Site-directed mutagenesis study of the Ile140 in conserved hydrophobic core of Bcl-xL

Protein and Peptide Letters

Volumn 19, Issue 9, 2012, Pages 991-996

  Zhang, Xin ^a   Tan, Ying ^a   Zhao, Rui ^a   Chu, Bizhu ^a   Tan, Chunyan ^a   Jiang, Yuyang ^a,b  

^a TSINGHUA UNIVERSITY   (China)

^b Tsinghua University   (China)

Author keywords

Bad BH3; Bcl xL; Binding; Hydrophobic core; Site directed mutagenesis; Stability

Indexed keywords

BH3 PROTEIN; ISOLEUCINE; ISOLEUCINE 140; ISOLEUCINE 182; MUTANT PROTEIN; PHENYLALANINE; PHENYLALANINE 191; PROTEIN BCL XL; TRYPTOPHAN; TRYPTOPHAN 137; TRYPTOPHAN 181; TRYPTOPHAN 188; UNCLASSIFIED DRUG;

ARTICLE; BINDING AFFINITY; BINDING ASSAY; CIRCULAR DICHROISM; HYDROPHOBIC CORE; PROTEIN CONFORMATION; PROTEIN FOLDING; PROTEIN FUNCTION; PROTEIN STABILITY; PROTEIN STRUCTURE; SITE DIRECTED MUTAGENESIS;

AMINO ACID SEQUENCE; BCL-X PROTEIN; HEP G2 CELLS; HUMANS; HYDROPHOBIC AND HYDROPHILIC INTERACTIONS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; PEPTIDE FRAGMENTS; POINT MUTATION; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN STABILITY; PROTEIN UNFOLDING; PROTO-ONCOGENE PROTEINS;

EID: 84865761481     PISSN: 09298665     EISSN: None     Source Type: Journal    
DOI: 10.2174/092986612802084500     Document Type: Article

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