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Volumn 12, Issue 4 SUPPL., 2010, Pages

Impact of gene patents and licensing practices on access to genetic testing for inherited susceptibility to cancer: Comparing breast and ovarian cancers with colon cancers

Author keywords

APC; BRCA; Breast cancer; Colon cancer; Colorectal cancer; Familial adenomatous polyposis; FAP; Genetic testing; Intellectual property; Lynch syndrome; MSH; Myriad Genetics; Patents

Indexed keywords

BRCA1 PROTEIN; BRCA2 PROTEIN; DNA;

EID: 77951479651     PISSN: 10983600     EISSN: None     Source Type: Journal    
DOI: 10.1097/GIM.0b013e3181d5a67b     Document Type: Review
Times cited : (47)

References (122)
  • 1
    • 77951474905 scopus 로고    scopus 로고
    • Washington DC: National Academies November 18, 2009
    • Rusconi W. Patenting and licensing of the breast cancer susceptibility genes\BRCA1 and BRCA2. Washington, DC: National Academies, 2005. Available at: http://www.genome.duke.edu/centers/cpg/documents/project1/clinical-genetic- testing/NAS%20Patents%20and%20BRCA%202-11-2005%20%282%29.pdf. Accessed November 18, 2009.
    • (2005) Patenting and Licensing of the Breast Cancer Susceptibility genes\BRCA1 and BRCA2
    • Rusconi, W.1
  • 2
    • 84876083286 scopus 로고    scopus 로고
    • National Human Genome Research Institute September 25, 2008
    • National Human Genome Research Institute. Breast cancer information core. Available at: http://research.nhgri.nih.gov/bic/. Accessed September 25, 2008.
    • Breast Cancer Information Core.
  • 3
    • 15844409188 scopus 로고    scopus 로고
    • Architectures of genetic medicine: Comparing genetic testing for breast cancer in the USA and the UK
    • DOI 10.1177/0306312705047172
    • Parthasarathy S. Architectures of genetic medicine: comparing genetic testing for breast cancer in the USA and UK. Soc Stud Med 2005;35:5-40. (Pubitemid 40427611)
    • (2005) Social Studies of Science , vol.35 , Issue.1 , pp. 5-40
    • Parthasarathy, S.1
  • 4
    • 0002152982 scopus 로고    scopus 로고
    • Myriad Genetics, U.S. National Cancer Institute Salt Lake, Utah: Myriad Genetics
    • Myriad Genetics, U.S. National Cancer Institute. Memorandum of understanding. Salt Lake, Utah: Myriad Genetics, 1999.
    • (1999) Memorandum of Understanding
  • 7
    • 59849108362 scopus 로고    scopus 로고
    • Recommendations from the EGAPP Working Group: Genetic testing strategies in newly diagnosed individuals with colorectal cancer aimed at reducing morbidity and mortality from Lynch syndrome relatives
    • Evaluation of Genomic Applications in Practice and Prevention (EGAPP) Working Group
    • Evaluation of Genomic Applications in Practice and Prevention (EGAPP) Working Group. Recommendations from the EGAPP Working Group: genetic testing strategies in newly diagnosed individuals with colorectal cancer aimed at reducing morbidity and mortality from Lynch syndrome relatives. Genet Med 2009;11:35-41.
    • (2009) Genet Med , vol.11 , pp. 35-41
  • 8
    • 59849129653 scopus 로고    scopus 로고
    • EGAPP supplementary evidence review: DNA testing strategies aimed at reducing morbidity and mortality from Lynch syndrome
    • Palomaki GE, McClain MR, Melillo S, Hampel HL, Thibodeau SN. EGAPP supplementary evidence review: DNA testing strategies aimed at reducing morbidity and mortality from Lynch syndrome. Genet Med 2009; 11:42-65.
    • (2009) Genet Med , vol.11 , pp. 42-65
    • Palomaki, G.E.1    McClain, M.R.2    Melillo, S.3    Hampel, H.L.4    Thibodeau, S.N.5
  • 9
    • 33645084562 scopus 로고    scopus 로고
    • Spectrum of mutations in BRCA1, BRCA2, CHEK2, and TP53 in families at high risk of breast cancer
    • Walsh T, Casadei S, Coats KH, et al. Spectrum of mutations in BRCA1, BRCA2, CHEK2, and TP53 in families at high risk of breast cancer. JAMA 2006;295:1379-1388.
    • (2006) JAMA , vol.295 , pp. 1379-1388
    • Walsh, T.1    Casadei, S.2    Coats, K.H.3
  • 10
    • 77951433748 scopus 로고    scopus 로고
    • Washington, DC: House Judiciary Subcommittee on Courts, the Internet and Intellectual Property March 2, 2010
    • Statement of Marc Grodman at stifling or stimulating\the role of gene patents in research and genetic testing. Washington, DC: House Judiciary Subcommittee on Courts, the Internet and Intellectual Property, 2007. Available at: http://judiciary.house.gov/hearings/pdf/Grodman071030.pdf. Accessed March 2, 2010.
    • (2007) Statement of Marc Grodman at Stifling or Stimulating\the Role of Gene Patents in Research and Genetic Testing
  • 12
    • 77951452617 scopus 로고    scopus 로고
    • Detection of large rearrangement mutations in BRCA1 and BRCA2 in 528 high risk families from North America by quantitative PCR based gene dose analysis
    • Toronto Canada July 11, 2008
    • Judkins T, Hendrickson BC, Gonzales D, et al. Detection of large rearrangement mutations in BRCA1 and BRCA2 in 528 high risk families from North America by quantitative PCR based gene dose analysis. Paper presented at American Society of Human Genetics 54th Annual Meeting. Toronto, Canada, 2004. Available at: http://www.ashg.org/genetics/abstracts/abs04/f518.htm. Accessed July 11, 2008.
    • (2004) Paper Presented at American Society of Human Genetics 54th Annual Meeting
    • Judkins, T.1    Hendrickson, B.C.2    Gonzales, D.3
  • 13
    • 28744446802 scopus 로고    scopus 로고
    • Large BRCA1 gene deletions are found in 3% of German high-risk breast cancer families
    • Hartmann C, John A, Klaes R, et al. Large BRCA1 gene deletions are found in 3% of German high-risk breast cancer families. Hum Mutat 2004;24:534.
    • (2004) Hum Mutat , vol.24 , pp. 534
    • Hartmann, C.1    John, A.2    Klaes, R.3
  • 14
    • 77951427890 scopus 로고    scopus 로고
    • Recurrent intragenic rearrangement mutations in the tumor suppressor gene BRCA1: Prevalence results from 12,272 patients at high risk for breast and/or ovarian cancers and methods of biochemical analysis
    • Paper Presented at New Orleans, la
    • Hendrickson B, Judkins T, Deffenbaugh A, Pyne K, Ward B, Scholl T. Recurrent intragenic rearrangement mutations in the tumor suppressor gene BRCA1: Prevalence results from 12,272 patients at high risk for breast and/or ovarian cancers and methods of biochemical analysis. Paper presented at 40th Annual Meeting of the American Society of Clinical Oncology. New Orleans, LA, 2004.
    • (2004) 40th Annual Meeting of the American Society of Clinical Oncology
    • Hendrickson, B.1    Judkins, T.2    Deffenbaugh, A.3    Pyne, K.4    Ward, B.5    Scholl, T.6
  • 15
    • 77951445045 scopus 로고    scopus 로고
    • Clinical testing experience for large genomic rearrangements in the BRCA1 and BRCA2 genes for hereditary breast and ovarian cancer
    • San Diego, CA October
    • Spence W, Judkins T, Schoenberger J, et al. Clinical testing experience for large genomic rearrangements in the BRCA1 and BRCA2 genes for hereditary breast and ovarian cancer. Paper presented at American Society for Human Genetics Meeting. San Diego, CA, October 23-27, 2007.
    • (2007) Paper Presented at American Society for Human Genetics Meeting , pp. 23-27
    • Spence, W.1    Judkins, T.2    Schoenberger, J.3
  • 18
    • 77951460353 scopus 로고    scopus 로고
    • Genetic Technologies Limited. Public announcement for "personal use only." November 8, 2008
    • Genetic Technologies Limited. Further clarifications on BRCA testing. Public announcement for "personal use only." Available at: http://www.gtg. com.au/index.asp?menuid=060.070.130&artid= 10740&function=NewsArticle.Accessed November 8, 2008.
    • Further Clarifications on BRCA Testing
  • 21
    • 63449110558 scopus 로고    scopus 로고
    • The impact of human gene patents on innovation and access: A survey of human gene patent litigation
    • Holman CM. The impact of human gene patents on innovation and access: a survey of human gene patent litigation. UMKC Law Review 2007;76: 295-361.
    • (2007) UMKC Law Review , vol.76 , pp. 295-361
    • Holman, C.M.1
  • 23
    • 0037086542 scopus 로고    scopus 로고
    • Utilization of BRCA1/2 genetic testing in the clinical setting: Report from a single institution
    • DOI 10.1002/cncr.10420
    • Lee S, Bernhardt B, Helzlsouer K. Utilization of BRCA1/2 genetic testing in the clinical setting: report from a single institution. Cancer 2002;94: 1876-1885. (Pubitemid 34241127)
    • (2002) Cancer , vol.94 , Issue.6 , pp. 1876-1885
    • Lee, S.-C.1    Bernhardt, B.A.2    Helzlsouer, K.J.3
  • 25
    • 77951479701 scopus 로고    scopus 로고
    • Agency for Healthcare Research Rockville, MD: Agency for Healthcare Research and Quality, January 9 Accessed May 2007
    • Agency for Healthcare Research. Genetic tests for cancer: technology assessment. Rockville, MD: Agency for Healthcare Research and Quality, January 9, 2006. Available at: http://www.ahrq.gov/clinic/ta/gentests/gentests.pdf. Accessed May 5, 2007.
    • (2006) Genetic Tests for Cancer: Technology Assessment , vol.5
  • 26
    • 34247560762 scopus 로고    scopus 로고
    • American Cancer Society Accessed March 10 2010
    • American Cancer Society. Cancer facts and figures 2007. Available at: http://www.cancer.org/downloads/STT/CAFF2007PWsecured.pdf. Accessed March 10, 2010.
    • (2007) Cancer Facts and Figures
  • 27
    • 0003619249 scopus 로고    scopus 로고
    • American Cancer Society Accessed March 10 2010
    • American Cancer Society. Breast cancer facts and figures, 2005-2006. Available at: http://www.cancer.org/downloads/STT/CAFF2005BrF.pdf. Accessed March 10, 2010.
    • Breast Cancer Facts and Figures 2005-2006
  • 31
    • 77951470129 scopus 로고    scopus 로고
    • OncorMed June 30 1998. Gaithersburg, MD: OncorMed Accessed March 9 2010
    • OncorMed. SEC EDGAR filing information: form 10-Q\quarterly report, June 30 1998. Gaithersburg, MD: OncorMed, 1998. Available at: http://www.sec.gov/ Archives/edgar/data/922821/0000950133-98-003049.txt. Accessed March 9 2010.
    • (1998) SEC EDGAR Filing Information: Form 10-Q\quarterly Report
  • 32
    • 77951430807 scopus 로고    scopus 로고
    • OncorMed July 07 1998. Gaithersburg, MD: OncorMed Accessed March 9 2010
    • OncorMed. SEC EDGAR filing information: form 8-K\current report, July 07 1998. Gaithersburg, MD: OncorMed, 1998. Available at: http://www.sec.gov/ Archives/edgar/data/922821/0000950133-98-002539.txt. Accessed March 9 2010.
    • (1998) SEC EDGAR Filing Information: Form 8-K\current Report
  • 33
    • 77951451295 scopus 로고    scopus 로고
    • OncorMed September 30 1998. Gaithersburg, MD: OncorMed Accessed March 9 2010
    • OncorMed. SEC EDGAR Filing Information: form 15-12B\securities registration termination September 30, 1998. Gaithersburg, MD: OncorMed, 1998. Available at: http://www.sec.gov/Archives/edgar/data/922821/0000936392-98- 001309.txt. Accessed March 9, 2010.
    • (1998) SEC EDGAR Filing Information: Form 15-12B\securities Registration Termination
  • 34
    • 77951454005 scopus 로고    scopus 로고
    • Myriad Genetics: In the eye of the policy storm
    • GoldER, Carbone J. Myriad Genetics: in the eye of the policy storm. Genet Med 2010;12(suppl):S39-S70.
    • (2010) Genet Med , vol.12 , Issue.SUPPL
    • Gold, E.R.1    Carbone, J.2
  • 36
    • 77951431509 scopus 로고    scopus 로고
    • Baylor College of Medicine Medical Genetics Laboratories Accessed June 6 2008
    • Baylor College of Medicine Medical Genetics Laboratories. Prices and CPT codes. Available at: http://www.bcm.edu/geneticlabs/cptcodes.html. Accessed June 6, 2008.
    • Prices and CPT Codes
  • 39
    • 24644456397 scopus 로고    scopus 로고
    • Genetic risk assessment and BRCA mutation testing for breast and ovarian cancer susceptibility
    • United States Preventative Services Task Force
    • United States Preventative Services Task Force. Genetic risk assessment and BRCA mutation testing for breast and ovarian cancer susceptibility. Ann Intern Med 2005;143:355-361.
    • (2005) Ann Intern Med , vol.143 , pp. 355-361
  • 40
    • 39649088738 scopus 로고    scopus 로고
    • Hereditary nonpolyposis colorectal cancer: Diagnostic strategies and their implications
    • prepared by Tufts-New England Medical Center Evidence-based Practice Center under Contract No. 290-02-0022. Rockville, MD: Agency for Healthcare Research, May Accessed June 4 2008
    • Bonis P, Trikalinos T, Chung M, et al. Hereditary nonpolyposis colorectal cancer: diagnostic strategies and their implications. Evidence report/technology assessment No.150 prepared by Tufts-New England Medical Center Evidence-based Practice Center under Contract No. 290-02-0022. Rockville, MD: Agency for Healthcare Research, May 2007. Available at: http://www.ahrq.gov/ downloads/pub/evidence/pdf/hnpcc/hnpcc.pdf Accessed June 4, 2008.
    • (2007) Evidence Report/technology Assessment No. 150
    • Bonis, P.1    Trikalinos, T.2    Chung, M.3
  • 46
    • 0345832168 scopus 로고    scopus 로고
    • Screening and primary and secondary interventions for patients at high risk for ovarian cancer
    • Goldman NA, Restivo A, Goldberg GL. Screening and primary and secondary interventions for patients at high risk for ovarian cancer. Wom Oncol Rev 2003;3:269-274. (Pubitemid 38088444)
    • (2003) Women's Oncology Review , vol.3 , Issue.4 , pp. 269-274
    • Goldman, N.A.1    Restivo, A.2    Goldberg, G.L.3
  • 47
    • 0041765746 scopus 로고    scopus 로고
    • Managed care in the genomics era: Assessing the cost effectiveness of genetic tests
    • Higashi M, Veenstra D. Managed care in the genomics era: assessing the cost effectiveness of genetic tests. Am JManag Care 2003;9:493-500. (Pubitemid 36949536)
    • (2003) American Journal of Managed Care , vol.9 , Issue.7 , pp. 493-500
    • Higashi, M.K.1    Veenstra, D.L.2
  • 48
    • 33744810358 scopus 로고    scopus 로고
    • Comprehensive cost-utility analysis of newborn screening strategies
    • DOI 10.1542/peds.2005-2633H
    • Carroll A, Downs S. Comprehensive cost-utility analysis of newborn screening strategies. Pediatrics 2006;117(5 Pt 2):S287-S295. (Pubitemid 46071316)
    • (2006) Pediatrics , vol.117 , Issue.5
    • Carroll, A.E.1    Downs, S.M.2
  • 52
    • 77951471908 scopus 로고    scopus 로고
    • Agency for Healthcare Research Rockville, MD: Agency for Healthcare Research, July Accessed March 9 2010
    • Agency for Healthcare Research. U.S. Preventive Services Task Force: chemoprevention: breast cancer. Rockville, MD: Agency for Healthcare Research, July 2002 http://www.ahrq.gov/clinic/uspstf/uspsbrpv.htm. Accessed March 9 2010.
    • (2002) U.S. Preventive Services Task Force: Chemoprevention: Breast Cancer
  • 54
    • 0034955851 scopus 로고    scopus 로고
    • AGA technical review on hereditary colorectal cancer and genetic testing
    • American Gastroenterological Association. AGA technical review on hereditary colorectal cancer and genetic testing. Gastroenterology 2001;121: 198-213. (Pubitemid 32591530)
    • (2001) Gastroenterology , vol.121 , Issue.1 , pp. 198-213
    • Giardiello, F.M.1    Brensinger, J.D.2    Petersen, G.M.3
  • 56
    • 0032533172 scopus 로고    scopus 로고
    • Benefits of colonoscopic surveillance and prophylactic colectomy in patients with hereditary nonpolyposis colorectal cancer mutations
    • Syngal S, Weeks J, Schrag D, Garber J, Kuntz K. Benefits of colonoscopic surveillance and prophylactic colectomy in patients with hereditary nonpolyposis colorectal cancer mutations. Ann Intern Med 1998;192:787-796. (Pubitemid 28522813)
    • (1998) Annals of Internal Medicine , vol.129 , Issue.10 , pp. 787-796
    • Syngal, S.1    Weeks, J.C.2    Schrag, D.3    Garber, J.E.4    Kuntz, K.M.5
  • 57
    • 0042028293 scopus 로고    scopus 로고
    • Parameters for the treatment of patients with dominantly inherited colorectal cancer (familial adenomatous polyposis and hereditary nonpolyposis colorectal cancer)
    • American Society of Colon and Rectal Surgeons. Collaborative Group of the Americas on Inherited Colorectal Cancer and the Standards Committee of The American Society of Colon and Rectal Surgeons.
    • Church J, Simmang C, Standards Task Force, American Society of Colon and Rectal Surgeons, Collaborative Group of the Americas on Inherited Colorectal Cancer and the Standards Committee of The American Society of Colon and Rectal Surgeons. Parameters for the treatment of patients with dominantly inherited colorectal cancer (familial adenomatous polyposis and hereditary nonpolyposis colorectal cancer). Dis Colon Rectum 2003; 46:1001-1012.
    • (2003) Dis Colon Rectum , vol.46 , pp. 1001-1012
    • Church, J.1    Simmang, C.2    Task Force, S.3
  • 58
    • 0032912161 scopus 로고    scopus 로고
    • Disease gene patents: Overcoming unethical constraints on clinical laboratory medicine
    • Merz J. Disease gene patents: overcoming unethical constraints on clinical laboratory medicine. Clin Chem 1999;45:324-330.
    • (1999) Clin Chem , vol.45 , pp. 324-330
    • Merz, J.1
  • 59
    • 77951441130 scopus 로고    scopus 로고
    • Genetic tests for cancer not perfect
    • March 21
    • Doheny K. Genetic tests for cancer not perfect. HealthDay. March 21, 2006.
    • (2006) HealthDay
    • Doheny, K.1
  • 62
    • 77951428626 scopus 로고    scopus 로고
    • Myriad Genetics Laboratories December 19 2007
    • Myriad Genetics Laboratories. BRACAnalysis® technical specifications. Available at: http://www.myriadtests.com/provider/doc/tech-specs-brac. pdf Accessed December 19, 2007.
    • BRACAnalysis® Technical Specifications
  • 63
    • 77951464000 scopus 로고    scopus 로고
    • FDA approves study for breast cancer risk test by InterGenetics
    • September 20
    • Page D. FDA approves study for breast cancer risk test by InterGenetics. Journal Record. September 20, 2006.
    • (2006) Journal Record
    • Page, D.1
  • 65
    • 3242743707 scopus 로고    scopus 로고
    • Genetic testing and pharmacogenomics: Issues for determining the impact of healthcare delivery and costs
    • Phillips K, Veenstra D, Ramsey S, Van Bebber S, Sakowski J. Genetic testing and pharmacogenomics: issues for determining the impact of healthcare delivery and costs. Am J Manag Care 2004;10:425-432.
    • (2004) Am J Manag Care , vol.10 , pp. 425-432
    • Phillips, K.1    Veenstra, D.2    Ramsey, S.3    Van Bebber, S.4    Sakowski, J.5
  • 66
    • 77951461112 scopus 로고    scopus 로고
    • Myriad Genetics Accessed July 12 2008
    • Myriad Genetics. Myriad reimbursement assistance program. Available at: http://myriadtests.com/mrap.htm. Accessed July 12, 2008.
    • Myriad Reimbursement Assistance Program
  • 68
    • 77951488194 scopus 로고    scopus 로고
    • Perlegen eyes first-half 2009 launch of breast cancer Dx panel
    • September
    • Winnick E. Perlegen eyes first-half 2009 launch of breast cancer Dx panel. GenomeWeb News. September 25, 2008.
    • (2008) GenomeWeb News , vol.25
    • Winnick, E.1
  • 69
    • 77649143688 scopus 로고    scopus 로고
    • My genome, my self
    • January 7 Accessed January
    • Pinker S. My genome, my self. New York Times Magazine. January 7, 2009. Available at: http://www.nytimes.com/2009/01/11/magazine/11Genome-t. html?-r=2&scp=1&sq=pinker&st=cse. Accessed January 21, 2009.
    • (2009) New York Times Magazine , vol.21 , pp. 2009
    • Pinker, S.1
  • 70
    • 77951436054 scopus 로고    scopus 로고
    • Genetic technologies and breast cancer
    • October 27
    • O'Connor M. Genetic technologies and breast cancer. Courier-Mail. October 27, 2008.
    • (2008) Courier-Mail
    • O'Connor, M.1
  • 71
    • 77951434128 scopus 로고    scopus 로고
    • Call to act on breast cancer test
    • October 28
    • Shanahan L. Call to act on breast cancer test. The Age. October 28, 2008.
    • (2008) The Age
    • Shanahan, L.1
  • 72
    • 77951427176 scopus 로고    scopus 로고
    • Company seeks to monopolise breast cancer test
    • October 23 Accessed March 3 2010
    • Macey J. Company seeks to monopolise breast cancer test. ABC News Radio: The World Today. October 23, 2008. Available at: http://www.abc.net.au/news/ stories/2008/10/23/2399406.htm?site=news. Accessed March 3, 2010.
    • (2008) ABC News Radio: The World Today
    • MacEy, J.1
  • 74
    • 77951430078 scopus 로고    scopus 로고
    • A price on your genes
    • July 30
    • Cresswell A. A price on your genes. The Australian. July 30, 2008.
    • (2008) The Australian
    • Cresswell, A.1
  • 75
    • 77951439718 scopus 로고    scopus 로고
    • Consumer watchdog investigates gene company
    • October 23 Accessed November 8 2008
    • Macey J. Consumer watchdog investigates gene company. The World Today. October 23, 2008. Available at: http://www.abc.net.au/worldtoday/content/2008/ s2399139.htm. Accessed November 8, 2008.
    • (2008) The World Today
    • MacEy, J.1
  • 76
    • 77951440056 scopus 로고    scopus 로고
    • Examination of budget estimates 2008-2009. Additional information received. Health and ageing portfolio
    • December
    • Examination of budget estimates 2008-2009. Additional information received. Health and ageing portfolio. Community Affairs Committee, December 3, 2008.
    • Community Affairs Committee , vol.3 , pp. 2008
  • 79
    • 0034059965 scopus 로고    scopus 로고
    • Genetic testing, ethical concerns, and the role of patent law
    • Caulfield T, Gold ER. Genetic testing, ethical concerns, and the role of patent law. Clin Genet 2000;57:370-375.
    • (2000) Clin Genet , vol.57 , pp. 370-375
    • Caulfield, T.1    Gold, E.R.2
  • 80
    • 3142697174 scopus 로고    scopus 로고
    • Genetic testing for breast and ovarian cancer susceptibility: Evaluating direct-to-consumer marketing\Atlanta, Denver, Raleigh-Durham, and Seattle 2003
    • Centers for Disease Control and Prevention
    • Centers for Disease Control and Prevention. Genetic testing for breast and ovarian cancer susceptibility: evaluating direct-to-consumer marketing\Atlanta, Denver, Raleigh-Durham, and Seattle 2003. MMWR Morbid Mort Wkly Rep 2004; 53:603-606.
    • (2004) MMWR Morbid Mort Wkly Rep , vol.53 , pp. 603-606
  • 81
    • 20144389234 scopus 로고    scopus 로고
    • Impact of direct-to-consumer advertising for hereditary breast cancer testing on genetic services at a managed care organization: A naturally occurring experiment
    • Mouchawar J, Hensley-Alford S, Laurion S, et al. Impact of direct-to-consumer advertising for hereditary breast cancer testing on genetic services at a managed care organization: a naturally occurring experiment. Genet Med 2006;7:191-197.
    • (2006) Genet Med , vol.7 , pp. 191-197
    • Mouchawar, J.1    Hensley-Alford, S.2    Laurion, S.3
  • 82
    • 27344450445 scopus 로고    scopus 로고
    • Assessing controversial direct-to-consumer advertising for hereditary breast cancer testing: Reactions from women and their physicians in a managed care organization
    • Mouchawar J, Laurion S, RitzwollerD, Ellis J, Kulchak-Rahm A, Hensley-Alford S. Assessing controversial direct-to-consumer advertising for hereditary breast cancer testing: reactions from women and their physicians in a managed care organization. Am J Manag Care 2005;11:601-608.
    • (2005) Am J Manag Care , vol.11 , pp. 601-608
    • Mouchawar, J.1    Laurion, S.2    Ritzwollerd Ellis, J.3    Kulchak-Rahm, A.4    Hensley-Alford, S.5
  • 83
    • 16444378786 scopus 로고    scopus 로고
    • Utilization of BRCA1/BRCA2 mutation testing in newly diagnosed breast cancer patients
    • Schwartz M, Lerman C, Brogan B, et al. Utilization of BRCA1/BRCA2 mutation testing in newly diagnosed breast cancer patients. Cancer Epidemiol Biomarkers Prev 2005;14:1003-1007.
    • (2005) Cancer Epidemiol Biomarkers Prev , vol.14 , pp. 1003-1007
    • Schwartz, M.1    Lerman, C.2    Brogan, B.3
  • 85
    • 77951485550 scopus 로고    scopus 로고
    • Myriad Genetics Accessed November 15 2009
    • Myriad Genetics. Myriad Genetics reports results for third quarter of fiscal 2008. Available at: http://investor.myriad.com/releasedetail.cfm? ReleaseID=325474. Accessed November 15, 2009.
    • (2008) Myriad Genetics Reports Results for Third Quarter of Fiscal
  • 86
    • 26044455928 scopus 로고    scopus 로고
    • Writing effective insurance justification letters for cancer genetic testing: A streamlined approach
    • Shappell HL, Matloff ET. Writing effective insurance justification letters for cancer genetic testing: a streamlined approach. J Genet Couns 2001; 10:331-341.
    • (2001) J Genet Couns , vol.10 , pp. 331-341
    • Shappell, H.L.1    Matloff, E.T.2
  • 87
    • 34147142403 scopus 로고    scopus 로고
    • The role of financial factors in acceptance of clinical BRCA genetic testing
    • Kieran S, Loescher L, Lim K. The role of financial factors in acceptance of clinical BRCA genetic testing. Genet Test 2007;11:101-110.
    • (2007) Genet Test , vol.11 , pp. 101-110
    • Kieran, S.1    Loescher, L.2    Lim, K.3
  • 89
    • 0034124104 scopus 로고    scopus 로고
    • Current national health insurance coverage policies for breast and ovarian cancer prophylactic surgery
    • Kuerer H, Hwang E, Anthony J, et al. Current national health insurance coverage policies for breast and ovarian cancer prophylactic surgery. Ann Surg Oncol 2000;7:325-332.
    • (2000) Ann Surg Oncol , vol.7 , pp. 325-332
    • Kuerer, H.1    Hwang, E.2    Anthony, J.3
  • 90
    • 18544381115 scopus 로고    scopus 로고
    • Insurance reimbursement for risk-reducing mastectomy and oophorectomy in women with BRCA1 or BRCA2 mutations
    • Kauff N, Scheuer L, Robson M, et al. Insurance reimbursement for risk-reducing mastectomy and oophorectomy in women with BRCA1 or BRCA2 mutations. Genet Med 2001;3:422-425.
    • (2001) Genet Med , vol.3 , pp. 422-425
    • Kauff, N.1    Scheuer, L.2    Robson, M.3
  • 92
    • 77951429709 scopus 로고    scopus 로고
    • NCBI Sequence Viewer Accessed June 1 2007
    • NCBI Sequence Viewer. Homo sapiens breast cancer 1. Available at: http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NG-005905.1&from= 10511&to=91665&dopt=gb. Accessed June 1, 2007.
    • Homo Sapiens Breast Cancer 1
  • 93
    • 77951479690 scopus 로고    scopus 로고
    • NCBI Sequence Viewer Accessed June 1 2007
    • NCBI Sequence Viewer. Homo sapiens chromosome 13, reference assembly. Available at: http://www.ncbi.nlmnih.gov/entrez/viewer.fcgi?val=NC-000013. 9&from=31787617&to=31871809&dopt=gb. Accessed June 1,2007.
    • Homo Sapiens Chromosome 13, Reference Assembly
  • 94
    • 77951471151 scopus 로고    scopus 로고
    • NCBI Sequence Viewer Accessed March 3 2010
    • NCBI Sequence Viewer. Homo sapiens chromosome 5, reference assembly. Available at: http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NC- 000005.8&from=112101483&to=112209835&dopt=gb. Accessed March 3, 2010.
    • Homo Sapiens Chromosome 5, Reference Assembly
  • 95
    • 77951494816 scopus 로고    scopus 로고
    • NCBI Sequence Viewer Accessed March 3 2010
    • NCBI Sequence Viewer. Homo sapiens chromosome 3, reference assembly. Available at: http://www.ncbi.nlmnih.gov/entrez/viewer.fcgi?val=NC-000002. 10&from=47483767&to=47563864&dopt=gb. Accessed March 3, 2010.
    • Homo Sapiens Chromosome 3, Reference Assembly
  • 96
    • 77951429002 scopus 로고    scopus 로고
    • NCBI Sequence Viewer Accessed March 3 2010
    • NCBI Sequence Viewer. Homo sapiens chromosome 2, reference assembly. Available at: http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NC-000002. 10&from=47863790&to=47887596&dopt=gb. Accessed March 3, 2010.
    • Homo Sapiens Chromosome 2, Reference Assembly
  • 97
    • 0033974611 scopus 로고    scopus 로고
    • Prevention with tamoxifen or other hormones versus prophylactic surgery in BRCA1/2-positive women: A decision analysis
    • Grann V, Jacobson J, Whang W, et al. Prevention with tamoxifen or other hormones versus prophylactic surgery in BRCA1/2-positive women: a decision analysis. Cancer J Sci Am 2000;6:13-20.
    • (2000) Cancer J Sci Am , vol.6 , pp. 13-20
    • Grann, V.1    Jacobson, J.2    Whang, W.3
  • 98
    • 0036138716 scopus 로고    scopus 로고
    • Outcomes of tamoxifen chemoprevention for breast cancer in very high-risk women: A cost-effectiveness analysis
    • Hershman D, Sundararajan V, Jacobson J, Heitjan D, Neugut A, Grann V. Outcomes of tamoxifen chemoprevention for breast cancer in very high-risk women: a cost-effectiveness analysis. J Clin Oncol 2002;20:9-16.
    • (2002) J Clin Oncol , vol.20 , pp. 9-16
    • Hershman, D.1    Sundararajan, V.2    Jacobson, J.3    Heitjan, D.4    Neugut, A.5    Grann, V.6
  • 100
    • 0031931894 scopus 로고    scopus 로고
    • Decision analysis of prophylactic mastectomy and oophorectomy in BRCA1-positive or BRCA2-positive patients
    • Grann V, Panageas K, Whang W, Antman K, Neugut A. Decision analysis of prophylactic mastectomy and oophorectomy in BRCA1-positive or BRCA2-positive patients. J Clin Oncol 1998;16:979-985.
    • (1998) J Clin Oncol , vol.16 , pp. 979-985
    • Grann, V.1    Panageas, K.2    Whang, W.3    Antman, K.4    Neugut, A.5
  • 101
    • 0033997009 scopus 로고    scopus 로고
    • The cost effectiveness of testing for the BRCA1 and BRCA2 breast-ovarian cancer susceptibility genes
    • Tengs T, Berry D. The cost effectiveness of testing for the BRCA1 and BRCA2 breast-ovarian cancer susceptibility genes. Dis Manag Clin Outcome 2000;1:15-24.
    • (2000) Dis Manag Clin Outcome , vol.1 , pp. 15-24
    • Tengs, T.1    Berry, D.2
  • 102
    • 77951478398 scopus 로고    scopus 로고
    • National Cancer Institute Accessed February 1 2007
    • National Cancer Institute. Learning about colon cancer. Available at: http://www.genome.gov/10000466. Accessed February 1, 2007.
    • Learning about Colon Cancer
  • 103
    • 32544440463 scopus 로고    scopus 로고
    • Colorectal cancer test use among persons aged 50 years\United States 2001
    • Centers for Disease Control
    • Centers for Disease Control. Colorectal cancer test use among persons aged 50 years\United States 2001. MMWR Morbid Mort Wkly Rep 2003; 52:193-196.
    • (2003) MMWR Morbid Mort Wkly Rep , vol.52 , pp. 193-196
  • 104
    • 77951475251 scopus 로고    scopus 로고
    • v. United States Patent and Trademark Office, et al. Civil Action No. 09-4515 (RWS), Southern District of New York (S.D.N.Y.), filed May 12
    • Plaintiffs' Complaint. Association for Molecular Pathology, et al., v. United States Patent and Trademark Office, et al. Civil Action No. 09-4515 (RWS), Southern District of New York (S.D.N.Y.), filed May 12, 2009.
    • (2009) Association for Molecular Pathology, et Al.
    • Complaint, P.1
  • 105
    • 77951440409 scopus 로고    scopus 로고
    • Association for Molecular Pathology, et al. v. United States Patent and Trademark Office, et al. Civil Action No. 09-4515 (RWS), S.D.N.Y., filed July 13
    • Defendant United States Patent and Trademark Office's Memorandum of Law in Support of Motion to Dismiss. Association for Molecular Pathology, et al., v. United States Patent and Trademark Office, et al. Civil Action No. 09-4515 (RWS), S.D.N.Y., filed July 13, 2009.
    • (2009) Defendant United States Patent and Trademark Office's Memorandum of Law in Support of Motion to Dismiss
  • 106
    • 77951459632 scopus 로고    scopus 로고
    • Association for Molecular Pathology, et al. v. United States Patent and Trademark Office, et al. Civil Action No. 09-4515 (RWS), S.D.N.Y.
    • Memorandum of Law in Support of Defendants' Motion to Dismiss. Association for Molecular Pathology, et al., v. United States Patent and Trademark Office, et al. Civil Action No. 09-4515 (RWS), S.D.N.Y. filed July 13
    • (2009) Memorandum of Law in Support of Defendants' Motion to Dismiss
  • 107
    • 77951467933 scopus 로고    scopus 로고
    • Association for Molecular Pathology, et al. v. United States Patent and Trademark Office, et al., Civil Action No. 09-4515 (RWS), S.D.N.Y., filed August 26
    • Plaintiffs' Memorandum of Law in Support of Motion to Conduct Jurisdictional Discovery. Association for Molecular Pathology, et al., v. United States Patent and Trademark Office, et al., Civil Action No. 09-4515 (RWS), S.D.N.Y., filed August 26, 2009.
    • (2009) Plaintiffs' Memorandum of Law in Support of Motion to Conduct Jurisdictional Discovery
  • 108
    • 77951459237 scopus 로고    scopus 로고
    • Association for Molecular Pathology, et al. v. United States Patent and Trademark Office, et al., Civil Action No. 09-4515 (RWS), S.D.N.Y., filed August 26
    • Plaintiffs' Memorandum of Law in Support of Motion for Summary Judgment. Association for Molecular Pathology, et al., v. United States Patent and Trademark Office, et al., Civil Action No. 09-4515 (RWS), S.D.N.Y., filed August 26, 2009.
    • (2009) Plaintiffs' Memorandum of Law in Support of Motion for Summary Judgment
  • 109
    • 77951494101 scopus 로고    scopus 로고
    • Association for Molecular Pathology, et al. v. United States Patent and Trademark Office, et al., Civil Action No. 09-4515 (RWS), S.D.N.Y., filed November 1
    • Order to Deny Defendants' Motion to Dismiss. Association for Molecular Pathology, et al., v. United States Patent and Trademark Office, et al., Civil Action No. 09-4515 (RWS), S.D.N.Y., filed November 1, 2009.
    • (2009) Order to Deny Defendants' Motion to Dismiss
  • 110
    • 77951479121 scopus 로고    scopus 로고
    • Decision of the Technical Board of Appeal 3.3.04 of 13 November 2008 Case No. T 0666/05-3.3.04. European Patent Office Board of Appeals
    • European Patent Office Board of Appeals. Decision of the Technical Board of Appeal 3.3.04 of 13 November 2008, Case No. T 0666/05-3.3.04. European Patent Office Board of Appeals, 2008.
    • (2008) European Patent Office Board of Appeals
  • 111
    • 77951464178 scopus 로고    scopus 로고
    • New European Patent Specification, EP 0 705 903 B2
    • New European Patent Specification, EP 0 705 903 B2.
  • 112
    • 37549036689 scopus 로고    scopus 로고
    • Prevalence of pathogenic BRCA1 mutation carriers in 5 US racial/ethnic groups
    • John EM, Miron A, Gong G, et al. Prevalence of pathogenic BRCA1 mutation carriers in 5 US racial/ethnic groups. JAMA 2007;298:2869-2876.
    • (2007) JAMA , vol.298 , pp. 2869-2876
    • John, E.M.1    Miron, A.2    Gong, G.3
  • 113
    • 36549023516 scopus 로고    scopus 로고
    • The BRCA1 Askhenazi founder mutations occur on common haplotypes and are not highly correlated with anonymous single nucleotide polymorphisms likely to be used in genome-wide case-control association studies
    • Pereira LHM, Pineda MA, Rowe WH, et al. The BRCA1 Askhenazi founder mutations occur on common haplotypes and are not highly correlated with anonymous single nucleotide polymorphisms likely to be used in genome-wide case-control association studies. BMC Genet 2007;8:68.
    • (2007) BMC Genet , vol.8 , pp. 68
    • Pereira, L.H.M.1    Pineda, M.A.2    Rowe, W.H.3
  • 114
    • 77951429001 scopus 로고    scopus 로고
    • Ex-officio licensing in the medical sector: The French model
    • van Overwalle G editor Brussel: Bruylant
    • Zimmeren EV, Requena G. Ex-officio licensing in the medical sector: the French model. In: van Overwalle G, editor. Gene patents and public health. Brussel: Bruylant, 2007:123-147.
    • (2007) Gene Patents and Public Health , pp. 123-147
    • Zimmeren, E.V.1    Requena, G.2
  • 115
    • 77951476655 scopus 로고    scopus 로고
    • The Belgian compulsory license for public health [translation and summary of Debrulle J, de Cort L, Petit M. la licence obligatoire belge pour raisons de sante publique]
    • van Overwalle G, editor Brussel: Bruylant
    • Overwalle GV. The Belgian compulsory license for public health [translation and summary of Debrulle J, De Cort L, Petit M. La licence obligatoire belge pour raisons de sante publique]. In: van Overwalle G, editor. Gene patents and public health. Brussel: Bruylant, 2007:199-209.
    • (2007) Gene Patents and Public Health , pp. 199-209
    • Overwalle, G.V.1
  • 117
    • 77951448139 scopus 로고    scopus 로고
    • Genetic Technologies Limited Accessed March 10 2010
    • Genetic Technologies Limited. New position re BRCA testing http://www.gtglabs.com.au/announcements/new-position-re-brca-testing. Accessed March 10 2010.
    • New Position Re BRCA Testing
  • 122
    • 77951439706 scopus 로고    scopus 로고
    • Patently tricky dispute drags on: Who owns your genes
    • December 12
    • Dayton L. Patently tricky dispute drags on: who owns your genes. The Australian. December 12, 2009.
    • (2009) The Australian
    • Dayton, L.1


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