Comparison between in vivo mutagenicity and carcinogenicity in multiple organs by benzo[a]pyrene in the lacZ transgenic mouse (Muta(TM)Mouse)

Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis

Volumn 398, Issue 1-2, 1998, Pages 123-130

  Hakura, Atsushi ^a   Tsutsui, Yoshie ^a   Sonoda, Jiro ^a   Kai, Junko ^a   Imade, Toshio ^a   Shimada, Michiyo ^a   Sugihara, Yoshiki ^a   Mikami, Takashi ^a  

^a Drug Safety Research Laboratories   (Japan)

Author keywords

Benzo a pyrene; Carcinogenicity; In vivo mutagenicity; Muta(TM)mouse

Indexed keywords

BENZO[A]PYRENE; CARCINOGEN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CARCINOGENESIS; CARCINOGENICITY; CONTROLLED STUDY; GENE MUTATION; MOUSE; MUTAGEN TESTING; MUTAGENICITY; NONHUMAN; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL; TARGET ORGAN; TRANSGENIC MOUSE;

ANIMALS; BENZO(A)PYRENE; CARCINOGENS; LAC OPERON; MALE; MICE; MICE, INBRED BALB C; MICE, INBRED DBA; MICE, TRANSGENIC; MUTAGENS; NEOPLASMS, EXPERIMENTAL;

ANIMALIA; MUS MUSCULUS; ZEA MAYS;

EID: 0032574332     PISSN: 00275107     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0027-5107(97)00248-0     Document Type: Article

References (16)

1. Gossen J.A., de Leeuw W.J.F., Tan C.H.T., Lohman P.H.M., Berends F., Knook D.L., Zwarthoff E.C., Vijg J. Efficient rescue of integrated shuttle vectors from transgenic mice: a model for studying mutations in vivo. Proc. Natl. Acad. Sci. U.S.A. 86:1989;7981-7985.
2. Kohler S.W., Provost G.S., Fieck A., Kretz P.L., Bullock W.O., Sorge J.A., Putman D.L., Short J.M. Spectra of spontaneous and mutagen-induced mutations in the lacI gene in transgenic mice. Proc. Natl. Acad. Sci. U.S.A. 88:1991;7958-7962.
3. Myhr B.C. Validation studies with Muta™Mouse: a transgenic mouse model for detecting mutations in vivo. Environ. Mol. Mutagen. 18:1991;308-315.
4. Tao K.S., Urlando C., Heddle J.A. Comparison of somatic mutation in a transgenic vs. host locus. Proc. Natl. Acad. Sci. U.S.A. 90:1993;10681-10685.
5. Morrison V., Ashby J. A preliminary evaluation of the performance of the Muta™Mouse (lacZ) and Big Blue™ (lacI) transgenic mouse mutation assays. Mutagenesis. 9:1994;367-375.
6. Gonzalez F.J. Use of transgenic animals in carcinogenesis studies. Mol. Carcinog. 16:1996;63-67.
7. Heddle J.A., Swiger R.R. Risk estimation from somatic mutation assays. Mutat. Res. 365:1996;107-117.
8. Mientjes E.J., van Delft J.H.M., op't Hof B.M., Gossen J.A., Vijg J., Lohman P.H.M., Baan R.A. An improved selection method for λlacZ phages based on galactose sensitivity. Transgenic Res. 3:1994;67-69.
9. Mientjes E.J., Steenwinkel M.-J.S.T., van Delft J.H.M., Lohman P.H.M., Baan R.A. Comparison of the X-gal- and P-gal-based systems for screening of mutant λlacZ phages originating from the transgenic mouse strain 40.6. Mutat. Res. 360:1996;101-106.
10. Collaborative Study Group for the Transgenic Mouse Mutation Assay Organ variation in the mutagenicity of ethylnitrosorea in Muta™Mouse: results of the collaborative study on the transgenic mutation assay by JEMS/MMS. Environ. Mol. Mutagen. 28:1996;363-375.
11. IARC, IARC Monographs on the evaluation of the carcinogenic risk of chemicals to man: certain polycyclic aromatic hydrocarbons and heterocyclic compounds, Lyon, France, IARC, WHO 3 (1973) pp. 91-136.
12. Kulkarni M.S., Anderson M.W. Persistence of benzo(a)pyrene metabolite: DNA adducts in lung and liver of mice. Cancer Res. 44:1984;97-101.
13. Stowers S.J., Anderson M.W. Ubiquitous binding of benzo(a)pyrene metabolites to DNA and protein in tissues of the mouse and rabbit. Chem. Biol. Interact. 51:1984;151-166.
14. Stowers S.J., Anderson M.W. Formation and persistence of benzo(a)pyrene metabolite-DNA adducts. Environ. Health Perspect. 62:1985;31-39.
15. 32P-Postlabeling assay in mice of transplacental DNA damage induced by the environmental carcinogens safrole, 4-aminobiphenyl, and benzo(a)pyrene. Cancer Res. 46:1986;3046-3054.
16. Schurdak M.E., Randerath K. Effect of route of administration on tissue distribution of DNA adducts in mice: comparison of 7H-dibenzo(c,g)carbazole, benzo(a)pyrene, and 2-acetylaminofluorene. Cancer Res. 49:1989;2633-2638.