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Volumn 26, Issue 5, 1997, Pages 1079-1092

TGF-β-mediated hepatocellular apoptosis by rat and human hepatoma cells and primary rat hepatocytes

Author keywords

Apoptosis; Hepatocytes; Hepatoma cells; TGF

Indexed keywords

ALKALINE PHOSPHATASE; HOE 33342; TRANSFORMING GROWTH FACTOR BETA;

EID: 0030982229     PISSN: 01688278     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0168-8278(97)80117-1     Document Type: Article
Times cited : (88)

References (70)
  • 1
    • 0029314729 scopus 로고
    • Transforming growth factor-beta: An overview
    • Lawrence DA. Transforming growth factor-beta: an overview. Kidney Int. 47:1995;19-23.
    • (1995) Kidney Int , vol.47 , pp. 19-23
    • Lawrence, D.A.1
  • 3
    • 0029026662 scopus 로고
    • Transforming growth factor-beta (TGF-beta): A key-role in liver fibrogenesis
    • Bedossa P, Paradis V. Transforming growth factor-beta (TGF-beta): a key-role in liver fibrogenesis. J Hepatol. 22:1995;37-42.
    • (1995) J Hepatol , vol.22 , pp. 37-42
    • Bedossa, P.1    Paradis, V.2
  • 5
    • 0028109801 scopus 로고
    • Mechanisms of disease: Transforming growth factor-beta in tissue fibrosis
    • Border WA, Noble NA. Mechanisms of disease: transforming growth factor-beta in tissue fibrosis. N Engl J Med. 331:1994;1286-1292.
    • (1994) N Engl J Med , vol.331 , pp. 1286-1292
    • Border, W.A.1    Noble, N.A.2
  • 6
    • 0000742819 scopus 로고
    • Transforming growth factor-beta mRNA increases during liver regeneration. A possible paracrine mechanism of growth regulation
    • Braun L, Mead JE, Panzica M, Mikumo R, Bell GI, Fausto N. Transforming growth factor-beta mRNA increases during liver regeneration. A possible paracrine mechanism of growth regulation. Proc Natl Acad Sci USA. 85:1988;1539-1543.
    • (1988) Proc Natl Acad Sci USA , vol.85 , pp. 1539-1543
    • Braun, L.1    Mead, J.E.2    Panzica, M.3    Mikumo, R.4    Bell, G.I.5    Fausto, N.6
  • 7
    • 0025122144 scopus 로고
    • Liver regeneration: Molecular mechanisms of growth control
    • Michalopoulos GK. Liver regeneration: molecular mechanisms of growth control. FASEB J. 4:1990;176-187.
    • (1990) FASEB J , vol.4 , pp. 176-187
    • Michalopoulos, G.K.1
  • 9
    • 0028238284 scopus 로고
    • Liver cell death - Patterns and mechanisms
    • Alison MR, Sarraf CE. Liver cell death - patterns and mechanisms. Gut. 35:1994;577-581.
    • (1994) Gut , vol.35 , pp. 577-581
    • Alison, M.R.1    Sarraf, C.E.2
  • 10
    • 0027724039 scopus 로고
    • Apoptosis and necrosis - Basic types and mechanisms of cell death
    • Buja LM, Eigenbrodt ML, Eigenbrodt EH. Apoptosis and necrosis - basic types and mechanisms of cell death. Arch Pathol Lab Med. 117:1993;1208-1214.
    • (1993) Arch Pathol Lab Med , vol.117 , pp. 1208-1214
    • Buja, L.M.1    Eigenbrodt, M.L.2    Eigenbrodt, E.H.3
  • 11
    • 0028828301 scopus 로고
    • Transforming growth factor (beta 1) increases the number of apoptotic bodies and decreases intracellular pH in isolated periportal and perivenular rat hepatocytes
    • Benedetti A, Disario A, Baroni GS, Jezequel AM. Transforming growth factor (beta 1) increases the number of apoptotic bodies and decreases intracellular pH in isolated periportal and perivenular rat hepatocytes. Hepatology. 22:1995;1488-1498.
    • (1995) Hepatology , vol.22 , pp. 1488-1498
    • Benedetti, A.1    Disario, A.2    Baroni, G.S.3    Jezequel, A.M.4
  • 17
    • 0029294613 scopus 로고
    • In situ detection of fragmented DNA (TUNEL assay) fails to discriminate among apoptosis, necrosis, and autolytic cell death: A cautionary note
    • Grasl-Kraupp B, Ruttkay-Nedecky B, Koudelka H, Bukowska K, Bursch W, Schulte-Hermann R. In situ detection of fragmented DNA (TUNEL assay) fails to discriminate among apoptosis, necrosis, and autolytic cell death: a cautionary note. Hepatology. 21:1995;1465-1468.
    • (1995) Hepatology , vol.21 , pp. 1465-1468
    • Grasl-Kraupp, B.1    Ruttkay-Nedecky, B.2    Koudelka, H.3    Bukowska, K.4    Bursch, W.5    Schulte-Hermann, R.6
  • 18
    • 0026648674 scopus 로고
    • Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation
    • Gavrieli Y, Sherman Y, Ben-Sasson SA. Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation. J Cell Biol. 119:1992;493-501.
    • (1992) J Cell Biol , vol.119 , pp. 493-501
    • Gavrieli, Y.1    Sherman, Y.2    Ben-Sasson, S.A.3
  • 19
    • 0029872142 scopus 로고    scopus 로고
    • Induction of rat liver parenchymal cell apoptosis by hepatic myofibroblasts via transforming growth factor beta
    • Gressner AM, Polzar B, Lahme B, Mannherz HG. Induction of rat liver parenchymal cell apoptosis by hepatic myofibroblasts via transforming growth factor beta. Hepatology. 23:1996;571-581.
    • (1996) Hepatology , vol.23 , pp. 571-581
    • Gressner, A.M.1    Polzar, B.2    Lahme, B.3    Mannherz, H.G.4
  • 20
    • 0026348625 scopus 로고
    • Apoptosis: molecular, mechanisms in programmed cell death
    • Fesus L, Davies PJA, Piacentini M, Apoptosis: molecular, mechanisms in programmed cell death. Eur J Cell Biol. 56:1991;170-177.
    • (1991) Eur J Cell Biol , vol.56 , pp. 170-177
    • Fesus, L.1    Davies, P.J.A.2    Piacentini, M.3
  • 21
    • 0028959114 scopus 로고
    • Transforming growth factor-beta1 (TGF-beta1) and TGF-beta1 receptors in normal, cirrhotic, and neoplastic human livers
    • Bedossa P, Peltier E, Terris B, Franco D, Poynard T. Transforming growth factor-beta1 (TGF-beta1) and TGF-beta1 receptors in normal, cirrhotic, and neoplastic human livers. Hepatology. 21:1995;760-766.
    • (1995) Hepatology , vol.21 , pp. 760-766
    • Bedossa, P.1    Peltier, E.2    Terris, B.3    Franco, D.4    Poynard, T.5
  • 23
    • 0029159792 scopus 로고
    • Cell-specific expression of transforming growth factor-beta in rat liver - Evidence for autocrine regulation of hepatocyte proliferation
    • Bissell DM, Wang SS, Jarnagin WR, Roll FJ. Cell-specific expression of transforming growth factor-beta in rat liver - evidence for autocrine regulation of hepatocyte proliferation. J Clin Invest. 96:1995;447-455.
    • (1995) J Clin Invest , vol.96 , pp. 447-455
    • Bissell, D.M.1    Wang, S.S.2    Jarnagin, W.R.3    Roll, F.J.4
  • 24
    • 0029887145 scopus 로고    scopus 로고
    • Transforming growth factor-beta (TGF-beta) expression in isolated and cultured rat hepatocytes
    • Chunfang Gao, Gressner G, Zoremba M, Gressner AM. Transforming growth factor-beta (TGF-beta) expression in isolated and cultured rat hepatocytes. J Cell Physiol. 167:1996;394-405.
    • (1996) J Cell Physiol , vol.167 , pp. 394-405
    • Chunfang Gao1    Gressner, G.2    Zoremba, M.3    Gressner, A.M.4
  • 25
    • 0028176887 scopus 로고
    • Alpha-Smooth muscle actin-positive perisinusoidal stromal cells in human hepatocellular carcinoma
    • Enzan H, Himeno H, Iwamura S, Saibara T, Yamamoto Y, Hara H. Alpha-Smooth muscle actin-positive perisinusoidal stromal cells in human hepatocellular carcinoma. Hepatology. 19:1994;895-903.
    • (1994) Hepatology , vol.19 , pp. 895-903
    • Enzan, H.1    Himeno, H.2    Iwamura, S.3    Saibara, T.4    Yamamoto, Y.5    Hara, H.6
  • 26
    • 0029160612 scopus 로고
    • Treatment of rat hepatocytes with transforming growth factor-beta1 increases their mitogenic activity for cultured fat storing cells
    • Gressner AM, Lahme B. Treatment of rat hepatocytes with transforming growth factor-beta1 increases their mitogenic activity for cultured fat storing cells. Int Hepatol Commun. 4:1995;94-101.
    • (1995) Int Hepatol Commun , vol.4 , pp. 94-101
    • Gressner, A.M.1    Lahme, B.2
  • 27
    • 0001811918 scopus 로고
    • Preparation of isolated rat liver cells
    • Prescott D.M. New York: Academic Press
    • Seglen PO. Preparation of isolated rat liver cells. Prescott DM. Methods in Cell Biology. 8:1987;29-83 Academic Press, New York.
    • (1987) Methods in Cell Biology , vol.8 , pp. 29-83
    • Seglen, P.O.1
  • 28
    • 84945737937 scopus 로고
    • Preventive effects of acute inflammation on liver cell necrosis and inhibition of heparan sulfate synthesis in hepatocytes
    • Gressner AM, Pfeiffer T. Preventive effects of acute inflammation on liver cell necrosis and inhibition of heparan sulfate synthesis in hepatocytes. J Clin Chem Clin Biochem. 24:1986;821-829.
    • (1986) J Clin Chem Clin Biochem , vol.24 , pp. 821-829
    • Gressner, A.M.1    Pfeiffer, T.2
  • 29
    • 0016148014 scopus 로고
    • Characterization of differentiated and dedifferentiated clones from a rat hepatoma
    • Deschatrette J, Weiss MC. Characterization of differentiated and dedifferentiated clones from a rat hepatoma. Biochimie. 56:1974;1603-1611.
    • (1974) Biochimie , vol.56 , pp. 1603-1611
    • Deschatrette, J.1    Weiss, M.C.2
  • 30
    • 0019332750 scopus 로고
    • Human hepatocellular carcinoma cell lines secrete the major plasma proteins and hepatitis B surface antigen
    • Knowles BB, Howe CC, Aden DP. Human hepatocellular carcinoma cell lines secrete the major plasma proteins and hepatitis B surface antigen. Science. 209:1980;497-499.
    • (1980) Science , vol.209 , pp. 497-499
    • Knowles, B.B.1    Howe, C.C.2    Aden, D.P.3
  • 31
    • 0017184389 scopus 로고
    • A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding
    • Bradford MM. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem. 72:1976;248-254.
    • (1976) Anal Biochem , vol.72 , pp. 248-254
    • Bradford, M.M.1
  • 32
    • 0024994691 scopus 로고
    • Physicochemical activation of recombinant latent transforming growth factor-beta's 1, 2, and 3
    • Brown PD, Wakefield LM, Levinson AD, Sporn MB. Physicochemical activation of recombinant latent transforming growth factor-beta's 1, 2, and 3. Growth Factors. 3:1990;35-43.
    • (1990) Growth Factors , vol.3 , pp. 35-43
    • Brown, P.D.1    Wakefield, L.M.2    Levinson, A.D.3    Sporn, M.B.4
  • 33
    • 0028328817 scopus 로고
    • An assay for transforming growth factor-beta using cells transfected with a plasminogen activator inhibitor-1 promoter luciferase construct
    • Abe M, Harpel JG, Metz CN, Nunes I, Loskutoff DJ, Rifkin DB. An assay for transforming growth factor-beta using cells transfected with a plasminogen activator inhibitor-1 promoter luciferase construct. Anal Biochem. 216:1994;276-284.
    • (1994) Anal Biochem , vol.216 , pp. 276-284
    • Abe, M.1    Harpel, J.G.2    Metz, C.N.3    Nunes, I.4    Loskutoff, D.J.5    Rifkin, D.B.6
  • 34
    • 0026527581 scopus 로고
    • Activation of rat liver perisinusoidal lipocytes by transforming growth factors derived from myofibroblast-like cells - A potential mechanism of self-perpetuation in liver fibrogenesis
    • Bachem MG, Meyer DM, Melchior R, Sell KM, Gressner AM. Activation of rat liver perisinusoidal lipocytes by transforming growth factors derived from myofibroblast-like cells - a potential mechanism of self-perpetuation in liver fibrogenesis. J Clin Invest. 89:1992;19-27.
    • (1992) J Clin Invest , vol.89 , pp. 19-27
    • Bachem, M.G.1    Meyer, D.M.2    Melchior, R.3    Sell, K.M.4    Gressner, A.M.5
  • 37
    • 0018850985 scopus 로고
    • A simple, rapid, and sensitive DNA assay procedure
    • Labarca C, Paigen K. A simple, rapid, and sensitive DNA assay procedure. Anal Biochem. 102:1980;344-352.
    • (1980) Anal Biochem , vol.102 , pp. 344-352
    • Labarca, C.1    Paigen, K.2
  • 38
    • 0026018805 scopus 로고
    • Heparin and hormonal regulation of mRNA synthesis and abundance of autocrine growth factors: Relevance to clonal growth of tumors
    • Zvibel I, Halay E, Reid LM. Heparin and hormonal regulation of mRNA synthesis and abundance of autocrine growth factors: relevance to clonal growth of tumors. Mol Cell Biol. 11:1991;108-116.
    • (1991) Mol Cell Biol , vol.11 , pp. 108-116
    • Zvibel, I.1    Halay, E.2    Reid, L.M.3
  • 39
    • 0027534484 scopus 로고
    • Suramin inhibits growth and yet promotes insulin-like growth factor II expression in HepG2 cells
    • Kraft A, Reid LM, Zvibel I. Suramin inhibits growth and yet promotes insulin-like growth factor II expression in HepG2 cells. Cancer Res. 53:1993;652-657.
    • (1993) Cancer Res , vol.53 , pp. 652-657
    • Kraft, A.1    Reid, L.M.2    Zvibel, I.3
  • 40
    • 0027426056 scopus 로고
    • Apoptosis is induced by transforming growth factor-beta1 within 5 hours in regressing liver without significant fragmentation of the DNA
    • Oberhammer F, Bursch W, Tiefenbacher R, Fröschl G, Pavelka M, Purchio T, Schulte-Hermann R. Apoptosis is induced by transforming growth factor-beta1 within 5 hours in regressing liver without significant fragmentation of the DNA. Hepatology. 18:1993;1238-1246.
    • (1993) Hepatology , vol.18 , pp. 1238-1246
    • Oberhammer, F.1    Bursch, W.2    Tiefenbacher, R.3    Fröschl, G.4    Pavelka, M.5    Purchio, T.6    Schulte-Hermann, R.7
  • 41
    • 0030067146 scopus 로고    scopus 로고
    • The antiandrogen cyproterone acetate induces synthesis of transforming growth factor-beta1 in the parenchymal cells of the liver accompanied by an enhanced sensitivity to undergo apoptosis and necrosis without inflammation
    • Oberhammer F, Nagy P, Tiefenbacher R, Fröschl G, Bouzahzah B, Thorgeirsson SS, Carr B. The antiandrogen cyproterone acetate induces synthesis of transforming growth factor-beta1 in the parenchymal cells of the liver accompanied by an enhanced sensitivity to undergo apoptosis and necrosis without inflammation. Hepatology. 23:1996;329-337.
    • (1996) Hepatology , vol.23 , pp. 329-337
    • Oberhammer, F.1    Nagy, P.2    Tiefenbacher, R.3    Fröschl, G.4    Bouzahzah, B.5    Thorgeirsson, S.S.6    Carr, B.7
  • 42
    • 0027968569 scopus 로고
    • Plasmin cleaves betaglycan and releases a 60 kDa transforming growth factor-beta complex from the cell surface
    • LaMarre J, Vasudevan J, Gonias SL. Plasmin cleaves betaglycan and releases a 60 kDa transforming growth factor-beta complex from the cell surface. Biochem J. 302:1994;199-205.
    • (1994) Biochem J , vol.302 , pp. 199-205
    • Lamarre, J.1    Vasudevan, J.2    Gonias, S.L.3
  • 43
    • 0023916551 scopus 로고
    • Proteolytic activation of latent transforming growth factor-beta from fibroblast-conditioned medium
    • Lyons RM, Keski-Oja J, Moses HL. Proteolytic activation of latent transforming growth factor-beta from fibroblast-conditioned medium. J Cell Biol. 106:1988;1659-1665.
    • (1988) J Cell Biol , vol.106 , pp. 1659-1665
    • Lyons, R.M.1    Keski-Oja, J.2    Moses, H.L.3
  • 44
    • 0025215307 scopus 로고
    • Mechanisms of activation of latent recombinant transforming growth factor beta-1 by plasmin
    • Lyons RM, Gentry LE, Purchio AF, Moses HL. Mechanisms of activation of latent recombinant transforming growth factor beta-1 by plasmin. J Cell Biol. 110:1990;1361-1367.
    • (1990) J Cell Biol , vol.110 , pp. 1361-1367
    • Lyons, R.M.1    Gentry, L.E.2    Purchio, A.F.3    Moses, H.L.4
  • 45
    • 0027305971 scopus 로고
    • Thrombospondin causes activation of latent transforming growth factor-beta secreted by endothelial cells by a novel mechanism
    • Schultz-Cherry S, Murphy-Ullrich JE. Thrombospondin causes activation of latent transforming growth factor-beta secreted by endothelial cells by a novel mechanism. J Cell Biol. 122:1993;923-932.
    • (1993) J Cell Biol , vol.122 , pp. 923-932
    • Schultz-Cherry, S.1    Murphy-Ullrich, J.E.2
  • 46
    • 0028138619 scopus 로고
    • The type 1 repeats of thrombospondin 1 activate latent transforming growth factor-beta
    • Schultz-Cherry S, Lawler J, Murphy-Ullrich JE. The type 1 repeats of thrombospondin 1 activate latent transforming growth factor-beta. J Biol Chem. 269:1994;26783-26788.
    • (1994) J Biol Chem , vol.269 , pp. 26783-26788
    • Schultz-Cherry, S.1    Lawler, J.2    Murphy-Ullrich, J.E.3
  • 47
    • 0026059613 scopus 로고
    • Cellular activation of latent transforming growth factor beta requires binding to the cation-independent mannose 6-phosphate/insulin-like growth factor type II receptor
    • Dennis PA, Rifkin DB. Cellular activation of latent transforming growth factor beta requires binding to the cation-independent mannose 6-phosphate/insulin-like growth factor type II receptor. Proc Natl Acad Sci USA. 88:1991;580-584.
    • (1991) Proc Natl Acad Sci USA , vol.88 , pp. 580-584
    • Dennis, P.A.1    Rifkin, D.B.2
  • 48
    • 0029048875 scopus 로고
    • Insulin-like growth factor-II/mannose 6-phosphate receptor is expressed on CCl4-exposed rat fat-storing cells and facilitates activation of latent transforming growth factor-beta in cocultures with sinusoidal endothelial cells
    • Debleser PJ, Jannes P, Buul-Offers van SC, Hoogerbrugge CM, Schravendijk van CFH, Niki T, Rogiers V, Brande van den JL, Wisse E, Geerts A. Insulin-like growth factor-II/mannose 6-phosphate receptor is expressed on CCl4-exposed rat fat-storing cells and facilitates activation of latent transforming growth factor-beta in cocultures with sinusoidal endothelial cells. Hepatology. 21:1995;1429-1437.
    • (1995) Hepatology , vol.21 , pp. 1429-1437
    • Debleser, P.J.1    Jannes, P.2    Buul-Offers Van, S.C.3    Hoogerbrugge, C.M.4    Schravendijk Van, C.F.H.5    Niki, T.6    Rogiers, V.7    Brande Van Den, J.L.8    Wisse, E.9    Geerts, A.10
  • 51
    • 0025220466 scopus 로고
    • Modulation of c-myc expression by transforming growth factor-beta1 in human hepatoma cell lines
    • Ito N, Kawata S, Tamura S, Takaishi K, Saitoh R, Tarui S. Modulation of c-myc expression by transforming growth factor-beta1 in human hepatoma cell lines. Jpn J Cancer Res. 81:1990;216-219.
    • (1990) Jpn J Cancer Res , vol.81 , pp. 216-219
    • Ito, N.1    Kawata, S.2    Tamura, S.3    Takaishi, K.4    Saitoh, R.5    Tarui, S.6
  • 52
    • 0028256266 scopus 로고
    • Characterization of apoptosis induced by transforming growth factor beta1 in human hepatoma cells
    • Chuang LY, Hung WC, Chang CC, Tsai JH. Characterization of apoptosis induced by transforming growth factor beta1 in human hepatoma cells. Anticancer Res. 14:1994;147-152.
    • (1994) Anticancer Res , vol.14 , pp. 147-152
    • Chuang, L.Y.1    Hung, W.C.2    Chang, C.C.3    Tsai, J.H.4
  • 53
    • 0026584374 scopus 로고
    • In vitro apoptosis in the human hepatoma cell line induced by transforming growth factor beta 1
    • Lin JK, Chou CK. In vitro apoptosis in the human hepatoma cell line induced by transforming growth factor beta 1. Cancer Res. 52:1992;385-388.
    • (1992) Cancer Res , vol.52 , pp. 385-388
    • Lin, J.K.1    Chou, C.K.2
  • 54
    • 0027164326 scopus 로고
    • Growth inhibition by transforming growth factor-beta (TGF-beta) type I is restored in TGF-beta-resistant hepatoma cells after expression of TGF-beta receptor type II cDNA
    • Inagaki M, Moustakas A, Lin HY, Lodish HF, Carr BI. Growth inhibition by transforming growth factor-beta (TGF-beta) type I is restored in TGF-beta-resistant hepatoma cells after expression of TGF-beta receptor type II cDNA. Proc Natl Acad Sci USA. 90:1993;5359-5363.
    • (1993) Proc Natl Acad Sci USA , vol.90 , pp. 5359-5363
    • Inagaki, M.1    Moustakas, A.2    Lin, H.Y.3    Lodish, H.F.4    Carr, B.I.5
  • 55
    • 0027679506 scopus 로고
    • Induction of apoptosis by transforming growth factor-beta1 in the rat hepatoma cell line McA-RH7777: A possible association with tissue transglutaminase expression
    • Fukuda K, Kojiro M, Chiu JF. Induction of apoptosis by transforming growth factor-beta1 in the rat hepatoma cell line McA-RH7777: a possible association with tissue transglutaminase expression. Hepatology. 18:1993;945-953.
    • (1993) Hepatology , vol.18 , pp. 945-953
    • Fukuda, K.1    Kojiro, M.2    Chiu, J.F.3
  • 56
    • 0029968187 scopus 로고    scopus 로고
    • The herbal medicine inchio-ko-to inhibits liver cell apoptosis induced by transforming growth factor-beta1
    • Yamamoto M, Ogawa K, Morita M, Fukuda K, Komatsu Y. The herbal medicine inchio-ko-to inhibits liver cell apoptosis induced by transforming growth factor-beta1. Hepatology. 23:1996;552-559.
    • (1996) Hepatology , vol.23 , pp. 552-559
    • Yamamoto, M.1    Ogawa, K.2    Morita, M.3    Fukuda, K.4    Komatsu, Y.5
  • 57
    • 0025075102 scopus 로고
    • Effects of phorbol ester on cell growth inhibition by transforming growth factor-beta1 in human hepatoma cell lines
    • Takaishi K, Kawata S, Ito N, Tamura S, Shirai Y, Tarui S. Effects of phorbol ester on cell growth inhibition by transforming growth factor-beta1 in human hepatoma cell lines. Biochem Biophys Res Commun. 171:1990;91-96.
    • (1990) Biochem Biophys Res Commun , vol.171 , pp. 91-96
    • Takaishi, K.1    Kawata, S.2    Ito, N.3    Tamura, S.4    Shirai, Y.5    Tarui, S.6
  • 58
    • 0022519967 scopus 로고
    • Differential effects of transforming growth factor-beta on proliferation of normal and malignant rat liver epithelial cells in culture
    • McMahon JB, Richards WL, Campo del AA, Song MKH, Thorgeirsson SS. Differential effects of transforming growth factor-beta on proliferation of normal and malignant rat liver epithelial cells in culture. Cancer Res. 46:1986;4665-4671.
    • (1986) Cancer Res , vol.46 , pp. 4665-4671
    • McMahon, J.B.1    Richards, W.L.2    Campo Del, A.A.3    Song, M.K.H.4    Thorgeirsson, S.S.5
  • 59
    • 0025695509 scopus 로고
    • Altered responsiveness of rat liver epithelial cells to transforming growth factor-beta1 following their transformation with v-raf
    • Huggett AC, Hampton LL, Ford CP, Wirth PJ, Thorgeirsson SS. Altered responsiveness of rat liver epithelial cells to transforming growth factor-beta1 following their transformation with v-raf. Cancer Res. 50:1990;7468-7475.
    • (1990) Cancer Res , vol.50 , pp. 7468-7475
    • Huggett, A.C.1    Hampton, L.L.2    Ford, C.P.3    Wirth, P.J.4    Thorgeirsson, S.S.5
  • 60
    • 0026352909 scopus 로고
    • Development of resistance to the growth inhibitory effects of transforming growth factor beta1 during the spontaneous transformation of rat liver epithelial cells
    • Huggett AC, Ellis PA, Ford CP, Hampton LL, Rimoldi D, Thorgeirsson SS. Development of resistance to the growth inhibitory effects of transforming growth factor beta1 during the spontaneous transformation of rat liver epithelial cells. Cancer Res. 51:1991;5929-5936.
    • (1991) Cancer Res , vol.51 , pp. 5929-5936
    • Huggett, A.C.1    Ellis, P.A.2    Ford, C.P.3    Hampton, L.L.4    Rimoldi, D.5    Thorgeirsson, S.S.6
  • 61
    • 0023657105 scopus 로고
    • Inhibition of proliferation of normal, preneoplastic, and neoplastic rat hepatocytes by transforming growth factor-beta1
    • Wollenberg GK, Semple E, Quinn BA, Hayes MA. Inhibition of proliferation of normal, preneoplastic, and neoplastic rat hepatocytes by transforming growth factor-beta1. Cancer Res. 47:1987;6595-6599.
    • (1987) Cancer Res , vol.47 , pp. 6595-6599
    • Wollenberg, G.K.1    Semple, E.2    Quinn, B.A.3    Hayes, M.A.4
  • 62
    • 0025130979 scopus 로고
    • A transforming growth factor-beta2 (TGF-beta2)-like immunosuppressive factor in amniotic fluid and localization of TGF-beta2 mRNA in the pregnant uterus
    • Altman DJ, Schneider SL, Thompson DA, Cheng HL, Tomasi TB. A transforming growth factor-beta2 (TGF-beta2)-like immunosuppressive factor in amniotic fluid and localization of TGF-beta2 mRNA in the pregnant uterus. J Exp Med. 172:1990;1391-1401.
    • (1990) J Exp Med , vol.172 , pp. 1391-1401
    • Altman, D.J.1    Schneider, S.L.2    Thompson, D.A.3    Cheng, H.L.4    Tomasi, T.B.5
  • 63
    • 0025374704 scopus 로고
    • Alpha-macroglobulin and serum preferentially counteract the mito-inhibitory effect of transforming growth factor-beta2 in rat hepatocytes
    • LaMarre J, Wollenberg GK, Gauldie J, Hayes MA. Alpha-macroglobulin and serum preferentially counteract the mito-inhibitory effect of transforming growth factor-beta2 in rat hepatocytes. Lab Invest. 62:1990;545-551.
    • (1990) Lab Invest , vol.62 , pp. 545-551
    • Lamarre, J.1    Wollenberg, G.K.2    Gauldie, J.3    Hayes, M.A.4
  • 64
    • 0025785601 scopus 로고
    • Biology of disease: Cytokine binding and clearance properties of proteinase-activated alpha2-macroglobulins
    • LaMarre J, Wollenberg GK, Gonias SL, Hayes MA. Biology of disease: cytokine binding and clearance properties of proteinase-activated alpha2-macroglobulins. Lab Invest. 65:1991;3-14.
    • (1991) Lab Invest , vol.65 , pp. 3-14
    • Lamarre, J.1    Wollenberg, G.K.2    Gonias, S.L.3    Hayes, M.A.4
  • 65
    • 0028989617 scopus 로고
    • Resistance to TGF-beta-induced elimination of transformed cells is required during tumor progression (review-hypothesis)
    • Bauer G. Resistance to TGF-beta-induced elimination of transformed cells is required during tumor progression (review-hypothesis). Intern J Oncol. 6:1995;1227-1229.
    • (1995) Intern J Oncol , vol.6 , pp. 1227-1229
    • Bauer, G.1
  • 66
    • 33746521801 scopus 로고
    • The cellular basis of hepatic fibrosis
    • Friedman SL. The cellular basis of hepatic fibrosis. N Engl J Med. 328:1993;1828-1835.
    • (1993) N Engl J Med , vol.328 , pp. 1828-1835
    • Friedman, S.L.1
  • 67
    • 0028346868 scopus 로고
    • Activation of proteoglycan synthesis in injured liver - A brief review of molecular and cellular aspects
    • Gressner AM. Activation of proteoglycan synthesis in injured liver - a brief review of molecular and cellular aspects. Eur J Clin Chem Clin Biochem. 32:1994;225-237.
    • (1994) Eur J Clin Chem Clin Biochem , vol.32 , pp. 225-237
    • Gressner, A.M.1
  • 68
    • 0029121317 scopus 로고
    • Molecular mechanisms of liver fibrogenesis - A homage to the role of activated fat-storing cells
    • Gressner AM, Bachem MG. Molecular mechanisms of liver fibrogenesis - a homage to the role of activated fat-storing cells. Digestion. 56:1995;335-346.
    • (1995) Digestion , vol.56 , pp. 335-346
    • Gressner, A.M.1    Bachem, M.G.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.