-
1
-
-
33749319703
-
Type, density, and location of immune cells within human colorectal tumors predict clinical outcome
-
DOI 10.1126/science.1129139
-
Galon J, Costes A, Sanchez-Cabo F et al (2006) Type, density, and location of immune cells within human colorectal tumors predict clinical outcome. Science 313:1960-1964 (Pubitemid 44498003)
-
(2006)
Science
, vol.313
, Issue.5795
, pp. 1960-1964
-
-
Galon, J.1
Costes, A.2
Sanchez-Cabo, F.3
Kirilovsky, A.4
Mlecnik, B.5
Lagorce-Pages, C.6
Tosolini, M.7
Camus, M.8
Berger, A.9
Wind, P.10
Zinzindohoue, F.11
Bruneval, P.12
Cugnenc, P.-H.13
Trajanoski, Z.14
Fridman, W.-H.15
Pages, F.16
-
2
-
-
79952093380
-
Histopathologic- based prognostic factors of colorectal cancers are associated with the state of the local immune reaction
-
Mlecnik B, Tosolini M, Kirilovsky A et al (2011) Histopathologic- based prognostic factors of colorectal cancers are associated with the state of the local immune reaction. J Clin Oncol 29:610-618
-
(2011)
J Clin Oncol
, vol.29
, pp. 610-618
-
-
Mlecnik, B.1
Tosolini, M.2
Kirilovsky, A.3
-
3
-
-
79956329617
-
Tumor-infiltrating cd8+ Lymphocytes predict clinical outcome in breast cancer
-
Mahmoud SM, Paish EC, Powe DG et al (2011) Tumor-infiltrating CD8+ lymphocytes predict clinical outcome in breast cancer. J Clin Oncol 29:1949-1955
-
(2011)
J Clin Oncol
, vol.29
, pp. 1949-1955
-
-
Mahmoud, S.M.1
Paish, E.C.2
Powe, D.G.3
-
4
-
-
0037448353
-
Intratumoral T cells, recurrence, and survival in epithelial ovarian cancer
-
DOI 10.1056/NEJMoa020177
-
Zhang L, Conejo-Garcia JR, Katsaros D et al (2003) Intratumoral T cells, recurrence, and survival in epithelial ovarian cancer. N Engl J Med 348:203-213 (Pubitemid 36077915)
-
(2003)
New England Journal of Medicine
, vol.348
, Issue.3
, pp. 203-213
-
-
Zhang, L.1
Conejo-Garcia, J.R.2
Katsaros, D.3
Gimotty, P.A.4
Massobrio, M.5
Regnani, G.6
Makrigiannakis, A.7
Gray, H.8
Schlienger, K.9
Liebman, M.N.10
Rubin, S.C.11
Coukos, G.12
-
5
-
-
0030425747
-
Neoplastic progression and prognosis in melanoma
-
Elder DE, Van Belle P, Elenitsas R et al (1996) Neoplastic progression and prognosis in melanoma. Semin Cutan Med Surg 15:336-348 (Pubitemid 27197972)
-
(1996)
Seminars in Cutaneous Medicine and Surgery
, vol.15
, Issue.4
, pp. 336-348
-
-
Elder, D.E.1
Van Belle, P.2
Elenitsas, R.3
Halpern, A.4
Guerry, D.5
-
6
-
-
77958006271
-
Association of gene expression profile in melanoma and survival to a dendritic cell-based vaccine
-
Gajewski TF, Zha Y, Thurner B, Schuler G (2009) Association of gene expression profile in melanoma and survival to a dendritic cell-based vaccine. J Clin Oncol 27:9002
-
(2009)
J Clin Oncol
, vol.27
, pp. 9002
-
-
Gajewski, T.F.1
Zha, Y.2
Thurner, B.3
Schuler, G.4
-
7
-
-
66149156276
-
Chemokine expression in melanoma metastases associated with cd8+ T-cell recruitment
-
Harlin H, Meng Y, Peterson AC et al (2009) Chemokine expression in melanoma metastases associated with CD8+ T-cell recruitment. Cancer Res 69:3077-3085
-
(2009)
Cancer Res
, vol.69
, pp. 3077-3085
-
-
Harlin, H.1
Meng, Y.2
Peterson, A.C.3
-
8
-
-
77958012775
-
Gene signature in melanoma associated with clinical activity: A potential clue to unlock cancer immunotherapy
-
Gajewski TF, Louahed J, Brichard VG (2010) Gene signature in melanoma associated with clinical activity: A potential clue to unlock cancer immunotherapy. Cancer J 16:399-403
-
(2010)
Cancer J
, vol.16
, pp. 399-403
-
-
Gajewski, T.F.1
Louahed, J.2
Brichard, V.G.3
-
9
-
-
79251522796
-
A single center experience with high-dose il-2 treatment for patients with advanced melanoma and pilot investigation of a novel gene expression signature as a predictor of response
-
(Abstract 9003
-
Sullivan RJ, Hoshida Y, Brunet J et al (2009) A single center experience with high-dose IL-2 treatment for patients with advanced melanoma and pilot investigation of a novel gene expression signature as a predictor of response. J Clin Oncol 27:15S (Abstract 9003
-
(2009)
J Clin Oncol
, vol.27
-
-
Sullivan, R.J.1
Hoshida, Y.2
Brunet, J.3
-
10
-
-
82155168544
-
A prospective phase ii trial exploring the association between tumor microenvironment biomarkers and clinical activity of ipilimumab in advanced melanoma
-
Hamid O, Schmidt H, Nissan A et al (2011) A prospective phase II trial exploring the association between tumor microenvironment biomarkers and clinical activity of ipilimumab in advanced melanoma. J Transl Med 9:204
-
(2011)
J Transl Med
, vol.9
, pp. 204
-
-
Hamid, O.1
Schmidt, H.2
Nissan, A.3
-
11
-
-
84865691034
-
An immune-Active tumor microenvironment favors clinical response to ipilimumab
-
Ji RR, Chasalow SD, Wang L et al (2011) An immune-Active tumor microenvironment favors clinical response to ipilimumab. Cancer Immunol Immunother
-
(2011)
Cancer Immunol Immunother
-
-
Ji, R.R.1
Chasalow, S.D.2
Wang, L.3
-
12
-
-
33745632047
-
+ T cells in a patient with malignant melanoma ascites
-
DOI 10.1007/s00262-005-0118-2
-
Harlin H, Kuna TV, Peterson AC et al (2006) Tumor progression despite massive influx of activated CD8(?) T cells in a patient with malignant melanoma ascites. Cancer Immunol Immunother 55:1185-1197 (Pubitemid 43992045)
-
(2006)
Cancer Immunology, Immunotherapy
, vol.55
, Issue.10
, pp. 1185-1197
-
-
Harlin, H.1
Kuna, T.V.2
Peterson, A.C.3
Meng, Y.4
Gajewski, T.F.5
-
13
-
-
33746214819
-
+ T cells in the circulation but not in the tumor site
-
Appay V, Jandus C, Voelter V et al (2006) New generation vaccine induces effective melanoma-specific CD8+ T cells in the circulation but not in the tumor site. J Immunol 177:1670-1678 (Pubitemid 44092503)
-
(2006)
Journal of Immunology
, vol.177
, Issue.3
, pp. 1670-1678
-
-
Appay, V.1
Jandus, C.2
Voelter, V.3
Reynard, S.4
Coupland, S.E.5
Rimoldi, D.6
Lienard, D.7
Guillaume, P.8
Krieg, A.M.9
Cerottini, J.-C.10
Romero, P.11
Leyvraz, S.12
Rufer, N.13
Speiser, D.E.14
-
14
-
-
0038181111
-
+ T cells at tumor site in spite of antitumor immunity to self-antigens in human metastatic melanoma
-
Mortarini R, Piris A, Maurichi A et al (2003) Lack of terminally differentiated tumor-specific CD8+ T cells at tumor site in spite of antitumor immunity to self-Antigens in human metastatic melanoma. Cancer Res 63:2535-2545 (Pubitemid 36605194)
-
(2003)
Cancer Research
, vol.63
, Issue.10
, pp. 2535-2545
-
-
Mortarini, R.1
Piris, A.2
Maurichi, A.3
Molla, A.4
Bersani, I.5
Bono, A.6
Bartoli, C.7
Santinami, M.8
Lombardo, C.9
Ravagnani, F.10
Cascinelli, N.11
Parmiani, G.12
Anichini, A.13
-
15
-
-
0035863298
-
254-262 in melanoma
-
Valmori D, Dutoit V, Rubio-Godoy V et al (2001) Frequent cytolytic T-cell responses to peptide MAGE-A10(254-262) in melanoma. Cancer Res 61:509-512 (Pubitemid 32128608)
-
(2001)
Cancer Research
, vol.61
, Issue.2
, pp. 509-512
-
-
Valmori, D.1
Dutoit, V.2
Rubio-Godoy, V.3
Chambaz, C.4
Lienard, D.5
Guillaume, P.6
Romero, P.7
Cerottini, J.-C.8
Rimoldi, D.9
-
16
-
-
0037811736
-
Immunization with melan-A peptide-pulsed peripheral blood mononuclear cells plus recombinant human interleukin-12 induces clinical activity and T-cell responses in advanced melanoma
-
DOI 10.1200/JCO.2003.12.144
-
Peterson AC, Harlin H, Gajewski TF (2003) Immunization with Melan-A peptide-pulsed peripheral blood mononuclear cells plus recombinant human interleukin-12 induces clinical activity and T-cell responses in advancedmelanoma. JClinOncol 21:2342-2348 (Pubitemid 46628465)
-
(2003)
Journal of Clinical Oncology
, vol.21
, Issue.12
, pp. 2342-2348
-
-
Peterson, A.C.1
Harlin, H.2
Gajewski, T.F.3
-
17
-
-
2642683198
-
Simultaneous humoral and cellular immune response against cancer-testis antigen NY-ESO-1: Definition of human histocompatibility leukocyte antigen (HLA)-A2-binding peptide epitopes
-
DOI 10.1084/jem.187.2.265
-
Jager E, Chen YT, Drijfhout JW et al (1998) Simultaneous humoral and cellular immune response against cancer-Testis antigen NY-ESO-1: definition of human histocompatibility leukocyte antigen (HLA)-A2-binding peptide epitopes. J Exp Med 187:265-270 (Pubitemid 28060443)
-
(1998)
Journal of Experimental Medicine
, vol.187
, Issue.2
, pp. 265-270
-
-
Jager, E.1
Chen, Y.-T.2
Drijfhout, J.W.3
Karbach, J.4
Ringhoffer, M.5
Jager, D.6
Arand, M.7
Wada, H.8
Noguchi, Y.9
Stockert, E.10
Old, L.J.11
Knuth, A.12
-
18
-
-
33744932670
-
Paraneoplastic Syndromes Affecting the Nervous System
-
DOI 10.1053/j.seminoncol.2006.03.008, PII S0093775406001151
-
Darnell RB, Posner JB (2006) Paraneoplastic syndromes affecting the nervous system. Semin Oncol 33:270-298 (Pubitemid 43849931)
-
(2006)
Seminars in Oncology
, vol.33
, Issue.3
, pp. 270-298
-
-
Darnell, R.B.1
Posner, J.B.2
-
19
-
-
25144483466
-
Autoantibody signatures in prostate cancer
-
DOI 10.1056/NEJMoa051931
-
Wang X, Yu J, Sreekumar A et al (2005) Autoantibody signatures in prostate cancer. N Engl J Med 353:1224-1235 (Pubitemid 41345944)
-
(2005)
New England Journal of Medicine
, vol.353
, Issue.12
, pp. 1224-1235
-
-
Wang, X.1
Yu, J.2
Sreekumar, A.3
Varambally, S.4
Shen, R.5
Giacherio, D.6
Mehra, R.7
Montie, J.E.8
Pienta, K.J.9
Sanda, M.G.10
Kantoff, P.W.11
Rubin, M.A.12
Wei, J.T.13
Ghosh, D.14
Chinnaiyan, A.M.15
-
20
-
-
34848819211
-
Failure at the effector phase: Immune barriers at the level of the melanoma tumor microenvironment
-
DOI 10.1158/1078-0432.CCR-07-0892
-
Gajewski TF (2007) Failure at the effector phase: immune barriers at the level of the melanoma tumor microenvironment. Clin Cancer Res 13:5256-5261 (Pubitemid 47510348)
-
(2007)
Clinical Cancer Research
, vol.13
, Issue.18
, pp. 5256-5261
-
-
Gajewski, T.F.1
-
21
-
-
0842325739
-
+ T Cells
-
DOI 10.1158/0008-5472.CAN-03-3259
-
Blank C, Brown I, Peterson AC et al (2004) PD-L1/B7H-1 inhibits the effector phase of tumor rejection by T cell receptor (TCR) transgenic CD8+ T cells. Cancer Res 64:1140-1145 (Pubitemid 38176921)
-
(2004)
Cancer Research
, vol.64
, Issue.3
, pp. 1140-1145
-
-
Blank, C.1
Brown, I.2
Peterson, A.C.3
Spiotto, M.4
Iwai, Y.5
Honjo, T.6
Gajewski, T.F.7
-
22
-
-
33749135271
-
+ T cell anergy and promotes tumor rejection
-
Brown IE, Blank C, Kline J et al (2006) Homeostatic proliferation as an isolated variable reverses CD8+ T cell anergy and promotes tumor rejection. J Immunol 177:4521-4529 (Pubitemid 44469783)
-
(2006)
Journal of Immunology
, vol.177
, Issue.7
, pp. 4521-4529
-
-
Brown, I.E.1
Blank, C.2
Kline, J.3
Kacha, A.K.4
Gajewski, T.F.5
-
23
-
-
49649121241
-
Homeostatic proliferation plus regulatory t-cell depletion promotes potent rejection of b16 melanoma
-
Kline J, Brown IE, Zha YY et al (2008) Homeostatic proliferation plus regulatory T-cell depletion promotes potent rejection of B16 melanoma. Clin Cancer Res 14:3156-3167
-
(2008)
Clin Cancer Res
, vol.14
, pp. 3156-3167
-
-
Kline, J.1
Brown, I.E.2
Zha, Y.Y.3
-
24
-
-
0142137237
-
Evidence for a tumoral immune resistance mechanism based on tryptophan degradation by indoleamine 2,3-dioxygenase
-
DOI 10.1038/nm934
-
Uyttenhove C, Pilotte L, Theate I et al (2003) Evidence for a tumoral immune resistance mechanism based on tryptophan degradation by indoleamine 2,3-dioxygenase. Nat Med 9:1269-1274 (Pubitemid 37279849)
-
(2003)
Nature Medicine
, vol.9
, Issue.10
, pp. 1269-1274
-
-
Uyttenhove, C.1
Pilotte, L.2
Theate, I.3
Stroobant, V.4
Colau, D.5
Parmentier, N.6
Boon, T.7
Van Den Eynde, B.J.8
-
25
-
-
80355136945
-
Host type i ifn signals are required for antitumor cd8+ T cell responses through cd8{alpha}? Dendritic cells
-
Fuertes MB, Kacha AK, Kline J et al (2011) Host type I IFN signals are required for antitumor CD8+ T cell responses through CD8{alpha}? dendritic cells. J Exp Med
-
(2011)
J Exp Med
-
-
Fuertes, M.B.1
Kacha, A.K.2
Kline, J.3
-
26
-
-
67249158956
-
Identification of a dendritic cell receptor that couples sensing of necrosis to immunity
-
Sancho D, Joffre OP, Keller AM et al (2009) Identification of a dendritic cell receptor that couples sensing of necrosis to immunity. Nature 458:899-903
-
(2009)
Nature
, vol.458
, pp. 899-903
-
-
Sancho, D.1
Joffre, O.P.2
Keller, A.M.3
-
27
-
-
80355147292
-
Type i interferon is selectively required by dendritic cells for immune rejection of tumors
-
Diamond MS, Kinder M, Matsushita H et al (2011) Type I interferon is selectively required by dendritic cells for immune rejection of tumors. J Exp Med 208:1989-2003
-
(2011)
J Exp Med
, vol.208
, pp. 1989-2003
-
-
Diamond, M.S.1
Kinder, M.2
Matsushita, H.3
-
28
-
-
56449097442
-
Batf3 deficiency reveals a critical role for cd8alpha? Dendritic cells in cytotoxic t cell immunity
-
Hildner K, Edelson BT, Purtha WE et al (2008) Batf3 deficiency reveals a critical role for CD8alpha? dendritic cells in cytotoxic T cell immunity. Science 322:1097-1100
-
(2008)
Science
, vol.322
, pp. 1097-1100
-
-
Hildner, K.1
Edelson, B.T.2
Purtha, W.E.3
-
31
-
-
45749112103
-
Tumor therapy in mice via antigen targeting to a novel, DC-restricted C-type lectin
-
DOI 10.1172/JCI34584
-
Sancho D, Mourao-Sa D, Joffre OP et al (2008) Tumor therapy in mice via antigen targeting to a novel, DC-restricted C-Type lectin. J Clin Invest 118:2098-2110 (Pubitemid 351872329)
-
(2008)
Journal of Clinical Investigation
, vol.118
, Issue.6
, pp. 2098-2110
-
-
Sancho, D.1
Mourao-Sa, D.2
Joffre, O.P.3
Schulz, O.4
Rogers, N.C.5
Pennington, D.J.6
Carlyle, J.R.7
Sousa, C.R.8
-
32
-
-
53349178089
-
Sting is an endoplasmic reticulum adaptor that facilitates innate immune signalling
-
Ishikawa H, Barber GN (2008) STING is an endoplasmic reticulum adaptor that facilitates innate immune signalling. Nature 455:674-678
-
(2008)
Nature
, vol.455
, pp. 674-678
-
-
Ishikawa, H.1
Barber, G.N.2
-
33
-
-
73949135474
-
Distinct and complementary functions of mda5 and tlr3 in poly(i:c)- mediated activation of mouse nk cells
-
McCartney S, Vermi W, Gilfillan S et al (2009) Distinct and complementary functions of MDA5 and TLR3 in poly(I:C)- mediated activation of mouse NK cells. J Exp Med 206: 2967-2976
-
(2009)
J Exp Med
, vol.206
, pp. 2967-2976
-
-
McCartney, S.1
Vermi, W.2
Gilfillan, S.3
-
35
-
-
33947663623
-
The role of the purinergic p2x7 receptor in inflammation
-
Lister MF, Sharkey J, Sawatzky DA et al (2007) The role of the purinergic P2X7 receptor in inflammation. J Inflamm (Lond) 4:5
-
(2007)
J Inflamm (Lond
, vol.4
, pp. 5
-
-
Lister, M.F.1
Sharkey, J.2
Sawatzky, D.A.3
-
36
-
-
79953758259
-
A potential role for p2x7r in allergic airway inflammation in mice and humans
-
Muller T, Vieira RP, Grimm M et al (2011) A potential role for P2X7R in allergic airway inflammation in mice and humans. Am J Respir Cell Mol Biol 44:456-464
-
(2011)
Am J Respir Cell Mol Biol
, vol.44
, pp. 456-464
-
-
Muller, T.1
Vieira, R.P.2
Grimm, M.3
-
37
-
-
34948820602
-
Toll-like receptor 4-dependent contribution of the immune system to anticancer chemotherapy and radiotherapy
-
DOI 10.1038/nm1622, PII NM1622
-
Apetoh L, Ghiringhelli F, Tesniere A et al (2007) Toll-like receptor 4-dependent contribution of the immune system to anticancer chemotherapy and radiotherapy. Nat Med 13:1050-1059 (Pubitemid 47517504)
-
(2007)
Nature Medicine
, vol.13
, Issue.9
, pp. 1050-1059
-
-
Apetoh, L.1
Ghiringhelli, F.2
Tesniere, A.3
Obeid, M.4
Ortiz, C.5
Criollo, A.6
Mignot, G.7
Maiuri, M.C.8
Ullrich, E.9
Saulnier, P.10
Yang, H.11
Amigorena, S.12
Ryffel, B.13
Barrat, F.J.14
Saftig, P.15
Levi, F.16
Lidereau, R.17
Nogues, C.18
Mira, J.-P.19
Chompret, A.20
Joulin, V.21
Clavel-Chapelon, F.22
Bourhis, J.23
Andre, F.24
Delaloge, S.25
Tursz, T.26
Kroemer, G.27
Zitvogel, L.28
more..
-
38
-
-
70350569295
-
Activation of the nlrp3 inflammasome in dendritic cells induces il-1betadependent adaptive immunity against tumors
-
Ghiringhelli F, Apetoh L, Tesniere A et al (2009) Activation of the NLRP3 inflammasome in dendritic cells induces IL-1betadependent adaptive immunity against tumors. Nat Med 15:1170- 1178
-
(2009)
Nat Med
, vol.15
, pp. 1170-1178
-
-
Ghiringhelli, F.1
Apetoh, L.2
Tesniere, A.3
-
39
-
-
34548438559
-
High serum IFN-α activity is a heritable risk factor for systemic lupus erythematosus
-
DOI 10.1038/sj.gene.6364408, PII 6364408
-
Niewold TB, Hua J, Lehman TJ et al (2007) High serum IFNalpha activity is a heritable risk factor for systemic lupus erythematosus. Genes Immun 8:492-502 (Pubitemid 47365615)
-
(2007)
Genes and Immunity
, vol.8
, Issue.6
, pp. 492-502
-
-
Niewold, T.B.1
Hua, J.2
Lehman, T.J.A.3
Harley, J.B.4
Crow, M.K.5
-
40
-
-
75749110600
-
Genetic variation at the irf7/phrf1 locus is associated with autoantibody profile and serum interferon-Alpha activity in lupus patients
-
Salloum R, Franek BS, Kariuki SN et al (2010) Genetic variation at the IRF7/PHRF1 locus is associated with autoantibody profile and serum interferon-Alpha activity in lupus patients. Arthr Rheum 62:553-561
-
(2010)
Arthr Rheum
, vol.62
, pp. 553-561
-
-
Salloum, R.1
Franek, B.S.2
Kariuki, S.N.3
|