Over-expression of Na+/H+ exchanger 1 and its clinicopathologic significance in hepatocellular carcinoma

Medical Oncology

Volumn 27, Issue 4, 2010, Pages 1109-1113

  Yang, Xuekang ^a   Wang, Desheng ^a   Dong, Wei ^a   Song, Zhenshun ^a   Dou, Kefeng ^a  

^a FOURTH MILITARY MEDICAL UNIVERSITY   (China)

Author keywords

Clinicopathological correlation; Hepatocellular carcinoma; Na+ H+ exchanger 1; Prognosis; Tumor progression

Indexed keywords

MESSENGER RNA; SODIUM PROTON EXCHANGE PROTEIN 1; TUMOR MARKER;

ADULT; AGED; ARTICLE; CANCER GROWTH; CANCER INVASION; CANCER SIZE; CANCER STAGING; CONTROLLED STUDY; CORRELATION ANALYSIS; FEMALE; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; KAPLAN MEIER METHOD; LIVER CELL CARCINOMA; MAJOR CLINICAL STUDY; MALE; METASTASIS; PRIORITY JOURNAL; PROGNOSIS; PROTEIN EXPRESSION; PROTEIN INDUCTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SURVIVAL TIME; WESTERN BLOTTING;

ADULT; AGED; AGED, 80 AND OVER; BLOTTING, WESTERN; CARCINOMA, HEPATOCELLULAR; CATION TRANSPORT PROTEINS; FEMALE; HUMANS; LIVER NEOPLASMS; MALE; MIDDLE AGED; NEOPLASM INVASIVENESS; NEOPLASM STAGING; PROGNOSIS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; SODIUM-HYDROGEN ANTIPORTER; SURVIVAL RATE; TUMOR MARKERS, BIOLOGICAL;

EID: 79951773265     PISSN: 13570560     EISSN: None     Source Type: Journal    
DOI: 10.1007/s12032-009-9343-4     Document Type: Article

References (26)

1. Poon RT, Fan ST, Wong J. Risk factors, prevention, and management of postoperative recurrence after resection of hepatocellular carcinoma. Ann Surg. 2000;232:10-24. (Pubitemid 30456545)
2. Capocaccia R, et al. Hepatocellular carcinoma: trends of incidence and survival in Europe and the United States at the end of the 20th century. Am J Gastroenterol. 2007;102:1661-70. (Pubitemid 47206702)
3. El-Serag HB. Hepatocellular carcinoma: recent trends in the United States. Gastroenterology. 2004;127:27-34.
4. Oka H, Tamori A, Kuroki T, Kobayashi K, Yamamoto S. Prospective study of alpha-fetoprotein in cirrhotic patients monitored for development of hepatocellular carcinoma. Hepatology. 1994;19:61-6.
5. Mita Y, et al. The usefulness of determining des-γ-carboxyl prothrombin by sensitive enzyme immunoassay in the early diagnosis of patients with hepatocellular carcinoma. Cancer. 1998;82:1643-8. (Pubitemid 28208912)
6. Weidner N, Semple JP, Welch WR, Folkman J. Tumor angiogenesis correlates with metastasis in invasive breast carcinoma. N Engl J Med. 1991;324:1-8.
7. Macchiarini P, Fontanini G, Hardin MJ, Squartini F, Angeletti CA. Relation of neovascularisation to metastasis of non-smalllung cancer. Lancet. 1992;340:145-6.
8. Weidner N, Carroll PR, Flax J, Blumenfeld W, Folkman J. Tumor angiogenesis correlates with metastasis in invasive prostate carcinoma. Am J Pathol. 1993;143:401-9. (Pubitemid 24058195)
9. Chambers AF, Matrisian LM. Changing views of the role of matrix metalloproteinases in metastasis. J Natl Cancer Inst. 1997;89:1260-70. (Pubitemid 27371946)
10. Duffy MJ. The role of proteolytic enzymes in cancer invasion and metastasis. Clin Exp Metastasis. 1992;10:145-55.
11. Mignatti P, Rifkin DB. Biology and biochemistry of proteinases in tumor invasion. Physiol Rev. 1993;73:161-95. (Pubitemid 23065437)
12. + exchangers. J Biol Chem. 2000;275:1-4. (Pubitemid 30038944)
13. + exchanger. Biochem J. 2007;401(3):623-31.
14. + exchanger. Can J Physiol Pharmacol. 2006;84:1081-95. (Pubitemid 46465921)
15. + exchanger family, regulates osteoclast differentiation and survival. Biochem Biophys Res Commun. 2008;369:320-6.
16. Wang DS, et al. Involvement of RhoA in progression of human hepatocellular carcinoma. J Gastroenterol Hepatol. 2007;22:1916-20.
17. Tominaga T, Barber DL. Na-H exchange acts downstream of RhoA to regulate integrin-induced cell adhesion and spreading. Mol Biol Cell. 1998;9(8):2287-303. (Pubitemid 28373640)
18. + exchanger NHE1. J Cell Sci. 2000;113(20):3649-62.
19. + exchange. J Physiol. 2005;225:225-38. (Pubitemid 41167317)
20. Huang XH, Ji GQ, Wu YH, Wan B, Yu L. LAMA4, highly expressed in human hepatocellular carcinoma from Chinese patients, is a novel marker of tumor invasion and metastasis. J Cancer Res Clin Oncol. 2008;134:705-14.
21. Gillies RJ, Raghunand N, Karczmar GS, Bhujwalla ZM. MRI of the tumor microenvironment. J Magn Reson Imaging. 2002;16:430-50. (Pubitemid 35167878)
22. + exchanger. Leuk Res. 2007;31:507-14. (Pubitemid 46198933)
23. + exchanger in metastasis. Nat Rev Cancer. 2005;5(10):786-95. (Pubitemid 41400778)
24. + exchange. J Physiol. 2005;567:225-38. (Pubitemid 41167317)
25. + exchanger-1 induces cytoskeletal changes involving reciprocal RhoA and Rac1 signaling, resulting in motility and invasion in MDA-MB-435 cells. Breast Cancer Res. 2004;6:616-28.
26. + exchanger (NHE1) creates acidic microenvironments leading to hyaluronidase-2 and cathepsin B activation and breast tumor cell invasion. J Biol Chem. 2004;279:26991-7007. (Pubitemid 38812535)