and smooth muscle: their role in reduced adrenergic sensitivity. Am J Physiol. 1991;261:H1275-H1283.
7. Nelson SH, Steinsland OS, Johnson RL, Suresh MS, Gifford A, Ehardt JS. Pregnancy-induced alterations of neurogenic constriction and dilation of human uterine artery. Am J Physiol. 1995;268:H1694-H1701.
8. Cooke CL, Davidge ST. Pregnancy-induced alterations of vascular function in mouse mesenteric and uterine arteries. Biol Reprod. 2003;68:1072-1077.
9. Gandley RE, Conrad KP, McLaughlin MK. Endothelin and nitric oxide mediate reduced myogenic reactivity of small renal arteries from pregnant rats. Am J Physiol Regul Integr Comp Physiol. 2001;280:R1-R7.
10. Veerareddy S, Cooke CL, Baker PN, Davidge ST. Vascular adaptations to pregnancy in mice: effects on myogenic tone. Am J Physiol Heart Circ Physiol. 2002;283:H2226-H2233.
11. Xiao D, Buchholz JN, Zhang L. Pregnancy attenuates uterine artery pressure-dependent vascular tone: role of PKC/ERK pathway. Am J Physiol Heart Circ Physiol. 2006;290:H2337-H2343.
12. + channel activity and attenuates myogenic tone in uterine arteries. Hypertension. 2011;58:1132-1139.
13. Chang K, Xiao D, Huang X, Longo LD, Zhang L. Chronic hypoxia increases pressure-dependent myogenic tone of the uterine artery in pregnant sheep: role of ERK/PKC pathway. Am J Physiol Heart Circ Physiol. 2009;296:H1840-H1849.
14. Zamudio S, Palmer SK, Droma T, Stamm E, Coffin C, Moore LG. Effect of altitude on uterine artery blood flow during normal pregnancy. J Appl Physiol. 1995;79:7-14.
15. Julian CG, Galan HL, Wilson MJ, Desilva W, Cioffi-Ragan D, Schwartz J, Moore LG. Lower uterine artery blood flow and higher endothelin relative to nitric oxide metabolite levels are associated with reductions in birth weight at high altitude. Am J Physiol Regul Integr Comp Physiol. 2008;295:R906-R915.
16. Zamudio S, Palmer SK, Dahms TE, Berman JC, Young DA, Moore LG. Alterations in uteroplacental blood flow precede hypertension in preeclampsia at high altitude. J Appl Physiol. 1995;79:15-22.
17. Palmer SK, Moore LG, Young D, Cregger B, Berman JC, Zamudio S. Altered blood pressure course during normal pregnancy and increased preeclampsia at high altitude (3100 meters) in Colorado. Am J Obstet Gynecol. 1999;180:1161-1168.
18. Khalil RA, Granger JP. Vascular mechanisms of increased arterial pressure in preeclampsia: lessons from animal models. Am J Physiol Regul Integr Comp Physiol. 2002;283:R29-R45.
19. George EM, Granger JP. Mechanisms and potential therapies for preeclampsia. Curr Hypertens Rep. 2011;13:269-275.
20. Moore LG, Charles SM, Julian CG. Humans at high altitude: hypoxia and fetal growth. Respir Physiol Neurobiol. 2011;178:181-190.
21. Ca) and arteriolar myogenic signaling. FEBS Lett. 2010;584:2033-2042.
22. Brayden JE, Nelson MT. Regulation of arterial tone by activation of calcium-dependent potassium channels. Science. 1992;256:532-535.
23. Brenner R, Perez GJ, Bonev AD, Eckman DM, Kosek JC, Wiler SW, Patterson AJ, Nelson MT, Aldrich RW. Vasoregulation by the β1 subunit of the calcium-activated potassium channel. Nature. 2000;407:870-876.
24. 2+ spark/STOC coupling and elevated blood pressure. Circ Res. 2000;87:E53-E60.
25. Sausbier M, Arntz C, Bucurenciu I, Zhao H, Zhou XB, Sausbier U, Feil S, Kamm S, Essin K, Sailer CA, Abdullah U, Krippeit-Drews P, Feil R, Hofmann F, Knaus HG, Kenyon C, Shipston MJ, Storm JF, Neuhuber W, Korth M, Schubert R, Gollasch M, Ruth P. Elevated blood pressure linked to primary hyperaldosteronism and impaired vasodilation in BK channeldeficient mice. Circulation. 2005;112:60-68.
26. + channels modulate basal and E2β-induced rises in uterine blood flow in ovine pregnancy. Am J Physiol Heart Circ Physiol. 2001;281:H422-H431.
27. + channels regulate basal uteroplacental blood flow in ovine pregnancy. J Soc Gynecol Investig. 2005;12:402-408.
28. + channel and cGMP-dependent signaling pathway in uterine vascular smooth muscle. Am J Physiol Heart Circ Physiol. 2009;296:H1878-H1887.
29. + channels in the remission phase of pulmonary hypertension in chronic obstructive pulmonary diseases. Cardiovasc Res. 2003;60:326-336.
30. + channel β1-subunit and altered vasoregulation in hypoxia. Circulation. 2005;112:1309-1315.
31. + channel currents in rat cerebral arterial muscle cells. Am J Physiol Heart Circ Physiol. 2008;294:H107-H120.
32. Chang K, Xiao D, Huang X, Xue Z, Yang S, Longo LD, Zhang L. Chronic hypoxia inhibits sex steroid hormone-mediated attenuation of ovine uterine arterial myogenic tone in pregnancy. Hypertension. 2010;56:750-757.
33. Xiao D, Huang X, Yang S, Zhang L. Direct chronic effect of steroid hormones in attenuating uterine arterial myogenic tone: role of protein kinase c/extracellular signal-regulated kinase 1/2. Hypertension. 2009;54:352-358.
34. Catchpole HR. Hormonal mechanisms in pregnancy and parturition. In: Cole HH, Cupps PT, eds. Reproduction in Domestic Animals. 3rd ed. New York, NY: Academic Press; 1977.
35. Nelson MT, Quayle JM. Physiological roles and properties of potassium channels in arterial smooth muscle. Am J Physiol. 1995;268:C799-C822.
36. White MM, Zhang L. Effects of chronic hypoxia on maternal vasodilation and vascular reactivity in guinea pig and ovine pregnancy. High Alt Med Biol. 2003;4:157-169.
37. Broughton BR, Walker BR, Resta TC. Chronic hypoxia induces Rho kinase-dependent myogenic tone in small pulmonary arteries. Am J Physiol Lung Cell Mol Physiol. 2008;294:L797-L806.
38. Yang XR, Lin AH, Hughes JM, Flavahan NA, Cao YN, Liedtke W, Sham JS. Upregulation of osmo-mechanosensitive TRPV4 channel facilitates chronic hypoxia induced myogenic tone and pulmonary hypertension. Am J Physiol Lung Cell Mol Physiol. 2011;302:L555-L568.
39. 2+-activated potassium channels by retaining the gating in the bursting states. J Gen Physiol. 1999;113:425-440.
40. 2+ sensitivity. J Gen Physiol. 2000;116:411-432.
41. 2+ sparks underlies hyporeactivity of arterial smooth muscle in shock. Circ Res. 2007;101:493-502.
42. Amberg GC, Santana LF. Downregulation of the BK channel β1 subunit in genetic hypertension. Circ Res. 2003;93:965-971.
43. + channels in vascular smooth muscle during hypertension. J Clin Invest. 2003;112:717-724.
44. Platoshyn O, Yu Y, Golovina VA, McDaniel SS, Krick S, Li L, Wang JY, Rubin LJ, Yuan JX. Chronic hypoxia decreases KV channel expression and function in pulmonary artery myocytes. Am J Physiol Lung Cell Mol Physiol. 2001;280:L801-L812.
45. Koritzinsky M, Magagnin MG, van den BT, Seigneuric R, Savelkouls K, Dostie J, Pyronnet S, Kaufman RJ, Weppler SA, Voncken JW, Lambin P, Koumenis C, Sonenberg N, Wouters BG. Gene expression during acute and prolonged hypoxia is regulated by distinct mechanisms of translational control. EMBO J. 2006;25:1114-1125.
46. Simon MC, Liu L, Barnhart BC, Young RM. Hypoxia-induced signaling in the cardiovascular system. Annu Rev Physiol. 2008;70:51-71.
47. 2+ spark frequency in smooth muscle cells from cerebral arteries. Am J Physiol. 1997;273:C2090-C2095.
48. Schubert R, Noack T, Serebryakov VN. Protein kinase C reduces the KCa current of rat tail artery smooth muscle cells. Am J Physiol. 1999;276:C648-C658.
49. + channels in cultured rat mesenteric artery smooth muscle cells. Biol Pharm Bull. 2000;23:1450-1454.
50. Ca channel activity in pulmonary arterial smooth muscle. Am J Physiol Lung Cell Mol Physiol. 2004;286:L149-L155.
51. + currents in pulmonary arterial myocytes. Am J Physiol. 1999;277:L431-L439.
52. Zhang YC, Ni W, Zhang ZK, Xu YJ. The effect of protein kinase C on voltage-gated potassium channel in pulmonary artery smooth muscle cells from rats exposed to chronic hypoxia. Chin Med J (Engl). 2004;117:19-23.
53. Yip R. Altitude and birth weight. J Pediatr. 1987;111:869-876.
54. Keyes LE, Armaza JF, Niermeyer S, Vargas E, Young DA, Moore LG Intrauterine growth restriction, preeclampsia, and intrauterine mortality at high altitude in Bolivia. Pediatr Res. 2003;54:20-25.
55. Alexander BT, Bennett WA, Khalil RA, Granger JP. Preeclampsia: linking placental ischemia with cardiovascular-renal dysfunction. News Physiol Sci. 2001;16:282-286.
56. Sholook MM, Gilbert JS, Sedeek MH, Huang M, Hester RL, Granger JP. Systemic hemodynamic and regional blood flow changes in response to chronic reductions in uterine perfusion pressure in pregnant rats. Am J Physiol Heart Circ Physiol. 2007;293:H2080-H2084.