Elucidation of the molecular basis of selective recognition uncovers the interaction site for the core domain of scorpion α-toxins on sodium channels

Journal of Biological Chemistry

Volumn 286, Issue 40, 2011, Pages 35209-35217

  Gur, Maya ^a   Kahn, Roy ^a   Karbat, Izhar ^a   Regev, Noa ^a   Wang, Jinti ^b   Catterall, William A ^b   Gordon, Dalia ^a   Gurevitz, Michael ^a  

^a TEL AVIV UNIVERSITY   (Israel)

^b UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

C-TERMINAL REGIONS; HIGH SENSITIVITY; HIGHLY SENSITIVE; INTERACTION SITE; MAMMALIAN BRAIN; MOLECULAR BASIS; MOLECULAR LEVELS; PEPTIDE TOXIN; RAT BRAIN; SELECTIVE RECOGNITION; SODIUM CHANNEL; TOXIN ACTIVITY; XENOPUS OOCYTE;

MAMMALS; METABOLITES; SODIUM;

TOXIC MATERIALS;

ASPARAGINE; COMPLEMENTARY DNA; COMPLEMENTARY RNA; GLUCOSE; SCORPION VENOM; SODIUM CHANNEL; VOLTAGE GATED SODIUM CHANNEL;

ARTICLE; BINDING SITE; CARBOXY TERMINAL SEQUENCE; CHIMERA; CONTROLLED STUDY; DEPOLARIZATION; DROSOPHILA; NONHUMAN; OOCYTE; PRIORITY JOURNAL; PROTEIN DOMAIN; VOLTAGE CLAMP; XENOPUS;

AMINO ACID MOTIFS; AMINO ACID SEQUENCE; ANIMALS; BRAIN; DNA, COMPLEMENTARY; DROSOPHILA; MOLECULAR CONFORMATION; MOLECULAR SEQUENCE DATA; MUTAGENESIS; MUTATION; NEUROTOXINS; RATS; SCORPION VENOMS; SCORPIONS; SEA ANEMONES; SEQUENCE HOMOLOGY, AMINO ACID; SODIUM CHANNELS; XENOPUS;

HEXAPODA; MAMMALIA; RATTUS; SCORPIONES;

EID: 80053416574     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M111.259507     Document Type: Article

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