Lower uterine artery blood flow and higher endothelin relative to nitric oxide metabolite levels are associated with reductions in birth weight at high altitude

American Journal of Physiology - Regulatory Integrative and Comparative Physiology

Volumn 295, Issue 3, 2008, Pages

  Julian, Colleen Glyde ^a,b   Galan, Henry L ^a   Wilson, Megan J ^a,b   Desilva, Wendy ^a   Cioffi Ragan, Darleen ^a   Schwartz, Joel ^a   Moore, Lorna G ^a,b  

^a UNIVERSITY OF COLORADO SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF COLORADO   (United States)

Author keywords

Fetal growth restriction; Hypoxia; Pregnancy; Small for gestational age; Uteroplacental oxygen delivery

Indexed keywords

ANGIOGENIC FACTOR; ENDOTHELIN; ENDOTHELIN 1; NITRIC OXIDE; PLACENTAL GROWTH FACTOR; PROTEIN TYROSINE KINASE; OXYGEN;

ADULT; ALTITUDE; ARTERY BLOOD FLOW; ARTERY DIAMETER; ARTICLE; DOPPLER FLOWMETRY; FEMALE; FETUS GROWTH; GESTATIONAL AGE; HUMAN; LOW BIRTH WEIGHT; MALE; METABOLITE; NEWBORN; PLACENTA CIRCULATION; PREGNANCY; PRIORITY JOURNAL; PUERPERIUM; SMALL FOR DATE INFANT; UTERINE ARTERY; BIRTH WEIGHT; FEMUR; HEAD; HISTOLOGY; INTRAUTERINE GROWTH RETARDATION; METABOLISM; PATHOPHYSIOLOGY; PHYSIOLOGY; REGRESSION ANALYSIS; UNITED STATES; UTERUS; VASCULARIZATION;

ADULT; ALTITUDE; BIRTH WEIGHT; COLORADO; ENDOTHELIN-1; FEMALE; FEMUR; FETAL GROWTH RETARDATION; HEAD; HUMANS; INFANT, NEWBORN; INFANT, SMALL FOR GESTATIONAL AGE; NITRIC OXIDE; OXYGEN; PREGNANCY; REGRESSION ANALYSIS; UTERUS;

EID: 54049086553     PISSN: 03636119     EISSN: 15221490     Source Type: Journal    
DOI: 10.1152/ajpregu.00164.2008     Document Type: Article

References (38)

1. Arslan M, Yazici G, Erdem A, Erdem M, Arslan EO, Himmetoglu O. Endothelin 1 and leptin in the pathophysiology of intrauterine growth restriction. Int J Gynaecol Obstet 84: 120-126, 2004.
2. Barker DJ. Fetal origins of cardiovascular disease. Ann Med 31: 3-6, 1999.
3. Carter A. Factors affecting gas transfer across the placenta and the oxygen supply to the fetus. J Dev Physiol 12: 305-322, 1989.
4. Clapp JF. Influence of endurance exercise and diet on human placental development and fetal growth. Placenta 27: 527-534, 2006.
5. Conrad K, Kerchner L, Mosher M. Plasma and 24-h NO(x) and cGMP during normal pregnancy and preeclampsia in women on a reduced NO(x) diet. Am J Physiol Renal Physiol 277: F48-F57, 1999.
6. Dupuis J, Stewart D, Cernacek P, Gosselin G. Human pulmonary circulation is an important site for both clearance and production of endothelin-1. Circulation 94: 1578-1584, 1996.
7. Erdem A, Erdem M, Himmetoglu O, Yildirim G, Arslan M. Maternal and fetal plasma endothelin levels in intrauterine growth restriction: relation to umbilical artery Doppler flow velocimetry. J Perinat Med 31: 52-59, 2003.
8. Furuhashi N, Kimura H, Nagae H, Yajima A. Maternal plasma endothelin levels and fetal status in normal and preeclamptic pregnancies. Gynecol Obstet Invest 39: 88-92, 1995.
9. Galan HL, Rigano S, Chyu J, Beaty B, Bozzo M, Hobbins JC, Ferrazzi E. Comparison of low- and high-altitude Doppler velocimetry in the peripheral and central circulations of normal fetuses. Am J Obstet Gynecol 183: 1158-1161, 2000.
10. Galan HL, Rigano S, Radaelli T, Cetin I, Bozzo M, Chyu J, Hobbins JC, Ferrazzi E. Reduction of subcutaneous mass, but not lean mass, in normal fetuses in Denver, Colorado. Am J Obstet Gynecol 185: 839-844, 2001.
11. Gilbert WM. Pregnancy outcomes associated with intrauterine growth restriction. Am J Obstet Gynecol 188: 1596-1599, 2003.
12. Giussani DA, Seamus P, Anstee S, Barker D. Effects of altitude versus economic status on birth weight and body shape at birth. Pediatr Res 49: 490-494, 2001.
13. Jensen GM, Moore LG. The effect of high altitude and other risk factors on birthweight: independent or interactive effects? Am J Public Health 87: 1003-1007, 1997.
14. Julian CG, Vargas E, Armaza JF, Wilson MJ, Niermeyer S, Villena M, Moore LG. High-altitude ancestry protects against hypoxia-associated reductions in fetal growth. Arch Dis Child Fetal Neonatal Ed 92: F372-F377, 2007.
15. Keyes LE, Armaza JF, Niermeyer S, Vargas E, Young D, Villena M, Moore LG. Intrauterine growth restriction, preeclampsia and intrauterine mortality at high altitude in Bolivia. Pediatr Res 54: 20-25, 2003.
16. Krampl E, Lees C, Bland JM, Dorado JE, Gonzalo M, Campbell S. Fetal biometry at 4300 m compared to sea level in Peru. Ultrasound Obstet Gynecol 16: 9-18, 2000.
17. Levine RJ, Maynard SE, Qian C, Lim KH, England LJ, Yu KF, Schisterman EF, Thadhani R, Sachs BP, Epstein FH, Sibai BM, Sukhatme VP, Karumanchi SA. Circulating angiogenic factors and the risk of preeclampsia. N Engl J Med 350: 672-683, 2004.
18. Maynard S, Min J, Merchan J, Lim K, Li J, Mondal S, Liberman T, Morgan J, Sellke F, Stillman I, Epstein F, Sukhatme V, Karumanchi S. Excess placental soluble fms-like tyrosine kinase 1 (sFlt1) may contribute to endothelial dysfunction, hypertension, and proteinuria in pre-eclampsia. J Clin Invest 111: 649-658, 2003.
19. Maynard SE, Min JY, Merchan J, Lim KH, Li J, Mondal S, Libermann TA, Morgan JP, Sellke FW, Stillman IE, Epstein FH, Sukhatme VP, Karumanchi SA. Excess placental soluble fms-like tyrosine kinase 1 (sFlt1) may contribute to endothelial dysfunction, hypertension, and proteinuria in preeclampsia. J Clin Invest 111: 649-658, 2003.
20. Moore LG, Rounds SS, Jahnigen D, Grover RF, Reeves JT. Infant birth weight is related to maternal arterial oxygenation at high altitude. J Appl Physiol 52: 695-699, 1982.
21. Morawietz HTR, Szibor M, Rueckschloss U, Schubert A, Bartling B, Darmer D, Holtz J. Regulation of endothelin system by shear stress in human endothelial cells. J Physiol: 761-770, 2000.
22. Papageorghiou A, Yu CK, Nicolaides KH. The role of uterine artery Doppler in predicting adverse pregnancy outcome. Best Pract Res Clin Obstet Gynaecol 18: 383-396, 2004.
23. Prefumo F, Bhide A, Sairam S, Penna L, Hollis B, Thilaganathan B. Effect of parity on second-trimester uterine artery Doppler flow velocity and waveforms. Ultasound Obstet Gynecol 23: 46-49, 2004.
24. Rockwell LC, Keyes LE, Moore LG. Chronic hypoxia diminishes pregnancy-associated DNA synthesis in guinea pig uteroplacental arteries. Placenta 21: 313-319, 2000.
25. Savvidou M, Yu C, Harland L, Hingorani A, Nicolaides K. Maternal serum concentration of soluble fms-like tyrosine kinase 1 and vascular endothelial growth factor in women with abnormal uterine artery Doppler and in those with fetal growth restriction. Am J Obstet Gynecol 195: 1668-1673, 2006.
26. Steiner DRS, Gonzalez NC, Wood JG. Interaction between reactive oxygen species and nitric oxide in the microvasculature response to systemic hypoxia. J Appl Physiol 93: 1411-1418, 2002.
27. Thaete LG, Dewey ER, Neerhof MG. Endothelin and the regulation of uterine and placental perfusion in hypoxia-induced fetal growth restriction. J Soc Gynecol Investig 11: 16-21, 2004.
28. Vargas M, Vargas E, Julian C, Armaza JF, Rodriguez A, Tellez W, Niermeyer S, Wilson M, Parra E, Shriver M, Moore L. Determinants of blood oxygenation during pregnancy in Andean and European residents of high altitude. Am J Physiol Regul Integr Comp Physiol 293: R1303-R1312, 2007.
29. White MM, McCullough RE, Dyckes R, Robertson AD, Moore LG. Chronic hypoxia, pregnancy, and endothelium-mediated relaxation in guinea pig uterine and thoracic arteries. Am J Physiol Heart Circ Physiol 278: H2069-H2075, 2000.
30. White MM, Zhang L. Effects of chronic hypoxia on maternal vascular changes in guinea pig and ovine pregnancy. High Alt Med Biol 4: 157-169, 2003.
31. Williams RL, Creasy RK, Cunningham GC, Hawes WE, Norris FD, Tashiro M. Fetal growth and perinatal viability in California. Obstet Gynecol 59: 624-632, 1982.
32. Wilson MJ, Lopez M, Vargas M, Julian C, Tellez W, Rodriguez A, Bingham A, Armaza JF, Niermeyer S, Shriver M, Vargas E, Moore LG. Greater uterine artery blood flow during pregnancy in multigenerational (Andean) than shorter-term (European) high-altitude residents. Am J Physiol Regul Integr Comp Physiol 293: R1313-R1324, 2007.
33. Yallampalli C, Garfield RE. Inhibition of nitric oxide synthesis in rats during pregnancy produces signs similar to those of preeclampsia. Am J Obstet Gynecol 169: 1316-1320, 1993.
34. Yip R. Altitude and birth weight. J Pediatr 111: 869-876, 1987.
35. Zamudio S, Palmer SK, Dahms TE, Berman JC, Young DA, Moore LG. Alterations in uteroplacental blood flow precede hypertension in preeclampsia at high altitude. J Appl Physiol 79: 15-22, 1995.
36. Zamudio S, Palmer SK, Droma T, Stamm E, Coffin C, Moore LG. Effect of altitude on uterine artery blood flow during normal pregnancy. J Appl Physiol 79: 7-14, 1995.
37. Zamudio S, Postigo L, Illsley N, Rodriguez C, Heredia G, Brimacombe M, Echalar L, Torricis T, Tellez W, Maldonado I, Balanza E, Alvarez T, Ameller J, Vargas E. Maternal oxygen delivery is not related to altitude- and ancestry-associated differences in human fetal growth. J Physiol 582: 883-895, 2007.
38. Zhao B, Cai J, Boulton M. Expression of placenta growth factor is regulated by both VEGF and hyperglycaemia via VEGFR-2. Molec Res 68: 239-264, 2004.