Spinal cannabinoid receptor type 2 agonist reduces mechanical allodynia and induces mitogen-activated protein kinase phosphatases in a rat model of neuropathic pain

Journal of Pain

Volumn 13, Issue 9, 2012, Pages 836-848

  Landry, Russell P ^a   Martinez, Elena ^a   Deleo, Joyce A ^a,b,c   Romero Sandoval, E Alfonso ^a,b  

^a DARTMOUTH HITCHCOCK MEDICAL CENTER   (United States)

^b DARTMOUTH MEDICAL SCHOOL   (United States)

^c EMMANUEL COLLEGE   (United States)

Author keywords

CB2 receptors; MAPK phosphatase; mitogen activated protein kinase (MAPK); pain; spinal cord

Indexed keywords

2 METHYL 3 (1 NAPHTHOYL) 1 PROPYLINDOLE; CANNABINOID 2 RECEPTOR AGONIST; DUAL SPECIFICITY PHOSPHATASE 6; MITOGEN ACTIVATED PROTEIN KINASE PHOSPHATASE; MITOGEN ACTIVATED PROTEIN KINASE PHOSPHATASE 1; SYNAPTOPHYSIN; TRIPTOLIDE;

ALLODYNIA; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ANTINOCICEPTION; ARTICLE; CONTROLLED STUDY; DRUG EFFECT; IN VIVO STUDY; MALE; MICROGLIA; NERVE INJURY; NEUROPATHIC PAIN; NONHUMAN; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; RAT;

4-NITROPHENYLPHOSPHATASE; ANIMALS; DISEASE MODELS, ANIMAL; DITERPENES; DUAL SPECIFICITY PHOSPHATASE 1; DUAL SPECIFICITY PHOSPHATASE 6; EPOXY COMPOUNDS; GENE EXPRESSION REGULATION; HYPERALGESIA; IMMUNOSUPPRESSIVE AGENTS; INDOLES; MALE; MITOGEN-ACTIVATED PROTEIN KINASE PHOSPHATASES; NERVE TISSUE PROTEINS; NEURALGIA; PHENANTHRENES; RATS; RATS, SPRAGUE-DAWLEY; RECEPTOR, CANNABINOID, CB2; SIGNAL TRANSDUCTION; SPINAL CORD; TIME FACTORS;

EID: 84865750181     PISSN: 15265900     EISSN: 15288447     Source Type: Journal    
DOI: 10.1016/j.jpain.2012.05.013     Document Type: Article

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