Blocking the Na+/H+ exchanger 1 with cariporide (HOE642) reduces the hypoxia-induced invasion of human tongue squamous cell carcinoma

International Journal of Oral and Maxillofacial Surgery

Volumn 41, Issue 10, 2012, Pages 1206-1210

  Lv, C ^a   Yang, X ^b   Yu, B ^a   Ma, Q ^a   Liu, Bin ^a   Liu, Yanpu ^a  

^a FOURTH MILITARY MEDICAL UNIVERSITY   (China)

^b FOURTH MILITARY MEDICAL UNIVERSITY   (China)

Author keywords

cariporide; cell invasion; human tongue squamous cell carcinoma; Na+ H+ exchanger 1; tumour microenvironment

Indexed keywords

CARIPORIDE; GELATINASE B; HYPOXIA INDUCIBLE FACTOR 1ALPHA; SODIUM PROTON EXCHANGE PROTEIN 1;

ARTICLE; CANCER CELL CULTURE; CANCER INVASION; CONTROLLED STUDY; DOWN REGULATION; DRUG MECHANISM; HUMAN; HUMAN CELL; HYPOXIA; TONGUE CARCINOMA;

ANOXIA; CARCINOMA, SQUAMOUS CELL; CATION TRANSPORT PROTEINS; DOWN-REGULATION; GUANIDINES; HUMANS; HYDROGEN-ION CONCENTRATION; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; MATRIX METALLOPROTEINASE 9; MATRIX METALLOPROTEINASE INHIBITORS; NEOPLASM INVASIVENESS; NEOPLASM METASTASIS; SODIUM-HYDROGEN ANTIPORTER; SULFONES; TONGUE NEOPLASMS; TUMOR CELLS, CULTURED; TUMOR MICROENVIRONMENT;

EID: 84865794297     PISSN: 09015027     EISSN: 13990020     Source Type: Journal    
DOI: 10.1016/j.ijom.2012.03.001     Document Type: Article

References (25)

1. A. Jemal, R. Siegel, J. Xu, and E. Ward Cancer statistics, 2010 CA Cancer J Clin 60 5 2010 277 300
2. H. Myoung, M.J. Kim, S.D. Hong, J.I. Lee, C.Y. Lim, and S.P. Hong Expression of membrane type I-matrix metalloproteinase in oral squamous cell carcinoma Cancer Lett 185 2 2002 201 209
3. F.C. Bidard, J.Y. Pierga, A. Vincent-Salomon, and M.F. Poupon A class action against the microenvironment: do cancer cells cooperate in metastasis? Cancer Metastasis Rev 27 1 2008 5 10
4. A. Williams, T. Collard, and C. Paraskeva An acidic environment leads to p53 dependent induction of apoptosis in human adenoma and carcinoma cell lines: implications for clonal selection during colorectal carcinogenesis Oncogene 18 21 1999 3199 3204
5. A. Paradiso, R.A. Cardone, A. Bellizzi, A. Bagorda, L. Guerra, and M. Tommasino The Na+-H+ exchanger-1 induces cytoskeletal changes involving reciprocal RhoA and Rac1 signaling, resulting in motility and invasion in MDA-MB-435 cells Breast Cancer Res 6 6 2004 R616 R628
6. S. Curran, and G. Murray Matrix metalloproteinases: molecular aspects of their roles in tumour invasion and metastasis Eur J Cancer 36 13 2000 1621 1630
7. T. Itoh, M. Tanioka, H. Matsuda, H. Nishimoto, T. Yoshioka, and R. Suzuki Experimental metastasis is suppressed in MMP-9-deficient mice Clin Exp Metastasis 17 2 1999 177 181
8. H. Watanabe, I. Nakanishi, K. Yamashita, T. Hayakawa, and Y. Okada Matrix metalloproteinase-9 (92 kDa gelatinase/type IV collagenase) from U937 monoblastoid cells: correlation with cellular invasion J Cell Sci 104 4 1993 991 999
9. L. Counillon, and J. Pouyssgur The expanding family of eucaryotic Na+/H+ exchangers J Biol Chem 275 1 2000 1 4
10. M.J. Boyer, and I.F. Tannock Regulation of intracellular pH in tumor cell lines: influence of microenvironmental conditions Cancer Res 52 16 1992 4441 4447
11. A. Lagana, J. Vadnais, P. Le, T. Nguyen, R. Laprade, and I. Nabi Regulation of the formation of tumor cell pseudopodia by the Na (+)/H (+) exchanger NHE1 J Cell Sci 113 20 2000 3649 3662
12. S.J. Reshkin, A. Bellizzi, V. Albarani, L. Guerra, M. Tommasino, and A. Paradiso Phosphoinositide 3-kinase is involved in the tumor-specific activation of human breast cancer cell Na+/H+ exchange, motility, and invasion induced by serum deprivation J Biol Chem 275 8 2000 5361 5369
13. X. Yang, D. Wang, W. Dong, Z. Song, and K. Dou Over-expression of Na+/H+ exchanger 1 and its clinicopathologic significance in hepatocellular carcinoma Med Oncol 27 2010 1109 1113
14. S. Pennacchietti, P. Michieli, M. Galluzzo, M. Mazzone, S. Giordano, and P.M. Comoglio Hypoxia promotes invasive growth by transcriptional activation of the met protooncogene Cancer Cell 3 4 2003 347 361
15. L.M. Postovit, M.A. Adams, G.E. Lash, J.P. Heaton, and C.H. Graham Oxygen-mediated regulation of tumor cell invasiveness J Biol Chem 277 38 2002 35730 35737
16. E. Rofstad Microenvironment-induced cancer metastasis Int J Radiat Biol 76 5 2000 589 605
17. P. Vaupel, F. Kallinowski, and P. Okunieff Blood flow, oxygen and nutrient supply, and metabolic microenvironment of human tumors: a review Cancer Res 49 23 1989 6449 6465
18. L.A. Shimoda, M. Fallon, S. Pisarcik, J. Wang, and G.L. Semenza HIF-1 regulates hypoxic induction of NHE1 expression and alkalinization of intracellular pH in pulmonary arterial myocytes Am J Physiol-Lung Cell Mol Physiol 291 5 2006 L941 L949
19. M. Kraus, and B. Wolf Implications of acidic tumor microenvironment for neoplastic growth and cancer treatment: a computer analysis Tumor Biol 17 3 1996 133 154
20. R. Martinez-Zaguilan, E.A. Seftor, R.E.B. Seftor, Y.W. Chu, R.J. Gillies, and M.J.C. Hendrix Acidic pH enhances the invasive behavior of human melanoma cells Clin Exp Metastasis 14 2 1996 176 186
21. G.L. Semenza Regulation of oxygen homeostasis by hypoxia-inducible factor 1 Physiology 24 2 2009 97 106
22. I.N. Rich, D. Worthington-White, O.A. Garden, and P. Musk Apoptosis of leukemic cells accompanies reduction in intracellular pH after targeted inhibition of the Na+/H+ exchanger Blood 95 4 2000 1427 1434
23. L.A. Liotta, and E.C. Kohn The microenvironment of the tumour-host interface Nature 411 6835 2001 375 379
24. D. Guttman, Y. Stern, T. Shpitzer, D. Ulanovski, T. Druzd, and R. Feinmesser Expression of MMP-9, TIMP-1, CD-34 and factor-8 as prognostic markers for squamous cell carcinoma of the tongue Oral Oncol 40 8 2004 798 803
25. P. Luanna Expression profile of genes regulated by activity of the Na-H exchanger NHE1 BMC Genomics 46 5 2004 1471 2164