Adenoviral CCN3/NOV gene transfer fails to mitigate liver fibrosis in an experimental bile duct ligation model because of hepatocyte apoptosis

Liver International

Volumn 32, Issue 9, 2012, Pages 1342-1353

  Borkham Kamphorst, Erawan ^a   Huss, Sebastian ^b   Van de Leur, Eddy ^a   Haas, Ute ^a   Weiskirchen, Ralf ^a  

^a UNIVERSITY HOSPITAL RWTH AACHEN   (Germany)

^b UNIVERSITY OF COLOGNE   (Germany)

Author keywords

Animal models; Apoptosis; BDL; CCN protein; CCN2 CTGF; CCN3 NOV; EMT; Hepatic stellate cells; Hepatocytes; Inflammation; Liver fibrosis

Indexed keywords

ADENOVIRUS VECTOR; ALANINE AMINOTRANSFERASE; ALPHA SMOOTH MUSCLE ACTIN; ASPARTATE AMINOTRANSFERASE; CASPASE 3; CONNECTIVE TISSUE GROWTH FACTOR; CYSTEINE RICH PROTEIN 61; FAS LIGAND; GELATINASE B; NEPHROBLASTOMA OVEREXPRESSED PROTEIN; PROTEIN BAX; PROTEIN BCL 2; PROTEIN BCL XL; PROTEIN P21; REACTIVE OXYGEN METABOLITE; STRESS ACTIVATED PROTEIN KINASE; SYNAPTOPHYSIN; TISSUE INHIBITOR OF METALLOPROTEINASE 1; TRANSCRIPTION FACTOR SLUG; TRANSFORMING GROWTH FACTOR BETA;

ALANINE AMINOTRANSFERASE BLOOD LEVEL; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; BILE DUCT LIGATION; CELL SURVIVAL; CELLULAR IMMUNITY; CONTROLLED STUDY; CYTOMEGALOVIRUS; DISEASE COURSE; DOWN REGULATION; ENZYME ACTIVATION; ENZYME SYNTHESIS; EPITHELIAL MESENCHYMAL TRANSITION; GENE SILENCING; HUMORAL IMMUNITY; IN VITRO STUDY; IN VIVO STUDY; LIVER CELL; LIVER CIRCULATION; LIVER FIBROSIS; MOUSE; NONHUMAN; PROTEIN EXPRESSION; REGULATORY T LYMPHOCYTE; VIRAL GENE DELIVERY SYSTEM;

ADENOVIRIDAE; ANIMALS; APOPTOSIS; CELLS, CULTURED; CHOLESTASIS, EXTRAHEPATIC; COMMON BILE DUCT; DISEASE MODELS, ANIMAL; DISEASE PROGRESSION; GENE EXPRESSION; GENE TRANSFER TECHNIQUES; GENETIC VECTORS; HEPATOCYTES; LIGATION; LIVER CIRRHOSIS; MICE; MICE, INBRED C57BL; NEPHROBLASTOMA OVEREXPRESSED PROTEIN; REACTIVE OXYGEN SPECIES; RNA, MESSENGER;

EID: 84865767151     PISSN: 14783223     EISSN: 14783231     Source Type: Journal    
DOI: 10.1111/j.1478-3231.2012.02837.x     Document Type: Article

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